iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000012325.2	ENSCJAT00000023961.2	ENSCJAP00000022649.2
ENSCJAG00000012325.2	ENSCJAT00000023940.1	ENSCJAP00000022630.1
ENSCJAG00000012325.2	ENSCJAT00000023956.1	ENSCJAP00000022645.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.70e-60	196.9	337	375
UBD/Beta-Prp	1.40e-94	317.6	108	411

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH ++v+++ f s+ ++++s++dD+t++vWD++  ++ k
   Q: 337  GHDNWVRGVLFhSGgKFILSCADDKTLRVWDYKNKRCMK 375
           8**********9888****************99998876 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h s++t v f+p  s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 108  HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 196
           5668888********************************************************************************** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
            s++++p+gd++vs+s+d+ti++w+++tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++t+++  +l++ h++ v+++
   Q: 197  SSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVK-TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE-HEHVVECI 283
           *********************************.*********************************************9.******** PP
   S: 187  sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
           s+ +++                    ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ v f++ +++++s+++D+++r+Wd++++ 
   Q: 284  SWAPESsyssiseatgsetkksgkpgPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKR 372
           ***************************************************************************************** PP
   S: 256  llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           ++ktl+ h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 373  CMKTLNAHEHFVTSLDF-HKTAPYVVTGSVDQTVKVWECR 411
           *****************.99*****************985 PP

Organism

Callithrix jacchus

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. Also required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position.

Protein Sequence
(Fasta)

LLMVKKRREA YKNRAIADYL RSNGYEEAYS VFKKEAELDM NEELDKKYAG LLEKKWTSVI 60
RLQKKVMELE SKLNEAKEEF TSGGPLGQKR DPKEWIPRPP EKYALSGHRS PVTRVIFHPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCCTCCCT CCTCCCTCAC CCCCCTCCCT CCCCCTCCCC CGCCGGTGGA TGTGGAGTGA 60
AGGACGGAAG AGGCCCTGCG GAGGCGGCGG TGCAGCGCTC CGGTAAGGCG GCGCGGGTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-0472--Membrane
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000235--C:astral microtubule
GO:1904115--C:axon cytoplasm
GO:0005938--C:cell cortex
GO:0031252--C:cell leading edge
GO:0005813--C:centrosome
GO:0070062--C:extracellular exosome
GO:0000776--C:kinetochore
GO:0005875--C:microtubule associated complex
GO:0031514--C:motile cilium
GO:0005635--C:nuclear envelope
GO:0048471--C:perinuclear region of cytoplasm
GO:0032420--C:stereocilium
GO:0001675--P:acrosome assembly
GO:0030036--P:actin cytoskeleton organization
GO:0008344--P:adult locomotory behavior
GO:0001667--P:ameboidal-type cell migration
GO:0060117--P:auditory receptor cell development
GO:0048854--P:brain morphogenesis
GO:0051301--P:cell division
GO:0007268--P:chemical synaptic transmission
GO:0090102--P:cochlea development
GO:0021540--P:corpus callosum morphogenesis
GO:0043622--P:cortical microtubule organization
GO:0000132--P:establishment of mitotic spindle orientation
GO:0042249--P:establishment of planar polarity of embryonic epithelium
GO:0021766--P:hippocampus development
GO:0021819--P:layer formation in cerebral cortex
GO:0007611--P:learning or memory
GO:0051661--P:maintenance of centrosome location
GO:0090176--P:microtubule cytoskeleton organization involved in establishment of planar polarity
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0046329--P:negative regulation of JNK cascade
GO:0007405--P:neuroblast proliferation
GO:0050885--P:neuromuscular process controlling balance
GO:0001764--P:neuron migration
GO:0051081--P:nuclear envelope disassembly
GO:0036035--P:osteoclast development
GO:0001961--P:positive regulation of cytokine-mediated signaling pathway
GO:0061003--P:positive regulation of dendritic spine morphogenesis
GO:0040019--P:positive regulation of embryonic development
GO:0009306--P:protein secretion
GO:0043087--P:regulation of GTPase activity
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:0008090--P:retrograde axonal transport
GO:0019226--P:transmission of nerve impulse
GO:0047496--P:vesicle transport along microtubule

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	99.25	0.00e+00	837.00
IUUC-Apl-004024	Anas platyrhynchos	96.34	0.00e+00	831.00
IUUC-Aca-004564	Anolis carolinensis	96.10	0.00e+00	825.00
IUUC-Ago-007862	Ashbya gossypii	26.32	4.00e-36	145.00
IUUC-Acl-008360	Aspergillus clavatus	46.06	3.00e-102	365.00
IUUC-Afl-008502	Aspergillus flavus	45.69	2.00e-94	339.00
IUUC-Afu-008848	Aspergillus fumigatus	46.72	6.00e-104	370.00
IUUC-Ani-009173	Aspergillus nidulans	42.18	1.00e-88	320.00
IUUC-Ang-009873	Aspergillus niger	44.68	4.00e-92	331.00
IUUC-Aor-009973	Aspergillus oryzae	43.58	2.00e-89	322.00
IUUC-Ate-010523	Aspergillus terreus	41.35	5.00e-88	318.00
IUUC-Ame-010969	Astyanax mexicanus	92.44	0.00e+00	802.00
IUUC-Bgr-011972	Blumeria graminis	46.54	3.00e-102	365.00
IUUC-Bta-013106	Bos taurus	97.56	0.00e+00	836.00
IUUC-Bci-013615	Botrytis cinerea	43.61	1.00e-95	343.00
IUUC-Cel-018459	Caenorhabditis elegans	56.20	3.00e-145	508.00
IUUC-Cfa-020749	Canis familiaris	97.56	0.00e+00	836.00
IUUC-Cpo-022371	Cavia porcellus	97.56	0.00e+00	836.00
IUUC-Csa-023524	Chlorocebus sabaeus	99.42	0.00e+00	721.00
IUUC-Cho-024764	Choloepus hoffmanni	89.22	0.00e+00	680.00
IUUC-Cin-025753	Ciona intestinalis	68.86	4.00e-175	607.00
IUUC-Csv-025817	Ciona savignyi	67.32	5.00e-178	616.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	45.86	9.00e-95	340.00
IUUC-Cne-027087	Cryptococcus neoformans	50.39	3.00e-110	391.00
IUUC-Dre-028314	Danio rerio	90.98	0.00e+00	796.00
IUUC-Dno-029050	Dasypus novemcinctus	97.32	0.00e+00	836.00
IUUC-Dor-030222	Dipodomys ordii	89.27	0.00e+00	754.00
IUUC-Dse-031164	Dothistroma septosporum	42.62	3.00e-99	355.00
IUUC-Dme-031745	Drosophila melanogaster	67.88	9.00e-167	579.00
IUUC-Ete-032508	Echinops telfairi	99.64	6.00e-169	586.00
IUUC-Eca-034288	Equus caballus	99.50	0.00e+00	830.00
IUUC-Eeu-034984	Erinaceus europaeus	89.02	0.00e+00	750.00
IUUC-Fca-036498	Felis catus	97.56	0.00e+00	836.00
IUUC-Fal-036920	Ficedula albicollis	96.34	0.00e+00	831.00
IUUC-Fox-037996	Fusarium oxysporum	45.45	1.00e-101	363.00
IUUC-Fso-038160	Fusarium solani	43.26	2.00e-96	346.00
IUUC-Gmo-038983	Gadus morhua	91.46	0.00e+00	790.00
IUUC-Ggr-040051	Gaeumannomyces graminis	46.11	2.00e-96	345.00
IUUC-Gga-040623	Gallus gallus	96.34	0.00e+00	831.00
IUUC-Gac-041613	Gasterosteus aculeatus	90.49	0.00e+00	788.00
IUUC-Ggo-045410	Gorilla gorilla	89.22	0.00e+00	725.00
IUUC-Hsa-046358	Homo sapiens	97.32	0.00e+00	835.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	97.56	0.00e+00	836.00
IUUC-Kpa-049351	Komagataella pastoris	28.67	2.00e-41	163.00
IUUC-Lch-049936	Latimeria chalumnae	94.39	0.00e+00	813.00
IUUC-Loc-052476	Lepisosteus oculatus	95.99	0.00e+00	804.00
IUUC-Lma-053170	Leptosphaeria maculans	48.42	5.00e-99	354.00
IUUC-Laf-053713	Loxodonta africana	98.29	0.00e+00	838.00
IUUC-Mcc-054628	Macaca mulatta	97.07	0.00e+00	833.00
IUUC-Meu-055927	Macropus eugenii	86.28	3.00e-140	490.00
IUUC-Mor-056962	Magnaporthe oryzae	44.12	2.00e-95	342.00
IUUC-Mpo-057583	Magnaporthe poae	46.15	4.00e-92	331.00
IUUC-Mla-058819	Melampsora laricipopulina	47.19	1.00e-115	409.00
IUUC-Mga-059945	Meleagris gallopavo	96.10	0.00e+00	830.00
IUUC-Mvi-060403	Microbotryum violaceum	48.54	1.00e-124	439.00
IUUC-Mmr-061289	Microcebus murinus	98.77	0.00e+00	836.00
IUUC-Mdo-061912	Monodelphis domestica	96.83	0.00e+00	830.00
IUUC-Mmu-063253	Mus musculus	97.56	0.00e+00	836.00
IUUC-Mpu-066638	Mustela putorius furo	97.56	0.00e+00	836.00
IUUC-Mlu-067267	Myotis lucifugus	98.05	0.00e+00	835.00
IUUC-Nfi-068571	Neosartorya fischeri	45.10	2.00e-96	345.00
IUUC-Ncr-068895	Neurospora crassa	50.13	1.00e-103	369.00
IUUC-Nle-069087	Nomascus leucogenys	96.72	0.00e+00	678.00
IUUC-Opr-070579	Ochotona princeps	97.32	0.00e+00	836.00
IUUC-Ont-072432	Oreochromis niloticus	92.20	0.00e+00	801.00
IUUC-Oan-073072	Ornithorhynchus anatinus	97.56	0.00e+00	836.00
IUUC-Ocu-074180	Oryctolagus cuniculus	97.32	0.00e+00	836.00
IUUC-Ola-086772	Oryzias latipes	91.71	0.00e+00	793.00
IUUC-Oga-088219	Otolemur garnettii	98.04	0.00e+00	838.00
IUUC-Oar-090394	Ovis aries	97.56	0.00e+00	836.00
IUUC-Ptr-091517	Pan troglodytes	97.56	0.00e+00	836.00
IUUC-Pan-092421	Papio anubis	97.07	0.00e+00	833.00
IUUC-Psi-093370	Pelodiscus sinensis	96.59	0.00e+00	832.00
IUUC-Pma-094319	Petromyzon marinus	88.83	0.00e+00	643.00
IUUC-Pno-094815	Phaeosphaeria nodorum	46.30	8.00e-102	363.00
IUUC-Pfo-097089	Poecilia formosa	91.22	0.00e+00	795.00
IUUC-Pab-098421	Pongo abelii	97.56	0.00e+00	836.00
IUUC-Pca-100120	Procavia capensis	72.68	4.00e-161	560.00
IUUC-Pva-102960	Pteropus vampyrus	97.32	0.00e+00	832.00
IUUC-Pgr-103538	Puccinia graminis	46.53	8.00e-115	407.00
IUUC-Ptt-103990	Puccinia triticina	40.08	9.00e-41	161.00
IUUC-Pte-104261	Pyrenophora teres	46.54	1.00e-101	363.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	46.78	5.00e-102	364.00
IUUC-Rno-105123	Rattus norvegicus	97.56	0.00e+00	836.00
IUUC-Sce-106208	Saccharomyces cerevisiae	29.77	6.00e-36	145.00
IUUC-Sha-107010	Sarcophilus harrisii	96.59	0.00e+00	828.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	32.42	2.00e-63	236.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	44.36	2.00e-96	346.00
IUUC-Sar-113309	Sorex araneus	99.25	0.00e+00	825.00
IUUC-Sre-115003	Sporisorium reilianum	48.63	2.00e-121	429.00
IUUC-Ssc-116148	Sus scrofa	97.56	0.00e+00	836.00
IUUC-Tgu-117299	Taeniopygia guttata	96.10	0.00e+00	828.00
IUUC-Tru-118179	Takifugu rubripes	89.76	0.00e+00	788.00
IUUC-Tsy-119493	Tarsius syrichta	96.10	0.00e+00	820.00
IUUC-Tni-120355	Tetraodon nigroviridis	90.73	0.00e+00	762.00
IUUC-Tre-121977	Trichoderma reesei	42.83	5.00e-99	354.00
IUUC-Tvi-122661	Trichoderma virens	44.78	2.00e-97	349.00
IUUC-Tme-127031	Tuber melanosporum	47.41	2.00e-100	359.00
IUUC-Tbe-127492	Tupaia belangeri	83.08	1.00e-115	409.00
IUUC-Ttr-128929	Tursiops truncatus	97.32	0.00e+00	835.00
IUUC-Uma-129347	Ustilago maydis	46.35	5.00e-118	417.00
IUUC-Vda-129837	Verticillium dahliae	45.26	2.00e-98	352.00
IUUC-Vpa-130532	Vicugna pacos	82.90	0.00e+00	646.00
IUUC-Xtr-131985	Xenopus tropicalis	95.12	0.00e+00	824.00
IUUC-Xma-133314	Xiphophorus maculatus	91.71	0.00e+00	797.00
IUUC-Yli-134403	Yarrowia lipolytica	40.81	2.00e-73	269.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence