iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000007168.12	ENST00000397195.9	ENSP00000380378.4
ENSG00000007168.12	ENST00000570400.1	ENSP00000460258.1
ENSG00000007168.12	ENST00000574468.1	ENSP00000460591.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513
UBD/Beta-Prp	Beta-Prp	21070969

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.40e-59	196.9	190	229
UBD/Beta-Prp	2.30e-94	317.6	107	410

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllks 38
           gH   v+++a  ++ +++vs+s+D+tik+W++ tg ++k+
   Q: 190  GHDHNVSSVAImPNgDHIVSASRDKTIKMWEVQTGYCVKT 229
           899*******99777********************99875 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlsl 100
           h s++t v f+p  s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v s+
   Q: 107  HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSV 198
           5668888************************************************************************************* PP
   S: 101  sfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsng 192
           +++p+gd++vs+s+d+ti++w+++tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++t+++  +l++ h++ v+++s+ +++
   Q: 199  AIMPNGDHIVSASRDKTIKMWEVQTGYCVK-TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE-HEHVVECISWAPES 288
           ******************************.*********************************************9.************** PP
   S: 193  ....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn 264
                               ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ v f++ +++++s+++D+++r+Wd++++ ++ktl+ h+
   Q: 289  syssiseatgsetkksgkpgPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHE 380
           ******************************************************************************************** PP
   S: 265  ssvisvavlsfgdnvlvlgsedskvniwklk 295
           + v+s ++ + + +++v+gs d++v++w+++
   Q: 381  HFVTSLDF-HKTAPYVVTGSVDQTVKVWECR 410
           ********.99*****************985 PP

Organism

Homo sapiens

Functional Description
(View)

Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed:22956769).

Protein Sequence
(Fasta)

MVLSQRQRDE LNRAIADYLR SNGYEEAYSV FKKEAELDVN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEFT SGGPLGQKRD PKEWIPRPPE KYALSGHRSP VTRVIFHPVF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCAGAAAG GGGCGGTAGG TGGCCGGGCC CCGCTGCCTC TCGCGCCTCC CGGGGCCCGC 60
CACACACGGT GCCAACGGGA CGCCGCGGTC GGCCGCATGA GCGCAAAAGC AGGGCAGCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0225--Disease mutation
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-0451--Lissencephaly
KW-0472--Membrane
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0000235--C:astral microtubule
GO:1904115--C:axon cytoplasm
GO:0005938--C:cell cortex
GO:0031252--C:cell leading edge
GO:0090724--C:central region of growth cone
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005871--C:kinesin complex
GO:0000776--C:kinetochore
GO:0005875--C:microtubule associated complex
GO:0031514--C:motile cilium
GO:0043025--C:neuronal cell body
GO:0005635--C:nuclear envelope
GO:0031965--C:nuclear membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0032420--C:stereocilium
GO:0034452--F:dynactin binding
GO:0070840--F:dynein complex binding
GO:0008201--F:heparin binding
GO:0008017--F:microtubule binding
GO:0004623--F:phospholipase A2 activity
GO:0043274--F:phospholipase binding
GO:0051219--F:phosphoprotein binding
GO:0042803--F:protein homodimerization activity
GO:0001675--P:acrosome assembly
GO:0030036--P:actin cytoskeleton organization
GO:0008344--P:adult locomotory behavior
GO:0001667--P:ameboidal-type cell migration
GO:0060117--P:auditory receptor cell development
GO:0048854--P:brain morphogenesis
GO:0021987--P:cerebral cortex development
GO:0021895--P:cerebral cortex neuron differentiation
GO:0007268--P:chemical synaptic transmission
GO:0097711--P:ciliary basal body docking
GO:0090102--P:cochlea development
GO:0021540--P:corpus callosum morphogenesis
GO:0043622--P:cortical microtubule organization
GO:0051660--P:establishment of centrosome localization
GO:0000132--P:establishment of mitotic spindle orientation
GO:0042249--P:establishment of planar polarity of embryonic epithelium
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0007281--P:germ cell development
GO:0021766--P:hippocampus development
GO:0021819--P:layer formation in cerebral cortex
GO:0007611--P:learning or memory
GO:0016042--P:lipid catabolic process
GO:0051661--P:maintenance of centrosome location
GO:0000226--P:microtubule cytoskeleton organization
GO:0090176--P:microtubule cytoskeleton organization involved in establishment of planar polarity
GO:0031023--P:microtubule organizing center organization
GO:0007017--P:microtubule-based process
GO:0007067--P:mitotic nuclear division
GO:0046329--P:negative regulation of JNK cascade
GO:0010977--P:negative regulation of neuron projection development
GO:0007405--P:neuroblast proliferation
GO:0050885--P:neuromuscular process controlling balance
GO:0001764--P:neuron migration
GO:0051081--P:nuclear envelope disassembly
GO:0007097--P:nuclear migration
GO:0036035--P:osteoclast development
GO:0046469--P:platelet activating factor metabolic process
GO:0045773--P:positive regulation of axon extension
GO:0001961--P:positive regulation of cytokine-mediated signaling pathway
GO:0061003--P:positive regulation of dendritic spine morphogenesis
GO:0040019--P:positive regulation of embryonic development
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0009306--P:protein secretion
GO:0043087--P:regulation of GTPase activity
GO:0070507--P:regulation of microtubule cytoskeleton organization
GO:2000574--P:regulation of microtubule motor activity
GO:0008090--P:retrograde axonal transport
GO:0007062--P:sister chromatid cohesion
GO:0017145--P:stem cell division
GO:0019226--P:transmission of nerve impulse
GO:0047496--P:vesicle transport along microtubule

KEGG

hsa:5048

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	99.75	0.00e+00	832.00
IUUC-Apl-004024	Anas platyrhynchos	99.02	0.00e+00	852.00
IUUC-Aca-004564	Anolis carolinensis	98.78	0.00e+00	846.00
IUUC-Ago-007862	Ashbya gossypii	27.23	1.00e-38	154.00
IUUC-Acl-008360	Aspergillus clavatus	46.53	8.00e-105	374.00
IUUC-Afl-008502	Aspergillus flavus	46.21	2.00e-94	339.00
IUUC-Afu-008848	Aspergillus fumigatus	47.19	1.00e-106	380.00
IUUC-Ani-009173	Aspergillus nidulans	42.54	2.00e-90	326.00
IUUC-Ang-009873	Aspergillus niger	44.56	2.00e-94	339.00
IUUC-Aor-009973	Aspergillus oryzae	43.94	4.00e-92	332.00
IUUC-Ate-010523	Aspergillus terreus	41.81	2.00e-90	325.00
IUUC-Ame-010969	Astyanax mexicanus	94.63	0.00e+00	820.00
IUUC-Bgr-011972	Blumeria graminis	47.73	2.00e-105	375.00
IUUC-Bta-013106	Bos taurus	99.76	0.00e+00	855.00
IUUC-Bci-013615	Botrytis cinerea	44.58	7.00e-99	354.00
IUUC-Cel-018459	Caenorhabditis elegans	57.42	1.00e-148	519.00
IUUC-Cja-018755	Callithrix jacchus	97.32	0.00e+00	835.00
IUUC-Cfa-020749	Canis familiaris	99.76	0.00e+00	855.00
IUUC-Cpo-022371	Cavia porcellus	99.76	0.00e+00	855.00
IUUC-Csa-023524	Chlorocebus sabaeus	99.42	0.00e+00	721.00
IUUC-Cho-024764	Choloepus hoffmanni	89.22	0.00e+00	679.00
IUUC-Cin-025753	Ciona intestinalis	71.05	2.00e-180	624.00
IUUC-Csv-025817	Ciona savignyi	69.51	0.00e+00	634.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	46.81	7.00e-98	350.00
IUUC-Cne-027087	Cryptococcus neoformans	50.39	3.00e-110	392.00
IUUC-Dre-028314	Danio rerio	93.66	0.00e+00	816.00
IUUC-Dno-029050	Dasypus novemcinctus	99.51	0.00e+00	854.00
IUUC-Dor-030222	Dipodomys ordii	91.46	0.00e+00	771.00
IUUC-Dse-031164	Dothistroma septosporum	43.58	8.00e-102	363.00
IUUC-Dme-031745	Drosophila melanogaster	70.07	7.00e-172	596.00
IUUC-Ete-032508	Echinops telfairi	82.93	0.00e+00	687.00
IUUC-Eca-034288	Equus caballus	99.25	0.00e+00	828.00
IUUC-Eeu-034984	Erinaceus europaeus	91.22	0.00e+00	768.00
IUUC-Fca-036498	Felis catus	99.76	0.00e+00	855.00
IUUC-Fal-036920	Ficedula albicollis	99.02	0.00e+00	852.00
IUUC-Fox-037996	Fusarium oxysporum	46.41	2.00e-104	373.00
IUUC-Fso-038160	Fusarium solani	44.10	3.00e-99	355.00
IUUC-Gmo-038983	Gadus morhua	93.66	0.00e+00	809.00
IUUC-Ggr-040051	Gaeumannomyces graminis	45.11	4.00e-98	352.00
IUUC-Gga-040623	Gallus gallus	99.02	0.00e+00	852.00
IUUC-Gac-041613	Gasterosteus aculeatus	92.93	0.00e+00	807.00
IUUC-Ggo-045410	Gorilla gorilla	88.97	0.00e+00	724.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	99.76	0.00e+00	855.00
IUUC-Kpa-049351	Komagataella pastoris	29.60	2.00e-43	170.00
IUUC-Lch-049936	Latimeria chalumnae	96.59	0.00e+00	830.00
IUUC-Loc-052476	Lepisosteus oculatus	95.74	0.00e+00	802.00
IUUC-Lma-053170	Leptosphaeria maculans	46.67	4.00e-101	361.00
IUUC-Laf-053713	Loxodonta africana	97.80	0.00e+00	835.00
IUUC-Mcc-054628	Macaca mulatta	99.27	0.00e+00	852.00
IUUC-Meu-055927	Macropus eugenii	86.28	4.00e-140	490.00
IUUC-Mor-056962	Magnaporthe oryzae	45.08	2.00e-98	352.00
IUUC-Mpo-057583	Magnaporthe poae	45.05	3.00e-94	338.00
IUUC-Mla-058819	Melampsora laricipopulina	48.31	8.00e-119	420.00
IUUC-Mga-059945	Meleagris gallopavo	98.78	0.00e+00	850.00
IUUC-Mvi-060403	Microbotryum violaceum	50.11	5.00e-129	454.00
IUUC-Mmr-061289	Microcebus murinus	99.75	0.00e+00	832.00
IUUC-Mdo-061912	Monodelphis domestica	99.02	0.00e+00	848.00
IUUC-Mmu-063253	Mus musculus	99.76	0.00e+00	855.00
IUUC-Mpu-066638	Mustela putorius furo	99.76	0.00e+00	855.00
IUUC-Mlu-067267	Myotis lucifugus	98.04	0.00e+00	836.00
IUUC-Nfi-068571	Neosartorya fischeri	45.57	6.00e-99	354.00
IUUC-Ncr-068895	Neurospora crassa	48.41	1.00e-105	376.00
IUUC-Nle-069087	Nomascus leucogenys	99.40	0.00e+00	696.00
IUUC-Opr-070579	Ochotona princeps	99.51	0.00e+00	854.00
IUUC-Ont-072432	Oreochromis niloticus	94.63	0.00e+00	821.00
IUUC-Oan-073072	Ornithorhynchus anatinus	99.76	0.00e+00	855.00
IUUC-Ocu-074180	Oryctolagus cuniculus	99.51	0.00e+00	854.00
IUUC-Ola-086772	Oryzias latipes	94.15	0.00e+00	812.00
IUUC-Oga-088219	Otolemur garnettii	97.56	0.00e+00	834.00
IUUC-Oar-090394	Ovis aries	99.76	0.00e+00	855.00
IUUC-Ptr-091517	Pan troglodytes	99.76	0.00e+00	855.00
IUUC-Pan-092421	Papio anubis	99.27	0.00e+00	852.00
IUUC-Psi-093370	Pelodiscus sinensis	99.27	0.00e+00	852.00
IUUC-Pma-094319	Petromyzon marinus	88.83	0.00e+00	642.00
IUUC-Pno-094815	Phaeosphaeria nodorum	47.26	1.00e-104	373.00
IUUC-Pfo-097089	Poecilia formosa	93.66	0.00e+00	813.00
IUUC-Pab-098421	Pongo abelii	99.76	0.00e+00	855.00
IUUC-Pca-100120	Procavia capensis	72.77	1.00e-163	568.00
IUUC-Pva-102960	Pteropus vampyrus	99.51	0.00e+00	850.00
IUUC-Pgr-103538	Puccinia graminis	47.87	2.00e-118	419.00
IUUC-Ptt-103990	Puccinia triticina	42.46	1.00e-44	174.00
IUUC-Pte-104261	Pyrenophora teres	47.49	7.00e-105	374.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	47.73	4.00e-105	375.00
IUUC-Rno-105123	Rattus norvegicus	99.76	0.00e+00	855.00
IUUC-Sce-106208	Saccharomyces cerevisiae	27.29	4.00e-36	145.00
IUUC-Sha-107010	Sarcophilus harrisii	98.78	0.00e+00	847.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	32.34	2.00e-64	239.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	44.71	2.00e-99	355.00
IUUC-Sar-113309	Sorex araneus	99.00	0.00e+00	823.00
IUUC-Sre-115003	Sporisorium reilianum	50.00	2.00e-125	442.00
IUUC-Ssc-116148	Sus scrofa	99.76	0.00e+00	855.00
IUUC-Tgu-117299	Taeniopygia guttata	98.78	0.00e+00	848.00
IUUC-Tru-117721	Takifugu rubripes	93.17	0.00e+00	805.00
IUUC-Tsy-119493	Tarsius syrichta	98.29	0.00e+00	838.00
IUUC-Tni-120355	Tetraodon nigroviridis	93.17	0.00e+00	781.00
IUUC-Tre-121977	Trichoderma reesei	43.64	5.00e-101	361.00
IUUC-Tvi-122661	Trichoderma virens	43.84	7.00e-100	357.00
IUUC-Tme-127031	Tuber melanosporum	49.38	8.00e-104	370.00
IUUC-Tbe-127492	Tupaia belangeri	83.08	2.00e-115	409.00
IUUC-Ttr-128929	Tursiops truncatus	99.51	0.00e+00	852.00
IUUC-Uma-129347	Ustilago maydis	47.72	4.00e-122	431.00
IUUC-Vda-129837	Verticillium dahliae	45.69	1.00e-99	356.00
IUUC-Vpa-130532	Vicugna pacos	85.23	0.00e+00	663.00
IUUC-Xtr-131985	Xenopus tropicalis	97.32	0.00e+00	840.00
IUUC-Xma-133314	Xiphophorus maculatus	94.15	0.00e+00	816.00
IUUC-Yli-134403	Yarrowia lipolytica	38.34	6.00e-74	271.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence