iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ola-086772

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Lissencephaly-1 homolog

Genbank Nucleotide ID

BAAF04035093

Gene Name

pafah1b1b (1 of many); pafah1b1; LIS1; PAFAH1B1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000007910.1	ENSORLT00000009922.1	ENSORLP00000009921.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.50e-59	194.8	336	374
UBD/Beta-Prp	6.10e-94	314.8	107	410

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gH ++v+++ f ++ +++vs++dD+t+++WD++  ++ k
   Q: 336  GHDNWVRGILFhPGgKFIVSCADDKTLRIWDYKNKRCMK 374
           8***********999****************99998876 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h s++t v f+p  s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+++gk+l+++s D+tik+wd++ ++c++t++gh+++v
   Q: 107  HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDQTGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195
           5678889********************************************************************************** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
            s++++p+gd++vs+s+d+ti++w++ tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++++++  +l++ h++ v+++
   Q: 196  SSVAIMPNGDHIVSASRDKTIKMWEVATGYCVK-TFAGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVASKECKAELRE-HEHVVECI 282
           *********************************.*********************************************9.******** PP
   S: 187  sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
           s+ +++                    ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ + f+p ++++vs+++D+++riWd++++ 
   Q: 283  SWAPESasptileatgsetkksgkpgPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGILFHPGGKFIVSCADDKTLRIWDYKNKR 371
           ***************************************************************************************** PP
   S: 256  llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           ++ktl  h++ v+s ++ +   + +v+gs d++v++w+++
   Q: 372  CMKTLCAHEHFVTSLDF-HKAAPFVVTGSVDQTVKVWECR 410
           *****************.999****************985 PP

Organism

Oryzias latipes

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.

Protein Sequence
(Fasta)

MVLSQRQRDE LNRAIADYLR SNGYEEAYST FKKEAELDNN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEIT LGGPVTQKRD PKEWIPRPPE RYALSGHRSP VTRVIFHPVF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCAGAGAC CGCACTTCAC CTCCGCATCA CAAGATCACA CTCAGGAGCG GAAAAAACTC 60
ACGCCCTTTT CGGGTCGTGT TGCCGTTGGT GACGACTGGA GATATCCTCA GACAGCCGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005815--C:microtubule organizing center
GO:0030154--P:cell differentiation
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0007399--P:nervous system development
GO:0006810--P:transport

KEGG

ola:101169717

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001589	Ailuropoda melanoleuca	93.98	0.00e+00	790.00
IUUC-Apl-004024	Anas platyrhynchos	94.15	0.00e+00	812.00
IUUC-Aca-004564	Anolis carolinensis	93.66	0.00e+00	805.00
IUUC-Ang-009873	Aspergillus niger	44.81	2.00e-93	336.00
IUUC-Ame-010969	Astyanax mexicanus	95.85	0.00e+00	828.00
IUUC-Bgr-011972	Blumeria graminis	47.26	5.00e-104	371.00
IUUC-Bta-013106	Bos taurus	94.15	0.00e+00	813.00
IUUC-Cel-018459	Caenorhabditis elegans	57.18	4.00e-148	517.00
IUUC-Cja-018755	Callithrix jacchus	91.71	0.00e+00	793.00
IUUC-Cfa-020749	Canis familiaris	94.15	0.00e+00	813.00
IUUC-Cpo-022371	Cavia porcellus	94.15	0.00e+00	813.00
IUUC-Csa-023524	Chlorocebus sabaeus	93.04	0.00e+00	681.00
IUUC-Cho-024764	Choloepus hoffmanni	83.56	0.00e+00	641.00
IUUC-Cin-025753	Ciona intestinalis	71.53	0.00e+00	629.00
IUUC-Csv-025817	Ciona savignyi	70.24	0.00e+00	641.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	47.03	5.00e-98	351.00
IUUC-Dre-028314	Danio rerio	94.63	0.00e+00	822.00
IUUC-Dno-029050	Dasypus novemcinctus	93.90	0.00e+00	812.00
IUUC-Dor-030222	Dipodomys ordii	85.85	0.00e+00	729.00
IUUC-Ete-032508	Echinops telfairi	78.29	0.00e+00	654.00
IUUC-Eca-034288	Equus caballus	93.48	0.00e+00	786.00
IUUC-Eeu-034984	Erinaceus europaeus	85.61	0.00e+00	726.00
IUUC-Fca-036498	Felis catus	94.15	0.00e+00	813.00
IUUC-Fal-036920	Ficedula albicollis	94.15	0.00e+00	812.00
IUUC-Gmo-038983	Gadus morhua	96.10	0.00e+00	827.00
IUUC-Gga-040623	Gallus gallus	94.15	0.00e+00	812.00
IUUC-Gac-041613	Gasterosteus aculeatus	97.07	0.00e+00	837.00
IUUC-Ggo-045410	Gorilla gorilla	83.71	0.00e+00	683.00
IUUC-Hsa-046358	Homo sapiens	94.15	0.00e+00	812.00
IUUC-Itr-047890	Ictidomys tridecemlineatus	94.15	0.00e+00	813.00
IUUC-Lch-049936	Latimeria chalumnae	94.88	0.00e+00	817.00
IUUC-Loc-052476	Lepisosteus oculatus	95.49	0.00e+00	802.00
IUUC-Laf-053713	Loxodonta africana	92.18	0.00e+00	793.00
IUUC-Mcc-054628	Macaca mulatta	93.66	0.00e+00	810.00
IUUC-Meu-055927	Macropus eugenii	80.51	3.00e-132	464.00
IUUC-Mga-059945	Meleagris gallopavo	93.90	0.00e+00	811.00
IUUC-Mvi-060403	Microbotryum violaceum	50.45	5.00e-130	457.00
IUUC-Mmr-061289	Microcebus murinus	93.98	0.00e+00	790.00
IUUC-Mdo-061912	Monodelphis domestica	93.41	0.00e+00	805.00
IUUC-Mmu-063253	Mus musculus	94.15	0.00e+00	813.00
IUUC-Mpu-066638	Mustela putorius furo	94.15	0.00e+00	813.00
IUUC-Mlu-067267	Myotis lucifugus	92.65	0.00e+00	796.00
IUUC-Nfi-068571	Neosartorya fischeri	45.39	9.00e-100	357.00
IUUC-Nle-069087	Nomascus leucogenys	94.63	0.00e+00	663.00
IUUC-Opr-070579	Ochotona princeps	93.90	0.00e+00	812.00
IUUC-Ont-072432	Oreochromis niloticus	97.07	0.00e+00	836.00
IUUC-Oan-073072	Ornithorhynchus anatinus	94.15	0.00e+00	813.00
IUUC-Ocu-074180	Oryctolagus cuniculus	93.90	0.00e+00	812.00
IUUC-Oga-088219	Otolemur garnettii	91.93	0.00e+00	792.00
IUUC-Oar-090394	Ovis aries	94.15	0.00e+00	813.00
IUUC-Ptr-091517	Pan troglodytes	94.15	0.00e+00	813.00
IUUC-Pan-092421	Papio anubis	93.66	0.00e+00	810.00
IUUC-Psi-093370	Pelodiscus sinensis	93.90	0.00e+00	811.00
IUUC-Pma-094319	Petromyzon marinus	86.25	0.00e+00	635.00
IUUC-Pfo-097089	Poecilia formosa	97.80	0.00e+00	842.00
IUUC-Pab-098421	Pongo abelii	94.15	0.00e+00	813.00
IUUC-Pca-100120	Procavia capensis	69.06	6.00e-155	540.00
IUUC-Pva-102960	Pteropus vampyrus	93.90	0.00e+00	808.00
IUUC-Pgr-103538	Puccinia graminis	47.43	2.00e-118	419.00
IUUC-Ptt-103990	Puccinia triticina	43.50	2.00e-45	177.00
IUUC-Rno-105123	Rattus norvegicus	94.15	0.00e+00	813.00
IUUC-Sce-106208	Saccharomyces cerevisiae	28.51	1.00e-37	150.00
IUUC-Sha-107010	Sarcophilus harrisii	93.17	0.00e+00	804.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	33.26	7.00e-67	247.00
IUUC-Sar-113309	Sorex araneus	93.23	0.00e+00	780.00
IUUC-Ssc-116148	Sus scrofa	94.15	0.00e+00	813.00
IUUC-Tgu-117299	Taeniopygia guttata	93.90	0.00e+00	810.00
IUUC-Tru-117721	Takifugu rubripes	96.34	0.00e+00	833.00
IUUC-Tsy-119493	Tarsius syrichta	93.41	0.00e+00	801.00
IUUC-Tni-120355	Tetraodon nigroviridis	96.83	0.00e+00	811.00
IUUC-Tbe-127492	Tupaia belangeri	61.32	2.00e-121	429.00
IUUC-Ttr-128929	Tursiops truncatus	94.15	0.00e+00	811.00
IUUC-Vda-129837	Verticillium dahliae	46.15	9.00e-100	357.00
IUUC-Vpa-130532	Vicugna pacos	80.05	0.00e+00	627.00
IUUC-Xtr-131985	Xenopus tropicalis	93.41	0.00e+00	810.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence