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Tag Content
iUUCD ID IUUC-Pno-094815
Ensembl Protein ID SNOT_14296
UniProt Accession Q0U1B1; LIS1_PHANO
Genbank Protein ID EAT78167.1
Protein Name Nuclear distribution protein PAC1; Lissencephaly-1 homolog; nudF homolog
Genbank Nucleotide ID CH445355
Gene Name PAC1; LIS1; SNOG_14296
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
SNOG_14296 SNOT_14296 SNOT_14296
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 4.70e-47 155.2 200 247
UBD/Beta-Prp 9.10e-66 221.4 112 406
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.........sd.tllvsGsdDgtikvWDlrtgvllks 38
    gH sv++++f s+ +llvs+s+D+t++vWD++tg ++k+
   Q: 200 GHDHSVSAIRFvpsgaagspSSgNLLVSASRDKTLRVWDVTTGYCVKT 247
    8******************8557********************99875 PP
   


   UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk..ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsf 102
    ++h s+itcv+f+p s la+gs+d tik+wd++ g l r+++gh+++v +v+f + +l+++s+D tik+wd+s +k ++tl gh++sv +++f
   Q: 112 QSHRSPITCVAFHPVFSSLASGSEDTTIKIWDWELGELERTVKGHTKGVLDVDFGGPRGgtLLASCSSDLTIKLWDPSdEYKNIRTLPGHDHSVSAIRF 210
    56788*************************************************8544446**************887699****************** PP
   S: 103 sp........sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysls...... 187
    p sg+ lvs+s+d+t+rvwd+ tg+c++ t +gh ++v+ v+ + dg+ l s+++D+t rlWd ++g+ t+ g h++ +++++
   Q: 211 VPsgaagspsSGNLLVSASRDKTLRVWDVTTGYCVK-TIRGHADWVRDVSPSFDGRWLLSAGNDQTARLWDASSGEAKCTFLG-HEHVIECVTiappvs 307
    **9999999888************************.*********************************************9.*********888877 PP
   S: 188 ...............fdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdl.rsgdllktlqlhnssvisv 270
    ++s+ +++++gs+d+t+k+wd +g+ ++tl gh+++v+ + f+p +++l+s+s+D++ir+Wdl + g ++k+++ +s+++s+
   Q: 308 yanlaslaglkkpppLSSSAEFVATGSRDKTIKIWDG-RGTLIKTLAGHDNWVRALIFHPGGKYLLSASDDKTIRCWDLtQEGRCVKVVTDAHSHFVSC 405
    77766666666666666666****************9.8889************************************83579********99988887 PP
   S: 271 a 271
   
   Q: 406 M 406
    5 PP
   

Organism Phaeosphaeria nodorum
Functional Description
(View)

Functional Description



     Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.
Protein Sequence
(Fasta)
MSAILTDRQA EELHKAIIAY LGVINAPKTA AAFREEVNFS AAFDDATRKK YEGLLEKKWT 60
SVVRLQKKVL ELEQRNQSLQ SELDSTTPTS LLRRNQDPSS WLPRAPARHT LQSHRSPITC 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Pno-094815|E3,WD_repeat;UBD,Beta-Prp|Phaeosphaeria nodorum
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGAGCGCCA TATTGACCGA CCGCCAGGCC GAAGAGCTGT GAGACAGACC TGCATTCCTG 60
CCACCACACC CCGTATTGAC CATGAGGCAG CCACAAGGCC ATAATCGCAT ACCTGGGAGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Pno-094815|E3,WD_repeat;UBD,Beta-Prp|Phaeosphaeria nodorum
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005938--C:cell cortex
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0000922--C:spindle pole
GO:0008017--F:microtubule binding
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0007097--P:nuclear migration
GO:2000574--P:regulation of microtubule motor activity
GO:0000003--P:reproduction
GO:0047496--P:vesicle transport along microtubule

KEGG pno:SNOG_14296
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001589 Ailuropoda melanoleuca 47.19 3.00e-104 370.00
IUUC-Apl-004024 Anas platyrhynchos 47.26 1.00e-107 381.00
IUUC-Aca-004564 Anolis carolinensis 47.02 2.00e-105 374.00
IUUC-Ago-007862 Ashbya gossypii 30.51 1.00e-42 165.00
IUUC-Acl-008360 Aspergillus clavatus 72.16 0.00e+00 678.00
IUUC-Afl-008502 Aspergillus flavus 63.19 3.00e-164 569.00
IUUC-Afu-008848 Aspergillus fumigatus 73.88 0.00e+00 727.00
IUUC-Ani-009173 Aspergillus nidulans 62.12 4.00e-172 595.00
IUUC-Ang-009873 Aspergillus niger 59.13 1.00e-161 561.00
IUUC-Aor-009973 Aspergillus oryzae 60.81 3.00e-159 552.00
IUUC-Ate-010523 Aspergillus terreus 60.00 3.00e-166 576.00
IUUC-Ame-011154 Astyanax mexicanus 46.30 2.00e-106 377.00
IUUC-Bgr-011972 Blumeria graminis 73.65 0.00e+00 717.00
IUUC-Bta-013106 Bos taurus 47.26 9.00e-108 381.00
IUUC-Bci-013615 Botrytis cinerea 75.97 0.00e+00 723.00
IUUC-Cel-018459 Caenorhabditis elegans 43.67 1.00e-94 337.00
IUUC-Cja-018755 Callithrix jacchus 46.30 1.00e-104 371.00
IUUC-Cfa-020749 Canis familiaris 47.26 9.00e-108 381.00
IUUC-Cpo-022371 Cavia porcellus 47.26 9.00e-108 381.00
IUUC-Csa-023524 Chlorocebus sabaeus 47.59 1.00e-90 324.00
IUUC-Cho-024764 Choloepus hoffmanni 45.11 1.00e-89 321.00
IUUC-Cin-025753 Ciona intestinalis 47.12 8.00e-100 355.00
IUUC-Csv-025817 Ciona savignyi 46.63 2.00e-103 367.00
IUUC-Cgl-026529 Colletotrichum gloeosporioides 75.86 0.00e+00 697.00
IUUC-Cne-027087 Cryptococcus neoformans 52.98 8.00e-118 415.00
IUUC-Dre-028314 Danio rerio 46.06 3.00e-105 373.00
IUUC-Dno-029050 Dasypus novemcinctus 47.26 9.00e-108 381.00
IUUC-Dor-030222 Dipodomys ordii 43.83 5.00e-98 349.00
IUUC-Dse-031164 Dothistroma septosporum 69.16 0.00e+00 674.00
IUUC-Dme-031745 Drosophila melanogaster 47.42 6.00e-99 352.00
IUUC-Ete-032508 Echinops telfairi 48.23 3.00e-72 263.00
IUUC-Eca-034288 Equus caballus 46.70 3.00e-103 366.00
IUUC-Eeu-034984 Erinaceus europaeus 43.58 6.00e-97 345.00
IUUC-Fca-036498 Felis catus 47.26 9.00e-108 381.00
IUUC-Fal-036920 Ficedula albicollis 47.26 1.00e-107 381.00
IUUC-Fox-037996 Fusarium oxysporum 68.80 0.00e+00 670.00
IUUC-Fso-038160 Fusarium solani 66.16 0.00e+00 637.00
IUUC-Gmo-038983 Gadus morhua 46.54 4.00e-106 376.00
IUUC-Ggr-040051 Gaeumannomyces graminis 66.81 0.00e+00 640.00
IUUC-Gga-040623 Gallus gallus 47.26 1.00e-107 381.00
IUUC-Gac-041613 Gasterosteus aculeatus 46.38 2.00e-105 374.00
IUUC-Ggo-045410 Gorilla gorilla 45.38 5.00e-88 315.00
IUUC-Hsa-046358 Homo sapiens 47.26 1.00e-107 381.00
IUUC-Hvu-047729 Hordeum vulgare 29.55 3.00e-28 118.00
IUUC-Itr-047890 Ictidomys tridecemlineatus 47.26 9.00e-108 381.00
IUUC-Kpa-049351 Komagataella pastoris 31.49 1.00e-49 188.00
IUUC-Lch-049936 Latimeria chalumnae 47.02 8.00e-107 378.00
IUUC-Loc-052476 Lepisosteus oculatus 46.94 1.00e-103 367.00
IUUC-Lma-053170 Leptosphaeria maculans 91.54 0.00e+00 820.00
IUUC-Laf-053713 Loxodonta africana 47.33 2.00e-105 374.00
IUUC-Mcc-054628 Macaca mulatta 47.26 1.00e-107 380.00
IUUC-Meu-055927 Macropus eugenii 40.43 8.00e-53 198.00
IUUC-Mor-056962 Magnaporthe oryzae 67.31 0.00e+00 657.00
IUUC-Mpo-057583 Magnaporthe poae 67.02 3.00e-180 622.00
IUUC-Mla-058819 Melampsora laricipopulina 48.29 7.00e-121 425.00
IUUC-Mga-059945 Meleagris gallopavo 47.02 3.00e-107 380.00
IUUC-Mvi-060403 Microbotryum violaceum 51.71 2.00e-132 463.00
IUUC-Mmr-061289 Microcebus murinus 47.19 2.00e-104 370.00
IUUC-Mdo-061912 Monodelphis domestica 47.02 7.00e-107 378.00
IUUC-Mmu-063253 Mus musculus 47.26 9.00e-108 381.00
IUUC-Mpu-066638 Mustela putorius furo 47.26 9.00e-108 381.00
IUUC-Mlu-067267 Myotis lucifugus 46.51 2.00e-104 370.00
IUUC-Nfi-068571 Neosartorya fischeri 69.81 0.00e+00 668.00
IUUC-Ncr-068895 Neurospora crassa 72.16 0.00e+00 671.00
IUUC-Nle-069087 Nomascus leucogenys 46.48 3.00e-88 316.00
IUUC-Opr-070579 Ochotona princeps 47.26 9.00e-108 381.00
IUUC-Ont-072432 Oreochromis niloticus 46.78 1.00e-106 378.00
IUUC-Oan-073072 Ornithorhynchus anatinus 47.26 9.00e-108 381.00
IUUC-Ocu-074180 Oryctolagus cuniculus 47.26 9.00e-108 381.00
IUUC-Obr-076138 Oryza brachyantha 29.37 9.00e-29 120.00
IUUC-Ola-086815 Oryzias latipes 46.54 7.00e-106 375.00
IUUC-Oga-088219 Otolemur garnettii 46.30 6.00e-105 372.00
IUUC-Oar-090394 Ovis aries 47.26 9.00e-108 381.00
IUUC-Ptr-091517 Pan troglodytes 47.26 9.00e-108 381.00
IUUC-Pan-092421 Papio anubis 47.26 1.00e-107 380.00
IUUC-Psi-093370 Pelodiscus sinensis 47.26 3.00e-107 380.00
IUUC-Pma-094319 Petromyzon marinus 46.72 3.00e-88 316.00
IUUC-Pfo-097089 Poecilia formosa 46.78 3.00e-106 376.00
IUUC-Pab-098421 Pongo abelii 47.26 9.00e-108 381.00
IUUC-Pca-100120 Procavia capensis 39.14 4.00e-63 233.00
IUUC-Pva-102960 Pteropus vampyrus 47.02 2.00e-106 377.00
IUUC-Pgr-103538 Puccinia graminis 50.43 3.00e-125 440.00
IUUC-Ptt-103990 Puccinia triticina 40.77 2.00e-40 158.00
IUUC-Pte-104261 Pyrenophora teres 93.94 0.00e+00 860.00
IUUC-Pyt-104780 Pyrenophora triticirepentis 93.72 0.00e+00 859.00
IUUC-Rno-105123 Rattus norvegicus 47.26 9.00e-108 381.00
IUUC-Sce-106208 Saccharomyces cerevisiae 28.69 4.00e-40 157.00
IUUC-Sha-107010 Sarcophilus harrisii 47.02 5.00e-107 379.00
IUUC-Sja-107899 Schizosaccharomyces japonicus 37.65 4.00e-69 253.00
IUUC-Ssl-108571 Sclerotinia sclerotiorum 76.36 0.00e+00 694.00
IUUC-Sar-113309 Sorex araneus 46.45 1.00e-101 361.00
IUUC-Sre-115003 Sporisorium reilianum 48.70 5.00e-125 439.00
IUUC-Ssc-116148 Sus scrofa 47.26 9.00e-108 381.00
IUUC-Tgu-117299 Taeniopygia guttata 47.26 1.00e-107 380.00
IUUC-Tru-117721 Takifugu rubripes 46.30 5.00e-106 375.00
IUUC-Tsy-119493 Tarsius syrichta 47.02 4.00e-106 376.00
IUUC-Tni-120355 Tetraodon nigroviridis 46.38 6.00e-105 372.00
IUUC-Tre-121977 Trichoderma reesei 61.01 5.00e-167 578.00
IUUC-Tvi-122661 Trichoderma virens 61.88 3.00e-168 583.00
IUUC-Tur-126181 Triticum urartu 29.17 1.00e-27 117.00
IUUC-Tme-127031 Tuber melanosporum 69.93 0.00e+00 639.00
IUUC-Tbe-127492 Tupaia belangeri 41.33 1.00e-49 188.00
IUUC-Ttr-128929 Tursiops truncatus 47.26 3.00e-107 380.00
IUUC-Uma-129347 Ustilago maydis 50.76 1.00e-126 444.00
IUUC-Vda-129837 Verticillium dahliae 71.12 0.00e+00 662.00
IUUC-Vpa-130532 Vicugna pacos 40.69 2.00e-86 310.00
IUUC-Xtr-131985 Xenopus tropicalis 47.26 2.00e-107 380.00
IUUC-Xma-133314 Xiphophorus maculatus 46.54 8.00e-106 375.00
IUUC-Yli-134403 Yarrowia lipolytica 42.77 8.00e-102 362.00
Created Date 25-Jun-2017

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