iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-117721

UUCD1 version

UUC-TaR-00872

Ensembl Protein ID

ENSTRUP00000040433.1

UniProt Accession

H2UU09; H2UU09_TAKRU

Protein Name

Lissencephaly-1 homolog

Gene Name

pafah1b1b (1 of many); LOC101075526; LIS1; PAFAH1B1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000015825.1	ENSTRUT00000040575.1	ENSTRUP00000040433.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.80e-60	198.7	148	186
UBD/Beta-Prp	4.10e-92	309.8	107	410

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvllk 37
           gHtdsv +++f  +++ll+s+s D tik+WD+ ++ +++
   Q: 148  GHTDSVQDISFdlTGKLLASCSADMTIKLWDFQSFECIR 186
           8**********9666*******************99987 PP

UBD/Beta-Prp

   S: 9    hksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsv 97
           h s++t v f+p  s+++++s+d+tikvwd++tg++ r+l+gh++ v++++f+ +gk+l+++s D+tik+wd+++++c++t++gh+++v
   Q: 107  HRSPVTHVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDLTGKLLASCSADMTIKLWDFQSFECIRTMHGHDHNV 195
           6678999********************************************************************************** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvysl 186
            s++++p+gd+++s+s+d+t ++w++ tg+c++ t++gh+++v++v+ ++dg l++s+s+D+tvr+W ++++++  +l++ h++ v+++
   Q: 196  SSVAIMPNGDHIISASRDKTMKMWEVATGYCVK-TFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVASKECKAELRE-HEHVVECI 282
           *********************************.*********************************************9.******** PP
   S: 187  sfdsng....................kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgd 255
           s+ +++                    ++l+sgs+d+t+k+wd++tg c++tl gh+++v+ v f+p + ++v++++D+++riWd++++ 
   Q: 283  SWAPESahptileatgfeskksgkpgPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHPGGRFIVTCADDKTLRIWDYKNKR 371
           ***************************************************************************************** PP
   S: 256  llktlqlhnssvisvavlsfgdnvlvlgsedskvniwklk 295
           ++ktl  h++ v+s ++ + + +++v+gs d++v++w+++
   Q: 372  CMKTLCAHEHFVTSLDF-HKTAPYVVTGSVDQTVKVWECR 410
           *****************.99*****************985 PP

Organism

Takifugu rubripes

Functional Description
(View)

Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.

Protein Sequence
(Fasta)

MVLSQRQRDE LNRAIADYLR SNGYEEAYST FKKEAELDNN EELDKKYAGL LEKKWTSVIR 60
LQKKVMELES KLNEAKEEIT LGGPVSQKRD PKEWIPRPPE RYALSGHRSP VTHVIFHPVF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTCCTATA ACTGCAATCT TAAGCTTCCT GCCCAACCTC AGAGTTGTGA ATTAAACCAA 60
AACCCACTGG CTTGTAAGTG CATTGTGACC GGTAACCCAT CCTGGGTCCT GTTATGATCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0221--Differentiation
KW-0493--Microtubule
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR017252--Dynein_regulator_LIS1
IPR020472--G-protein_beta_WD-40_rep
IPR006594--LisH
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50896--LISH
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08513--LisH
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00667--LisH
SM00320--WD40

Gene Ontology

GO:1904115--C:axon cytoplasm
GO:0005938--C:cell cortex
GO:0005813--C:centrosome
GO:0000776--C:kinetochore
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0008017--F:microtubule binding
GO:0051301--P:cell division
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007281--P:germ cell development
GO:0031023--P:microtubule organizing center organization
GO:0007067--P:mitotic nuclear division
GO:0022008--P:neurogenesis
GO:0007097--P:nuclear migration
GO:2000574--P:regulation of microtubule motor activity
GO:0008090--P:retrograde axonal transport
GO:0047496--P:vesicle transport along microtubule

KEGG

tru:101075526

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004564	Anolis carolinensis	92.93	0.00e+00	798.00
IUUC-Acl-008360	Aspergillus clavatus	46.31	3.00e-104	371.00
IUUC-Afu-008848	Aspergillus fumigatus	46.96	3.00e-106	378.00
IUUC-Ani-009173	Aspergillus nidulans	42.43	5.00e-90	324.00
IUUC-Ang-009873	Aspergillus niger	43.80	1.00e-92	333.00
IUUC-Ame-010969	Astyanax mexicanus	95.12	0.00e+00	823.00
IUUC-Bgr-011972	Blumeria graminis	47.02	3.00e-103	369.00
IUUC-Bci-013615	Botrytis cinerea	44.82	3.00e-99	355.00
IUUC-Cel-018459	Caenorhabditis elegans	56.20	5.00e-147	513.00
IUUC-Cre-022578	Chlamydomonas reinhardtii	36.08	7.00e-52	197.00
IUUC-Cin-025753	Ciona intestinalis	71.05	0.00e+00	626.00
IUUC-Csv-025817	Ciona savignyi	70.00	0.00e+00	639.00
IUUC-Cgl-026529	Colletotrichum gloeosporioides	46.56	3.00e-98	352.00
IUUC-Dre-028314	Danio rerio	94.88	0.00e+00	822.00
IUUC-Ete-032508	Echinops telfairi	77.56	0.00e+00	649.00
IUUC-Gmo-038983	Gadus morhua	94.15	0.00e+00	813.00
IUUC-Gac-041613	Gasterosteus aculeatus	96.34	0.00e+00	831.00
IUUC-Ggo-045410	Gorilla gorilla	82.46	0.00e+00	677.00
IUUC-Hsa-046358	Homo sapiens	93.17	0.00e+00	805.00
IUUC-Lch-049936	Latimeria chalumnae	93.17	0.00e+00	805.00
IUUC-Loc-052476	Lepisosteus oculatus	94.49	0.00e+00	795.00
IUUC-Meu-055927	Macropus eugenii	80.14	3.00e-131	460.00
IUUC-Mor-056962	Magnaporthe oryzae	44.36	8.00e-98	350.00
IUUC-Mla-058819	Melampsora laricipopulina	46.97	6.00e-117	414.00
IUUC-Mvi-060403	Microbotryum violaceum	49.77	4.00e-129	454.00
IUUC-Nfi-068571	Neosartorya fischeri	45.59	5.00e-99	354.00
IUUC-Ont-072432	Oreochromis niloticus	95.85	0.00e+00	827.00
IUUC-Ola-086772	Oryzias latipes	96.34	0.00e+00	833.00
IUUC-Psi-093370	Pelodiscus sinensis	92.93	0.00e+00	804.00
IUUC-Pma-094319	Petromyzon marinus	86.82	0.00e+00	638.00
IUUC-Pno-094815	Phaeosphaeria nodorum	46.30	7.00e-103	367.00
IUUC-Pfo-097089	Poecilia formosa	96.10	0.00e+00	831.00
IUUC-Pca-100120	Procavia capensis	68.81	6.00e-154	536.00
IUUC-Pgr-103538	Puccinia graminis	47.20	1.00e-117	416.00
IUUC-Ptt-103990	Puccinia triticina	42.28	3.00e-44	173.00
IUUC-Pte-104261	Pyrenophora teres	46.54	6.00e-103	367.00
IUUC-Pyt-104780	Pyrenophora triticirepentis	46.78	2.00e-103	369.00
IUUC-Sja-107899	Schizosaccharomyces japonicus	32.80	3.00e-65	242.00
IUUC-Ssl-108571	Sclerotinia sclerotiorum	44.95	7.00e-100	357.00
IUUC-Tsy-119493	Tarsius syrichta	92.44	0.00e+00	794.00
IUUC-Tni-120355	Tetraodon nigroviridis	98.54	0.00e+00	821.00
IUUC-Tme-127031	Tuber melanosporum	47.77	2.00e-102	366.00
IUUC-Tbe-127492	Tupaia belangeri	60.56	1.00e-120	426.00
IUUC-Vda-129837	Verticillium dahliae	45.67	2.00e-99	356.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence