iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046773

UUCD1 version

UUC-HoS-01016

Ensembl Protein ID

ENSP00000342434.4

UniProt Accession

Q9UIG0; B9EGK3; D3DXE9; O95039; O95247; O95277; Q6P1K4; Q86UJ6; BAZ1B_HUMAN

Genbank Protein ID

AAD08675.1; AAC97879.1; BAA89210.1; AAD04720.1; AAP22332.1; EAW69680.1; EAW69681.1; AAH65029.1; AAI36521.1

Protein Name

Tyrosine-protein kinase BAZ1B; Bromodomain adjacent to zinc finger domain protein 1B; Williams syndrome transcription factor; Williams-Beuren syndrome chromosomal region 10 protein; Williams-Beuren syndrome chromosomal region 9 protein; hWALp2

Genbank Nucleotide ID

AF084479; AF072810; AB032253; AC005074; AC005089; CH471200; CH471200; BC065029; BC136520

Gene Name

BAZ1B; WBSC10; WBSCR10; WBSCR9; WSTF

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000009954.10	ENST00000339594.8	ENSP00000342434.4

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	6.50e-12	47.1	1185	1232

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           + C+vC+++ged+ +l+ C++C+++fH  Cl ++   e+p+ e w Cp C+
   Q: 1185 ARCKVCRKKGEDD-KLILCDECNKAFHLFCLRPA-LYEVPDGE-WQCPACQ 1232
           57*********98.6*******************.*******8.******7 PP

Organism

Homo sapiens

Functional Description
(View)

Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.

Protein Sequence
(Fasta)

MAPLLGRKPF PLVKPLPGEE PLFTIPHTQE AFRTREEYEA RLERYSERIW TCKSTGSSQL 60
THKEAWEEEQ EVAELLKEEF PAWYEKLVLE MVHHNTASLE KLVDTAWLEI MTKYAVGEEC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGCCCGGG GGAGGAGGGG AATCTCCCGC CATTTTTCAA TAATTTCCTC CGGTGCTGCT 60
GAGGAGGAGT CGTGACTGCC GGCCGCCGGG ACCCGAAGCG GAGGTCGGCG GGGGGCTGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0103--Bromodomain
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-1017--Isopeptide bond
KW-0418--Kinase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
KW-0832--Ubl conjugation
KW-0856--Williams-Beuren syndrome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR018501--DDT_dom
IPR009071--HMG_box_dom
IPR028942--WHIM1_dom
IPR028941--WHIM2_dom
IPR013136--WSTF_Acf1_Cbp146
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS50827--DDT
PS51136--WAC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00439--Bromodomain
PF00628--PHD
PF10537--WAC_Acf1_DNA_bd
PF15612--WHIM1
PF15613--WSD

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00571--DDT
SM00249--PHD

Gene Ontology

GO:0000793--C:condensed chromosome
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005721--C:pericentric heterochromatin
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0035173--F:histone kinase activity
GO:0070577--F:lysine-acetylated histone binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0071884--F:vitamin D receptor activator activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006333--P:chromatin assembly or disassembly
GO:0048096--P:chromatin-mediated maintenance of transcription
GO:0006302--P:double-strand break repair
GO:0003007--P:heart morphogenesis
GO:0016572--P:histone phosphorylation
GO:0045815--P:positive regulation of gene expression, epigenetic
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:9031

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002113	Ailuropoda melanoleuca	96.27	0.00e+00	2476.00
IUUC-Apl-003454	Anas platyrhynchos	79.99	0.00e+00	2157.00
IUUC-Ame-011469	Astyanax mexicanus	62.02	0.00e+00	1288.00
IUUC-Bta-012408	Bos taurus	94.67	0.00e+00	2534.00
IUUC-Cja-019194	Callithrix jacchus	97.10	0.00e+00	2613.00
IUUC-Cfa-021083	Canis familiaris	95.63	0.00e+00	2555.00
IUUC-Cpo-021422	Cavia porcellus	93.23	0.00e+00	2387.00
IUUC-Csa-023848	Chlorocebus sabaeus	99.06	0.00e+00	2675.00
IUUC-Dre-027895	Danio rerio	62.19	0.00e+00	1335.00
IUUC-Dno-029686	Dasypus novemcinctus	93.88	0.00e+00	2539.00
IUUC-Dor-030625	Dipodomys ordii	81.54	0.00e+00	1304.00
IUUC-Ete-032702	Echinops telfairi	93.21	0.00e+00	1005.00
IUUC-Eca-033647	Equus caballus	96.48	0.00e+00	2541.00
IUUC-Eeu-034626	Erinaceus europaeus	88.32	0.00e+00	2070.00
IUUC-Fca-036092	Felis catus	95.99	0.00e+00	2128.00
IUUC-Fal-037127	Ficedula albicollis	78.70	0.00e+00	2162.00
IUUC-Gmo-039455	Gadus morhua	58.33	0.00e+00	1025.00
IUUC-Gga-041120	Gallus gallus	79.26	0.00e+00	2093.00
IUUC-Gac-041873	Gasterosteus aculeatus	60.44	0.00e+00	1333.00
IUUC-Ggo-045317	Gorilla gorilla	99.86	0.00e+00	2622.00
IUUC-Itr-049026	Ictidomys tridecemlineatus	93.37	0.00e+00	2439.00
IUUC-Lch-050271	Latimeria chalumnae	69.92	0.00e+00	1663.00
IUUC-Loc-052699	Lepisosteus oculatus	65.94	0.00e+00	1036.00
IUUC-Mcc-055171	Macaca mulatta	98.99	0.00e+00	2671.00
IUUC-Meu-055990	Macropus eugenii	84.95	0.00e+00	2034.00
IUUC-Mga-059913	Meleagris gallopavo	78.77	0.00e+00	1992.00
IUUC-Mmr-061681	Microcebus murinus	95.89	0.00e+00	2570.00
IUUC-Mdo-062486	Monodelphis domestica	87.08	0.00e+00	2256.00
IUUC-Mmu-063460	Mus musculus	91.12	0.00e+00	2292.00
IUUC-Mpu-066324	Mustela putorius furo	92.91	0.00e+00	1303.00
IUUC-Mlu-067334	Myotis lucifugus	94.14	0.00e+00	2598.00
IUUC-Nle-069983	Nomascus leucogenys	99.53	0.00e+00	2713.00
IUUC-Opr-070678	Ochotona princeps	85.77	0.00e+00	759.00
IUUC-Ont-071565	Oreochromis niloticus	60.60	0.00e+00	991.00
IUUC-Ocu-074779	Oryctolagus cuniculus	94.40	0.00e+00	2427.00
IUUC-Obr-076214	Oryza brachyantha	42.47	1.00e-11	67.00
IUUC-Ola-086746	Oryzias latipes	60.20	0.00e+00	1376.00
IUUC-Oga-088475	Otolemur garnettii	91.11	0.00e+00	2461.00
IUUC-Oar-090191	Ovis aries	93.05	0.00e+00	2438.00
IUUC-Ptr-090963	Pan troglodytes	98.92	0.00e+00	2660.00
IUUC-Pan-091819	Papio anubis	98.90	0.00e+00	2097.00
IUUC-Psi-093967	Pelodiscus sinensis	81.55	0.00e+00	2069.00
IUUC-Pfo-096939	Poecilia formosa	58.45	0.00e+00	1019.00
IUUC-Pab-098679	Pongo abelii	99.21	0.00e+00	2495.00
IUUC-Pop-099061	Populus trichocarpa	65.52	5.00e-09	55.50
IUUC-Pva-102969	Pteropus vampyrus	95.36	0.00e+00	2377.00
IUUC-Rno-104927	Rattus norvegicus	91.64	0.00e+00	2328.00
IUUC-Sha-107021	Sarcophilus harrisii	84.68	0.00e+00	2095.00
IUUC-Ssc-116243	Sus scrofa	95.48	0.00e+00	2553.00
IUUC-Tgu-117073	Taeniopygia guttata	76.57	0.00e+00	1826.00
IUUC-Tru-118265	Takifugu rubripes	59.28	0.00e+00	1389.00
IUUC-Ttr-128885	Tursiops truncatus	91.80	0.00e+00	2078.00
IUUC-Vvi-131714	Vitis vinifera	50.00	2.00e-12	67.00
IUUC-Xtr-131812	Xenopus tropicalis	64.05	0.00e+00	1571.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence