iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000011332.19	ENST00000420980.6	ENSP00000397354.2
ENSG00000011332.19	ENST00000416611.5	ENSP00000390223.1
ENSG00000011332.19	ENST00000418517.5	ENSP00000408201.1
ENSG00000011332.19	ENST00000355526.8	ENSP00000347716.4
ENSG00000011332.19	ENST00000456296.5	ENSP00000411569.1
ENSG00000011332.19	ENST00000614244.4	ENSP00000483226.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.10e-12	48.7	354	400

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C +Cg +++d+ +l+ C++C++ +H  Cl+++   e p+ + w C  C 
   Q: 354  SCSLCGTSENDD-QLLFCDDCDRGYHMYCLSPP-MAEPPEGS-WSCHLCL 400
           7********987.7*******************.77777776.******5 PP

Organism

Homo sapiens

Functional Description
(View)

May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Protein Sequence
(Fasta)

MGGLSARPTA GRTDPAGTCW GQDPGSKMAT VIPGPLSLGE DFYREAIEHC RSYNARLCAE 60
RSLRLPFLDS QTGVAQNNCY IWMEKTHRGP GLAPGQIYTY PARCWRKKRR LNILEDPRLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCAGCCCCA AGAATGAATG AAATCGTAGC GCGCTGGGCG GCAGAGCGGG CGGCGCAGGC 60
CGGGCTGGGC CCGCGCGCGG CGGCAGCGGC GCCCCGGGCC GGAGGCGGCC CAGCCGAGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0524--Neurogenesis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025750--Requiem/DPF_N_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00628--PHD
PF14051--Requiem_N

SMART

SM00249--PHD

Gene Ontology

GO:0005737--C:cytoplasm
GO:0071565--C:nBAF complex
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0007399--P:nervous system development
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:8193

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001316	Ailuropoda melanoleuca	99.76	0.00e+00	797.00
IUUC-Aca-004761	Anolis carolinensis	86.60	0.00e+00	629.00
IUUC-Ame-011556	Astyanax mexicanus	79.83	2.00e-160	558.00
IUUC-Bta-013085	Bos taurus	94.59	0.00e+00	726.00
IUUC-Cja-020005	Callithrix jacchus	93.90	4.00e-163	566.00
IUUC-Cpo-021668	Cavia porcellus	91.73	0.00e+00	666.00
IUUC-Csa-024238	Chlorocebus sabaeus	97.64	0.00e+00	790.00
IUUC-Dre-027738	Danio rerio	79.45	1.00e-179	622.00
IUUC-Dno-029041	Dasypus novemcinctus	100.00	0.00e+00	720.00
IUUC-Ete-032515	Echinops telfairi	93.60	0.00e+00	660.00
IUUC-Fca-035543	Felis catus	99.76	0.00e+00	797.00
IUUC-Gac-042351	Gasterosteus aculeatus	78.87	2.00e-173	601.00
IUUC-Ggo-044774	Gorilla gorilla	99.48	0.00e+00	734.00
IUUC-Itr-048666	Ictidomys tridecemlineatus	96.73	0.00e+00	734.00
IUUC-Lch-049484	Latimeria chalumnae	79.64	1.00e-134	473.00
IUUC-Loc-052898	Lepisosteus oculatus	76.50	1.00e-166	579.00
IUUC-Mcc-055662	Macaca mulatta	97.18	0.00e+00	717.00
IUUC-Meu-056874	Macropus eugenii	83.46	1.00e-168	585.00
IUUC-Mmr-061293	Microcebus murinus	100.00	0.00e+00	723.00
IUUC-Mmu-064024	Mus musculus	95.23	0.00e+00	724.00
IUUC-Mpu-066648	Mustela putorius furo	99.52	0.00e+00	795.00
IUUC-Nle-069746	Nomascus leucogenys	93.59	0.00e+00	682.00
IUUC-Ont-072320	Oreochromis niloticus	77.19	8.00e-176	609.00
IUUC-Ola-086430	Oryzias latipes	78.32	7.00e-171	593.00
IUUC-Oga-088070	Otolemur garnettii	97.48	0.00e+00	734.00
IUUC-Oar-090336	Ovis aries	88.94	0.00e+00	664.00
IUUC-Ptr-091481	Pan troglodytes	99.67	2.00e-165	574.00
IUUC-Pan-092328	Papio anubis	100.00	0.00e+00	798.00
IUUC-Pfo-096233	Poecilia formosa	77.25	1.00e-176	612.00
IUUC-Pab-098560	Pongo abelii	100.00	0.00e+00	798.00
IUUC-Pca-100612	Procavia capensis	92.59	4.00e-70	258.00
IUUC-Rno-105001	Rattus norvegicus	98.45	0.00e+00	739.00
IUUC-Ssc-115701	Sus scrofa	99.48	0.00e+00	726.00
IUUC-Tni-120860	Tetraodon nigroviridis	75.96	7.00e-168	583.00
IUUC-Ttr-128890	Tursiops truncatus	83.12	0.00e+00	637.00
IUUC-Xtr-131925	Xenopus tropicalis	86.28	0.00e+00	656.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence