iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000012817.15	ENST00000317961.8	ENSP00000322408.4
ENSG00000012817.15	ENST00000382806.6	ENSP00000372256.2
ENSG00000012817.15	ENST00000440077.5	ENSP00000398543.1
ENSG00000012817.15	ENST00000415360.1	ENSP00000389433.1
ENSG00000012817.15	ENST00000447300.1	ENSP00000416377.1
ENSG00000012817.15	ENST00000541639.5	ENSP00000444293.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
THPA	HPM
DNA & RNA Element
circBase	circRNADb	CircNet	miRTarBase
microRNA	TRANSFAC	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
OMIM
Drug and target
DrugBank	GRAC
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	BioGRID
mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	3.20e-14	54.5	316	362

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC +g+ed+ +l+ C+ C++++H  Cl ++  +e p+   w CpkC 
   Q: 316  ICQVCSRGDEDD-KLLFCDGCDDNYHIFCLLPP-LPEIPRGI-WRCPKCI 362
           7*********88.6*******************.******97.******5 PP

Organism

Homo sapiens

Functional Description
(View)

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks.

Protein Sequence
(Fasta)

MEPGCDEFLP PPECPVFEPS WAEFQDPLGY IAKIRPIAEK SGICKIRPPA DWQPPFAVEV 60
DNFRFTPRVQ RLNELEAQTR VKLNYLDQIA KFWEIQGSSL KIPNVERKIL DLYSLSKIVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATTTTAAAA AAGATCCGGC CATACTATTT TTATCTTGCT TTTTCGTTCT GTCGCAGTAC 60
TGTTTAATAT GAGTCCAGCG ACGGCTCTGT GACTGTTTTC CTCTGGTAAA ATCGCTCTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001606--ARID_dom
IPR003347--JmjC_dom
IPR003349--JmjN
IPR013637--Lys_sp_deMease-like_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR004198--Znf_C5HC2
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51011--ARID
PS51184--JMJC
PS51183--JMJN
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF01388--ARID
PF02373--JmjC
PF02375--JmjN
PF00628--PHD
PF08429--PLU-1
PF02928--zf-C5HC2

SMART

SM00501--BRIGHT
SM00558--JmjC
SM00545--JmjN
SM00249--PHD

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0050681--F:androgen receptor binding
GO:0003677--F:DNA binding
GO:0032452--F:histone demethylase activity
GO:0032453--F:histone demethylase activity (H3-K4 specific)
GO:0016706--F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0008270--F:zinc ion binding
GO:0034720--P:histone H3-K4 demethylation
GO:0060765--P:regulation of androgen receptor signaling pathway
GO:0006355--P:regulation of transcription, DNA-templated
GO:0002457--P:T cell antigen processing and presentation
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:8284

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Csa-023682	Chlorocebus sabaeus	93.06	0.00e+00	2684.00
IUUC-Gmo-039140	Gadus morhua	60.15	0.00e+00	1689.00
IUUC-Mcc-055474	Macaca mulatta	95.41	0.00e+00	2801.00
IUUC-Ptr-091415	Pan troglodytes	97.01	0.00e+00	2778.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence