iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosSNP	PhosphositePlus
dbPTM	HPRD	Phospho.ELM	UniProt
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RBR	RBR	19741096; 19224863; 16513638

Classification

Family	E-value	Score	Start	End
E3 activity/RBR	1.00e-52	179.6	132	332

Active Site

Position(s)	Description	Evidence
316	N/A	{ECO:0000250\|UniProtKB:Q9Y4X5}

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpekleeseikellveeelykryekllleevveadaalkw 90
           C++Cll++s+++++ +++C+h+ C +Cl+qyl+++i+e++ ++iscp  ec+e++++++i+ +l+++ l+++ye+++l++++ ad++++w
   Q: 132  CPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIEISESR-VNISCP--ECTERFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRW 218
           ****************************************.9*****..89*************************************** PP
   S: 91   cpapdCslvvllekea..eklevecekcgkefCveCkeewHeglsCkelkeklakteeek.......eeaeskelleanskkCpkCkvyi 171
           cpapdC ++v++  +a  +kl++ +e+cg+efC++Ck++wH++++C+++++++a++ + +       + ++++ ++++++k+Cp+C +yi
   Q: 219  CPAPDCGYAVIAFGCAscPKLTCGREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRtirsssiSYSQESGAAADDIKPCPRCAAYI 308
           *************999889************************************99998999*99999999****************** PP
   S: 172  ek..negCnhmtCakCkaefCwlC 193
           +k  +++CnhmtCa C++efCwlC
   Q: 309  IKmnDGSCNHMTCAVCGCEFCWLC 332
           *997889***************** PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.

Protein Sequence
(Fasta)

MQEQEIGFIS KYNEGLCVNT DPVSILTSIL DMSLHRQMGS DRDLQSSASS VSLPSVKKAP 60
KKRRISIGSL FRRKKDNKRK SRELNGGVDG IASIESIHSE MCTDKNSIFS TNTSSDNGLT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCTTCGCCG CGCCCTCTTC TCTCATTGGC ACTGCCTGTC TACTGCCGAG GGCATTTGAG 60
TGTGGGACCC ATGCCCTGCA TTTCTTCGCT ACCCCACAGC TTCTGCTCAT GGTAATATCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF01485--IBR

SMART

SM00647--IBR
SM00184--RING

Gene Ontology

GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0016021--C:integral component of membrane
GO:0000151--C:ubiquitin ligase complex
GO:0008134--F:transcription factor binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0000226--P:microtubule cytoskeleton organization
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

hsa:25897

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001958	Ailuropoda melanoleuca	98.21	0.00e+00	1417.00
IUUC-Apl-003427	Anas platyrhynchos	89.57	0.00e+00	1173.00
IUUC-Aca-004252	Anolis carolinensis	86.55	0.00e+00	1136.00
IUUC-Ame-011434	Astyanax mexicanus	74.94	0.00e+00	887.00
IUUC-Bta-013558	Bos taurus	97.85	0.00e+00	1411.00
IUUC-Cel-018626	Caenorhabditis elegans	55.49	1.00e-111	397.00
IUUC-Cja-019070	Callithrix jacchus	99.16	0.00e+00	1428.00
IUUC-Cfa-020286	Canis familiaris	97.85	0.00e+00	1414.00
IUUC-Cpo-022015	Cavia porcellus	96.54	0.00e+00	1381.00
IUUC-Csa-023975	Chlorocebus sabaeus	98.81	0.00e+00	1400.00
IUUC-Cho-024442	Choloepus hoffmanni	82.82	0.00e+00	1188.00
IUUC-Cin-025143	Ciona intestinalis	55.41	2.00e-43	169.00
IUUC-Dre-028422	Danio rerio	73.34	0.00e+00	882.00
IUUC-Dno-029018	Dasypus novemcinctus	96.92	0.00e+00	1312.00
IUUC-Dor-030548	Dipodomys ordii	93.65	0.00e+00	658.00
IUUC-Eca-034249	Equus caballus	97.85	0.00e+00	1412.00
IUUC-Eeu-035298	Erinaceus europaeus	97.96	0.00e+00	851.00
IUUC-Fca-035912	Felis catus	97.73	0.00e+00	1411.00
IUUC-Fal-037488	Ficedula albicollis	87.74	0.00e+00	1140.00
IUUC-Gmo-038893	Gadus morhua	82.22	0.00e+00	811.00
IUUC-Gga-040380	Gallus gallus	89.22	0.00e+00	1143.00
IUUC-Gac-041421	Gasterosteus aculeatus	76.50	0.00e+00	892.00
IUUC-Ggo-044893	Gorilla gorilla	99.76	0.00e+00	1439.00
IUUC-Itr-048257	Ictidomys tridecemlineatus	98.21	0.00e+00	1414.00
IUUC-Lch-049774	Latimeria chalumnae	84.99	0.00e+00	1132.00
IUUC-Loc-052040	Lepisosteus oculatus	77.19	0.00e+00	1009.00
IUUC-Laf-053874	Loxodonta africana	97.49	0.00e+00	1377.00
IUUC-Mcc-054817	Macaca mulatta	98.67	2.00e-113	401.00
IUUC-Meu-056648	Macropus eugenii	90.68	1.00e-175	610.00
IUUC-Mga-060175	Meleagris gallopavo	88.16	0.00e+00	1166.00
IUUC-Mmr-060800	Microcebus murinus	98.57	0.00e+00	1420.00
IUUC-Mdo-061827	Monodelphis domestica	87.33	0.00e+00	1134.00
IUUC-Mmu-064134	Mus musculus	93.57	0.00e+00	1287.00
IUUC-Mpu-066076	Mustela putorius furo	97.73	0.00e+00	1407.00
IUUC-Mlu-068218	Myotis lucifugus	96.54	0.00e+00	1331.00
IUUC-Nle-069707	Nomascus leucogenys	99.69	0.00e+00	1120.00
IUUC-Opr-070977	Ochotona princeps	96.53	0.00e+00	1374.00
IUUC-Ont-072373	Oreochromis niloticus	79.62	0.00e+00	942.00
IUUC-Oan-073376	Ornithorhynchus anatinus	90.43	7.00e-175	606.00
IUUC-Ocu-074878	Oryctolagus cuniculus	96.54	0.00e+00	1356.00
IUUC-Ola-086472	Oryzias latipes	78.81	0.00e+00	934.00
IUUC-Oga-088377	Otolemur garnettii	98.08	0.00e+00	1402.00
IUUC-Oar-089540	Ovis aries	97.37	0.00e+00	1404.00
IUUC-Ptr-090613	Pan troglodytes	100.00	0.00e+00	1442.00
IUUC-Pan-092879	Papio anubis	99.05	0.00e+00	1401.00
IUUC-Psi-093201	Pelodiscus sinensis	89.94	0.00e+00	1137.00
IUUC-Pma-094620	Petromyzon marinus	69.94	0.00e+00	813.00
IUUC-Pfo-096615	Poecilia formosa	84.14	0.00e+00	899.00
IUUC-Pca-100625	Procavia capensis	95.33	0.00e+00	1364.00
IUUC-Pva-103110	Pteropus vampyrus	87.35	0.00e+00	1076.00
IUUC-Rno-105998	Rattus norvegicus	92.86	0.00e+00	1283.00
IUUC-Sha-107523	Sarcophilus harrisii	86.44	0.00e+00	1133.00
IUUC-Sar-113089	Sorex araneus	94.13	0.00e+00	964.00
IUUC-Ssc-115471	Sus scrofa	97.37	0.00e+00	1369.00
IUUC-Tgu-117080	Taeniopygia guttata	88.11	0.00e+00	1180.00
IUUC-Tru-117547	Takifugu rubripes	79.34	0.00e+00	897.00
IUUC-Tsy-119143	Tarsius syrichta	97.26	0.00e+00	1396.00
IUUC-Tni-119693	Tetraodon nigroviridis	75.47	0.00e+00	892.00
IUUC-Ttr-129175	Tursiops truncatus	97.37	0.00e+00	1389.00
IUUC-Vpa-130594	Vicugna pacos	90.62	0.00e+00	1300.00
IUUC-Xtr-132579	Xenopus tropicalis	87.39	0.00e+00	1152.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence