iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC
DNA & RNA Element
AREsite	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	18794354; 18936169

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-29	102.7	184	218
UBD/Beta-Prp	3.20e-40	139.8	161	361

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrt 32
           gH  ++ ++++    d +l+++s D  +k+WD+r+
   Q: 184  GHRQEILAVSWsprYDYILATASADSRVKLWDVRR 218
           8**********96543678*************986 PP

UBD/Beta-Prp

   S: 69   tgseDrtikvwdlstgkcvhtlkghedsvlslsfsp.sgdklvsGshdrtirvwdletgq.clee..............tlsghdgvvncvv 144
            g +   +++ dl++g+c h+l+gh +++l++s+sp +++ l+++s+d+ +++wd++  + cl +               ++ h+g vn+++
   Q: 161  VGTRGPKVQLCDLKSGSCSHILQGHRQEILAVSWSPrYDYILATASADSRVKLWDVRRASgCLITldqhngkksqavesANTAHNGKVNGLC 252
           555666677889************************888999**************987636666*************************** PP
   S: 145  vhpdgnllvsGslDrtvrlWdlktgkllrtl....tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfsp 232
           + +dg  l + ++D+ +rlW++++g+           + ++  + +     + e+v + + +t+ ++ + +ge +  l+gh ++v +  f +
   Q: 253  FTSDGLHLLTVGTDNRMRLWNSSNGENTLVNygkvCNNSKKGLKFTVSCGCSSEFVFVPYGSTIAVYTVYSGEQITMLKGHYKTVDCCVFQS 344
           *****99*************996654333334444223444444444455559*************************************** PP
   S: 233  nderlvsgssDgsiriW 249
           n + l+sgs D  i  W
   Q: 345  NFQELYSGSRDCNILAW 361
           ***************99 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes.

Protein Sequence
(Fasta)

MLGFLSARQT GLEDPLRLRR AESTRRVLGL ELNKDRDVER IHGGGINTLD IEPVEGRYML 60
SGGSDGVIVL YDLENSSRQS YYTCKAVCSI GRDHPDVHRY SVETVQWYPH DTGMFTSSSF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCAGTCCCG CCCCTGAGCT CTGTCATGGC GACGTCCAGT GCTCCAGCCG GTGTGAGGAC 60
ACGATATGCT GGGGTTTTTG TCCGCACGCC AAACGGGTTT GGAGGACCCT CTTCGCCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0172--Cockayne syndrome
KW-0181--Complete proteome
KW-0209--Deafness
KW-0225--Disease mutation
KW-0227--DNA damage
KW-0234--DNA repair
KW-0242--Dwarfism
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0016363--C:nuclear matrix
GO:0005654--C:nucleoplasm
GO:0000109--C:nucleotide-excision repair complex
GO:0005634--C:nucleus
GO:0043234--C:protein complex
GO:0032403--F:protein complex binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006289--P:nucleotide-excision repair
GO:0045739--P:positive regulation of DNA repair
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0006979--P:response to oxidative stress
GO:0009411--P:response to UV
GO:0010165--P:response to X-ray
GO:0006283--P:transcription-coupled nucleotide-excision repair

KEGG

hsa:1161

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001170	Aegilops tauschii	30.09	8.00e-37	149.00
IUUC-Aml-002201	Ailuropoda melanoleuca	93.94	0.00e+00	787.00
IUUC-Atr-002784	Amborella trichopoda	37.18	6.00e-41	161.00
IUUC-Apl-003202	Anas platyrhynchos	81.32	0.00e+00	658.00
IUUC-Aca-004708	Anolis carolinensis	80.46	1.00e-176	612.00
IUUC-Aly-006144	Arabidopsis lyrata	30.15	5.00e-44	172.00
IUUC-Ath-006673	Arabidopsis thaliana	39.71	5.00e-45	175.00
IUUC-Acl-008195	Aspergillus clavatus	38.29	7.00e-43	168.00
IUUC-Afl-008406	Aspergillus flavus	36.36	7.00e-39	154.00
IUUC-Afu-008759	Aspergillus fumigatus	36.06	6.00e-40	158.00
IUUC-Ani-009380	Aspergillus nidulans	35.10	7.00e-41	161.00
IUUC-Ang-009820	Aspergillus niger	36.76	4.00e-39	155.00
IUUC-Aor-010092	Aspergillus oryzae	36.67	1.00e-43	170.00
IUUC-Ate-010491	Aspergillus terreus	36.30	2.00e-44	173.00
IUUC-Bta-012825	Bos taurus	93.95	0.00e+00	780.00
IUUC-Bci-013856	Botrytis cinerea	31.58	3.00e-52	199.00
IUUC-Bdi-014899	Brachypodium distachyon	32.84	5.00e-64	238.00
IUUC-Bol-015337	Brassica oleracea	37.93	1.00e-44	174.00
IUUC-Bra-018089	Brassica rapa	37.93	1.00e-44	174.00
IUUC-Cja-018725	Callithrix jacchus	96.97	0.00e+00	805.00
IUUC-Cfa-021162	Canis familiaris	94.44	0.00e+00	789.00
IUUC-Cpo-022190	Cavia porcellus	94.44	0.00e+00	792.00
IUUC-Cre-022960	Chlamydomonas reinhardtii	37.14	4.00e-40	159.00
IUUC-Csa-023610	Chlorocebus sabaeus	100.00	0.00e+00	826.00
IUUC-Cho-024689	Choloepus hoffmanni	92.70	0.00e+00	721.00
IUUC-Cin-025324	Ciona intestinalis	40.16	1.00e-80	293.00
IUUC-Csv-026059	Ciona savignyi	38.37	3.00e-73	269.00
IUUC-Cgl-026384	Colletotrichum gloeosporioides	33.23	1.00e-38	154.00
IUUC-Cme-027182	Cyanidioschyzon merolae	28.66	5.00e-13	69.70
IUUC-Dre-028696	Danio rerio	72.50	1.00e-176	612.00
IUUC-Dno-029102	Dasypus novemcinctus	94.44	0.00e+00	792.00
IUUC-Dor-030361	Dipodomys ordii	77.02	3.00e-179	621.00
IUUC-Dse-031167	Dothistroma septosporum	29.46	2.00e-44	173.00
IUUC-Ete-032856	Echinops telfairi	75.51	6.00e-178	616.00
IUUC-Eca-033611	Equus caballus	95.56	0.00e+00	683.00
IUUC-Eeu-034583	Erinaceus europaeus	71.72	4.00e-162	564.00
IUUC-Fca-036481	Felis catus	94.44	0.00e+00	791.00
IUUC-Fal-037327	Ficedula albicollis	77.94	3.00e-165	573.00
IUUC-Fox-037684	Fusarium oxysporum	30.52	1.00e-43	171.00
IUUC-Fso-038306	Fusarium solani	32.55	5.00e-54	205.00
IUUC-Gmo-039043	Gadus morhua	67.85	4.00e-163	567.00
IUUC-Ggr-039783	Gaeumannomyces graminis	33.67	9.00e-38	151.00
IUUC-Gga-041085	Gallus gallus	85.06	0.00e+00	632.00
IUUC-Gac-042328	Gasterosteus aculeatus	67.08	1.00e-158	552.00
IUUC-Gma-042916	Glycine max	32.01	9.00e-58	217.00
IUUC-Ggo-045627	Gorilla gorilla	91.04	0.00e+00	741.00
IUUC-Hvu-047678	Hordeum vulgare	32.06	3.00e-34	139.00
IUUC-Itr-048648	Ictidomys tridecemlineatus	95.20	0.00e+00	799.00
IUUC-Kpa-049386	Komagataella pastoris	30.33	2.00e-43	169.00
IUUC-Lch-050590	Latimeria chalumnae	79.31	4.00e-162	563.00
IUUC-Lpe-051725	Leersia perrieri	32.80	3.00e-35	142.00
IUUC-Loc-051788	Lepisosteus oculatus	74.23	2.00e-179	621.00
IUUC-Lma-053082	Leptosphaeria maculans	33.71	2.00e-54	206.00
IUUC-Laf-053809	Loxodonta africana	94.71	0.00e+00	790.00
IUUC-Mcc-054998	Macaca mulatta	99.29	1.00e-167	582.00
IUUC-Meu-055929	Macropus eugenii	77.39	0.00e+00	636.00
IUUC-Mor-057003	Magnaporthe oryzae	33.63	3.00e-48	186.00
IUUC-Mtr-057921	Medicago truncatula	32.03	6.00e-57	214.00
IUUC-Mga-059449	Meleagris gallopavo	65.59	1.00e-125	442.00
IUUC-Mmr-061609	Microcebus murinus	92.07	0.00e+00	743.00
IUUC-Mdo-062564	Monodelphis domestica	85.14	0.00e+00	724.00
IUUC-Mmu-063904	Mus musculus	89.67	0.00e+00	753.00
IUUC-Mac-064716	Musa acuminata	36.16	2.00e-40	159.00
IUUC-Mpu-066617	Mustela putorius furo	94.19	0.00e+00	789.00
IUUC-Mlu-067054	Myotis lucifugus	91.67	0.00e+00	768.00
IUUC-Nfi-068467	Neosartorya fischeri	36.90	1.00e-34	140.00
IUUC-Nle-069731	Nomascus leucogenys	100.00	0.00e+00	826.00
IUUC-Opr-070297	Ochotona princeps	68.62	1.00e-87	316.00
IUUC-Ont-072558	Oreochromis niloticus	70.32	2.00e-164	571.00
IUUC-Oan-072864	Ornithorhynchus anatinus	85.96	5.00e-27	111.00
IUUC-Ocu-074415	Oryctolagus cuniculus	95.20	0.00e+00	797.00
IUUC-Oba-075759	Oryza barthii	39.47	8.00e-43	168.00
IUUC-Obr-076387	Oryza brachyantha	37.91	7.00e-45	174.00
IUUC-Ogl-077924	Oryza glaberrima	40.60	3.00e-17	82.00
IUUC-Ogu-078186	Oryza glumaepatula	34.20	9.00e-63	234.00
IUUC-Oin-079389	Oryza indica	33.71	2.00e-46	179.00
IUUC-Olo-080916	Oryza longistaminata	28.43	3.00e-16	78.20
IUUC-Ome-081471	Oryza meridionalis	38.95	3.00e-40	159.00
IUUC-Oni-082449	Oryza nivara	38.95	5.00e-40	158.00
IUUC-Opu-083210	Oryza punctata	38.95	2.00e-42	166.00
IUUC-Oru-085159	Oryza rufipogon	39.47	5.00e-43	168.00
IUUC-Osa-085926	Oryza sativa	39.86	6.00e-33	133.00
IUUC-Ola-087084	Oryzias latipes	67.59	1.00e-165	575.00
IUUC-Olu-087853	Ostreococcus lucimarinus	28.35	5.00e-39	155.00
IUUC-Oga-089008	Otolemur garnettii	93.48	0.00e+00	780.00
IUUC-Oar-089259	Ovis aries	94.46	0.00e+00	783.00
IUUC-Ptr-091112	Pan troglodytes	99.24	0.00e+00	815.00
IUUC-Pan-092303	Papio anubis	100.00	8.00e-75	271.00
IUUC-Psi-093050	Pelodiscus sinensis	82.16	0.00e+00	697.00
IUUC-Pma-094259	Petromyzon marinus	56.19	7.00e-128	450.00
IUUC-Pno-094798	Phaeosphaeria nodorum	30.89	1.00e-50	194.00
IUUC-Ppa-095477	Physcomitrella patens	31.19	1.00e-53	203.00
IUUC-Pfo-096855	Poecilia formosa	67.16	1.00e-163	569.00
IUUC-Pab-098096	Pongo abelii	99.24	0.00e+00	820.00
IUUC-Pop-098800	Populus trichocarpa	36.40	4.00e-45	175.00
IUUC-Pca-100187	Procavia capensis	92.23	3.00e-113	402.00
IUUC-Ppe-101759	Prunus persica	36.00	2.00e-43	170.00
IUUC-Pva-102438	Pteropus vampyrus	78.05	2.00e-91	329.00
IUUC-Pte-104197	Pyrenophora teres	33.33	4.00e-50	192.00
IUUC-Pyt-104421	Pyrenophora triticirepentis	33.33	1.00e-49	191.00
IUUC-Rno-106087	Rattus norvegicus	90.43	0.00e+00	760.00
IUUC-Sce-106276	Saccharomyces cerevisiae	26.80	4.00e-12	66.60
IUUC-Sha-106831	Sarcophilus harrisii	82.41	0.00e+00	690.00
IUUC-Sja-107681	Schizosaccharomyces japonicus	33.07	4.00e-57	215.00
IUUC-Spo-108294	Schizosaccharomyces pombe	34.83	6.00e-64	238.00
IUUC-Ssl-108613	Sclerotinia sclerotiorum	32.67	6.00e-52	198.00
IUUC-Smo-109008	Selaginella moellendorffii	40.90	2.00e-76	279.00
IUUC-Sit-110300	Setaria italica	29.95	2.00e-52	199.00
IUUC-Sly-111441	Solanum lycopersicum	28.94	7.00e-45	174.00
IUUC-Stu-111995	Solanum tuberosum	28.74	5.00e-45	175.00
IUUC-Sar-113196	Sorex araneus	84.03	2.00e-130	458.00
IUUC-Sbi-113790	Sorghum bicolor	40.00	2.00e-43	170.00
IUUC-Ssc-115609	Sus scrofa	94.44	0.00e+00	794.00
IUUC-Tgu-116927	Taeniopygia guttata	79.70	0.00e+00	663.00
IUUC-Tru-118164	Takifugu rubripes	68.98	4.00e-171	593.00
IUUC-Tsy-119151	Tarsius syrichta	89.90	0.00e+00	741.00
IUUC-Tni-120896	Tetraodon nigroviridis	68.25	1.00e-161	562.00
IUUC-Tca-121592	Theobroma cacao	29.37	2.00e-45	176.00
IUUC-Tre-122023	Trichoderma reesei	34.73	4.00e-49	189.00
IUUC-Tvi-122507	Trichoderma virens	35.10	4.00e-50	192.00
IUUC-Tae-125730	Triticum aestivum	33.73	1.00e-59	223.00
IUUC-Tur-126092	Triticum urartu	30.29	3.00e-34	139.00
IUUC-Tbe-127422	Tupaia belangeri	71.35	3.00e-152	531.00
IUUC-Ttr-129097	Tursiops truncatus	91.41	0.00e+00	767.00
IUUC-Vda-130014	Verticillium dahliae	36.05	4.00e-51	195.00
IUUC-Vpa-130782	Vicugna pacos	94.96	0.00e+00	792.00
IUUC-Vvi-131494	Vitis vinifera	34.65	2.00e-43	170.00
IUUC-Xtr-132165	Xenopus tropicalis	77.84	0.00e+00	629.00
IUUC-Xma-133205	Xiphophorus maculatus	67.83	3.00e-167	581.00
IUUC-Yli-134614	Yarrowia lipolytica	32.86	1.00e-59	224.00
IUUC-Zma-135861	Zea mays	34.15	4.00e-60	225.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence