iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-035489

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02189279

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000014898.3	ENSFCAT00000014902.3	ENSFCAP00000013819.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.30e-127	425.0	547	876

Active Site

Position(s)	Description	Evidence
846	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 547  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 635
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilge...tkeeeLkpgGenipVtneNkeeYvkl 176
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+   t++++Lkp+G++i+VtneNk+eY++l
   Q: 636  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQqlqTYQVDLKPNGSEIMVTNENKREYIDL 719
           ***********************************99...6666..7********9966422267778********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafL 265
           v+++r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +      ++L
   Q: 720  VIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLM-----XRLL 803
           *****************************************************************************998.....58** PP
   S: 266  qFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           qFvTg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 804  QFVTGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 876
           ************************************************************************8 PP

Organism

Felis catus

Protein Sequence
(Fasta)

TRDDFLGQVD IPLNHLPTED PTMERPYTFK DFLLRPRSHK SRVKGFLRLK MAYMPKNGGQ 60
DEENSEQRED MEHGWEVVDS NDSASQHQEE LPPPPLPPGW EEKVDNLGRT YYVNHNNRTT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCCGAGACG ACTTCCTGGG ACAGGTGGAC ATACCCCTGA ATCATCTCCC GGTAAGGACC 60
ATTACCTGCT TCATGGTGCA TGCCGTGAGC AGCGCTTTTC ATTGTTTCCG GTTGGGTATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	93.55	0.00e+00	1526.00
IUUC-Apl-003893	Anas platyrhynchos	90.95	0.00e+00	1523.00
IUUC-Aca-004744	Anolis carolinensis	87.57	0.00e+00	1462.00
IUUC-Ame-010810	Astyanax mexicanus	67.76	0.00e+00	1090.00
IUUC-Bta-012679	Bos taurus	95.25	0.00e+00	1562.00
IUUC-Cja-018732	Callithrix jacchus	95.14	0.00e+00	1597.00
IUUC-Cfa-021226	Canis familiaris	95.36	0.00e+00	1583.00
IUUC-Cpo-021671	Cavia porcellus	92.65	0.00e+00	1523.00
IUUC-Csa-023344	Chlorocebus sabaeus	92.90	0.00e+00	1573.00
IUUC-Cho-024832	Choloepus hoffmanni	97.46	0.00e+00	720.00
IUUC-Dre-027770	Danio rerio	76.57	0.00e+00	1229.00
IUUC-Dno-029466	Dasypus novemcinctus	94.46	0.00e+00	1585.00
IUUC-Dor-030138	Dipodomys ordii	91.23	0.00e+00	1474.00
IUUC-Ete-033145	Echinops telfairi	85.32	0.00e+00	1228.00
IUUC-Eca-033445	Equus caballus	95.59	0.00e+00	1540.00
IUUC-Eeu-035247	Erinaceus europaeus	86.88	0.00e+00	1359.00
IUUC-Fal-037604	Ficedula albicollis	88.26	0.00e+00	1496.00
IUUC-Gmo-039674	Gadus morhua	74.24	0.00e+00	1194.00
IUUC-Gga-040703	Gallus gallus	90.27	0.00e+00	1521.00
IUUC-Gac-042020	Gasterosteus aculeatus	77.21	0.00e+00	1231.00
IUUC-Ggo-045332	Gorilla gorilla	92.53	0.00e+00	1558.00
IUUC-Hsa-045968	Homo sapiens	94.68	0.00e+00	1580.00
IUUC-Lch-050443	Latimeria chalumnae	84.41	0.00e+00	1397.00
IUUC-Loc-052662	Lepisosteus oculatus	79.19	0.00e+00	1252.00
IUUC-Laf-053850	Loxodonta africana	92.87	0.00e+00	1564.00
IUUC-Mcc-055821	Macaca mulatta	94.46	0.00e+00	1579.00
IUUC-Meu-056712	Macropus eugenii	79.50	0.00e+00	674.00
IUUC-Mga-059264	Meleagris gallopavo	70.67	0.00e+00	1014.00
IUUC-Mmr-060798	Microcebus murinus	90.42	0.00e+00	1459.00
IUUC-Mdo-062173	Monodelphis domestica	91.58	0.00e+00	1577.00
IUUC-Mmu-064136	Mus musculus	93.56	0.00e+00	1548.00
IUUC-Mpu-066765	Mustela putorius furo	95.81	0.00e+00	1566.00
IUUC-Mlu-067565	Myotis lucifugus	93.33	0.00e+00	1537.00
IUUC-Nle-069070	Nomascus leucogenys	90.51	0.00e+00	1484.00
IUUC-Opr-071044	Ochotona princeps	91.58	0.00e+00	1140.00
IUUC-Ont-072044	Oreochromis niloticus	76.14	0.00e+00	1262.00
IUUC-Oan-073032	Ornithorhynchus anatinus	90.68	0.00e+00	1405.00
IUUC-Ocu-074160	Oryctolagus cuniculus	90.85	0.00e+00	1501.00
IUUC-Ola-087467	Oryzias latipes	76.23	0.00e+00	1243.00
IUUC-Oga-088460	Otolemur garnettii	90.28	0.00e+00	1509.00
IUUC-Oar-090198	Ovis aries	94.46	0.00e+00	1545.00
IUUC-Ptr-090939	Pan troglodytes	94.68	0.00e+00	1580.00
IUUC-Pan-092284	Papio anubis	94.57	0.00e+00	1577.00
IUUC-Psi-093645	Pelodiscus sinensis	91.29	0.00e+00	1523.00
IUUC-Pma-094364	Petromyzon marinus	79.05	0.00e+00	818.00
IUUC-Pab-098088	Pongo abelii	94.68	0.00e+00	1581.00
IUUC-Pca-100714	Procavia capensis	75.23	0.00e+00	1211.00
IUUC-Pva-102354	Pteropus vampyrus	92.53	0.00e+00	1520.00
IUUC-Rno-105318	Rattus norvegicus	93.56	0.00e+00	1545.00
IUUC-Sha-107482	Sarcophilus harrisii	94.00	0.00e+00	1592.00
IUUC-Ssc-115950	Sus scrofa	69.05	0.00e+00	1120.00
IUUC-Tgu-117130	Taeniopygia guttata	90.84	0.00e+00	1525.00
IUUC-Tru-118610	Takifugu rubripes	77.29	0.00e+00	1263.00
IUUC-Tsy-119492	Tarsius syrichta	92.19	0.00e+00	1552.00
IUUC-Tni-120113	Tetraodon nigroviridis	71.66	0.00e+00	1196.00
IUUC-Ttr-128235	Tursiops truncatus	93.95	0.00e+00	1029.00
IUUC-Xtr-132859	Xenopus tropicalis	86.78	0.00e+00	1454.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence