iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045332

UUCD1 version

UUC-GoG-00528

Ensembl Protein ID

ENSGGOP00000013401.2

UniProt Accession

G3RD09; G3RD09_GORGO

Protein Name

Uncharacterized protein

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000013730.2	ENSGGOT00000022796.1	ENSGGOP00000022625.1
ENSGGOG00000013730.2	ENSGGOT00000013787.2	ENSGGOP00000013401.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.60e-135	450.7	660	991

Active Site

Position(s)	Description	Evidence
961	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 660  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 748
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 749  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 832
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 833  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 921
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 922  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 991
           *********************************************************************8 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

PGGLCRALPG RERLQSPVHA VPLQHGTSHS RLLVTWPGAG GDQDFSSPPL LLLGETDHLH 60
LDLPLSPLPS SDELFLPGIC DPYVKLSLYV ADENRELALV QTKTIKKTLN PKWNEEFYFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTGTTCTCC TTCTCACAGG GAGAGTCCCG TATTCTCAGA GTAAAAGTTG TTTCTGGAAT 60
TGATCTCGCC AAAAAGGACA TCTTTGGAGC CAGGTATGTT GGCTTTGTTT TTATTTCTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	97.52	0.00e+00	1702.00
IUUC-Apl-003893	Anas platyrhynchos	92.95	0.00e+00	1663.00
IUUC-Aca-004744	Anolis carolinensis	89.77	0.00e+00	1606.00
IUUC-Ago-007742	Ashbya gossypii	48.91	3.00e-161	562.00
IUUC-Acl-008273	Aspergillus clavatus	49.26	1.00e-163	570.00
IUUC-Afl-008713	Aspergillus flavus	49.01	4.00e-161	561.00
IUUC-Afu-009103	Aspergillus fumigatus	49.02	9.00e-164	570.00
IUUC-Ani-009259	Aspergillus nidulans	48.45	4.00e-162	565.00
IUUC-Ang-009738	Aspergillus niger	49.33	4.00e-162	565.00
IUUC-Aor-010053	Aspergillus oryzae	58.05	3.00e-101	361.00
IUUC-Ate-010529	Aspergillus terreus	49.42	2.00e-164	572.00
IUUC-Ame-010810	Astyanax mexicanus	86.58	0.00e+00	1029.00
IUUC-Bgr-012148	Blumeria graminis	47.91	3.00e-154	538.00
IUUC-Bta-012679	Bos taurus	95.56	0.00e+00	1581.00
IUUC-Bci-013785	Botrytis cinerea	47.99	5.00e-156	545.00
IUUC-Cel-018564	Caenorhabditis elegans	52.84	0.00e+00	633.00
IUUC-Cja-018732	Callithrix jacchus	96.91	0.00e+00	1752.00
IUUC-Cfa-021226	Canis familiaris	95.73	0.00e+00	1706.00
IUUC-Cpo-021671	Cavia porcellus	98.36	0.00e+00	1718.00
IUUC-Csa-023344	Chlorocebus sabaeus	95.50	0.00e+00	1739.00
IUUC-Cho-024832	Choloepus hoffmanni	100.00	0.00e+00	741.00
IUUC-Cin-025157	Ciona intestinalis	63.27	0.00e+00	788.00
IUUC-Csv-026098	Ciona savignyi	59.04	0.00e+00	653.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	48.34	2.00e-155	542.00
IUUC-Cne-026849	Cryptococcus neoformans	48.58	5.00e-158	551.00
IUUC-Dre-027770	Danio rerio	77.69	0.00e+00	1372.00
IUUC-Dno-029466	Dasypus novemcinctus	95.94	0.00e+00	1741.00
IUUC-Dor-030138	Dipodomys ordii	94.53	0.00e+00	1649.00
IUUC-Dse-031241	Dothistroma septosporum	47.70	6.00e-160	557.00
IUUC-Dme-032166	Drosophila melanogaster	67.30	0.00e+00	712.00
IUUC-Ete-033145	Echinops telfairi	91.62	0.00e+00	1299.00
IUUC-Eca-033445	Equus caballus	96.23	0.00e+00	1572.00
IUUC-Eeu-035247	Erinaceus europaeus	90.27	0.00e+00	1533.00
IUUC-Fca-035489	Felis catus	92.53	0.00e+00	1515.00
IUUC-Fal-037604	Ficedula albicollis	90.27	0.00e+00	1637.00
IUUC-Fox-037774	Fusarium oxysporum	48.76	9.00e-159	553.00
IUUC-Fso-038393	Fusarium solani	47.32	1.00e-153	537.00
IUUC-Gmo-039674	Gadus morhua	76.16	0.00e+00	1324.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.75	7.00e-156	544.00
IUUC-Gga-040703	Gallus gallus	92.21	0.00e+00	1666.00
IUUC-Gac-042020	Gasterosteus aculeatus	76.40	0.00e+00	1362.00
IUUC-Hsa-045968	Homo sapiens	97.55	0.00e+00	1752.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	64.65	0.00e+00	815.00
IUUC-Kpa-049273	Komagataella pastoris	49.33	7.00e-162	564.00
IUUC-Lch-050443	Latimeria chalumnae	85.57	0.00e+00	1431.00
IUUC-Loc-052662	Lepisosteus oculatus	79.44	0.00e+00	1370.00
IUUC-Laf-053850	Loxodonta africana	98.80	0.00e+00	1757.00
IUUC-Mcc-055821	Macaca mulatta	97.33	0.00e+00	1750.00
IUUC-Meu-056712	Macropus eugenii	85.27	0.00e+00	794.00
IUUC-Mor-057097	Magnaporthe oryzae	47.75	1.00e-156	546.00
IUUC-Mpo-057442	Magnaporthe poae	52.16	2.00e-145	509.00
IUUC-Mla-058996	Melampsora laricipopulina	48.11	6.00e-154	538.00
IUUC-Mga-059362	Meleagris gallopavo	62.70	0.00e+00	1101.00
IUUC-Mvi-060395	Microbotryum violaceum	53.70	6.00e-150	524.00
IUUC-Mmr-060798	Microcebus murinus	90.08	0.00e+00	1613.00
IUUC-Mdo-062173	Monodelphis domestica	93.51	0.00e+00	1714.00
IUUC-Mmu-064136	Mus musculus	95.20	0.00e+00	1704.00
IUUC-Mpu-066765	Mustela putorius furo	95.94	0.00e+00	1711.00
IUUC-Mlu-067565	Myotis lucifugus	93.17	0.00e+00	1553.00
IUUC-Nfi-068427	Neosartorya fischeri	49.02	5.00e-164	571.00
IUUC-Ncr-068918	Neurospora crassa	47.40	3.00e-157	549.00
IUUC-Nle-069070	Nomascus leucogenys	93.39	0.00e+00	1654.00
IUUC-Opr-071044	Ochotona princeps	99.20	0.00e+00	1206.00
IUUC-Ont-072044	Oreochromis niloticus	76.41	0.00e+00	1394.00
IUUC-Oan-073032	Ornithorhynchus anatinus	91.09	0.00e+00	1398.00
IUUC-Ocu-074160	Oryctolagus cuniculus	97.06	0.00e+00	1697.00
IUUC-Oba-075252	Oryza barthii	44.58	2.00e-90	329.00
IUUC-Ogu-077981	Oryza glumaepatula	44.33	3.00e-90	328.00
IUUC-Oin-079663	Oryza indica	44.58	8.00e-91	330.00
IUUC-Olo-080326	Oryza longistaminata	44.33	1.00e-89	326.00
IUUC-Oni-082342	Oryza nivara	44.58	1.00e-90	330.00
IUUC-Opu-083428	Oryza punctata	44.81	3.00e-91	332.00
IUUC-Oru-084559	Oryza rufipogon	44.58	2.00e-90	329.00
IUUC-Ola-087467	Oryzias latipes	77.57	0.00e+00	1377.00
IUUC-Oga-088460	Otolemur garnettii	91.22	0.00e+00	1549.00
IUUC-Oar-090198	Ovis aries	95.41	0.00e+00	1694.00
IUUC-Ptr-090939	Pan troglodytes	97.55	0.00e+00	1752.00
IUUC-Pan-092284	Papio anubis	97.33	0.00e+00	1750.00
IUUC-Psi-093645	Pelodiscus sinensis	92.74	0.00e+00	1656.00
IUUC-Pma-094364	Petromyzon marinus	82.67	0.00e+00	861.00
IUUC-Pno-095118	Phaeosphaeria nodorum	50.00	3.00e-163	568.00
IUUC-Pfo-096768	Poecilia formosa	72.07	0.00e+00	1167.00
IUUC-Pab-098088	Pongo abelii	97.33	0.00e+00	1748.00
IUUC-Pca-100714	Procavia capensis	76.36	0.00e+00	1367.00
IUUC-Pva-102354	Pteropus vampyrus	98.03	0.00e+00	1701.00
IUUC-Pgr-103620	Puccinia graminis	53.53	8.00e-148	517.00
IUUC-Ptt-103806	Puccinia triticina	53.38	9.00e-123	434.00
IUUC-Pte-104016	Pyrenophora teres	49.00	4.00e-162	565.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	49.00	4.00e-162	565.00
IUUC-Rno-105318	Rattus norvegicus	95.41	0.00e+00	1702.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.25	6.00e-164	571.00
IUUC-Sha-107482	Sarcophilus harrisii	95.01	0.00e+00	1592.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	48.58	6.00e-152	531.00
IUUC-Spo-108171	Schizosaccharomyces pombe	48.91	3.00e-160	558.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	48.49	1.00e-157	550.00
IUUC-Sit-110149	Setaria italica	45.29	4.00e-93	338.00
IUUC-Stu-112582	Solanum tuberosum	35.81	5.00e-55	209.00
IUUC-Sbi-113794	Sorghum bicolor	44.50	2.00e-92	335.00
IUUC-Ssc-115950	Sus scrofa	71.12	0.00e+00	1166.00
IUUC-Tgu-117130	Taeniopygia guttata	92.64	0.00e+00	1664.00
IUUC-Tru-118610	Takifugu rubripes	79.03	0.00e+00	1405.00
IUUC-Tsy-119492	Tarsius syrichta	93.46	0.00e+00	1713.00
IUUC-Tni-120113	Tetraodon nigroviridis	73.75	0.00e+00	1333.00
IUUC-Tre-122203	Trichoderma reesei	47.45	4.00e-152	531.00
IUUC-Tvi-122595	Trichoderma virens	47.27	2.00e-154	539.00
IUUC-Tme-126897	Tuber melanosporum	52.69	2.00e-147	516.00
IUUC-Tbe-127441	Tupaia belangeri	84.35	0.00e+00	841.00
IUUC-Ttr-128235	Tursiops truncatus	89.24	0.00e+00	1623.00
IUUC-Vda-129753	Verticillium dahliae	47.85	6.00e-157	548.00
IUUC-Vpa-130544	Vicugna pacos	75.84	0.00e+00	923.00
IUUC-Xtr-132859	Xenopus tropicalis	88.06	0.00e+00	1588.00
IUUC-Xma-133797	Xiphophorus maculatus	80.25	0.00e+00	1395.00
IUUC-Yli-134668	Yarrowia lipolytica	46.58	6.00e-162	564.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence