iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mla-058996

Ensembl Protein ID

EGG09709

UniProt Accession

F4RCD2; F4RCD2_MELLP

Genbank Protein ID

EGG09709.1

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

GL883096

Gene Name

MELLADRAFT_42401

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
MELLADRAFT_42401	EGG09709	EGG09709

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-123	412.5	512	843

Active Site

Position(s)	Description	Evidence
812	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           ++dlkkrl+++f gE+gld+gGv+ref++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr+l++a++++r+ld+ + +sfyk++l+
   Q: 512  PNDLKKRLMIKFDGEDGLDYGGVSREFFFLLSHEMFNPFYCLFEYSAVDNYTLQINPHSGV-NPEHLNYFKFIGRVLALAIFHRRFLDAYFITSFYKMILK 611
           689*********************************************************9.89************************************* PP
   S: 103  kklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevipl 203
           k+++l d+e+vd+e+++sl ++++n   di++  ++ +fsv++e++ge+ + +Lk++G+nipVt+eNk+eY++l++++r+++++  q++af  Gfne+ip+
   Q: 612  KRIQLADMESVDAEIFRSLSWMLDN---DITDV-IENSFSVEDEKFGEVVTIDLKEDGRNIPVTEENKKEYIDLITQWRIEKRVVDQFKAFLTGFNELIPQ 708
           ***********************99...9***8.******************************************************************* PP
   S: 204  ellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs 300
           +l+++F+e+elelli G+++idv+d+ k+t y+g y++d+++i+wFw++++++ +e+++++LqF+Tg+sr+P++Gf++l+    pr+f+i+k+++ ++lP+
   Q: 709  DLINVFDERELELLIGGMSDIDVDDWIKHTDYRG-YQQDDQVIKWFWQAVRAWPAEKKSRLLQFTTGTSRIPVNGFKDLQgsdgPRRFTIEKAGEITQLPK 808
           ********************************76.*********************************************************9999***** PP
   S: 301  snTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           s+TCfn+L+LP+Y++ ++l++k+++Aieet gF +
   Q: 809  SHTCFNRLDLPPYPNFDQLEQKITFAIEETLGFAV 843
           ********************************975 PP

Organism

Melampsora laricipopulina

Protein Sequence
(Fasta)

MSSGSAAPNP QRTKTVRLTV VAADGLSKRD VFRLPDPFAV VMVDGDHTKT TSAIKKTLNP 60
YWNESFDIQV KDSSVVTVQI FDQKKFKRKD QGFLGVINIR VSSVLDLDLG GDETLTRDLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTCCTCTT TACCATCATC ATCTTCATTA CCATCAACAC TCAAGCTCAA CAATCGAATT 60
CAAATCAATC AATCAACCCT CAGGATGTCG AGCGGATCTG CCGCTCCTAA CCCACAGCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005934--C:cellular bud tip
GO:0010008--C:endosome membrane
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0035091--F:phosphatidylinositol binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0034644--P:cellular response to UV
GO:0006333--P:chromatin assembly or disassembly
GO:0032511--P:late endosome to vacuole transport via multivesicular body sorting pathway
GO:0007005--P:mitochondrion organization
GO:0016973--P:poly(A)+ mRNA export from nucleus
GO:0045723--P:positive regulation of fatty acid biosynthetic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0010794--P:regulation of dolichol biosynthetic process
GO:0032443--P:regulation of ergosterol biosynthetic process
GO:0031384--P:regulation of initiation of mating projection growth
GO:0010793--P:regulation of mRNA export from nucleus
GO:0010796--P:regulation of multivesicular body size
GO:0006808--P:regulation of nitrogen utilization
GO:0019220--P:regulation of phosphate metabolic process
GO:2000203--P:regulation of ribosomal large subunit export from nucleus
GO:2000232--P:regulation of rRNA processing
GO:2000238--P:regulation of tRNA export from nucleus
GO:2000235--P:regulation of tRNA processing
GO:0010795--P:regulation of ubiquinone biosynthetic process
GO:0042493--P:response to drug
GO:0034517--P:ribophagy
GO:0070086--P:ubiquitin-dependent endocytosis
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

mlr:MELLADRAFT_42401

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	48.60	3.00e-155	540.00
IUUC-Apl-003752	Anas platyrhynchos	47.09	3.00e-159	553.00
IUUC-Aca-005338	Anolis carolinensis	45.95	3.00e-155	540.00
IUUC-Ago-007742	Ashbya gossypii	58.96	0.00e+00	941.00
IUUC-Acl-008273	Aspergillus clavatus	63.73	0.00e+00	1007.00
IUUC-Afl-008713	Aspergillus flavus	64.95	0.00e+00	1006.00
IUUC-Afu-009103	Aspergillus fumigatus	62.92	0.00e+00	986.00
IUUC-Ani-009259	Aspergillus nidulans	62.44	0.00e+00	1010.00
IUUC-Ang-009738	Aspergillus niger	64.09	0.00e+00	1034.00
IUUC-Aor-010053	Aspergillus oryzae	74.25	8.00e-138	480.00
IUUC-Ate-010529	Aspergillus terreus	65.07	0.00e+00	1027.00
IUUC-Ame-010810	Astyanax mexicanus	52.07	2.00e-143	501.00
IUUC-Bgr-012148	Blumeria graminis	77.71	0.00e+00	807.00
IUUC-Bta-012453	Bos taurus	52.28	1.00e-142	499.00
IUUC-Bci-013785	Botrytis cinerea	62.43	0.00e+00	1004.00
IUUC-Cel-018299	Caenorhabditis elegans	44.66	5.00e-147	513.00
IUUC-Cja-018732	Callithrix jacchus	47.86	2.00e-156	544.00
IUUC-Cfa-020258	Canis familiaris	46.23	1.00e-153	535.00
IUUC-Cpo-021671	Cavia porcellus	48.60	2.00e-155	541.00
IUUC-Csa-023805	Chlorocebus sabaeus	40.39	9.00e-149	518.00
IUUC-Cho-024695	Choloepus hoffmanni	46.12	3.00e-154	536.00
IUUC-Cin-025212	Ciona intestinalis	49.90	2.00e-143	501.00
IUUC-Csv-026256	Ciona savignyi	50.00	2.00e-143	500.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	61.66	0.00e+00	1009.00
IUUC-Cne-026849	Cryptococcus neoformans	64.65	0.00e+00	1101.00
IUUC-Dre-028245	Danio rerio	45.89	3.00e-153	533.00
IUUC-Dno-029466	Dasypus novemcinctus	47.22	1.00e-155	541.00
IUUC-Dor-030138	Dipodomys ordii	47.95	8.00e-151	525.00
IUUC-Dse-031241	Dothistroma septosporum	64.79	0.00e+00	1063.00
IUUC-Dme-032041	Drosophila melanogaster	51.33	4.00e-141	493.00
IUUC-Ete-032779	Echinops telfairi	44.52	2.00e-137	481.00
IUUC-Eca-033445	Equus caballus	48.60	2.00e-155	540.00
IUUC-Eeu-035247	Erinaceus europaeus	48.11	7.00e-155	539.00
IUUC-Fca-035605	Felis catus	36.25	2.00e-155	541.00
IUUC-Fal-037126	Ficedula albicollis	46.93	1.00e-159	554.00
IUUC-Fox-037774	Fusarium oxysporum	62.10	0.00e+00	1006.00
IUUC-Fso-038393	Fusarium solani	61.69	0.00e+00	983.00
IUUC-Gmo-039679	Gadus morhua	46.17	5.00e-149	519.00
IUUC-Ggr-040107	Gaeumannomyces graminis	62.41	0.00e+00	1008.00
IUUC-Gga-040703	Gallus gallus	47.62	6.00e-155	539.00
IUUC-Gac-042211	Gasterosteus aculeatus	45.23	2.00e-153	534.00
IUUC-Ggo-045332	Gorilla gorilla	48.60	3.00e-155	540.00
IUUC-Hsa-045968	Homo sapiens	48.60	1.00e-155	541.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	45.28	6.00e-154	535.00
IUUC-Kpa-049273	Komagataella pastoris	62.16	0.00e+00	1004.00
IUUC-Lch-050443	Latimeria chalumnae	48.28	8.00e-155	538.00
IUUC-Loc-052662	Lepisosteus oculatus	52.70	5.00e-141	493.00
IUUC-Lma-052980	Leptosphaeria maculans	61.55	2.00e-170	590.00
IUUC-Laf-053850	Loxodonta africana	48.60	3.00e-155	540.00
IUUC-Mcc-055821	Macaca mulatta	48.60	2.00e-155	541.00
IUUC-Meu-056436	Macropus eugenii	45.41	3.00e-119	420.00
IUUC-Mor-057097	Magnaporthe oryzae	63.61	0.00e+00	1043.00
IUUC-Mpo-057442	Magnaporthe poae	59.73	0.00e+00	923.00
IUUC-Mga-059661	Meleagris gallopavo	46.93	3.00e-159	553.00
IUUC-Mvi-060395	Microbotryum violaceum	68.45	0.00e+00	1120.00
IUUC-Mmr-061061	Microcebus murinus	46.56	1.00e-158	552.00
IUUC-Mdo-062173	Monodelphis domestica	45.71	5.00e-152	530.00
IUUC-Mmu-063202	Mus musculus	46.29	1.00e-148	518.00
IUUC-Mpu-066765	Mustela putorius furo	48.60	2.00e-155	540.00
IUUC-Mlu-067565	Myotis lucifugus	48.77	3.00e-155	540.00
IUUC-Nfi-068427	Neosartorya fischeri	64.19	0.00e+00	1013.00
IUUC-Ncr-068918	Neurospora crassa	62.05	0.00e+00	987.00
IUUC-Nle-069225	Nomascus leucogenys	52.81	3.00e-150	524.00
IUUC-Opr-071044	Ochotona princeps	48.11	1.00e-154	538.00
IUUC-Ont-071664	Oreochromis niloticus	47.52	8.00e-142	496.00
IUUC-Oan-073019	Ornithorhynchus anatinus	42.54	9.00e-147	512.00
IUUC-Ocu-074160	Oryctolagus cuniculus	48.20	4.00e-154	536.00
IUUC-Ola-087467	Oryzias latipes	52.07	6.00e-142	496.00
IUUC-Oga-088460	Otolemur garnettii	47.85	1.00e-155	541.00
IUUC-Oar-089797	Ovis aries	53.01	2.00e-143	500.00
IUUC-Ptr-090939	Pan troglodytes	48.60	1.00e-155	541.00
IUUC-Pan-092284	Papio anubis	47.78	9.00e-156	542.00
IUUC-Psi-093645	Pelodiscus sinensis	46.99	1.00e-156	545.00
IUUC-Pma-094364	Petromyzon marinus	52.29	3.00e-144	502.00
IUUC-Pno-095118	Phaeosphaeria nodorum	62.60	0.00e+00	1025.00
IUUC-Pfo-096768	Poecilia formosa	52.80	3.00e-143	500.00
IUUC-Pab-098088	Pongo abelii	48.60	2.00e-155	541.00
IUUC-Pca-100596	Procavia capensis	49.48	4.00e-140	490.00
IUUC-Pva-102354	Pteropus vampyrus	48.44	1.00e-154	538.00
IUUC-Pgr-103620	Puccinia graminis	89.15	0.00e+00	1120.00
IUUC-Ptt-103806	Puccinia triticina	88.49	0.00e+00	959.00
IUUC-Pte-104016	Pyrenophora teres	63.35	0.00e+00	1038.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	63.35	0.00e+00	1038.00
IUUC-Rno-105318	Rattus norvegicus	48.60	2.00e-155	541.00
IUUC-Sce-106289	Saccharomyces cerevisiae	67.80	0.00e+00	880.00
IUUC-Sha-107482	Sarcophilus harrisii	47.18	1.00e-154	538.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	61.98	0.00e+00	1039.00
IUUC-Spo-108171	Schizosaccharomyces pombe	63.56	0.00e+00	1039.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	63.68	0.00e+00	1002.00
IUUC-Sar-113761	Sorex araneus	45.60	7.00e-156	542.00
IUUC-Sre-114929	Sporisorium reilianum	73.67	0.00e+00	949.00
IUUC-Ssc-115368	Sus scrofa	45.82	2.00e-146	511.00
IUUC-Tgu-116632	Taeniopygia guttata	46.97	6.00e-157	545.00
IUUC-Tru-118442	Takifugu rubripes	45.47	2.00e-154	537.00
IUUC-Tsy-119492	Tarsius syrichta	48.60	2.00e-154	537.00
IUUC-Tni-119993	Tetraodon nigroviridis	47.28	9.00e-148	515.00
IUUC-Tre-122203	Trichoderma reesei	62.90	0.00e+00	981.00
IUUC-Tvi-122595	Trichoderma virens	62.51	0.00e+00	993.00
IUUC-Tme-126897	Tuber melanosporum	56.46	0.00e+00	869.00
IUUC-Tbe-127793	Tupaia belangeri	48.03	7.00e-135	472.00
IUUC-Ttr-128235	Tursiops truncatus	52.49	7.00e-144	502.00
IUUC-Uma-129332	Ustilago maydis	73.62	0.00e+00	916.00
IUUC-Vda-129753	Verticillium dahliae	62.52	0.00e+00	985.00
IUUC-Vpa-130503	Vicugna pacos	52.81	1.00e-139	489.00
IUUC-Xtr-132859	Xenopus tropicalis	47.48	1.00e-156	545.00
IUUC-Xma-133797	Xiphophorus maculatus	47.29	2.00e-149	521.00
IUUC-Yli-134668	Yarrowia lipolytica	69.12	0.00e+00	895.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence