iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067565

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02014584

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000004954.2	ENSMLUT00000004966.2	ENSMLUP00000004528.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.20e-136	453.8	544	875

Active Site

Position(s)	Description	Evidence
845	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 544  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 632
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 633  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 716
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++t yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 717  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHTIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 805
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+d+lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 806  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPDKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 875
           *********************************************************************8 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

TRDDFLGQVD VPLNHLPTED PTMERPYTFK DFLLRPRSHK SRVKGFLRLK MAYMPKNGGQ 60
DEENSEQRED MEHGWEVVDS NDSASQHQEE LPPPLPPGWE EKVDNLGRTY YVNHNNRSTQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACACGAGACG ACTTCCTGGG ACAGGTGGAC GTGCCCCTTA ATCATCTCCC GGTGAGGATG 60
GTTACCTGCT TTCTATTGCC TGTTGTGATC AGTGACTTCT CATTGTTTTC AGCTGGATAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	93.63	0.00e+00	1551.00
IUUC-Apl-003893	Anas platyrhynchos	91.92	0.00e+00	1556.00
IUUC-Aca-004744	Anolis carolinensis	89.43	0.00e+00	1503.00
IUUC-Ago-007742	Ashbya gossypii	49.41	8.00e-163	567.00
IUUC-Acl-008273	Aspergillus clavatus	49.26	6.00e-163	567.00
IUUC-Afl-008713	Aspergillus flavus	49.01	8.00e-161	560.00
IUUC-Afu-009103	Aspergillus fumigatus	49.02	6.00e-163	568.00
IUUC-Ani-009259	Aspergillus nidulans	49.16	4.00e-161	561.00
IUUC-Ang-009738	Aspergillus niger	49.33	1.00e-161	563.00
IUUC-Aor-010053	Aspergillus oryzae	58.39	8.00e-102	363.00
IUUC-Ate-010529	Aspergillus terreus	49.42	1.00e-163	570.00
IUUC-Ame-010810	Astyanax mexicanus	70.01	0.00e+00	1137.00
IUUC-Bgr-012148	Blumeria graminis	48.09	5.00e-154	538.00
IUUC-Bta-012679	Bos taurus	95.90	0.00e+00	1585.00
IUUC-Cel-018564	Caenorhabditis elegans	53.18	0.00e+00	635.00
IUUC-Cja-018732	Callithrix jacchus	95.79	0.00e+00	1620.00
IUUC-Cfa-021226	Canis familiaris	95.45	0.00e+00	1611.00
IUUC-Cpo-021671	Cavia porcellus	92.95	0.00e+00	1546.00
IUUC-Csa-023344	Chlorocebus sabaeus	93.76	0.00e+00	1591.00
IUUC-Cho-024832	Choloepus hoffmanni	99.43	0.00e+00	740.00
IUUC-Csv-026098	Ciona savignyi	59.04	0.00e+00	654.00
IUUC-Dre-027770	Danio rerio	78.84	0.00e+00	1273.00
IUUC-Dno-029466	Dasypus novemcinctus	95.45	0.00e+00	1610.00
IUUC-Dor-030138	Dipodomys ordii	91.65	0.00e+00	1497.00
IUUC-Dse-031241	Dothistroma septosporum	47.70	1.00e-159	557.00
IUUC-Ete-033145	Echinops telfairi	86.55	0.00e+00	1262.00
IUUC-Eca-033445	Equus caballus	95.79	0.00e+00	1566.00
IUUC-Eeu-035247	Erinaceus europaeus	87.37	0.00e+00	1387.00
IUUC-Fca-035489	Felis catus	93.56	0.00e+00	1529.00
IUUC-Fal-037604	Ficedula albicollis	89.41	0.00e+00	1540.00
IUUC-Fox-037774	Fusarium oxysporum	48.76	2.00e-158	552.00
IUUC-Gmo-039674	Gadus morhua	76.86	0.00e+00	1244.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.50	8.00e-156	544.00
IUUC-Gga-040703	Gallus gallus	91.13	0.00e+00	1554.00
IUUC-Gac-042020	Gasterosteus aculeatus	79.19	0.00e+00	1269.00
IUUC-Ggo-045332	Gorilla gorilla	93.74	0.00e+00	1581.00
IUUC-Hsa-045968	Homo sapiens	95.79	0.00e+00	1605.00
IUUC-Lch-050443	Latimeria chalumnae	87.49	0.00e+00	1449.00
IUUC-Loc-052662	Lepisosteus oculatus	81.36	0.00e+00	1293.00
IUUC-Laf-053850	Loxodonta africana	93.17	0.00e+00	1588.00
IUUC-Mcc-055821	Macaca mulatta	95.68	0.00e+00	1603.00
IUUC-Meu-056712	Macropus eugenii	79.42	0.00e+00	681.00
IUUC-Mor-057097	Magnaporthe oryzae	47.50	1.00e-156	546.00
IUUC-Mla-058996	Melampsora laricipopulina	54.55	3.00e-150	526.00
IUUC-Mga-059264	Meleagris gallopavo	71.68	0.00e+00	1052.00
IUUC-Mvi-060395	Microbotryum violaceum	53.91	1.00e-150	527.00
IUUC-Mmr-060798	Microcebus murinus	91.38	0.00e+00	1478.00
IUUC-Mdo-062173	Monodelphis domestica	92.43	0.00e+00	1605.00
IUUC-Mmu-064136	Mus musculus	94.77	0.00e+00	1570.00
IUUC-Mpu-066765	Mustela putorius furo	96.02	0.00e+00	1588.00
IUUC-Nfi-068427	Neosartorya fischeri	49.02	2.00e-163	569.00
IUUC-Nle-069070	Nomascus leucogenys	91.82	0.00e+00	1513.00
IUUC-Opr-071044	Ochotona princeps	95.67	0.00e+00	1194.00
IUUC-Ont-072044	Oreochromis niloticus	77.74	0.00e+00	1309.00
IUUC-Oan-073032	Ornithorhynchus anatinus	90.53	0.00e+00	1416.00
IUUC-Ocu-074160	Oryctolagus cuniculus	92.16	0.00e+00	1529.00
IUUC-Ola-087467	Oryzias latipes	78.65	0.00e+00	1295.00
IUUC-Oga-088460	Otolemur garnettii	92.26	0.00e+00	1549.00
IUUC-Oar-090198	Ovis aries	95.11	0.00e+00	1568.00
IUUC-Ptr-090939	Pan troglodytes	95.79	0.00e+00	1605.00
IUUC-Pan-092284	Papio anubis	95.68	0.00e+00	1602.00
IUUC-Psi-093645	Pelodiscus sinensis	92.04	0.00e+00	1556.00
IUUC-Pma-094364	Petromyzon marinus	82.63	0.00e+00	860.00
IUUC-Pno-095118	Phaeosphaeria nodorum	47.73	2.00e-163	569.00
IUUC-Pab-098088	Pongo abelii	95.79	0.00e+00	1605.00
IUUC-Pca-100714	Procavia capensis	76.68	0.00e+00	1229.00
IUUC-Pva-102354	Pteropus vampyrus	93.63	0.00e+00	1553.00
IUUC-Pgr-103620	Puccinia graminis	53.73	2.00e-148	519.00
IUUC-Ptt-103806	Puccinia triticina	53.62	2.00e-123	436.00
IUUC-Rno-105318	Rattus norvegicus	94.89	0.00e+00	1572.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.58	5.00e-165	574.00
IUUC-Sha-107482	Sarcophilus harrisii	95.24	0.00e+00	1607.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	48.67	1.00e-157	550.00
IUUC-Sre-114929	Sporisorium reilianum	52.27	5.00e-148	518.00
IUUC-Ssc-115950	Sus scrofa	70.80	0.00e+00	1165.00
IUUC-Tgu-117130	Taeniopygia guttata	91.92	0.00e+00	1560.00
IUUC-Tru-118610	Takifugu rubripes	79.14	0.00e+00	1313.00
IUUC-Tsy-119492	Tarsius syrichta	93.06	0.00e+00	1574.00
IUUC-Tni-120113	Tetraodon nigroviridis	73.89	0.00e+00	1245.00
IUUC-Tre-122203	Trichoderma reesei	47.45	8.00e-152	531.00
IUUC-Ttr-128235	Tursiops truncatus	98.38	0.00e+00	1081.00
IUUC-Vda-129753	Verticillium dahliae	47.85	8.00e-157	547.00
IUUC-Xtr-132859	Xenopus tropicalis	88.52	0.00e+00	1499.00
IUUC-Xma-133797	Xiphophorus maculatus	79.64	0.00e+00	1304.00
IUUC-Yli-134668	Yarrowia lipolytica	46.42	1.00e-161	563.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence