iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088460

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03056953

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000015613.2	ENSOGAT00000015625.2	ENSOGAP00000013993.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-135	451.1	543	874

Active Site

Position(s)	Description	Evidence
844	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 543  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 631
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 632  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 715
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 716  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 804
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 805  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 874
           *********************************************************************8 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

TRDDFLGQVD VPLSHLPTED PTMERPYTFK DFLLRPRSHK SRVKGFLRLK MAYMPKNGGQ 60
DEESGEQRDD VEHGWEVVDS NDSASQHQEE LPPPPLPPGW EEKVDNLGRT YYVNHNNRTT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCCGAGACG ACTTCCTGGG CCAGGTGGAC GTGCCCCTTA GTCATCTTCC GGTAAGGGCA 60
TCACATGTGT TCTGCTACAT GCTGTGGGAG GTGGTTTATT TTCAGAGTAA TTTCTTGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	91.56	0.00e+00	1514.00
IUUC-Apl-003893	Anas platyrhynchos	90.19	0.00e+00	1534.00
IUUC-Aca-004744	Anolis carolinensis	86.45	0.00e+00	1470.00
IUUC-Ago-007742	Ashbya gossypii	48.91	1.00e-161	563.00
IUUC-Acl-008273	Aspergillus clavatus	49.26	9.00e-164	570.00
IUUC-Afl-008713	Aspergillus flavus	49.01	2.00e-161	562.00
IUUC-Afu-009103	Aspergillus fumigatus	49.02	8.00e-164	570.00
IUUC-Ani-009259	Aspergillus nidulans	49.16	1.00e-161	563.00
IUUC-Ang-009738	Aspergillus niger	49.33	5.00e-162	565.00
IUUC-Aor-010053	Aspergillus oryzae	58.05	2.00e-101	361.00
IUUC-Ate-010529	Aspergillus terreus	49.42	2.00e-164	573.00
IUUC-Ame-010810	Astyanax mexicanus	70.14	0.00e+00	1135.00
IUUC-Bgr-012148	Blumeria graminis	47.91	4.00e-154	538.00
IUUC-Bta-012679	Bos taurus	93.06	0.00e+00	1531.00
IUUC-Bci-013785	Botrytis cinerea	47.99	3.00e-156	545.00
IUUC-Cel-018564	Caenorhabditis elegans	52.53	0.00e+00	632.00
IUUC-Cja-018732	Callithrix jacchus	93.63	0.00e+00	1575.00
IUUC-Cfa-021226	Canis familiaris	93.16	0.00e+00	1567.00
IUUC-Cpo-021671	Cavia porcellus	91.45	0.00e+00	1523.00
IUUC-Csa-023344	Chlorocebus sabaeus	91.40	0.00e+00	1564.00
IUUC-Cho-024832	Choloepus hoffmanni	100.00	0.00e+00	741.00
IUUC-Cin-025157	Ciona intestinalis	63.95	0.00e+00	788.00
IUUC-Csv-026098	Ciona savignyi	59.04	0.00e+00	654.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	48.34	2.00e-155	542.00
IUUC-Cne-026849	Cryptococcus neoformans	47.53	1.00e-158	553.00
IUUC-Dre-027770	Danio rerio	77.67	0.00e+00	1246.00
IUUC-Dno-029466	Dasypus novemcinctus	93.61	0.00e+00	1579.00
IUUC-Dor-030138	Dipodomys ordii	89.88	0.00e+00	1466.00
IUUC-Dse-031241	Dothistroma septosporum	47.70	6.00e-160	558.00
IUUC-Dme-032166	Drosophila melanogaster	67.09	0.00e+00	710.00
IUUC-Ete-033145	Echinops telfairi	83.71	0.00e+00	1215.00
IUUC-Eca-033445	Equus caballus	93.61	0.00e+00	1534.00
IUUC-Eeu-035247	Erinaceus europaeus	85.63	0.00e+00	1356.00
IUUC-Fca-035489	Felis catus	90.51	0.00e+00	1469.00
IUUC-Fal-037604	Ficedula albicollis	87.50	0.00e+00	1505.00
IUUC-Fox-037774	Fusarium oxysporum	48.76	8.00e-159	554.00
IUUC-Fso-038393	Fusarium solani	47.41	8.00e-154	537.00
IUUC-Gmo-039674	Gadus morhua	75.06	0.00e+00	1216.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.75	6.00e-156	544.00
IUUC-Gga-040703	Gallus gallus	89.51	0.00e+00	1526.00
IUUC-Gac-042020	Gasterosteus aculeatus	78.65	0.00e+00	1255.00
IUUC-Ggo-045332	Gorilla gorilla	91.45	0.00e+00	1553.00
IUUC-Hsa-045968	Homo sapiens	93.39	0.00e+00	1574.00
IUUC-Kpa-049273	Komagataella pastoris	49.16	5.00e-162	564.00
IUUC-Lch-050443	Latimeria chalumnae	84.07	0.00e+00	1397.00
IUUC-Loc-052662	Lepisosteus oculatus	80.14	0.00e+00	1264.00
IUUC-Laf-053850	Loxodonta africana	91.79	0.00e+00	1560.00
IUUC-Mcc-055821	Macaca mulatta	93.27	0.00e+00	1573.00
IUUC-Meu-056712	Macropus eugenii	75.83	0.00e+00	645.00
IUUC-Mor-057097	Magnaporthe oryzae	47.75	2.00e-156	546.00
IUUC-Mpo-057442	Magnaporthe poae	52.16	2.00e-145	510.00
IUUC-Mla-058996	Melampsora laricipopulina	47.48	1.00e-155	543.00
IUUC-Mga-059264	Meleagris gallopavo	69.82	0.00e+00	1018.00
IUUC-Mvi-060395	Microbotryum violaceum	53.70	7.00e-150	524.00
IUUC-Mmr-060798	Microcebus murinus	90.00	0.00e+00	1456.00
IUUC-Mdo-062173	Monodelphis domestica	90.62	0.00e+00	1574.00
IUUC-Mmu-064136	Mus musculus	92.47	0.00e+00	1542.00
IUUC-Mpu-066765	Mustela putorius furo	93.39	0.00e+00	1541.00
IUUC-Mlu-067565	Myotis lucifugus	92.26	0.00e+00	1520.00
IUUC-Nfi-068427	Neosartorya fischeri	49.02	5.00e-164	571.00
IUUC-Ncr-068918	Neurospora crassa	47.40	2.00e-157	550.00
IUUC-Nle-069070	Nomascus leucogenys	89.41	0.00e+00	1482.00
IUUC-Opr-071044	Ochotona princeps	96.43	0.00e+00	1198.00
IUUC-Ont-072044	Oreochromis niloticus	76.44	0.00e+00	1283.00
IUUC-Oan-073032	Ornithorhynchus anatinus	88.37	0.00e+00	1387.00
IUUC-Ocu-074160	Oryctolagus cuniculus	89.86	0.00e+00	1493.00
IUUC-Ola-087467	Oryzias latipes	77.78	0.00e+00	1269.00
IUUC-Oar-090198	Ovis aries	92.70	0.00e+00	1528.00
IUUC-Ptr-090939	Pan troglodytes	93.39	0.00e+00	1574.00
IUUC-Pan-092284	Papio anubis	93.39	0.00e+00	1576.00
IUUC-Psi-093645	Pelodiscus sinensis	90.42	0.00e+00	1533.00
IUUC-Pma-094364	Petromyzon marinus	82.63	0.00e+00	859.00
IUUC-Pno-095118	Phaeosphaeria nodorum	48.17	4.00e-164	571.00
IUUC-Pab-098088	Pongo abelii	93.39	0.00e+00	1575.00
IUUC-Pca-100714	Procavia capensis	78.34	0.00e+00	1257.00
IUUC-Pva-102354	Pteropus vampyrus	91.22	0.00e+00	1519.00
IUUC-Pgr-103620	Puccinia graminis	53.53	8.00e-148	517.00
IUUC-Ptt-103806	Puccinia triticina	53.38	1.00e-122	433.00
IUUC-Pte-104016	Pyrenophora teres	49.00	4.00e-162	565.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	49.00	4.00e-162	565.00
IUUC-Rno-105318	Rattus norvegicus	92.70	0.00e+00	1543.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.25	7.00e-164	571.00
IUUC-Sha-107482	Sarcophilus harrisii	92.18	0.00e+00	1563.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	48.74	5.00e-152	531.00
IUUC-Spo-108171	Schizosaccharomyces pombe	48.91	1.00e-160	560.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	48.49	8.00e-158	550.00
IUUC-Ssc-115950	Sus scrofa	71.12	0.00e+00	1175.00
IUUC-Tgu-117130	Taeniopygia guttata	89.74	0.00e+00	1531.00
IUUC-Tru-118610	Takifugu rubripes	78.11	0.00e+00	1286.00
IUUC-Tsy-119492	Tarsius syrichta	91.22	0.00e+00	1536.00
IUUC-Tni-120113	Tetraodon nigroviridis	72.57	0.00e+00	1220.00
IUUC-Tre-122203	Trichoderma reesei	47.45	3.00e-152	532.00
IUUC-Tvi-122595	Trichoderma virens	47.27	2.00e-154	539.00
IUUC-Ttr-128235	Tursiops truncatus	98.92	0.00e+00	1084.00
IUUC-Vda-129753	Verticillium dahliae	47.85	6.00e-157	548.00
IUUC-Xtr-132859	Xenopus tropicalis	87.36	0.00e+00	1471.00
IUUC-Xma-133797	Xiphophorus maculatus	78.93	0.00e+00	1278.00
IUUC-Yli-134668	Yarrowia lipolytica	46.42	2.00e-162	566.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence