iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098088

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase NEDD4-like

Genbank Nucleotide ID

ABGA01205491

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000009186.2	ENSPPYT00000010725.1	ENSPPYP00000010317.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.40e-135	450.8	630	961

Active Site

Position(s)	Description	Evidence
931	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 630  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 718
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+t++++Lkp+G++i+VtneNk+eY++lv++
   Q: 719  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 802
           ***********************************99...6666..7****************************************** PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d++++  yk+gy +++p+iqwFw+++  +++e+r ++LqFv
   Q: 803  WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHSIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLLQFV 891
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           Tg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 892  TGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 961
           *********************************************************************8 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

LIEDQGESRI LRVKVVSGID LAKKDIFGAS DPYVKLSLYV ADENRELALV QTKTIKKTLN 60
PKWNEEFYFR VNPSNHRLLF EVFDENRLTR DDFLGQVDVP LSHLPTEDPT MERPYTFKDF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTGATTGAGG ATCAGGTTTT TAACCTCTTT TGGTTTGTTC TCCTTCTCGC GGGGAGAGTC 60
CCGTATTCTC AGAGTAAAAG TTGTTTCTGG AATTGATCTC GCCAAAAAAG GACATCTTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

PRINTS

PR00360--C2DOMAIN

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	95.86	0.00e+00	1699.00
IUUC-Apl-003893	Anas platyrhynchos	94.16	0.00e+00	1711.00
IUUC-Aca-004744	Anolis carolinensis	91.15	0.00e+00	1667.00
IUUC-Ago-007742	Ashbya gossypii	48.91	1.00e-161	563.00
IUUC-Acl-008273	Aspergillus clavatus	49.26	7.00e-164	571.00
IUUC-Afl-008713	Aspergillus flavus	49.01	2.00e-161	563.00
IUUC-Afu-009103	Aspergillus fumigatus	49.02	5.00e-164	571.00
IUUC-Ani-009259	Aspergillus nidulans	48.53	4.00e-162	565.00
IUUC-Ang-009738	Aspergillus niger	49.33	3.00e-162	565.00
IUUC-Aor-010053	Aspergillus oryzae	58.05	2.00e-101	361.00
IUUC-Ate-010529	Aspergillus terreus	49.42	1.00e-164	573.00
IUUC-Ame-010810	Astyanax mexicanus	71.98	0.00e+00	1252.00
IUUC-Bgr-012148	Blumeria graminis	47.91	3.00e-154	538.00
IUUC-Bta-012679	Bos taurus	97.95	0.00e+00	1603.00
IUUC-Bci-013785	Botrytis cinerea	47.99	4.00e-156	545.00
IUUC-Cel-018564	Caenorhabditis elegans	52.84	0.00e+00	634.00
IUUC-Cja-018732	Callithrix jacchus	98.96	0.00e+00	1826.00
IUUC-Cfa-021226	Canis familiaris	97.81	0.00e+00	1802.00
IUUC-Cpo-021671	Cavia porcellus	96.56	0.00e+00	1758.00
IUUC-Csa-023344	Chlorocebus sabaeus	97.45	0.00e+00	1815.00
IUUC-Cho-024832	Choloepus hoffmanni	100.00	0.00e+00	743.00
IUUC-Csv-026098	Ciona savignyi	59.04	0.00e+00	654.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	48.34	1.00e-155	543.00
IUUC-Cne-026849	Cryptococcus neoformans	47.53	3.00e-159	555.00
IUUC-Dre-027770	Danio rerio	78.69	0.00e+00	1428.00
IUUC-Dno-029466	Dasypus novemcinctus	98.03	0.00e+00	1818.00
IUUC-Dor-030138	Dipodomys ordii	92.51	0.00e+00	1642.00
IUUC-Dse-031241	Dothistroma septosporum	47.70	3.00e-160	559.00
IUUC-Dme-032166	Drosophila melanogaster	67.30	0.00e+00	714.00
IUUC-Ete-033145	Echinops telfairi	89.17	0.00e+00	1290.00
IUUC-Eca-033445	Equus caballus	98.40	0.00e+00	1598.00
IUUC-Eeu-035247	Erinaceus europaeus	89.11	0.00e+00	1498.00
IUUC-Fca-035489	Felis catus	94.91	0.00e+00	1541.00
IUUC-Fal-037604	Ficedula albicollis	91.85	0.00e+00	1721.00
IUUC-Fox-037774	Fusarium oxysporum	48.76	7.00e-159	554.00
IUUC-Fso-038393	Fusarium solani	47.41	7.00e-154	537.00
IUUC-Gmo-039674	Gadus morhua	77.29	0.00e+00	1391.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.75	3.00e-156	545.00
IUUC-Gga-040703	Gallus gallus	93.67	0.00e+00	1750.00
IUUC-Gac-042020	Gasterosteus aculeatus	80.21	0.00e+00	1428.00
IUUC-Ggo-045332	Gorilla gorilla	97.44	0.00e+00	1749.00
IUUC-Hsa-045968	Homo sapiens	99.59	0.00e+00	1828.00
IUUC-Kpa-049273	Komagataella pastoris	45.30	2.00e-162	566.00
IUUC-Lch-050443	Latimeria chalumnae	86.93	0.00e+00	1445.00
IUUC-Loc-052662	Lepisosteus oculatus	80.71	0.00e+00	1443.00
IUUC-Laf-053850	Loxodonta africana	96.77	0.00e+00	1795.00
IUUC-Mcc-055821	Macaca mulatta	99.37	0.00e+00	1817.00
IUUC-Meu-056712	Macropus eugenii	81.93	0.00e+00	781.00
IUUC-Mor-057097	Magnaporthe oryzae	47.75	1.00e-156	547.00
IUUC-Mla-058996	Melampsora laricipopulina	53.94	6.00e-150	524.00
IUUC-Mvi-060395	Microbotryum violaceum	53.70	5.00e-150	525.00
IUUC-Mmr-060798	Microcebus murinus	94.59	0.00e+00	1684.00
IUUC-Mdo-062173	Monodelphis domestica	95.22	0.00e+00	1809.00
IUUC-Mmu-064136	Mus musculus	97.10	0.00e+00	1779.00
IUUC-Mpu-066765	Mustela putorius furo	98.33	0.00e+00	1784.00
IUUC-Mlu-067565	Myotis lucifugus	95.45	0.00e+00	1575.00
IUUC-Nfi-068427	Neosartorya fischeri	49.02	3.00e-164	572.00
IUUC-Ncr-068918	Neurospora crassa	47.40	2.00e-157	549.00
IUUC-Nle-069070	Nomascus leucogenys	95.75	0.00e+00	1733.00
IUUC-Opr-071044	Ochotona princeps	96.12	0.00e+00	1198.00
IUUC-Ont-072044	Oreochromis niloticus	78.15	0.00e+00	1461.00
IUUC-Oan-073032	Ornithorhynchus anatinus	92.99	0.00e+00	1443.00
IUUC-Ocu-074160	Oryctolagus cuniculus	95.32	0.00e+00	1737.00
IUUC-Ola-087467	Oryzias latipes	79.96	0.00e+00	1447.00
IUUC-Oga-088460	Otolemur garnettii	93.39	0.00e+00	1575.00
IUUC-Oar-090198	Ovis aries	97.71	0.00e+00	1767.00
IUUC-Ptr-090939	Pan troglodytes	99.59	0.00e+00	1828.00
IUUC-Pan-092284	Papio anubis	99.27	0.00e+00	1824.00
IUUC-Psi-093645	Pelodiscus sinensis	94.29	0.00e+00	1746.00
IUUC-Pma-094364	Petromyzon marinus	82.67	0.00e+00	864.00
IUUC-Pno-095118	Phaeosphaeria nodorum	48.32	5.00e-165	574.00
IUUC-Pca-100714	Procavia capensis	75.78	0.00e+00	1318.00
IUUC-Pva-102354	Pteropus vampyrus	95.93	0.00e+00	1693.00
IUUC-Pgr-103620	Puccinia graminis	53.53	3.00e-148	518.00
IUUC-Ptt-103806	Puccinia triticina	53.38	5.00e-123	435.00
IUUC-Pte-104016	Pyrenophora teres	49.00	3.00e-162	565.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	49.00	3.00e-162	565.00
IUUC-Rno-105318	Rattus norvegicus	96.67	0.00e+00	1758.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.25	5.00e-164	571.00
IUUC-Sha-107482	Sarcophilus harrisii	96.59	0.00e+00	1628.00
IUUC-Spo-108171	Schizosaccharomyces pombe	48.91	1.00e-160	560.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	48.49	9.00e-158	550.00
IUUC-Ssc-115950	Sus scrofa	70.23	0.00e+00	1180.00
IUUC-Tgu-117130	Taeniopygia guttata	94.38	0.00e+00	1752.00
IUUC-Tru-118610	Takifugu rubripes	80.33	0.00e+00	1471.00
IUUC-Tsy-119492	Tarsius syrichta	92.36	0.00e+00	1652.00
IUUC-Tni-120113	Tetraodon nigroviridis	75.10	0.00e+00	1360.00
IUUC-Tre-122203	Trichoderma reesei	46.86	3.00e-152	532.00
IUUC-Tvi-122595	Trichoderma virens	47.27	1.00e-154	540.00
IUUC-Tbe-127441	Tupaia belangeri	90.60	0.00e+00	795.00
IUUC-Ttr-128235	Tursiops truncatus	87.79	0.00e+00	1514.00
IUUC-Vda-129753	Verticillium dahliae	47.85	4.00e-157	548.00
IUUC-Xtr-132859	Xenopus tropicalis	89.95	0.00e+00	1667.00
IUUC-Xma-133797	Xiphophorus maculatus	81.41	0.00e+00	1464.00
IUUC-Yli-134668	Yarrowia lipolytica	46.58	2.00e-162	566.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence