iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107482

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01059989

Gene Name

NEDD4L

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000016231.1	ENSSHAT00000019275.1	ENSSHAP00000019119.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.60e-133	443.6	544	878

Active Site

Position(s)	Description	Evidence
848	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++ lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 544  PDVLKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFTFIGRVAGLAVFHGKLLDG 632
           57899************************************************************************************ PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilge...tkeeeLkpgGenipVtneNkeeYvkl 176
           ++ ++fyk++lgk+++l+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++ee++g+   t++++Lkp+G++i+VtneNk+eY++l
   Q: 633  FFIRPFYKMMLGKQITLNDMESVDSEYYNSLKWILEN---DPTE--LDLMFCIDEENFGQkiqTYQVDLKPNGSEIMVTNENKREYIDL 716
           ***********************************99...6666..7*********977422266777********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafL 265
           v+++r+ +++++q++af eGf+e++p++l+++F+e+elell+cG  ++dv+d+++++ yk+gy +++p+iqwFw+++  +++e+r ++L
   Q: 717  VIQWRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLGDVDVNDWRQHAIYKNGYCPNHPVIQWFWKAVLLMDAEKRIRLL 805
           ***************************************************************************************** PP
   S: 266  qFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           qFvTg+sr+P++Gfael     p+lf+i++++s+++lP+++TCfn+L+LP+Y++ e l+ekLl+A+e+++gFe
   Q: 806  QFVTGTSRVPMNGFAELYgsngPQLFTIEQWGSPEKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 878
           ************************************************************************8 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

TRDDFLGQVD VPLSHLPTED PTMERPYTFK DFLLRPRSHK SRVKGFLRLK MAYMPKNGGQ 60
DEENNDQRED LEHGWEVVDS NDSASQHQEE LPPPPLPPGW EEKVDNLGRT YYVNHNNRTT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAAGAGACG ACTTCCTTGG ACAAGTAGAC GTTCCTCTTA GTCATCTCCC GGTAAGGAAG 60
TTTAAGTTAC CTATATTTTA TGTGATGGAA AATAATTTTT AACTTGTGCC CTTTGATAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0019870--F:potassium channel inhibitor activity
GO:0019871--F:sodium channel inhibitor activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:1901017--P:negative regulation of potassium ion transmembrane transporter activity
GO:2000009--P:negative regulation of protein localization to cell surface
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:1903861--P:positive regulation of dendrite extension
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0003254--P:regulation of membrane depolarization
GO:0060306--P:regulation of membrane repolarization
GO:0010038--P:response to metal ion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	94.67	0.00e+00	1563.00
IUUC-Apl-003893	Anas platyrhynchos	94.32	0.00e+00	1583.00
IUUC-Aca-004744	Anolis carolinensis	91.16	0.00e+00	1527.00
IUUC-Acl-008273	Aspergillus clavatus	48.37	4.00e-162	565.00
IUUC-Afl-008713	Aspergillus flavus	46.17	6.00e-160	557.00
IUUC-Afu-009103	Aspergillus fumigatus	48.78	1.00e-162	566.00
IUUC-Ani-009259	Aspergillus nidulans	48.75	7.00e-160	557.00
IUUC-Ang-009738	Aspergillus niger	48.92	2.00e-160	559.00
IUUC-Aor-010053	Aspergillus oryzae	57.48	4.00e-100	357.00
IUUC-Ate-010529	Aspergillus terreus	46.82	1.00e-162	566.00
IUUC-Ame-010810	Astyanax mexicanus	70.30	0.00e+00	1139.00
IUUC-Bgr-012148	Blumeria graminis	47.52	2.00e-152	532.00
IUUC-Bta-012679	Bos taurus	96.14	0.00e+00	1598.00
IUUC-Bci-013785	Botrytis cinerea	47.60	3.00e-154	538.00
IUUC-Cel-018564	Caenorhabditis elegans	52.74	3.00e-180	625.00
IUUC-Cja-018732	Callithrix jacchus	97.16	0.00e+00	1641.00
IUUC-Cfa-021226	Canis familiaris	96.25	0.00e+00	1612.00
IUUC-Cpo-021671	Cavia porcellus	94.10	0.00e+00	1573.00
IUUC-Csa-023344	Chlorocebus sabaeus	94.77	0.00e+00	1613.00
IUUC-Cho-024832	Choloepus hoffmanni	98.87	0.00e+00	737.00
IUUC-Cin-025157	Ciona intestinalis	63.17	0.00e+00	781.00
IUUC-Csv-026098	Ciona savignyi	58.80	0.00e+00	648.00
IUUC-Dre-027770	Danio rerio	78.76	0.00e+00	1288.00
IUUC-Dno-029466	Dasypus novemcinctus	96.94	0.00e+00	1635.00
IUUC-Dor-030138	Dipodomys ordii	92.71	0.00e+00	1535.00
IUUC-Dse-031241	Dothistroma septosporum	48.37	3.00e-159	555.00
IUUC-Dme-032166	Drosophila melanogaster	66.67	0.00e+00	708.00
IUUC-Ete-033145	Echinops telfairi	87.78	0.00e+00	1276.00
IUUC-Eca-033445	Equus caballus	96.94	0.00e+00	1576.00
IUUC-Eeu-035247	Erinaceus europaeus	89.22	0.00e+00	1403.00
IUUC-Fca-035489	Felis catus	94.23	0.00e+00	1554.00
IUUC-Fal-037604	Ficedula albicollis	91.00	0.00e+00	1549.00
IUUC-Fox-037774	Fusarium oxysporum	48.52	1.00e-157	550.00
IUUC-Gmo-039674	Gadus morhua	76.07	0.00e+00	1236.00
IUUC-Ggr-040107	Gaeumannomyces graminis	47.51	8.00e-155	540.00
IUUC-Gga-040703	Gallus gallus	93.42	0.00e+00	1576.00
IUUC-Gac-042020	Gasterosteus aculeatus	79.71	0.00e+00	1286.00
IUUC-Ggo-045332	Gorilla gorilla	95.01	0.00e+00	1605.00
IUUC-Hsa-045968	Homo sapiens	96.82	0.00e+00	1625.00
IUUC-Lch-050443	Latimeria chalumnae	87.30	0.00e+00	1455.00
IUUC-Loc-052662	Lepisosteus oculatus	80.99	0.00e+00	1290.00
IUUC-Laf-053850	Loxodonta africana	95.35	0.00e+00	1612.00
IUUC-Mcc-055821	Macaca mulatta	96.71	0.00e+00	1623.00
IUUC-Meu-056712	Macropus eugenii	86.38	0.00e+00	729.00
IUUC-Mor-057097	Magnaporthe oryzae	47.51	1.00e-155	543.00
IUUC-Mpo-057442	Magnaporthe poae	51.84	3.00e-144	505.00
IUUC-Mla-058996	Melampsora laricipopulina	46.47	2.00e-154	539.00
IUUC-Mga-059264	Meleagris gallopavo	74.02	0.00e+00	1071.00
IUUC-Mvi-060395	Microbotryum violaceum	53.37	3.00e-148	519.00
IUUC-Mmr-060798	Microcebus murinus	92.19	0.00e+00	1503.00
IUUC-Mdo-062173	Monodelphis domestica	96.56	0.00e+00	1655.00
IUUC-Mmu-064136	Mus musculus	95.92	0.00e+00	1595.00
IUUC-Mpu-066765	Mustela putorius furo	96.48	0.00e+00	1600.00
IUUC-Mlu-067565	Myotis lucifugus	95.24	0.00e+00	1576.00
IUUC-Nfi-068427	Neosartorya fischeri	48.78	1.00e-162	566.00
IUUC-Ncr-068918	Neurospora crassa	47.50	6.00e-155	541.00
IUUC-Nle-069070	Nomascus leucogenys	93.08	0.00e+00	1534.00
IUUC-Opr-071044	Ochotona princeps	95.23	0.00e+00	1190.00
IUUC-Ont-072044	Oreochromis niloticus	78.13	0.00e+00	1324.00
IUUC-Oan-073032	Ornithorhynchus anatinus	93.51	0.00e+00	1446.00
IUUC-Ocu-074160	Oryctolagus cuniculus	92.97	0.00e+00	1551.00
IUUC-Ola-087467	Oryzias latipes	78.68	0.00e+00	1301.00
IUUC-Oga-088460	Otolemur garnettii	92.18	0.00e+00	1562.00
IUUC-Oar-090198	Ovis aries	95.35	0.00e+00	1581.00
IUUC-Ptr-090939	Pan troglodytes	96.82	0.00e+00	1625.00
IUUC-Pan-092284	Papio anubis	96.94	0.00e+00	1628.00
IUUC-Psi-093645	Pelodiscus sinensis	94.67	0.00e+00	1584.00
IUUC-Pma-094364	Petromyzon marinus	82.34	0.00e+00	862.00
IUUC-Pno-095118	Phaeosphaeria nodorum	47.65	2.00e-162	566.00
IUUC-Pfo-096768	Poecilia formosa	90.29	0.00e+00	957.00
IUUC-Pab-098088	Pongo abelii	96.59	0.00e+00	1622.00
IUUC-Pca-100714	Procavia capensis	77.98	0.00e+00	1262.00
IUUC-Pva-102354	Pteropus vampyrus	94.44	0.00e+00	1562.00
IUUC-Pgr-103620	Puccinia graminis	53.20	2.00e-146	513.00
IUUC-Ptt-103806	Puccinia triticina	53.00	2.00e-121	429.00
IUUC-Pte-104016	Pyrenophora teres	48.43	1.00e-160	560.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	48.43	1.00e-160	560.00
IUUC-Rno-105318	Rattus norvegicus	96.15	0.00e+00	1596.00
IUUC-Sce-106289	Saccharomyces cerevisiae	49.00	7.00e-163	567.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	48.67	2.00e-150	526.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	48.09	7.00e-156	544.00
IUUC-Ssc-115950	Sus scrofa	71.04	0.00e+00	1175.00
IUUC-Tgu-117130	Taeniopygia guttata	93.64	0.00e+00	1578.00
IUUC-Tru-118610	Takifugu rubripes	79.44	0.00e+00	1330.00
IUUC-Tsy-119492	Tarsius syrichta	94.78	0.00e+00	1598.00
IUUC-Tni-120113	Tetraodon nigroviridis	74.12	0.00e+00	1265.00
IUUC-Tre-122203	Trichoderma reesei	44.51	4.00e-151	528.00
IUUC-Tvi-122595	Trichoderma virens	47.04	1.00e-152	533.00
IUUC-Tme-126897	Tuber melanosporum	52.16	1.00e-145	510.00
IUUC-Tbe-127441	Tupaia belangeri	91.37	0.00e+00	727.00
IUUC-Ttr-128235	Tursiops truncatus	86.54	0.00e+00	1380.00
IUUC-Vda-129753	Verticillium dahliae	47.45	2.00e-155	542.00
IUUC-Xtr-132859	Xenopus tropicalis	89.91	0.00e+00	1509.00
IUUC-Xma-133797	Xiphophorus maculatus	80.09	0.00e+00	1317.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence