iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120113

UUCD1 version

UUC-TeN-00737

Ensembl Protein ID

ENSTNIP00000010330.1

UniProt Accession

H3CPZ6; H3CPZ6_TETNG

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000007521.1	ENSTNIT00000010511.1	ENSTNIP00000010330.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-132	442.7	623	953

Active Site

Position(s)	Description	Evidence
923	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef+ E+gld+gGv+re+++llske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld ++
   Q: 623  ILKARLWIEFESEKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVFHGKLLDGFF 711
           6899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk.lvvey 180
            ++fyk++lgk++sl+d+e+vd+e+y+slk+i+en   d +e  ldl+f+++e+++g+t++++Lkp+G+++ VtneNk+eY++ lv+++
   Q: 712  IRPFYKMMLGKQISLKDMESVDSEYYNSLKWILEN---DPTE--LDLRFCIDEDNFGQTYQVDLKPSGSDMVVTNENKNEYIDsLVIQW 795
           *********************************99...6666..7*************************************74789** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+ +++++q++af eGf+e+i ++l+++F+e+elell+cG  ++dv+d++++t yk+gy +++p+iqwFw+v+  +++e+r ++LqFvT
   Q: 796  RFVNRVQKQMNAFLEGFTELILIDLIKIFDENELELLMCGLGDVDVNDWRQHTVYKNGYCPNHPVIQWFWKVVLLMDAEKRIRLLQFVT 884
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           g+sr+P++Gfael     p+lf+i++++++d+lP+++TCfn+L+LP+Y+s e l+ekLl+A+e+++gFe
   Q: 885  GTSRVPMNGFAELYgsngPQLFTIEQWGTPDKLPRAHTCFNRLDLPTYESFEDLREKLLMAVENAQGFE 953
           ********************************************************************8 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

SDPYVKLSLY VADENRELSL VQTKTIKKTL NPKWNEEFFF RVCPQKHRLL FEVFDENRLT 60
RDDFLGQVDV PLSHLPTEDP AMERPYTFKD FLLRPRSHKS RVKGYLRLKM AYLPKQGGQE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGATCCAT ACGTCAAGCT TTCCCTTTAT GTGGCTGATG AGAACAGAGA GCTTTCTTTA 60
GTCCAGACAA AAACCATTAA AAAGGTAGGT GGTCCTCTAA AATTTGCCTG TGGCATATTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	74.38	0.00e+00	1319.00
IUUC-Apl-003893	Anas platyrhynchos	75.52	0.00e+00	1361.00
IUUC-Aca-004744	Anolis carolinensis	71.98	0.00e+00	1295.00
IUUC-Aor-010053	Aspergillus oryzae	57.53	1.00e-99	355.00
IUUC-Bta-012679	Bos taurus	73.39	0.00e+00	1221.00
IUUC-Cja-018732	Callithrix jacchus	75.21	0.00e+00	1352.00
IUUC-Cfa-021226	Canis familiaris	75.52	0.00e+00	1358.00
IUUC-Cpo-021671	Cavia porcellus	74.27	0.00e+00	1323.00
IUUC-Csa-023344	Chlorocebus sabaeus	73.72	0.00e+00	1334.00
IUUC-Cho-024832	Choloepus hoffmanni	94.05	0.00e+00	708.00
IUUC-Dre-027770	Danio rerio	79.23	0.00e+00	1372.00
IUUC-Dno-029466	Dasypus novemcinctus	75.52	0.00e+00	1350.00
IUUC-Dor-030138	Dipodomys ordii	71.90	0.00e+00	1273.00
IUUC-Ete-033145	Echinops telfairi	68.24	0.00e+00	982.00
IUUC-Eca-033445	Equus caballus	74.36	0.00e+00	1218.00
IUUC-Eeu-035247	Erinaceus europaeus	72.52	0.00e+00	1082.00
IUUC-Fca-035489	Felis catus	71.66	0.00e+00	1164.00
IUUC-Fal-037604	Ficedula albicollis	73.82	0.00e+00	1346.00
IUUC-Gmo-039674	Gadus morhua	80.29	0.00e+00	1420.00
IUUC-Gga-040703	Gallus gallus	75.52	0.00e+00	1356.00
IUUC-Gac-042020	Gasterosteus aculeatus	86.09	0.00e+00	1519.00
IUUC-Ggo-045332	Gorilla gorilla	74.17	0.00e+00	1333.00
IUUC-Hsa-045968	Homo sapiens	75.10	0.00e+00	1346.00
IUUC-Lch-050443	Latimeria chalumnae	75.11	0.00e+00	1244.00
IUUC-Loc-052662	Lepisosteus oculatus	77.24	0.00e+00	1333.00
IUUC-Laf-053850	Loxodonta africana	74.38	0.00e+00	1341.00
IUUC-Mcc-055821	Macaca mulatta	75.31	0.00e+00	1348.00
IUUC-Mmr-060798	Microcebus murinus	71.73	0.00e+00	1256.00
IUUC-Mdo-062173	Monodelphis domestica	73.95	0.00e+00	1353.00
IUUC-Mmu-064136	Mus musculus	74.90	0.00e+00	1333.00
IUUC-Mpu-066765	Mustela putorius furo	75.52	0.00e+00	1339.00
IUUC-Mlu-067565	Myotis lucifugus	73.67	0.00e+00	1222.00
IUUC-Nle-069070	Nomascus leucogenys	72.11	0.00e+00	1283.00
IUUC-Opr-071044	Ochotona princeps	77.27	0.00e+00	988.00
IUUC-Ont-072044	Oreochromis niloticus	83.65	0.00e+00	1556.00
IUUC-Oan-073032	Ornithorhynchus anatinus	70.13	0.00e+00	1102.00
IUUC-Ocu-074160	Oryctolagus cuniculus	73.78	0.00e+00	1308.00
IUUC-Ola-087467	Oryzias latipes	85.07	0.00e+00	1501.00
IUUC-Oga-088460	Otolemur garnettii	72.68	0.00e+00	1207.00
IUUC-Oar-090198	Ovis aries	74.50	0.00e+00	1325.00
IUUC-Ptr-090939	Pan troglodytes	75.10	0.00e+00	1346.00
IUUC-Pan-092284	Papio anubis	75.31	0.00e+00	1348.00
IUUC-Psi-093645	Pelodiscus sinensis	75.03	0.00e+00	1353.00
IUUC-Pfo-096768	Poecilia formosa	87.00	0.00e+00	910.00
IUUC-Pab-098088	Pongo abelii	75.31	0.00e+00	1348.00
IUUC-Pca-100714	Procavia capensis	64.97	0.00e+00	893.00
IUUC-Pva-102354	Pteropus vampyrus	73.72	0.00e+00	1319.00
IUUC-Rno-105318	Rattus norvegicus	74.90	0.00e+00	1335.00
IUUC-Sha-107482	Sarcophilus harrisii	74.45	0.00e+00	1253.00
IUUC-Ssc-115950	Sus scrofa	62.34	0.00e+00	1029.00
IUUC-Tgu-117130	Taeniopygia guttata	75.42	0.00e+00	1362.00
IUUC-Tru-118610	Takifugu rubripes	88.91	0.00e+00	1644.00
IUUC-Tsy-119492	Tarsius syrichta	71.15	0.00e+00	1244.00
IUUC-Ttr-128235	Tursiops truncatus	81.13	0.00e+00	912.00
IUUC-Xtr-132859	Xenopus tropicalis	74.92	0.00e+00	1352.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence