iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046226

Ensembl Protein ID

ENSP00000409555.2

UniProt Accession

Q15011; E9PGD1; O60644; Q6IAN8; Q96D92; HERP1_HUMAN

Genbank Protein ID

BAB07891.1; BAA03521.1; AAC09355.1; AAC09357.1; BAB19010.1; CAG33397.1; AAH00086.1; AAH08320.1; AAH09739.1; AAH32673.1

Protein Name

Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; Methyl methanesulfonate (MMF)-inducible fragment protein 1

Genbank Nucleotide ID

AB034989; D14695; AF055001; AF055003; AB034990; CR457116; AC012181; BC008320; BC009739; BC032673

Gene Name

HERPUD1; HERP; KIAA0025; MIF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000051108.14	ENST00000439977.6	ENSP00000409555.2
ENSG00000051108.14	ENST00000565966.5	ENSP00000456384.1
ENSG00000051108.14	ENST00000344114.8	ENSP00000340931.4
ENSG00000051108.14	ENST00000300302.9	ENSP00000300302.5
ENSG00000051108.14	ENST00000379792.6	ENSP00000369118.2
ENSG00000051108.14	ENST00000569429.5	ENSP00000457321.1
ENSG00000051108.14	ENST00000563343.5	ENSP00000455094.1
ENSG00000051108.14	ENST00000568358.1	ENSP00000457095.1
ENSG00000051108.14	ENST00000563911.5	ENSP00000455841.1
ENSG00000051108.14	ENST00000568651.1	ENSP00000457955.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	circRNADb	CircNet
miRTarBase	microRNA	TRANSFAC	miRecords
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	10922362; 11799129; 11804604; 12370023; 14550564; 19447887

Classification

Family	E-value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	1.50e-05	26.4	12	85

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 3    vtvksldgseltlkv..npsdtVaeLKekiekk.lgip.peqqrLiykGkiLeddktLady..glkdgstihll 70
           + vks++ ++ +l++  ++ ++V+ LK ++++     p pe+qrLiy+Gk+L d++ L d+  +   + ++hl+
   Q: 12   LLVKSPNQRHRDLELsgDRGWSVGHLKAHLSRVyPERPrPEDQRLIYSGKLLLDHQCLRDLlpKQEKRHVLHLV 85
           566666666666664347888*********999966666*********************98888888888887 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982).

Protein Sequence
(Fasta)

MESETEPEPV TLLVKSPNQR HRDLELSGDR GWSVGHLKAH LSRVYPERPR PEDQRLIYSG 60
KLLLDHQCLR DLLPKQEKRH VLHLVCNVKS PSKMPEINAK VAESTEEPAG SNRGQYPEDS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCCGCCTCA GCCAATGGGC GGCAGCCACA GAGCGTTCTG TCCGCAGAGC CGGGCGCGGG 60
GCTTCTATAA AAGGCGCCCG AAGCGGGGGC GCGCGCCCCA GAGACGTGAA CTGTCGTTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0834--Unfolded protein response

Interpro

IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

SMART

SM00213--UBQ

Gene Ontology

GO:0034704--C:calcium channel complex
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:1990037--C:Lewy body core
GO:0016020--C:membrane
GO:0044325--F:ion channel binding
GO:0032469--P:endoplasmic reticulum calcium ion homeostasis
GO:0043154--P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:1902236--P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO:2001243--P:negative regulation of intrinsic apoptotic signaling pathway
GO:0036499--P:PERK-mediated unfolded protein response
GO:1903071--P:positive regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0032092--P:positive regulation of protein binding
GO:0031396--P:regulation of protein ubiquitination
GO:0034976--P:response to endoplasmic reticulum stress
GO:0006986--P:response to unfolded protein
GO:0030970--P:retrograde protein transport, ER to cytosol
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:9709

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001647	Ailuropoda melanoleuca	90.81	5.00e-162	563.00
IUUC-Atr-002574	Amborella trichopoda	30.16	3.40e-01	27.70
IUUC-Apl-004142	Anas platyrhynchos	54.44	5.00e-79	287.00
IUUC-Acl-008367	Aspergillus clavatus	32.46	1.00e-05	45.40
IUUC-Afl-008623	Aspergillus flavus	41.07	2.00e-03	38.10
IUUC-Ani-009402	Aspergillus nidulans	33.70	9.00e-05	42.00
IUUC-Aor-010022	Aspergillus oryzae	41.07	2.00e-03	38.10
IUUC-Ate-010527	Aspergillus terreus	43.94	1.00e-05	44.70
IUUC-Ame-011187	Astyanax mexicanus	33.18	8.00e-51	194.00
IUUC-Bta-013339	Bos taurus	89.95	3.00e-156	544.00
IUUC-Cja-018806	Callithrix jacchus	94.64	4.00e-161	560.00
IUUC-Cfa-020141	Canis familiaris	91.34	3.00e-147	514.00
IUUC-Cpo-021802	Cavia porcellus	87.72	9.00e-165	573.00
IUUC-Csa-023973	Chlorocebus sabaeus	97.70	6.00e-179	620.00
IUUC-Cho-024463	Choloepus hoffmanni	84.55	3.00e-149	521.00
IUUC-Cin-025601	Ciona intestinalis	34.39	4.00e-14	72.40
IUUC-Csv-025997	Ciona savignyi	37.50	6.00e-10	56.20
IUUC-Cme-027117	Cyanidioschyzon merolae	38.24	2.00e-06	47.40
IUUC-Dno-029118	Dasypus novemcinctus	85.97	5.00e-171	593.00
IUUC-Dor-030815	Dipodomys ordii	84.82	2.00e-155	541.00
IUUC-Ete-033054	Echinops telfairi	69.74	9.00e-106	377.00
IUUC-Eca-033245	Equus caballus	88.50	8.00e-158	549.00
IUUC-Eeu-034795	Erinaceus europaeus	90.56	4.00e-166	577.00
IUUC-Fca-036200	Felis catus	92.13	1.00e-164	572.00
IUUC-Fal-036890	Ficedula albicollis	50.77	6.00e-76	277.00
IUUC-Fox-037920	Fusarium oxysporum	48.00	6.50e-01	28.10
IUUC-Gmo-038670	Gadus morhua	45.24	1.00e-37	150.00
IUUC-Gga-040151	Gallus gallus	53.04	3.00e-71	261.00
IUUC-Gac-041925	Gasterosteus aculeatus	37.50	4.00e-54	205.00
IUUC-Ggo-045103	Gorilla gorilla	98.92	3.00e-168	584.00
IUUC-Itr-048589	Ictidomys tridecemlineatus	91.88	6.00e-170	590.00
IUUC-Lch-050254	Latimeria chalumnae	49.61	2.00e-61	229.00
IUUC-Loc-052154	Lepisosteus oculatus	46.29	4.00e-62	232.00
IUUC-Laf-053533	Loxodonta africana	88.89	1.00e-171	595.00
IUUC-Mcc-055840	Macaca mulatta	98.47	0.00e+00	627.00
IUUC-Meu-056691	Macropus eugenii	80.13	4.00e-113	400.00
IUUC-Mga-060042	Meleagris gallopavo	53.94	4.00e-78	285.00
IUUC-Mmr-060875	Microcebus murinus	94.24	0.00e+00	630.00
IUUC-Mdo-062924	Monodelphis domestica	76.76	3.00e-128	451.00
IUUC-Mmu-063831	Mus musculus	88.75	3.00e-167	580.00
IUUC-Mpu-066883	Mustela putorius furo	90.81	9.00e-161	559.00
IUUC-Mlu-067932	Myotis lucifugus	83.79	2.00e-140	491.00
IUUC-Nfi-068353	Neosartorya fischeri	38.20	6.00e-06	46.20
IUUC-Nle-069005	Nomascus leucogenys	98.98	0.00e+00	630.00
IUUC-Opr-070231	Ochotona princeps	89.27	7.00e-165	573.00
IUUC-Ont-072578	Oreochromis niloticus	40.19	1.00e-45	177.00
IUUC-Oan-073354	Ornithorhynchus anatinus	70.83	8.00e-122	430.00
IUUC-Ocu-074495	Oryctolagus cuniculus	90.84	8.00e-163	567.00
IUUC-Ola-087167	Oryzias latipes	36.67	3.00e-60	225.00
IUUC-Oga-088825	Otolemur garnettii	93.35	9.00e-169	586.00
IUUC-Oar-089616	Ovis aries	89.27	2.00e-152	531.00
IUUC-Ptr-090458	Pan troglodytes	99.74	0.00e+00	632.00
IUUC-Pan-091940	Papio anubis	97.71	4.00e-179	620.00
IUUC-Psi-093972	Pelodiscus sinensis	56.15	2.00e-56	212.00
IUUC-Pfo-096041	Poecilia formosa	43.13	2.00e-48	186.00
IUUC-Pab-097734	Pongo abelii	98.98	0.00e+00	673.00
IUUC-Pca-100301	Procavia capensis	79.68	1.00e-87	315.00
IUUC-Pva-102349	Pteropus vampyrus	91.19	2.00e-173	602.00
IUUC-Rno-105129	Rattus norvegicus	87.21	8.00e-164	569.00
IUUC-Sha-107280	Sarcophilus harrisii	77.63	4.00e-148	518.00
IUUC-Sar-113496	Sorex araneus	81.63	2.00e-147	515.00
IUUC-Ssc-115558	Sus scrofa	94.17	1.00e-96	345.00
IUUC-Tgu-117337	Taeniopygia guttata	50.13	6.00e-84	304.00
IUUC-Tru-118741	Takifugu rubripes	37.92	2.00e-54	206.00
IUUC-Tsy-119527	Tarsius syrichta	94.50	1.00e-133	468.00
IUUC-Tni-119885	Tetraodon nigroviridis	37.59	2.00e-52	199.00
IUUC-Tre-121967	Trichoderma reesei	35.59	2.40e-02	34.70
IUUC-Tvi-122662	Trichoderma virens	35.38	1.10e-02	35.40
IUUC-Tbe-127599	Tupaia belangeri	86.14	4.00e-85	308.00
IUUC-Ttr-128320	Tursiops truncatus	83.42	2.00e-137	482.00
IUUC-Vpa-130608	Vicugna pacos	91.77	5.00e-166	577.00
IUUC-Xtr-131896	Xenopus tropicalis	45.34	8.00e-56	211.00
IUUC-Xma-133006	Xiphophorus maculatus	40.57	4.00e-68	251.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence