iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046662

UUCD1 version

UUC-HoS-00958

Ensembl Protein ID

ENSP00000362774.1

UniProt Accession

Q9HBD1; Q4VXB1; Q5JPD7; Q86ST6; Q8N3D6; Q96F27; Q9H5J2; Q9HBD2; Q9NWN9; Q9NXE1; RC3H2_HUMAN

Genbank Protein ID

AAG00432.1; AAG00433.1; BAA91073.1; BAA91340.1; BAB15634.1; CAI46182.1; CAD39091.1; CAI94964.1; CAI94964.1; EAW87547.1; AAH11688.2; AAH44642.1

Protein Name

Roquin-2; Membrane-associated nucleic acid-binding protein; RING finger and CCCH-type zinc finger domain-containing protein 2; RING finger protein 164; RING-type E3 ubiquitin transferase Roquin-2

Genbank Nucleotide ID

AF255303; AF255304; AK000308; AK000720; AK027042; AL833177; AL834431; AL359512; AC007066; CH471090; BC011688; BC044642

Gene Name

RC3H2; MNAB; RNF164

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000056586.15	ENST00000373670.5	ENSP00000362774.1
ENSG00000056586.15	ENST00000498479.5	ENSP00000474709.1
ENSG00000056586.15	ENST00000454740.5	ENSP00000398081.1
ENSG00000056586.15	ENST00000423239.6	ENSP00000411767.1
ENSG00000056586.15	ENST00000398671.2	ENSP00000381663.2
ENSG00000056586.15	ENST00000335387.9	ENSP00000335150.5
ENSG00000056586.15	ENST00000471874.2	ENSP00000474148.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	HINT	Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	24448648

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00015	23.9	14	51

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg...plvlpCgHvfhadClqkwpglknssskefrCP 43
           C+iC+++f++    p++l+C H+ +++Cl+k+         +  CP
   Q: 14   CPICYNEFDENvhkPISLGCSHTVCKTCLNKL--------HRKACP 51
           ********77633466899**********999........344566 PP

Organism

Homo sapiens

Functional Description
(View)

Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation (By similarity). May act as a ubiquitin E3 ligase. Involved in the ubiquitination of MAP3K5 (PubMed:24448648).

Protein Sequence
(Fasta)

MPVQAAQWTE FLSCPICYNE FDENVHKPIS LGCSHTVCKT CLNKLHRKAC PFDQTAINTD 60
IDVLPVNFAL LQLVGAQVPD HQSIKLSNLG ENKHYEVAKK CVEDLALYLK PLSGGKGVAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGTGGTGAG GAGGAGGAGG AGGAGGAGGC GGAGGTGGAG GGAGGAGGAG GAGGCCCCGT 60
CGCGGCCTTC GCCGCCGCCA ACGGGGCTGT CCCTGTAGCT CCCGATGGAG TTTGAGGTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0694--RNA-binding
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032670--RC3H2
IPR027370--Znf-RING_LisH
IPR000571--Znf_CCCH
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50103--ZF_C3H1
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00642--zf-CCCH
PF13445--zf-RING_UBOX

SMART

SM00184--RING
SM00356--ZnF_C3H1

Gene Ontology

GO:0009986--C:cell surface
GO:0016020--C:membrane
GO:0000932--C:P-body
GO:0003677--F:DNA binding
GO:0003729--F:mRNA binding
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001782--P:B cell homeostasis
GO:0060173--P:limb development
GO:0048286--P:lung alveolus development
GO:0048535--P:lymph node development
GO:0035264--P:multicellular organism growth
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0009791--P:post-embryonic development
GO:0010608--P:posttranscriptional regulation of gene expression
GO:0000209--P:protein polyubiquitination
GO:0048536--P:spleen development
GO:0043029--P:T cell homeostasis
GO:0042098--P:T cell proliferation
GO:0061470--P:T follicular helper cell differentiation

KEGG

hsa:54542

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002394	Ailuropoda melanoleuca	98.15	0.00e+00	2262.00
IUUC-Apl-004222	Anas platyrhynchos	89.29	0.00e+00	2040.00
IUUC-Ang-009644	Aspergillus niger	27.78	2.00e-03	37.40
IUUC-Bta-012366	Bos taurus	97.31	0.00e+00	2214.00
IUUC-Cel-018474	Caenorhabditis elegans	48.72	2.00e-08	55.50
IUUC-Cja-019462	Callithrix jacchus	99.41	0.00e+00	2252.00
IUUC-Cpo-021406	Cavia porcellus	97.15	0.00e+00	2204.00
IUUC-Csa-023857	Chlorocebus sabaeus	99.53	0.00e+00	1980.00
IUUC-Cho-024281	Choloepus hoffmanni	84.65	0.00e+00	696.00
IUUC-Dre-028035	Danio rerio	54.55	0.00e+00	1046.00
IUUC-Dno-029311	Dasypus novemcinctus	96.31	0.00e+00	2217.00
IUUC-Dor-030104	Dipodomys ordii	93.28	0.00e+00	1777.00
IUUC-Ete-032926	Echinops telfairi	88.02	0.00e+00	1435.00
IUUC-Eca-034318	Equus caballus	98.24	0.00e+00	2255.00
IUUC-Fca-035557	Felis catus	97.98	0.00e+00	2254.00
IUUC-Fal-037375	Ficedula albicollis	90.38	0.00e+00	2075.00
IUUC-Gga-040314	Gallus gallus	89.21	0.00e+00	2001.00
IUUC-Ggo-045647	Gorilla gorilla	99.66	0.00e+00	2256.00
IUUC-Itr-047974	Ictidomys tridecemlineatus	96.65	0.00e+00	1407.00
IUUC-Loc-052585	Lepisosteus oculatus	62.13	0.00e+00	1241.00
IUUC-Laf-054151	Loxodonta africana	96.05	0.00e+00	2197.00
IUUC-Mcc-055136	Macaca mulatta	99.58	0.00e+00	2256.00
IUUC-Meu-056747	Macropus eugenii	99.21	5.00e-143	502.00
IUUC-Mga-060133	Meleagris gallopavo	89.22	0.00e+00	2004.00
IUUC-Mmr-061559	Microcebus murinus	98.15	0.00e+00	2256.00
IUUC-Mdo-061870	Monodelphis domestica	93.59	0.00e+00	2011.00
IUUC-Mmu-063500	Mus musculus	95.30	0.00e+00	2215.00
IUUC-Mpu-066281	Mustela putorius furo	97.31	0.00e+00	2233.00
IUUC-Mlu-067576	Myotis lucifugus	95.22	0.00e+00	2245.00
IUUC-Nle-069921	Nomascus leucogenys	99.08	0.00e+00	2326.00
IUUC-Opr-070470	Ochotona princeps	93.04	0.00e+00	1399.00
IUUC-Ont-071268	Oreochromis niloticus	58.24	0.00e+00	1143.00
IUUC-Oan-073576	Ornithorhynchus anatinus	93.15	0.00e+00	1941.00
IUUC-Ocu-073971	Oryctolagus cuniculus	97.90	0.00e+00	2213.00
IUUC-Oga-088315	Otolemur garnettii	98.07	0.00e+00	2263.00
IUUC-Oar-090393	Ovis aries	97.48	0.00e+00	2242.00
IUUC-Ptr-091666	Pan troglodytes	99.66	0.00e+00	2255.00
IUUC-Pan-092630	Papio anubis	97.98	0.00e+00	2203.00
IUUC-Psi-093944	Pelodiscus sinensis	88.28	0.00e+00	2064.00
IUUC-Pfo-097469	Poecilia formosa	53.88	0.00e+00	1008.00
IUUC-Pab-098468	Pongo abelii	95.63	0.00e+00	2127.00
IUUC-Pca-100792	Procavia capensis	88.69	0.00e+00	1307.00
IUUC-Pva-103070	Pteropus vampyrus	95.55	0.00e+00	2214.00
IUUC-Rno-105194	Rattus norvegicus	95.63	0.00e+00	2219.00
IUUC-Sha-106725	Sarcophilus harrisii	92.98	0.00e+00	2143.00
IUUC-Sar-112923	Sorex araneus	95.63	0.00e+00	2236.00
IUUC-Ssc-115411	Sus scrofa	97.73	0.00e+00	2248.00
IUUC-Tgu-116794	Taeniopygia guttata	89.37	0.00e+00	2045.00
IUUC-Tru-118270	Takifugu rubripes	56.71	0.00e+00	947.00
IUUC-Tsy-119636	Tarsius syrichta	96.14	0.00e+00	2191.00
IUUC-Tni-120659	Tetraodon nigroviridis	58.87	0.00e+00	1021.00
IUUC-Tbe-127317	Tupaia belangeri	97.19	0.00e+00	1472.00
IUUC-Ttr-129141	Tursiops truncatus	98.54	0.00e+00	1377.00
IUUC-Vpa-130204	Vicugna pacos	97.57	0.00e+00	2301.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence