iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000056972.18	ENST00000359831.8	ENSP00000352889.4
ENSG00000056972.18	ENST00000340026.10	ENSP00000345984.6

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/U-box	U-box	19825828

Organism

Homo sapiens

Functional Description
(View)

Interacts with IKBKG/NF-kappa B essential modulator, with CHUK/IKK-alpha and with IKBKB/IKK-beta. Interacts with TRAF6.

Protein Sequence
(Fasta)

MPPQLQETRM NRSIPVEVDE SEPYPSQLLK PIPEYSPEEE SEPPAPNIRN MAPNSLSAPT 60
MLHNSSGDFS QAHSTLKLAN HQRPVSRQVT CLRTQVLEDS EDSFCRRHPG LGKAFPSGCS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGCAATGCT GATGTTTTAA GCAGTTAGAG GAGGTGGAAG AAGCTCGACT CCCTCTTCTT 60
CCCCATTATC TGCCCACAAT CCCCTCCTTT GGAGCTGCTA ATGATTACTA ATTCTTAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0621--Polymorphism
KW-1185--Reference proteome

Interpro

IPR013568--SEFIR_dom
IPR000157--TIR_dom

PROSITE

PS51534--SEFIR

Pfam

PF08357--SEFIR

Gene Ontology

GO:0005622--C:intracellular
GO:0001783--P:B cell apoptotic process
GO:0006959--P:humoral immune response
GO:0048305--P:immunoglobulin secretion
GO:0035556--P:intracellular signal transduction
GO:0002230--P:positive regulation of defense response to virus by host
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling

KEGG

hsa:10758

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002194	Ailuropoda melanoleuca	84.37	0.00e+00	803.00
IUUC-Apl-003292	Anas platyrhynchos	65.16	2.00e-135	475.00
IUUC-Aca-005173	Anolis carolinensis	52.08	1.00e-129	456.00
IUUC-Ame-010632	Astyanax mexicanus	52.31	3.00e-49	187.00
IUUC-Bta-012676	Bos taurus	83.01	0.00e+00	827.00
IUUC-Bol-016235	Brassica oleracea	29.41	2.00e-02	35.00
IUUC-Bra-017363	Brassica rapa	29.41	1.90e-02	35.00
IUUC-Cja-019819	Callithrix jacchus	92.42	0.00e+00	954.00
IUUC-Cfa-020618	Canis familiaris	80.70	0.00e+00	724.00
IUUC-Cpo-021337	Cavia porcellus	81.42	0.00e+00	835.00
IUUC-Csa-023655	Chlorocebus sabaeus	95.58	0.00e+00	977.00
IUUC-Cho-024547	Choloepus hoffmanni	78.48	0.00e+00	751.00
IUUC-Dre-028655	Danio rerio	47.31	3.00e-45	175.00
IUUC-Dno-029255	Dasypus novemcinctus	84.33	0.00e+00	836.00
IUUC-Dor-030858	Dipodomys ordii	79.72	0.00e+00	723.00
IUUC-Ete-032597	Echinops telfairi	66.78	1.00e-90	327.00
IUUC-Eca-033990	Equus caballus	87.94	0.00e+00	894.00
IUUC-Eeu-034594	Erinaceus europaeus	81.36	0.00e+00	818.00
IUUC-Fca-035932	Felis catus	86.44	0.00e+00	900.00
IUUC-Fal-037433	Ficedula albicollis	54.90	5.00e-136	478.00
IUUC-Gmo-039640	Gadus morhua	55.83	7.00e-39	152.00
IUUC-Gga-040229	Gallus gallus	53.60	1.00e-137	483.00
IUUC-Gac-041660	Gasterosteus aculeatus	57.46	1.00e-52	199.00
IUUC-Gma-043508	Glycine max	28.75	1.40e-01	32.30
IUUC-Ggo-044913	Gorilla gorilla	89.67	0.00e+00	947.00
IUUC-Itr-047865	Ictidomys tridecemlineatus	92.36	4.00e-134	470.00
IUUC-Lch-049621	Latimeria chalumnae	52.33	1.00e-88	320.00
IUUC-Loc-052498	Lepisosteus oculatus	41.06	4.00e-60	225.00
IUUC-Laf-053734	Loxodonta africana	83.54	0.00e+00	827.00
IUUC-Mcc-054884	Macaca mulatta	95.30	0.00e+00	983.00
IUUC-Meu-056225	Macropus eugenii	61.96	2.00e-89	323.00
IUUC-Mga-059442	Meleagris gallopavo	58.19	9.00e-130	457.00
IUUC-Mmr-061017	Microcebus murinus	89.88	0.00e+00	982.00
IUUC-Mdo-062163	Monodelphis domestica	72.13	0.00e+00	693.00
IUUC-Mmu-064394	Mus musculus	77.80	0.00e+00	759.00
IUUC-Mpu-066777	Mustela putorius furo	84.25	0.00e+00	891.00
IUUC-Mlu-068135	Myotis lucifugus	84.96	0.00e+00	849.00
IUUC-Nle-070002	Nomascus leucogenys	93.66	0.00e+00	939.00
IUUC-Opr-070530	Ochotona princeps	69.82	0.00e+00	644.00
IUUC-Ont-071530	Oreochromis niloticus	53.06	5.00e-50	190.00
IUUC-Oan-073155	Ornithorhynchus anatinus	86.11	5.00e-83	300.00
IUUC-Ocu-074761	Oryctolagus cuniculus	73.81	0.00e+00	700.00
IUUC-Ola-086465	Oryzias latipes	55.90	2.00e-44	171.00
IUUC-Oga-088791	Otolemur garnettii	88.32	0.00e+00	931.00
IUUC-Oar-090442	Ovis aries	81.59	0.00e+00	829.00
IUUC-Ptr-091482	Pan troglodytes	99.13	0.00e+00	1015.00
IUUC-Pan-092343	Papio anubis	89.61	0.00e+00	883.00
IUUC-Psi-093042	Pelodiscus sinensis	58.59	1.00e-165	576.00
IUUC-Pfo-097008	Poecilia formosa	59.77	3.00e-48	184.00
IUUC-Pab-098135	Pongo abelii	98.43	0.00e+00	1014.00
IUUC-Pca-100508	Procavia capensis	80.33	0.00e+00	787.00
IUUC-Pva-103048	Pteropus vampyrus	87.41	0.00e+00	918.00
IUUC-Rno-105238	Rattus norvegicus	74.43	0.00e+00	714.00
IUUC-Sha-107315	Sarcophilus harrisii	70.58	0.00e+00	703.00
IUUC-Ssc-116085	Sus scrofa	84.60	0.00e+00	828.00
IUUC-Tgu-116885	Taeniopygia guttata	65.63	3.00e-133	468.00
IUUC-Tru-118396	Takifugu rubripes	59.24	6.00e-55	206.00
IUUC-Tni-120375	Tetraodon nigroviridis	57.65	2.00e-56	211.00
IUUC-Tbe-128139	Tupaia belangeri	94.57	5.00e-117	414.00
IUUC-Ttr-128651	Tursiops truncatus	82.87	0.00e+00	816.00
IUUC-Vpa-130559	Vicugna pacos	76.05	0.00e+00	721.00
IUUC-Xtr-132354	Xenopus tropicalis	50.57	2.00e-70	259.00
IUUC-Xma-134194	Xiphophorus maculatus	60.34	2.00e-43	169.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence