iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000057663.13	ENST00000636335.1	ENSP00000490221.1
ENSG00000057663.13	ENST00000343245.7	ENSP00000343313.3
ENSG00000057663.13	ENST00000369070.5	ENSP00000358066.2
ENSG00000057663.13	ENST00000360666.5	ENSP00000353884.4
ENSG00000057663.13	ENST00000613993.1	ENSP00000483135.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2	LncRNADisease
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/Other	23.39	2.00e-09	58.20	IUUC-Sce-106216

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Homo sapiens

Functional Description
(View)

Forms a conjugate with ATG12. The ATG5-ATG12 conjugate forms a complex with several units of ATG16L. Interacts with TECPR1; the interaction is direct and does not take place when ATG16L is associated with the ATG5-ATG12 conjugate. ATG12-ATG5 interacts with MAVS, MGA and RARRES3. Interacts with ATG3, ATG7 and ATG10. Interacts with FADD. Interacts transiently interacts with hepatitis C virus (HCV) protein NS5B during HCV infection.

Protein Sequence
(Fasta)

MTDDKDVLRD VWFGRIPTCF TLYQDEITER EAEPYYLLLP RVSYLTLVTD KVKKHFQKVM 60
RQEDISEIWF EYEGTPLKWH YPIGLLFDLL ASSSALPWNI TVHFKSFPEK DLLHCPSKDA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGACGTCAT CTCCGGGCGC CGAGGGTGAC TGGACTTGTG GTGCGCTGCC AGGGCTCCGC 60
AGCGTTGCCG GTTGTATTCG CTGGATACCA GAGGGCGGAA GTGCAGCAGG GTTCAGCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation

Interpro

IPR007239--Atg5

Pfam

PF04106--APG5

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0005776--C:autophagosome
GO:0005930--C:axoneme
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0044233--C:ER-mitochondrion membrane contact site
GO:0016020--C:membrane
GO:0030670--C:phagocytic vesicle membrane
GO:0034045--C:pre-autophagosomal structure membrane
GO:0035973--P:aggrephagy
GO:0019883--P:antigen processing and presentation of endogenous antigen
GO:0006915--P:apoptotic process
GO:0000045--P:autophagosome assembly
GO:0006914--P:autophagy
GO:0001974--P:blood vessel remodeling
GO:0006501--P:C-terminal protein lipidation
GO:0019725--P:cellular homeostasis
GO:0006995--P:cellular response to nitrogen starvation
GO:0071500--P:cellular response to nitrosative stress
GO:0060047--P:heart contraction
GO:0045087--P:innate immune response
GO:0016236--P:macroautophagy
GO:0000422--P:mitophagy
GO:0043066--P:negative regulation of apoptotic process
GO:0060548--P:negative regulation of cell death
GO:2000619--P:negative regulation of histone H4-K16 acetylation
GO:0050765--P:negative regulation of phagocytosis
GO:0031397--P:negative regulation of protein ubiquitination
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0039689--P:negative stranded viral RNA replication
GO:0045060--P:negative thymic T cell selection
GO:0044804--P:nucleophagy
GO:0048840--P:otolith development
GO:0070257--P:positive regulation of mucus secretion
GO:0043687--P:post-translational protein modification
GO:0061739--P:protein lipidation involved in autophagosome assembly
GO:1902017--P:regulation of cilium assembly
GO:0002739--P:regulation of cytokine secretion involved in immune response
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
GO:0042493--P:response to drug
GO:0009620--P:response to fungus
GO:0042311--P:vasodilation
GO:0055015--P:ventricular cardiac muscle cell development

KEGG

hsa:9474

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000583	Aegilops tauschii	32.35	6.00e-25	109.00
IUUC-Aml-002403	Ailuropoda melanoleuca	97.83	9.00e-157	545.00
IUUC-Atr-002645	Amborella trichopoda	26.41	9.00e-24	104.00
IUUC-Apl-003611	Anas platyrhynchos	90.55	4.00e-153	533.00
IUUC-Aca-004411	Anolis carolinensis	90.29	8.00e-151	526.00
IUUC-Aly-005636	Arabidopsis lyrata	26.97	4.00e-27	115.00
IUUC-Ath-006959	Arabidopsis thaliana	27.58	1.00e-27	117.00
IUUC-Ago-007978	Ashbya gossypii	26.88	4.00e-07	48.90
IUUC-Acl-008328	Aspergillus clavatus	25.70	2.00e-19	89.70
IUUC-Afl-008638	Aspergillus flavus	24.60	4.00e-24	105.00
IUUC-Afu-009042	Aspergillus fumigatus	25.96	6.00e-26	111.00
IUUC-Ani-009364	Aspergillus nidulans	29.11	6.00e-23	101.00
IUUC-Aor-009889	Aspergillus oryzae	24.60	4.00e-24	105.00
IUUC-Ate-010511	Aspergillus terreus	31.18	5.00e-10	55.80
IUUC-Ame-011644	Astyanax mexicanus	86.08	9.00e-38	147.00
IUUC-Bgr-012153	Blumeria graminis	28.15	6.00e-18	84.70
IUUC-Bta-012360	Bos taurus	98.74	4.00e-87	313.00
IUUC-Bci-013723	Botrytis cinerea	26.99	5.00e-16	78.20
IUUC-Bdi-014520	Brachypodium distachyon	22.59	1.00e-21	97.40
IUUC-Bol-016053	Brassica oleracea	26.87	9.00e-30	124.00
IUUC-Bra-017072	Brassica rapa	27.25	4.00e-30	125.00
IUUC-Cel-018529	Caenorhabditis elegans	35.64	6.00e-38	150.00
IUUC-Cja-019569	Callithrix jacchus	99.27	2.00e-159	554.00
IUUC-Cfa-020473	Canis familiaris	99.27	5.00e-159	553.00
IUUC-Cpo-021421	Cavia porcellus	96.73	3.00e-156	543.00
IUUC-Cre-022862	Chlamydomonas reinhardtii	29.31	4.00e-18	85.10
IUUC-Csa-024197	Chlorocebus sabaeus	99.27	1.00e-159	555.00
IUUC-Cho-024521	Choloepus hoffmanni	97.07	1.00e-132	464.00
IUUC-Cin-025119	Ciona intestinalis	45.28	5.00e-64	237.00
IUUC-Csv-026192	Ciona savignyi	46.27	6.00e-66	243.00
IUUC-Cgl-026686	Colletotrichum gloeosporioides	22.40	1.00e-08	53.90
IUUC-Dre-028466	Danio rerio	81.45	2.00e-135	474.00
IUUC-Dse-031228	Dothistroma septosporum	26.80	5.00e-31	128.00
IUUC-Dme-031703	Drosophila melanogaster	48.34	5.00e-73	267.00
IUUC-Ete-032482	Echinops telfairi	97.07	2.00e-133	468.00
IUUC-Eca-034036	Equus caballus	98.18	3.00e-158	550.00
IUUC-Eeu-035235	Erinaceus europaeus	98.11	1.00e-86	312.00
IUUC-Fca-036263	Felis catus	98.55	2.00e-158	551.00
IUUC-Fal-037064	Ficedula albicollis	90.55	1.00e-153	535.00
IUUC-Fox-037813	Fusarium oxysporum	25.80	4.00e-16	78.60
IUUC-Fso-038139	Fusarium solani	26.67	9.00e-18	84.00
IUUC-Gmo-039509	Gadus morhua	81.53	1.00e-111	395.00
IUUC-Ggr-040111	Gaeumannomyces graminis	25.39	6.00e-14	71.60
IUUC-Gga-040517	Gallus gallus	89.82	1.00e-151	528.00
IUUC-Gac-042270	Gasterosteus aculeatus	76.92	1.00e-116	412.00
IUUC-Gma-044400	Glycine max	35.54	6.00e-24	104.00
IUUC-Ggo-045048	Gorilla gorilla	99.27	1.00e-158	551.00
IUUC-Kpa-049174	Komagataella pastoris	25.00	1.00e-14	73.60
IUUC-Lch-049475	Latimeria chalumnae	88.73	1.00e-147	515.00
IUUC-Lpe-051283	Leersia perrieri	35.46	7.00e-24	106.00
IUUC-Loc-052446	Lepisosteus oculatus	84.36	2.00e-142	497.00
IUUC-Lma-053278	Leptosphaeria maculans	27.22	8.00e-30	124.00
IUUC-Laf-054020	Loxodonta africana	98.19	1.00e-157	548.00
IUUC-Mcc-055176	Macaca mulatta	100.00	3.00e-160	557.00
IUUC-Mor-057164	Magnaporthe oryzae	25.79	1.00e-16	80.10
IUUC-Mpo-057428	Magnaporthe poae	26.27	3.00e-13	69.30
IUUC-Mtr-058424	Medicago truncatula	35.37	9.00e-24	103.00
IUUC-Mla-058872	Melampsora laricipopulina	29.74	2.00e-29	123.00
IUUC-Mga-059859	Meleagris gallopavo	89.82	1.00e-151	528.00
IUUC-Mmr-061482	Microcebus murinus	99.27	5.00e-159	553.00
IUUC-Mdo-062371	Monodelphis domestica	95.64	9.00e-160	555.00
IUUC-Mmu-063139	Mus musculus	96.73	4.00e-157	546.00
IUUC-Mac-065332	Musa acuminata	34.48	3.00e-26	112.00
IUUC-Mpu-066783	Mustela putorius furo	98.55	4.00e-158	550.00
IUUC-Mlu-068165	Myotis lucifugus	96.03	1.00e-153	535.00
IUUC-Nfi-068578	Neosartorya fischeri	27.07	2.00e-27	116.00
IUUC-Ncr-068636	Neurospora crassa	24.24	4.00e-12	65.90
IUUC-Nle-069740	Nomascus leucogenys	99.64	4.00e-160	556.00
IUUC-Opr-070802	Ochotona princeps	99.37	1.00e-86	312.00
IUUC-Ont-072222	Oreochromis niloticus	79.27	4.00e-135	473.00
IUUC-Oan-072760	Ornithorhynchus anatinus	94.92	9.00e-113	399.00
IUUC-Ocu-074844	Oryctolagus cuniculus	96.51	7.00e-98	349.00
IUUC-Oba-075834	Oryza barthii	33.33	4.00e-25	108.00
IUUC-Obr-076230	Oryza brachyantha	32.69	9.00e-15	74.30
IUUC-Ogl-077554	Oryza glaberrima	33.33	4.00e-25	108.00
IUUC-Ogu-078687	Oryza glumaepatula	33.33	3.00e-25	109.00
IUUC-Oin-079677	Oryza indica	26.10	9.00e-27	114.00
IUUC-Olo-081078	Oryza longistaminata	36.11	2.00e-25	110.00
IUUC-Ome-081548	Oryza meridionalis	33.90	6.00e-28	119.00
IUUC-Oni-082050	Oryza nivara	33.90	9.00e-26	110.00
IUUC-Opu-083609	Oryza punctata	33.71	7.00e-26	111.00
IUUC-Oru-085057	Oryza rufipogon	33.90	1.00e-25	110.00
IUUC-Osa-085917	Oryza sativa	33.90	2.00e-25	110.00
IUUC-Ola-087032	Oryzias latipes	78.91	3.00e-133	467.00
IUUC-Olu-087877	Ostreococcus lucimarinus	25.88	2.60e-02	31.20
IUUC-Oga-088468	Otolemur garnettii	97.11	3.00e-161	560.00
IUUC-Oar-089751	Ovis aries	97.82	1.00e-157	548.00
IUUC-Ptr-091064	Pan troglodytes	100.00	3.00e-160	557.00
IUUC-Pan-092505	Papio anubis	98.92	1.00e-158	551.00
IUUC-Psi-093086	Pelodiscus sinensis	90.94	7.00e-154	536.00
IUUC-Pno-094825	Phaeosphaeria nodorum	28.47	1.00e-26	113.00
IUUC-Ppa-095419	Physcomitrella patens	33.13	1.00e-25	110.00
IUUC-Pfo-096224	Poecilia formosa	78.18	8.00e-133	466.00
IUUC-Pab-098501	Pongo abelii	99.27	5.00e-159	553.00
IUUC-Pop-099243	Populus trichocarpa	27.96	2.00e-25	110.00
IUUC-Ppe-101255	Prunus persica	26.48	4.00e-28	118.00
IUUC-Pva-102828	Pteropus vampyrus	97.45	1.00e-156	545.00
IUUC-Pgr-103672	Puccinia graminis	29.28	2.00e-25	110.00
IUUC-Ptt-104013	Puccinia triticina	27.05	1.00e-21	97.10
IUUC-Pyt-104615	Pyrenophora triticirepentis	27.69	4.00e-28	118.00
IUUC-Rno-106089	Rattus norvegicus	93.47	7.00e-134	469.00
IUUC-Sce-106216	Saccharomyces cerevisiae	23.39	2.00e-12	66.60
IUUC-Sha-106484	Sarcophilus harrisii	95.64	1.00e-159	555.00
IUUC-Sja-107699	Schizosaccharomyces japonicus	27.44	2.00e-26	112.00
IUUC-Spo-108177	Schizosaccharomyces pombe	28.11	1.00e-22	99.80
IUUC-Ssl-108475	Sclerotinia sclerotiorum	27.34	6.00e-16	77.80
IUUC-Smo-109473	Selaginella moellendorffii	27.22	1.00e-23	103.00
IUUC-Sit-110736	Setaria italica	25.22	2.00e-29	123.00
IUUC-Sly-111657	Solanum lycopersicum	36.59	1.00e-27	117.00
IUUC-Sar-113050	Sorex araneus	82.43	2.00e-107	381.00
IUUC-Sbi-114258	Sorghum bicolor	33.33	4.00e-26	112.00
IUUC-Sre-114902	Sporisorium reilianum	31.19	7.00e-23	102.00
IUUC-Ssc-116166	Sus scrofa	91.27	3.00e-147	513.00
IUUC-Tgu-116814	Taeniopygia guttata	89.82	3.00e-152	530.00
IUUC-Tru-118172	Takifugu rubripes	79.35	1.00e-133	468.00
IUUC-Tsy-119010	Tarsius syrichta	84.73	4.00e-135	473.00
IUUC-Tni-120397	Tetraodon nigroviridis	79.52	2.00e-101	361.00
IUUC-Tca-121283	Theobroma cacao	28.21	2.00e-29	123.00
IUUC-Tvi-122545	Trichoderma virens	24.05	3.00e-14	72.40
IUUC-Tae-122685	Triticum aestivum	31.58	9.00e-25	107.00
IUUC-Tur-126407	Triticum urartu	34.00	5.00e-25	108.00
IUUC-Tme-126913	Tuber melanosporum	30.88	1.00e-39	156.00
IUUC-Tbe-127738	Tupaia belangeri	91.33	1.00e-105	375.00
IUUC-Ttr-128528	Tursiops truncatus	97.82	4.00e-157	546.00
IUUC-Uma-129625	Ustilago maydis	28.11	2.00e-20	94.00
IUUC-Vda-129906	Verticillium dahliae	23.11	2.00e-10	59.30
IUUC-Vpa-130223	Vicugna pacos	96.73	1.00e-151	528.00
IUUC-Vvi-131617	Vitis vinifera	34.76	3.00e-25	109.00
IUUC-Xtr-132288	Xenopus tropicalis	86.18	1.00e-143	502.00
IUUC-Xma-134214	Xiphophorus maculatus	81.87	1.00e-96	345.00
IUUC-Yli-134377	Yarrowia lipolytica	24.88	2.00e-12	66.20
IUUC-Zma-135108	Zea mays	34.03	7.00e-24	104.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence