iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045918

UUCD1 version

UUC-HoS-00293

Ensembl Protein ID

ENSP00000263694.4

UniProt Accession

Q96DI7; B4DQJ1; O75938; O95320; SNR40_HUMAN

Genbank Protein ID

AAC69625.1; BAG60953.1; CAH71848.1; CAH71848.1; AAH01494.1; AAC64084.1

Protein Name

U5 small nuclear ribonucleoprotein 40 kDa protein; 38 kDa-splicing factor; Prp8-binding protein; U5 snRNP-specific 40 kDa protein; WD repeat-containing protein 57

Genbank Nucleotide ID

AF090988; AK298823; AL451070; AC114495; BC001494; AF083383

Gene Name

SNRNP40; PRP8BP; SFP38; WDR57

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000060688.12	ENST00000263694.8	ENSP00000263694.4
ENSG00000060688.12	ENST00000373720.3	ENSP00000362825.3

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.20e-46	154.2	149	183
UBD/Beta-Prp	3.70e-79	267.7	62	265

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrt 32
           gHt+ v+++     +  l+++GsdDgt+k+WD+r+
   Q: 149  GHTSFVNSCYParRGpQLVCTGSDDGTVKLWDIRK 183
           8*******9659955588999***********876 PP

UBD/Beta-Prp

   S: 48   lsgheaevtavkfspdgkilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdg 138
           lsghe+ev+++kf+p+g++l++++ Dr+i +w++  +++   tlkgh+  v+ l+++ +g+ l s+s d+t+ vwd etg+ ++  l+gh++
   Q: 62   LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYgDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVK-RLKGHTS 152
           8*******************************8765999*********************************************.******* PP
   S: 139  vvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvr 229
           +vn+      g +l+ +Gs+D+tv+lWd++ +  ++t++  +t +v  ++f++++ +++sg+ d+++k+wdl++++  +t++gh d v+ + 
   Q: 153  FVNSCYPARRGpQLVCTGSDDGTVKLWDIRKKAAIQTFQ--NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
           **************************************7..6************************************************** PP
   S: 230  fspnderlvsgssDgsiriWdlr 252
           +s+++ +l+s ++D+++r+Wd+r
   Q: 243  LSSEGSYLLSNAMDNTVRVWDVR 265
           *********************87 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs.

Protein Sequence
(Fasta)

MIEQQKRKGP ELPLVPVKRQ RHELLLGAGS GPGAGQQQAT PGALLQAGPP RCSSLQAPIM 60
LLSGHEGEVY CCKFHPNGST LASAGFDRLI LLWNVYGDCD NYATLKGHSG AVMELHYNTD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTGGCGGCG CTGAAGAGAC CGGTTGCCGC CATGATAGAA CAGCAGAAGC GTAAGGGCCC 60
AGAGTTGCCG CTGGTTCCAG TCAAGCGGCA GCGGCATGAG TTGCTGTTGG GAGCGGGGTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0488--Methylation
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0747--Spliceosome
KW-0832--Ubl conjugation
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0071013--C:catalytic step 2 spliceosome
GO:0005829--C:cytosol
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0071011--C:precatalytic spliceosome
GO:0005732--C:small nucleolar ribonucleoprotein complex
GO:0005682--C:U5 snRNP
GO:0003723--F:RNA binding
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006396--P:RNA processing
GO:0008380--P:RNA splicing
GO:0000375--P:RNA splicing, via transesterification reactions

KEGG

hsa:9410

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000138	Aegilops tauschii	56.59	7.00e-120	423.00
IUUC-Aml-001428	Ailuropoda melanoleuca	99.12	0.00e+00	629.00
IUUC-Atr-003164	Amborella trichopoda	58.99	1.00e-121	429.00
IUUC-Apl-003447	Anas platyrhynchos	96.86	6.00e-162	563.00
IUUC-Aca-004270	Anolis carolinensis	84.17	3.00e-169	587.00
IUUC-Aly-005659	Arabidopsis lyrata	59.76	1.00e-124	439.00
IUUC-Ath-006764	Arabidopsis thaliana	59.16	4.00e-124	437.00
IUUC-Acl-008324	Aspergillus clavatus	47.80	2.00e-95	342.00
IUUC-Afl-008607	Aspergillus flavus	49.66	1.00e-89	323.00
IUUC-Afu-008998	Aspergillus fumigatus	47.51	3.00e-95	341.00
IUUC-Ani-009363	Aspergillus nidulans	49.05	1.00e-95	342.00
IUUC-Ang-009513	Aspergillus niger	48.51	4.00e-85	308.00
IUUC-Aor-010237	Aspergillus oryzae	48.09	2.00e-96	345.00
IUUC-Ate-010374	Aspergillus terreus	46.20	2.00e-83	302.00
IUUC-Ame-010728	Astyanax mexicanus	83.84	6.00e-172	596.00
IUUC-Bgr-012297	Blumeria graminis	46.15	2.00e-70	258.00
IUUC-Bta-012433	Bos taurus	94.41	0.00e+00	650.00
IUUC-Bci-013763	Botrytis cinerea	50.16	7.00e-95	340.00
IUUC-Bdi-014490	Brachypodium distachyon	58.92	2.00e-119	422.00
IUUC-Bol-016479	Brassica oleracea	61.86	4.00e-124	437.00
IUUC-Bra-017219	Brassica rapa	62.14	5.00e-124	437.00
IUUC-Cel-018512	Caenorhabditis elegans	56.04	1.00e-113	403.00
IUUC-Cja-019308	Callithrix jacchus	94.69	0.00e+00	654.00
IUUC-Cfa-020998	Canis familiaris	94.97	0.00e+00	656.00
IUUC-Cpo-021580	Cavia porcellus	97.77	0.00e+00	650.00
IUUC-Cre-022859	Chlamydomonas reinhardtii	53.37	1.00e-107	383.00
IUUC-Csa-023456	Chlorocebus sabaeus	100.00	0.00e+00	661.00
IUUC-Cho-024644	Choloepus hoffmanni	99.35	3.00e-179	620.00
IUUC-Cin-025463	Ciona intestinalis	59.01	2.00e-126	445.00
IUUC-Cgl-026497	Colletotrichum gloeosporioides	45.61	4.00e-94	338.00
IUUC-Cne-026780	Cryptococcus neoformans	40.90	7.00e-67	247.00
IUUC-Dre-027671	Danio rerio	81.34	2.00e-176	611.00
IUUC-Dno-029769	Dasypus novemcinctus	94.97	0.00e+00	659.00
IUUC-Dor-030776	Dipodomys ordii	88.76	9.00e-85	306.00
IUUC-Dse-031316	Dothistroma septosporum	43.24	6.00e-87	314.00
IUUC-Dme-031756	Drosophila melanogaster	61.46	3.00e-124	438.00
IUUC-Ete-032753	Echinops telfairi	87.11	3.00e-164	570.00
IUUC-Eca-033979	Equus caballus	94.41	0.00e+00	650.00
IUUC-Eeu-034862	Erinaceus europaeus	99.28	4.00e-72	265.00
IUUC-Fca-036110	Felis catus	94.48	9.00e-159	552.00
IUUC-Fal-037648	Ficedula albicollis	96.77	1.00e-176	612.00
IUUC-Fox-037861	Fusarium oxysporum	45.95	4.00e-91	328.00
IUUC-Fso-038405	Fusarium solani	45.95	5.00e-91	327.00
IUUC-Gmo-039383	Gadus morhua	83.29	2.00e-172	598.00
IUUC-Ggr-040082	Gaeumannomyces graminis	44.14	2.00e-84	306.00
IUUC-Gga-040785	Gallus gallus	90.83	7.00e-180	623.00
IUUC-Gac-041645	Gasterosteus aculeatus	83.01	1.00e-169	588.00
IUUC-Gma-044329	Glycine max	60.44	3.00e-122	431.00
IUUC-Ggo-044800	Gorilla gorilla	90.35	1.00e-159	556.00
IUUC-Hvu-047342	Hordeum vulgare	57.23	2.00e-119	421.00
IUUC-Itr-048047	Ictidomys tridecemlineatus	91.78	2.00e-111	394.00
IUUC-Kpa-049149	Komagataella pastoris	33.98	3.00e-36	145.00
IUUC-Lch-050395	Latimeria chalumnae	87.43	0.00e+00	655.00
IUUC-Lpe-051275	Leersia perrieri	57.83	1.00e-120	427.00
IUUC-Loc-052666	Lepisosteus oculatus	86.15	3.00e-173	600.00
IUUC-Lma-053129	Leptosphaeria maculans	43.40	2.00e-89	322.00
IUUC-Laf-054512	Loxodonta africana	93.84	0.00e+00	649.00
IUUC-Mcc-055819	Macaca mulatta	100.00	0.00e+00	661.00
IUUC-Meu-056350	Macropus eugenii	81.72	5.00e-159	553.00
IUUC-Mor-057063	Magnaporthe oryzae	46.20	1.00e-91	329.00
IUUC-Mpo-057369	Magnaporthe poae	45.05	2.00e-85	309.00
IUUC-Mtr-058228	Medicago truncatula	59.49	9.00e-122	429.00
IUUC-Mla-059093	Melampsora laricipopulina	40.57	3.00e-70	258.00
IUUC-Mga-059719	Meleagris gallopavo	96.50	5.00e-178	616.00
IUUC-Mvi-060285	Microbotryum violaceum	40.06	1.00e-63	236.00
IUUC-Mmr-061685	Microcebus murinus	88.27	7.00e-170	589.00
IUUC-Mdo-062121	Monodelphis domestica	90.58	0.00e+00	635.00
IUUC-Mmu-063216	Mus musculus	94.41	0.00e+00	660.00
IUUC-Mac-065463	Musa acuminata	54.79	1.00e-110	392.00
IUUC-Mpu-066390	Mustela putorius furo	95.81	0.00e+00	664.00
IUUC-Mlu-066932	Myotis lucifugus	94.15	4.00e-180	624.00
IUUC-Nfi-068509	Neosartorya fischeri	47.51	4.00e-95	341.00
IUUC-Ncr-068870	Neurospora crassa	47.19	2.00e-92	332.00
IUUC-Nle-069539	Nomascus leucogenys	100.00	0.00e+00	660.00
IUUC-Opr-070555	Ochotona princeps	82.12	2.00e-166	578.00
IUUC-Ont-071490	Oreochromis niloticus	82.78	5.00e-170	590.00
IUUC-Oan-073044	Ornithorhynchus anatinus	79.29	1.00e-153	536.00
IUUC-Ocu-073764	Oryctolagus cuniculus	95.53	0.00e+00	666.00
IUUC-Oba-075704	Oryza barthii	58.51	1.00e-120	426.00
IUUC-Obr-076455	Oryza brachyantha	58.82	2.00e-120	426.00
IUUC-Ogl-077382	Oryza glaberrima	58.82	8.00e-121	426.00
IUUC-Ogu-078739	Oryza glumaepatula	58.51	9.00e-121	426.00
IUUC-Oin-079072	Oryza indica	58.51	9.00e-121	426.00
IUUC-Olo-080809	Oryza longistaminata	58.51	9.00e-121	426.00
IUUC-Ome-081677	Oryza meridionalis	58.51	3.00e-120	424.00
IUUC-Oni-082937	Oryza nivara	58.51	9.00e-121	426.00
IUUC-Opu-083510	Oryza punctata	58.51	9.00e-121	426.00
IUUC-Oru-084360	Oryza rufipogon	58.51	1.00e-120	426.00
IUUC-Osa-085640	Oryza sativa	58.51	1.00e-120	426.00
IUUC-Ola-086504	Oryzias latipes	82.45	3.00e-171	593.00
IUUC-Olu-087869	Ostreococcus lucimarinus	41.64	3.00e-63	234.00
IUUC-Oga-088773	Otolemur garnettii	94.41	0.00e+00	654.00
IUUC-Oar-089677	Ovis aries	93.63	0.00e+00	644.00
IUUC-Ptr-090724	Pan troglodytes	99.71	0.00e+00	630.00
IUUC-Pan-092683	Papio anubis	100.00	0.00e+00	661.00
IUUC-Psi-093415	Pelodiscus sinensis	97.72	9.00e-176	609.00
IUUC-Pma-094562	Petromyzon marinus	76.54	2.00e-169	588.00
IUUC-Pno-095014	Phaeosphaeria nodorum	46.93	1.00e-89	323.00
IUUC-Ppa-095822	Physcomitrella patens	57.87	1.00e-121	429.00
IUUC-Pfo-096579	Poecilia formosa	82.45	2.00e-168	584.00
IUUC-Pab-098313	Pongo abelii	100.00	0.00e+00	661.00
IUUC-Pop-099747	Populus trichocarpa	61.49	2.00e-123	434.00
IUUC-Pca-100871	Procavia capensis	85.00	1.00e-129	456.00
IUUC-Ppe-101389	Prunus persica	62.14	5.00e-124	437.00
IUUC-Pva-102468	Pteropus vampyrus	80.17	5.00e-149	520.00
IUUC-Pgr-103523	Puccinia graminis	41.77	8.00e-73	267.00
IUUC-Ptt-103930	Puccinia triticina	41.69	2.00e-72	266.00
IUUC-Pte-104299	Pyrenophora teres	46.33	1.00e-94	340.00
IUUC-Pyt-104564	Pyrenophora triticirepentis	46.63	2.00e-94	339.00
IUUC-Rno-105796	Rattus norvegicus	94.41	0.00e+00	653.00
IUUC-Sha-107191	Sarcophilus harrisii	90.58	0.00e+00	635.00
IUUC-Sja-107952	Schizosaccharomyces japonicus	37.92	2.00e-63	236.00
IUUC-Spo-108249	Schizosaccharomyces pombe	43.53	2.00e-80	292.00
IUUC-Ssl-108448	Sclerotinia sclerotiorum	49.53	3.00e-94	338.00
IUUC-Sit-110805	Setaria italica	57.59	1.00e-119	423.00
IUUC-Sly-111567	Solanum lycopersicum	61.71	3.00e-125	441.00
IUUC-Stu-112562	Solanum tuberosum	61.71	3.00e-126	444.00
IUUC-Sar-112991	Sorex araneus	98.63	1.00e-120	424.00
IUUC-Sbi-114010	Sorghum bicolor	58.58	1.00e-118	419.00
IUUC-Sre-114947	Sporisorium reilianum	42.99	4.00e-74	271.00
IUUC-Ssc-115371	Sus scrofa	94.41	0.00e+00	650.00
IUUC-Tgu-117429	Taeniopygia guttata	94.14	3.00e-174	604.00
IUUC-Tru-118081	Takifugu rubripes	83.06	3.00e-171	594.00
IUUC-Tsy-119101	Tarsius syrichta	82.40	3.00e-158	551.00
IUUC-Tni-120532	Tetraodon nigroviridis	83.01	2.00e-169	588.00
IUUC-Tca-121373	Theobroma cacao	59.64	9.00e-125	439.00
IUUC-Tre-122050	Trichoderma reesei	45.31	5.00e-90	324.00
IUUC-Tvi-122394	Trichoderma virens	42.77	2.00e-84	305.00
IUUC-Tae-124661	Triticum aestivum	57.36	4.00e-119	421.00
IUUC-Tme-126998	Tuber melanosporum	51.46	3.00e-94	338.00
IUUC-Tbe-128032	Tupaia belangeri	94.13	0.00e+00	655.00
IUUC-Ttr-129102	Tursiops truncatus	83.80	1.00e-158	552.00
IUUC-Uma-129363	Ustilago maydis	43.61	1.00e-77	283.00
IUUC-Vda-129891	Verticillium dahliae	47.37	2.00e-93	335.00
IUUC-Vpa-130827	Vicugna pacos	93.85	0.00e+00	647.00
IUUC-Vvi-131202	Vitis vinifera	56.57	3.00e-123	434.00
IUUC-Xtr-132769	Xenopus tropicalis	85.52	3.00e-171	594.00
IUUC-Xma-133147	Xiphophorus maculatus	82.45	5.00e-168	583.00
IUUC-Yli-134352	Yarrowia lipolytica	33.77	3.00e-36	145.00
IUUC-Zma-135294	Zea mays	58.39	1.00e-118	419.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence