iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000060709.14	ENST00000261655.8	ENSP00000261655.4
ENSG00000060709.14	ENST00000540658.1	ENSP00000439437.1
ENSG00000060709.14	ENST00000535703.5	ENSP00000440347.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.90e-22	78.3	955	1018

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqn.......ddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++ +lydy++ +       + eLt+  Gd+++v   e  + g  +g  el+g++Gl+P+nF e++ 
   Q: 955  RRMVALYDYDPREsspnvdvEAELTFCTGDIITVF-GEIDEDGFYYG--ELNGQKGLVPSNFLEEVP 1018
           578899***9987333333346************9.999999*****..9*************9985 PP

Organism

Homo sapiens

Functional Description
(View)

Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.

Protein Sequence
(Fasta)

MREAAERRQQ LQLEHDQALA VLSAKQQEID LLQKSKVREL EEKCRTQSEQ FNLLSRDLEK 60
FRQHAGKIDL LGGSAVAPLD ISTAPSKPFP QFMNGLATSL GKGQESAIGG SSAIGEYIRP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAAATGAAC TGAAGGATGC CACCCAGGGA GAGTATCTCC TGAGATCCCA TCATGCAGGC 60
CTTCCCACAA GGGCCCGGCA GCATGACAAG GTAGCTGATA CCACTGTCCA CAGACCATCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0770--Synapse

Interpro

IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50853--FN3
PS50002--SH3

Pfam

PF07653--SH3_2
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00060--FN3
SM00326--SH3

Gene Ontology

GO:0030054--C:cell junction
GO:0005886--C:plasma membrane
GO:0045202--C:synapse
GO:0010923--P:negative regulation of phosphatase activity

KEGG

hsa:23504

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001784	Ailuropoda melanoleuca	90.52	0.00e+00	796.00
IUUC-Apl-003375	Anas platyrhynchos	79.29	0.00e+00	1151.00
IUUC-Aca-005066	Anolis carolinensis	73.12	0.00e+00	1461.00
IUUC-Ame-010866	Astyanax mexicanus	58.16	0.00e+00	738.00
IUUC-Bta-013134	Bos taurus	85.52	0.00e+00	1208.00
IUUC-Cja-019313	Callithrix jacchus	96.02	0.00e+00	980.00
IUUC-Cfa-020985	Canis familiaris	84.78	0.00e+00	1194.00
IUUC-Cpo-021501	Cavia porcellus	82.21	0.00e+00	1232.00
IUUC-Csa-023054	Chlorocebus sabaeus	98.69	0.00e+00	1540.00
IUUC-Cme-027177	Cyanidioschyzon merolae	57.14	9.90e-01	27.70
IUUC-Dre-028295	Danio rerio	53.77	0.00e+00	962.00
IUUC-Dno-029819	Dasypus novemcinctus	69.37	0.00e+00	699.00
IUUC-Dme-032173	Drosophila melanogaster	36.40	4.00e-53	204.00
IUUC-Ete-032529	Echinops telfairi	72.01	0.00e+00	1352.00
IUUC-Eca-034034	Equus caballus	87.38	0.00e+00	1281.00
IUUC-Fca-035519	Felis catus	67.31	0.00e+00	953.00
IUUC-Fal-036780	Ficedula albicollis	73.21	0.00e+00	1065.00
IUUC-Gmo-039149	Gadus morhua	57.14	0.00e+00	629.00
IUUC-Gga-040811	Gallus gallus	79.21	0.00e+00	1167.00
IUUC-Gac-042154	Gasterosteus aculeatus	57.84	1.00e-178	620.00
IUUC-Ggo-044850	Gorilla gorilla	94.01	0.00e+00	1821.00
IUUC-Itr-048260	Ictidomys tridecemlineatus	84.95	0.00e+00	1648.00
IUUC-Lch-050208	Latimeria chalumnae	69.50	0.00e+00	1019.00
IUUC-Loc-051836	Lepisosteus oculatus	54.03	0.00e+00	766.00
IUUC-Laf-053657	Loxodonta africana	84.04	0.00e+00	1613.00
IUUC-Mcc-055422	Macaca mulatta	98.10	0.00e+00	1929.00
IUUC-Mga-060023	Meleagris gallopavo	70.03	0.00e+00	930.00
IUUC-Mdo-061893	Monodelphis domestica	81.57	0.00e+00	1183.00
IUUC-Mmu-063931	Mus musculus	84.05	0.00e+00	1611.00
IUUC-Mpu-065941	Mustela putorius furo	67.89	0.00e+00	921.00
IUUC-Nle-069981	Nomascus leucogenys	84.10	0.00e+00	1612.00
IUUC-Ont-072190	Oreochromis niloticus	61.14	0.00e+00	806.00
IUUC-Oan-073459	Ornithorhynchus anatinus	69.59	3.00e-117	416.00
IUUC-Ocu-074373	Oryctolagus cuniculus	77.29	0.00e+00	1110.00
IUUC-Ola-087451	Oryzias latipes	59.26	0.00e+00	713.00
IUUC-Oga-088056	Otolemur garnettii	80.61	0.00e+00	932.00
IUUC-Oar-090028	Ovis aries	81.61	0.00e+00	1156.00
IUUC-Pan-092794	Papio anubis	98.88	0.00e+00	1677.00
IUUC-Psi-093107	Pelodiscus sinensis	74.70	0.00e+00	1124.00
IUUC-Pfo-096786	Poecilia formosa	58.96	0.00e+00	768.00
IUUC-Pab-097556	Pongo abelii	97.43	0.00e+00	1927.00
IUUC-Pva-102492	Pteropus vampyrus	83.07	0.00e+00	818.00
IUUC-Rno-105643	Rattus norvegicus	84.26	0.00e+00	1049.00
IUUC-Sha-107544	Sarcophilus harrisii	79.04	0.00e+00	1618.00
IUUC-Ssc-115822	Sus scrofa	66.36	0.00e+00	859.00
IUUC-Tgu-116637	Taeniopygia guttata	77.16	0.00e+00	1041.00
IUUC-Tru-118109	Takifugu rubripes	56.16	1.00e-177	617.00
IUUC-Tni-120805	Tetraodon nigroviridis	62.32	0.00e+00	1231.00
IUUC-Xtr-132230	Xenopus tropicalis	45.67	1.00e-157	551.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence