iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000068885.14	ENST00000326448.11	ENSP00000312778.7
ENSG00000068885.14	ENST00000483325.1	ENSP00000417552.1
ENSG00000068885.14	ENST00000472555.5	ENSP00000420401.1
ENSG00000068885.14	ENST00000484963.5	ENSP00000420260.1
ENSG00000068885.14	ENST00000482317.5	ENSP00000418497.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.50e-13	52.0	228	256

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H+ ++t++a+ +d  l+++Gs  +t++++D
   Q: 228  HEHPITSVAWaPDgELFAVGS-FHTLRLCD 256
           99*********9978888887.689*9999 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia.

Protein Sequence
(Fasta)

MRLKISLLKE PKHQELVSCV GWTTAEELYS CSDDHQIVKW NLLTSETTQI VKLPDDIYPI 60
DFHWFPKSLG VKKQTQAESF VLTSSDGKFH LISKLGRVEK SVEAHCGAVL AGRWNYEGTA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAAATCTC CCAGCGGCAG CTTCAAGCCC GGACTTCGCC GCTCGGGCTC AAGGCCTCTA 60
TTTTCCAGGC GCTCGCGGAC AAGGCAGGAA GTAAGAGCGT GACAACCTGA CCAGGAAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0966--Cell projection
KW-1186--Ciliopathy
KW-0969--Cilium
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

SMART

SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0097542--C:ciliary tip
GO:0005929--C:cilium
GO:0005737--C:cytoplasm
GO:0030992--C:intraciliary transport particle B
GO:0060349--P:bone morphogenesis
GO:0002062--P:chondrocyte differentiation
GO:0060271--P:cilium assembly
GO:0035735--P:intraciliary transport involved in cilium assembly
GO:0050680--P:negative regulation of epithelial cell proliferation
GO:2000051--P:negative regulation of non-canonical Wnt signaling pathway
GO:1905515--P:non-motile cilium assembly
GO:0001649--P:osteoblast differentiation
GO:0045880--P:positive regulation of smoothened signaling pathway
GO:0007224--P:smoothened signaling pathway

KEGG

hsa:57560

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001564	Ailuropoda melanoleuca	97.29	0.00e+00	902.00
IUUC-Apl-003721	Anas platyrhynchos	85.31	0.00e+00	1373.00
IUUC-Aca-004488	Anolis carolinensis	85.94	0.00e+00	1388.00
IUUC-Ame-011402	Astyanax mexicanus	80.60	0.00e+00	815.00
IUUC-Bta-013037	Bos taurus	86.39	0.00e+00	1318.00
IUUC-Cel-018360	Caenorhabditis elegans	41.05	0.00e+00	670.00
IUUC-Cfa-020999	Canis familiaris	95.79	0.00e+00	1513.00
IUUC-Cpo-021333	Cavia porcellus	85.88	0.00e+00	1301.00
IUUC-Cre-022899	Chlamydomonas reinhardtii	46.60	0.00e+00	679.00
IUUC-Csa-023699	Chlorocebus sabaeus	99.48	0.00e+00	1565.00
IUUC-Cho-024904	Choloepus hoffmanni	86.96	0.00e+00	828.00
IUUC-Cin-025399	Ciona intestinalis	57.56	0.00e+00	961.00
IUUC-Csv-026186	Ciona savignyi	55.72	0.00e+00	930.00
IUUC-Dre-028276	Danio rerio	74.80	0.00e+00	1267.00
IUUC-Dno-029824	Dasypus novemcinctus	96.33	0.00e+00	1519.00
IUUC-Dor-031141	Dipodomys ordii	91.37	0.00e+00	1419.00
IUUC-Dme-031620	Drosophila melanogaster	36.24	1.00e-144	507.00
IUUC-Eca-033339	Equus caballus	94.85	0.00e+00	1491.00
IUUC-Eeu-034909	Erinaceus europaeus	93.42	0.00e+00	983.00
IUUC-Fca-035780	Felis catus	96.73	0.00e+00	1490.00
IUUC-Fal-037447	Ficedula albicollis	79.39	0.00e+00	1268.00
IUUC-Gga-040689	Gallus gallus	85.52	0.00e+00	1373.00
IUUC-Itr-048757	Ictidomys tridecemlineatus	96.26	0.00e+00	1108.00
IUUC-Lch-050459	Latimeria chalumnae	81.67	0.00e+00	1318.00
IUUC-Laf-053765	Loxodonta africana	94.18	0.00e+00	1461.00
IUUC-Mcc-055052	Macaca mulatta	99.48	0.00e+00	1565.00
IUUC-Meu-056368	Macropus eugenii	81.50	0.00e+00	1261.00
IUUC-Mga-059488	Meleagris gallopavo	85.81	0.00e+00	1379.00
IUUC-Mmr-061527	Microcebus murinus	96.51	0.00e+00	1498.00
IUUC-Mmu-063117	Mus musculus	94.72	0.00e+00	1492.00
IUUC-Mpu-066550	Mustela putorius furo	96.38	0.00e+00	1372.00
IUUC-Mlu-067772	Myotis lucifugus	91.60	0.00e+00	1400.00
IUUC-Nle-069215	Nomascus leucogenys	98.71	0.00e+00	1572.00
IUUC-Opr-070725	Ochotona princeps	73.83	0.00e+00	1102.00
IUUC-Ont-072147	Oreochromis niloticus	74.15	0.00e+00	1255.00
IUUC-Oga-088113	Otolemur garnettii	94.82	0.00e+00	1521.00
IUUC-Oar-089683	Ovis aries	92.30	0.00e+00	1448.00
IUUC-Ptr-091563	Pan troglodytes	99.61	0.00e+00	1583.00
IUUC-Pan-092042	Papio anubis	99.22	0.00e+00	1559.00
IUUC-Psi-093306	Pelodiscus sinensis	87.53	0.00e+00	1438.00
IUUC-Ppa-095694	Physcomitrella patens	44.53	0.00e+00	715.00
IUUC-Pfo-096800	Poecilia formosa	73.69	0.00e+00	1238.00
IUUC-Pab-098356	Pongo abelii	99.49	0.00e+00	1587.00
IUUC-Pva-102246	Pteropus vampyrus	91.03	0.00e+00	1405.00
IUUC-Rno-105195	Rattus norvegicus	94.34	0.00e+00	1494.00
IUUC-Sha-107056	Sarcophilus harrisii	94.23	0.00e+00	1481.00
IUUC-Smo-109240	Selaginella moellendorffii	44.16	3.00e-175	608.00
IUUC-Sar-113301	Sorex araneus	85.71	2.00e-147	516.00
IUUC-Ssc-116040	Sus scrofa	96.85	4.00e-148	517.00
IUUC-Tgu-117127	Taeniopygia guttata	81.68	0.00e+00	1322.00
IUUC-Tru-118663	Takifugu rubripes	71.43	0.00e+00	1203.00
IUUC-Tsy-119207	Tarsius syrichta	84.92	0.00e+00	1312.00
IUUC-Tni-120705	Tetraodon nigroviridis	70.03	0.00e+00	1191.00
IUUC-Ttr-128937	Tursiops truncatus	96.52	0.00e+00	1524.00
IUUC-Vpa-130518	Vicugna pacos	91.11	0.00e+00	1396.00
IUUC-Xtr-131879	Xenopus tropicalis	77.95	0.00e+00	1281.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence