iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-091629

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03098663

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000007102.5	ENSPTRT00000013107.4	ENSPTRP00000012140.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.20e-135	451.4	915	1244

Active Site

Position(s)	Description	Evidence
1214	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld 
   Q: 915  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDG 1001
           5899*********************************************************************************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           ++ ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk gG++i Vtn+Nk+eY+ lv
   Q: 1002 FFIRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLV 1083
           ***********************************99...6666..7**************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           +++r+ ++i++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy++++++iqwFw+++ +++se+r ++
   Q: 1084 IQWRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRL 1170
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           LqFvTg+sr+P++Gfael     p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 1171 LQFVTGTSRVPMNGFAELYgsngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 1244
           *************************************************************************8 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MAQSLRLHFA ARRSNTYPLS ETSGDDLDSH VHMCFKRPTR ISTSNVVQMK LTPRQTALAP 60
LIKENVQSQE RSSVPSSENV NKKSSCLQIS LQPTRYSGYL QSSNVLADSD DASFTCILKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCACAAA GCTTACGATT GCACTTTGCA GCCAGAAGAA GCAATACTTA CCCTTTGTCA 60
GAAACCTCCG GAGATGACTT GGATAGCCAT GTTCACATGT GCTTCAAAAG ACCAACACGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0044111--P:development involved in symbiotic interaction
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0031175--P:neuron projection development
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	94.44	0.00e+00	1415.00
IUUC-Ath-007472	Arabidopsis thaliana	44.90	8.00e-92	333.00
IUUC-Ame-011138	Astyanax mexicanus	83.75	0.00e+00	853.00
IUUC-Bta-012453	Bos taurus	90.32	0.00e+00	1331.00
IUUC-Cja-019034	Callithrix jacchus	95.51	0.00e+00	2315.00
IUUC-Cfa-020258	Canis familiaris	95.21	0.00e+00	1370.00
IUUC-Cpo-021648	Cavia porcellus	88.77	0.00e+00	1338.00
IUUC-Csa-023334	Chlorocebus sabaeus	97.06	0.00e+00	1382.00
IUUC-Cho-024672	Choloepus hoffmanni	83.53	0.00e+00	721.00
IUUC-Cin-025157	Ciona intestinalis	57.41	0.00e+00	838.00
IUUC-Dno-029159	Dasypus novemcinctus	88.58	0.00e+00	2058.00
IUUC-Dor-030729	Dipodomys ordii	80.15	0.00e+00	1047.00
IUUC-Dme-032166	Drosophila melanogaster	67.99	0.00e+00	714.00
IUUC-Ete-032409	Echinops telfairi	85.54	0.00e+00	1196.00
IUUC-Eca-033441	Equus caballus	95.49	0.00e+00	1336.00
IUUC-Eeu-034546	Erinaceus europaeus	73.46	0.00e+00	1387.00
IUUC-Fca-036384	Felis catus	94.68	0.00e+00	1413.00
IUUC-Fal-037547	Ficedula albicollis	80.93	0.00e+00	1199.00
IUUC-Gmo-039679	Gadus morhua	66.53	0.00e+00	979.00
IUUC-Gga-040524	Gallus gallus	82.02	0.00e+00	1206.00
IUUC-Ggo-045462	Gorilla gorilla	98.60	0.00e+00	1037.00
IUUC-Hsa-046479	Homo sapiens	97.86	0.00e+00	1437.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	83.17	0.00e+00	1207.00
IUUC-Lch-050445	Latimeria chalumnae	72.37	0.00e+00	1098.00
IUUC-Laf-053638	Loxodonta africana	82.97	0.00e+00	1246.00
IUUC-Mcc-055585	Macaca mulatta	97.33	0.00e+00	1395.00
IUUC-Meu-056897	Macropus eugenii	95.47	2.00e-171	596.00
IUUC-Mga-059362	Meleagris gallopavo	74.47	0.00e+00	1173.00
IUUC-Mvi-060395	Microbotryum violaceum	53.31	5.00e-150	525.00
IUUC-Mmr-061061	Microcebus murinus	94.81	0.00e+00	1438.00
IUUC-Mdo-062178	Monodelphis domestica	55.12	0.00e+00	1364.00
IUUC-Mmu-063318	Mus musculus	77.60	0.00e+00	1150.00
IUUC-Mac-065557	Musa acuminata	44.92	6.00e-89	324.00
IUUC-Mpu-066567	Mustela putorius furo	93.94	0.00e+00	1400.00
IUUC-Mlu-068148	Myotis lucifugus	94.13	0.00e+00	1388.00
IUUC-Nle-069225	Nomascus leucogenys	97.59	0.00e+00	1451.00
IUUC-Opr-070443	Ochotona princeps	77.12	0.00e+00	969.00
IUUC-Oan-073019	Ornithorhynchus anatinus	85.54	0.00e+00	1282.00
IUUC-Ocu-074409	Oryctolagus cuniculus	91.46	0.00e+00	1377.00
IUUC-Olo-080326	Oryza longistaminata	43.80	4.00e-90	328.00
IUUC-Oga-088241	Otolemur garnettii	86.51	0.00e+00	1238.00
IUUC-Oar-089797	Ovis aries	93.94	0.00e+00	1378.00
IUUC-Psi-093618	Pelodiscus sinensis	83.57	0.00e+00	1213.00
IUUC-Pab-098394	Pongo abelii	97.46	0.00e+00	1402.00
IUUC-Pop-099613	Populus trichocarpa	44.64	5.00e-93	337.00
IUUC-Pca-100568	Procavia capensis	72.33	0.00e+00	1467.00
IUUC-Pva-102303	Pteropus vampyrus	86.04	0.00e+00	1860.00
IUUC-Rno-106095	Rattus norvegicus	77.73	0.00e+00	1154.00
IUUC-Sha-107370	Sarcophilus harrisii	78.13	0.00e+00	1224.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	50.63	6.00e-157	547.00
IUUC-Sit-110149	Setaria italica	45.04	2.00e-95	345.00
IUUC-Sbi-113794	Sorghum bicolor	44.50	3.00e-94	342.00
IUUC-Tgu-117474	Taeniopygia guttata	81.20	0.00e+00	1207.00
IUUC-Tru-117675	Takifugu rubripes	65.10	0.00e+00	972.00
IUUC-Tsy-118806	Tarsius syrichta	89.07	0.00e+00	1093.00
IUUC-Tbe-127408	Tupaia belangeri	81.32	0.00e+00	1924.00
IUUC-Ttr-128437	Tursiops truncatus	85.05	0.00e+00	1963.00
IUUC-Vpa-130503	Vicugna pacos	87.74	0.00e+00	2117.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence