iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000069966.18	ENST00000261837.11	ENSP00000261837.7
ENSG00000069966.18	ENST00000396335.8	ENSP00000379626.4
ENSG00000069966.18	ENST00000561313.5	ENSP00000454185.1
ENSG00000069966.18	ENST00000560116.1	ENSP00000453176.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Variation
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.10e-42	141.2	235	275
UBD/Beta-Prp	4.90e-54	185.2	189	394

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf....sdtllvsGsdDgtikvWDlrtgvllk 37
           gH ++v cl++    +++++vsG+ D++ +vWD+r+g +++
   Q: 235  GHGADVLCLDLapseTGNTFVSGGCDKKAMVWDMRSGQCVQ 275
           8***********9644499********************98 PP

UBD/Beta-Prp

   S: 46   rslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp..sgdklvsGshdrtirvwdletgqcleetlsg 135
           +s+  h++  +a++f +++  ++t+s D+t  +wd+++g+ +++++gh ++vl+l++ p  +g+++vsG+ d+ ++vwd+++gqc++  ++ 
   Q: 189  KSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPseTGNTFVSGGCDKKAMVWDMRSGQCVQ-AFET 279
           567889999*********99***************************************9778************************.**** PP
   S: 136  hdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvk 226
           h++ +n+v++ p+g+ ++sGs+D t+rl+dl+ ++ +    ++       s++f+ +g+ l +g +d t+++wd+ +g+ v +l gh++ v+
   Q: 280  HESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYsKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVS 371
           ***************************************95333556778999*************************************** PP
   S: 227  svrfspnderlvsgssDgsiriW 249
            +r+sp+++ + sgs D ++r+W
   Q: 372  TLRVSPDGTAFCSGSWDHTLRVW 394
           *********************** PP

Organism

Homo sapiens

Functional Description
(View)

Heterotrimeric guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Protein Sequence
(Fasta)

MCDQTFLVNV FGSCDKCFKQ RALRPVFKKS QQLSYCSTCA EIMATEGLHE NETLASLKSE 60
AESLKGKLEE ERAKLHDVEL HQVAERVEAL GQFVMKTRRT LKGHGNKVLC MDWCKDKRRI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCACCTCTC ACCATCTGCT CTGTGGCTCC CAGTGCTGAC TCTGGAAGGT ATGTGCATGC 60
TGACATTCGG TTAAAATACT CCAGCTTTTG AAATGCTCAG AAAAGCATCC AGATGAGTAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0472--Membrane
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0807--Transducer
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR016346--Guanine_nucleotide-bd_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0016020--C:membrane
GO:0051087--F:chaperone binding
GO:0031682--F:G-protein gamma-subunit binding
GO:0005096--F:GTPase activator activity
GO:0003924--F:GTPase activity
GO:0004871--F:signal transducer activity
GO:1901386--P:negative regulation of voltage-gated calcium channel activity
GO:0043547--P:positive regulation of GTPase activity
GO:0006457--P:protein folding
GO:0007165--P:signal transduction

KEGG

hsa:10681

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001811	Ailuropoda melanoleuca	92.66	0.00e+00	766.00
IUUC-Apl-003399	Anas platyrhynchos	98.72	0.00e+00	650.00
IUUC-Aca-004861	Anolis carolinensis	93.42	0.00e+00	780.00
IUUC-Ame-011851	Astyanax mexicanus	92.02	0.00e+00	687.00
IUUC-Bta-012438	Bos taurus	99.15	0.00e+00	731.00
IUUC-Cel-018408	Caenorhabditis elegans	64.93	3.00e-139	488.00
IUUC-Cja-019086	Callithrix jacchus	100.00	0.00e+00	819.00
IUUC-Cfa-021255	Canis familiaris	97.71	0.00e+00	761.00
IUUC-Cpo-021398	Cavia porcellus	96.97	0.00e+00	801.00
IUUC-Csa-023776	Chlorocebus sabaeus	99.72	0.00e+00	733.00
IUUC-Cin-025305	Ciona intestinalis	57.92	1.00e-131	462.00
IUUC-Csv-026058	Ciona savignyi	57.60	4.00e-128	451.00
IUUC-Dre-028432	Danio rerio	84.81	0.00e+00	679.00
IUUC-Dno-029958	Dasypus novemcinctus	86.90	5.00e-147	513.00
IUUC-Dor-031013	Dipodomys ordii	99.22	5.00e-153	533.00
IUUC-Dme-031889	Drosophila melanogaster	68.60	5.00e-149	520.00
IUUC-Eca-033977	Equus caballus	94.18	0.00e+00	771.00
IUUC-Eeu-035079	Erinaceus europaeus	97.96	0.00e+00	799.00
IUUC-Fca-035693	Felis catus	92.44	0.00e+00	762.00
IUUC-Fal-037345	Ficedula albicollis	98.58	0.00e+00	729.00
IUUC-Gmo-039222	Gadus morhua	91.22	0.00e+00	661.00
IUUC-Gga-040320	Gallus gallus	98.58	0.00e+00	730.00
IUUC-Gac-042644	Gasterosteus aculeatus	91.50	0.00e+00	689.00
IUUC-Ggo-044489	Gorilla gorilla	95.96	0.00e+00	780.00
IUUC-Itr-048771	Ictidomys tridecemlineatus	93.67	8.00e-177	612.00
IUUC-Loc-052790	Lepisosteus oculatus	90.56	0.00e+00	724.00
IUUC-Laf-054255	Loxodonta africana	97.96	0.00e+00	804.00
IUUC-Mcc-055610	Macaca mulatta	99.49	0.00e+00	815.00
IUUC-Meu-056819	Macropus eugenii	86.48	0.00e+00	694.00
IUUC-Mga-059740	Meleagris gallopavo	87.28	0.00e+00	717.00
IUUC-Mmr-061221	Microcebus murinus	99.24	0.00e+00	820.00
IUUC-Mdo-062619	Monodelphis domestica	98.30	0.00e+00	726.00
IUUC-Mmu-064266	Mus musculus	99.24	0.00e+00	821.00
IUUC-Mpu-065766	Mustela putorius furo	99.34	0.00e+00	628.00
IUUC-Mlu-067221	Myotis lucifugus	91.69	0.00e+00	753.00
IUUC-Nle-069515	Nomascus leucogenys	99.68	0.00e+00	661.00
IUUC-Opr-070195	Ochotona princeps	90.84	0.00e+00	729.00
IUUC-Ont-071535	Oreochromis niloticus	78.73	5.00e-172	597.00
IUUC-Oan-072899	Ornithorhynchus anatinus	97.84	3.00e-107	380.00
IUUC-Ocu-074666	Oryctolagus cuniculus	99.67	0.00e+00	630.00
IUUC-Ola-086578	Oryzias latipes	92.61	0.00e+00	654.00
IUUC-Oga-089090	Otolemur garnettii	98.49	0.00e+00	812.00
IUUC-Oar-090017	Ovis aries	92.39	0.00e+00	744.00
IUUC-Ptr-091280	Pan troglodytes	90.38	0.00e+00	729.00
IUUC-Pan-092198	Papio anubis	99.06	0.00e+00	660.00
IUUC-Psi-093030	Pelodiscus sinensis	85.57	0.00e+00	721.00
IUUC-Pma-094140	Petromyzon marinus	83.10	5.00e-105	373.00
IUUC-Pfo-097182	Poecilia formosa	92.35	0.00e+00	668.00
IUUC-Pab-098157	Pongo abelii	100.00	0.00e+00	738.00
IUUC-Pca-100988	Procavia capensis	77.72	8.00e-172	596.00
IUUC-Pva-102232	Pteropus vampyrus	86.57	4.00e-177	613.00
IUUC-Rno-105526	Rattus norvegicus	95.77	0.00e+00	696.00
IUUC-Sha-106754	Sarcophilus harrisii	97.22	0.00e+00	760.00
IUUC-Ssc-115390	Sus scrofa	98.99	0.00e+00	815.00
IUUC-Tgu-117377	Taeniopygia guttata	87.79	0.00e+00	704.00
IUUC-Tru-117938	Takifugu rubripes	92.35	0.00e+00	655.00
IUUC-Tsy-119392	Tarsius syrichta	85.06	0.00e+00	668.00
IUUC-Tni-119834	Tetraodon nigroviridis	72.66	1.00e-165	575.00
IUUC-Tbe-127469	Tupaia belangeri	96.01	0.00e+00	733.00
IUUC-Ttr-128252	Tursiops truncatus	95.45	0.00e+00	775.00
IUUC-Vpa-130173	Vicugna pacos	80.95	8.00e-158	549.00
IUUC-Xtr-131803	Xenopus tropicalis	91.90	0.00e+00	731.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence