iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063364

UUCD1 version

UUC-MuM-00004

Ensembl Protein ID

ENSMUSP00000113035.1

UniProt Accession

O70263; O70264; Q8BRI8; Q8CFR3; LNX1_MOUSE

Genbank Protein ID

AAC40075.1; AAC40076.1; BAC31789.1; AAH40367.1

Protein Name

E3 ubiquitin-protein ligase LNX; Ligand of Numb protein X 1; Ligand of Numb-binding protein 1; Numb-binding protein 1; RING-type E3 ubiquitin transferase LNX

Genbank Nucleotide ID

AF034745; AF034746; AK044127; BC040367

Gene Name

Lnx1; Lnx

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000029228.15	ENSMUST00000039744.12	ENSMUSP00000040098.6
ENSMUSG00000029228.15	ENSMUST00000127396.7	ENSMUSP00000120886.1
ENSMUSG00000029228.15	ENSMUST00000121690.7	ENSMUSP00000113565.1
ENSMUSG00000029228.15	ENSMUST00000117388.7	ENSMUSP00000113035.1
ENSMUSG00000029228.15	ENSMUST00000140084.3	ENSMUSP00000117935.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Protein 3D Structure
PDB	MMDB
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	17553932

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.0018	19.9	45	83

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iCl+ + d pl +pCgH++++ Cl ++         ++ CP++r
   Q: 45   CHICLQALLD-PLDTPCGHTYCTLCLTNF------LVEKDFCPVDR 83
           99********.99*************888......66666699986 PP

Organism

Mus musculus

Functional Description
(View)

Isoform 2 provides an endocytic scaffold for IGSF5/JAM4.

Protein Sequence
(Fasta)

MNQPDLADDP DPSPEPLCIV CGQNHSPEEN HFYTYTEDVD DDLICHICLQ ALLDPLDTPC 60
GHTYCTLCLT NFLVEKDFCP VDRKPVVLQH CKKSSILVNK LLNKLLVTCP FTEHCTEVLQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCCACCTG TACACCGAAG TTGAGACCGG TCACAGCTCA GGCGGCCCTA GACGCTTCTG 60
GCACAGGGAT GGAGGCTGGC TGGTCACTGC TGCTTTGAAA GTCCCAAACA TCTTTGAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001478--PDZ
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50106--PDZ
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00595--PDZ

SMART

SM00228--PDZ
SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0030165--F:PDZ domain binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051260--P:protein homooligomerization
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:16924

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002005	Ailuropoda melanoleuca	86.03	0.00e+00	1191.00
IUUC-Apl-003561	Anas platyrhynchos	71.51	0.00e+00	989.00
IUUC-Aca-005346	Anolis carolinensis	71.12	0.00e+00	1034.00
IUUC-Bta-012970	Bos taurus	86.75	0.00e+00	1216.00
IUUC-Cja-019412	Callithrix jacchus	86.75	0.00e+00	1243.00
IUUC-Cfa-020735	Canis familiaris	86.75	0.00e+00	1263.00
IUUC-Cpo-022198	Cavia porcellus	77.41	0.00e+00	1047.00
IUUC-Dre-028841	Danio rerio	49.25	6.00e-29	119.00
IUUC-Dno-028889	Dasypus novemcinctus	87.95	0.00e+00	1272.00
IUUC-Dor-030810	Dipodomys ordii	79.06	0.00e+00	927.00
IUUC-Fca-036264	Felis catus	87.47	0.00e+00	1204.00
IUUC-Fal-037198	Ficedula albicollis	71.80	0.00e+00	1046.00
IUUC-Gga-040766	Gallus gallus	67.71	0.00e+00	994.00
IUUC-Ggo-045057	Gorilla gorilla	87.98	0.00e+00	1274.00
IUUC-Hsa-046470	Homo sapiens	87.98	0.00e+00	1300.00
IUUC-Itr-048393	Ictidomys tridecemlineatus	89.71	0.00e+00	1328.00
IUUC-Lch-050081	Latimeria chalumnae	63.66	0.00e+00	915.00
IUUC-Loc-052884	Lepisosteus oculatus	61.74	0.00e+00	895.00
IUUC-Laf-054498	Loxodonta africana	88.52	0.00e+00	1275.00
IUUC-Meu-056401	Macropus eugenii	53.29	4.00e-139	488.00
IUUC-Mga-059504	Meleagris gallopavo	72.08	0.00e+00	1030.00
IUUC-Mmr-060696	Microcebus murinus	62.46	0.00e+00	759.00
IUUC-Mdo-062731	Monodelphis domestica	80.08	0.00e+00	1156.00
IUUC-Mpu-066626	Mustela putorius furo	86.48	0.00e+00	1250.00
IUUC-Mlu-068207	Myotis lucifugus	86.31	0.00e+00	1217.00
IUUC-Nle-069304	Nomascus leucogenys	88.52	0.00e+00	1305.00
IUUC-Opr-071080	Ochotona princeps	74.23	0.00e+00	1048.00
IUUC-Ont-072002	Oreochromis niloticus	58.29	0.00e+00	788.00
IUUC-Ola-086477	Oryzias latipes	57.60	0.00e+00	820.00
IUUC-Oga-089142	Otolemur garnettii	85.13	0.00e+00	1230.00
IUUC-Oar-090359	Ovis aries	86.20	0.00e+00	1230.00
IUUC-Ptr-090797	Pan troglodytes	88.11	0.00e+00	1300.00
IUUC-Pan-091910	Papio anubis	87.43	0.00e+00	1286.00
IUUC-Psi-093386	Pelodiscus sinensis	73.40	0.00e+00	1037.00
IUUC-Pfo-096370	Poecilia formosa	58.16	0.00e+00	788.00
IUUC-Pab-097761	Pongo abelii	88.49	0.00e+00	1005.00
IUUC-Pva-102443	Pteropus vampyrus	87.73	0.00e+00	953.00
IUUC-Rno-106030	Rattus norvegicus	95.47	0.00e+00	1402.00
IUUC-Sha-107609	Sarcophilus harrisii	78.07	0.00e+00	1134.00
IUUC-Sar-113333	Sorex araneus	84.79	0.00e+00	1236.00
IUUC-Ssc-116222	Sus scrofa	78.56	0.00e+00	1102.00
IUUC-Tgu-117019	Taeniopygia guttata	72.18	0.00e+00	1019.00
IUUC-Tru-118481	Takifugu rubripes	60.33	0.00e+00	834.00
IUUC-Tni-119796	Tetraodon nigroviridis	52.82	0.00e+00	699.00
IUUC-Tbe-127538	Tupaia belangeri	84.84	0.00e+00	1211.00
IUUC-Ttr-128787	Tursiops truncatus	84.86	0.00e+00	1177.00
IUUC-Xtr-132476	Xenopus tropicalis	63.11	0.00e+00	843.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence