iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012920

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

DAAA02049882

Gene Name

FBXW11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000015376.6	ENSBTAT00000061118.2	ENSBTAP00000053291.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.40e-58	191.1	429	463
UBD/Beta-Prp	8.10e-69	232.2	342	507

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 429  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 463
           8**********.44****************977665 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
           +l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ 
   Q: 342  TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR- 425
           4556679*************9..8**************************************..************************. PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           +l+gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 426  VLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 507
           ***************9..***********************************99.************..99**************7 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MKDKNTPVDP KWHVLANTSV MEDQNEDESP KKSTLWQISN GTSSVIVSRK RPSEGNYQKE 60
KDLCIKYFDQ WSESDQVEFV EHLISRMCHY QHGHINSYLK PMLQRDFITA LPEQGLDHIA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAAGATA AAAACACCCC TGTTGACCCA AAATGGCACG TGTTAGCCGT AAGTCAAACA 60
GCTTTTGGGT TGGTATTGAT TGGTACACTC TAATTTGGGT TTTCAAAATT ACATTTTGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001397	Ailuropoda melanoleuca	100.00	0.00e+00	1023.00
IUUC-Apl-003449	Anas platyrhynchos	98.28	0.00e+00	1055.00
IUUC-Aca-004341	Anolis carolinensis	99.10	0.00e+00	912.00
IUUC-Ang-009766	Aspergillus niger	31.41	5.00e-52	199.00
IUUC-Ame-011393	Astyanax mexicanus	90.12	0.00e+00	964.00
IUUC-Cel-018392	Caenorhabditis elegans	63.16	0.00e+00	635.00
IUUC-Cja-018879	Callithrix jacchus	100.00	0.00e+00	1023.00
IUUC-Cfa-020021	Canis familiaris	100.00	0.00e+00	1023.00
IUUC-Cpo-022151	Cavia porcellus	99.42	0.00e+00	1054.00
IUUC-Csa-024095	Chlorocebus sabaeus	99.80	0.00e+00	1055.00
IUUC-Cho-024658	Choloepus hoffmanni	99.53	1.00e-126	446.00
IUUC-Dre-028160	Danio rerio	90.38	0.00e+00	965.00
IUUC-Dno-029485	Dasypus novemcinctus	89.19	0.00e+00	929.00
IUUC-Dor-030498	Dipodomys ordii	99.60	0.00e+00	1016.00
IUUC-Dse-031287	Dothistroma septosporum	28.95	1.00e-52	201.00
IUUC-Eca-033804	Equus caballus	100.00	0.00e+00	1021.00
IUUC-Fca-035887	Felis catus	99.61	0.00e+00	1065.00
IUUC-Fal-036783	Ficedula albicollis	98.46	0.00e+00	1061.00
IUUC-Gmo-038590	Gadus morhua	91.30	0.00e+00	929.00
IUUC-Gga-040628	Gallus gallus	98.08	0.00e+00	1055.00
IUUC-Gac-041305	Gasterosteus aculeatus	90.89	0.00e+00	932.00
IUUC-Ggo-044604	Gorilla gorilla	100.00	0.00e+00	1023.00
IUUC-Hsa-046139	Homo sapiens	100.00	0.00e+00	1023.00
IUUC-Lch-050460	Latimeria chalumnae	96.13	0.00e+00	1034.00
IUUC-Laf-053968	Loxodonta africana	98.85	0.00e+00	1065.00
IUUC-Mcc-055822	Macaca mulatta	95.71	0.00e+00	1052.00
IUUC-Mga-059225	Meleagris gallopavo	98.83	0.00e+00	1046.00
IUUC-Mvi-060284	Microbotryum violaceum	44.95	2.00e-69	257.00
IUUC-Mmr-060746	Microcebus murinus	100.00	0.00e+00	1023.00
IUUC-Mdo-062005	Monodelphis domestica	99.22	0.00e+00	1050.00
IUUC-Mmu-063851	Mus musculus	98.46	0.00e+00	1062.00
IUUC-Mpu-065716	Mustela putorius furo	99.03	0.00e+00	1060.00
IUUC-Mlu-067001	Myotis lucifugus	99.80	0.00e+00	1055.00
IUUC-Nle-069788	Nomascus leucogenys	97.27	0.00e+00	1021.00
IUUC-Opr-071229	Ochotona princeps	99.80	0.00e+00	1021.00
IUUC-Ont-071792	Oreochromis niloticus	91.50	0.00e+00	940.00
IUUC-Oan-072782	Ornithorhynchus anatinus	98.46	0.00e+00	1061.00
IUUC-Ocu-074894	Oryctolagus cuniculus	98.85	0.00e+00	1065.00
IUUC-Ola-086985	Oryzias latipes	89.92	0.00e+00	959.00
IUUC-Oga-088604	Otolemur garnettii	93.62	0.00e+00	1047.00
IUUC-Oar-090412	Ovis aries	98.85	0.00e+00	1064.00
IUUC-Ptr-091039	Pan troglodytes	99.80	0.00e+00	1021.00
IUUC-Pan-092770	Papio anubis	98.80	0.00e+00	1016.00
IUUC-Psi-093887	Pelodiscus sinensis	97.70	0.00e+00	1051.00
IUUC-Pno-094808	Phaeosphaeria nodorum	29.50	2.00e-45	177.00
IUUC-Pfo-096783	Poecilia formosa	90.31	0.00e+00	962.00
IUUC-Pva-102547	Pteropus vampyrus	99.80	0.00e+00	1016.00
IUUC-Rno-105246	Rattus norvegicus	98.46	0.00e+00	1061.00
IUUC-Sha-107339	Sarcophilus harrisii	99.22	0.00e+00	1050.00
IUUC-Spo-108200	Schizosaccharomyces pombe	32.14	2.00e-66	246.00
IUUC-Tgu-116541	Taeniopygia guttata	98.27	0.00e+00	1056.00
IUUC-Tru-117671	Takifugu rubripes	89.34	0.00e+00	950.00
IUUC-Tni-120359	Tetraodon nigroviridis	89.58	0.00e+00	950.00
IUUC-Tbe-127418	Tupaia belangeri	93.32	0.00e+00	936.00
IUUC-Ttr-129131	Tursiops truncatus	100.00	0.00e+00	1022.00
IUUC-Vpa-130668	Vicugna pacos	100.00	0.00e+00	1021.00
IUUC-Xma-133187	Xiphophorus maculatus	95.36	7.00e-158	549.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence