iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033804

UUCD1 version

UUC-EqC-00325

Ensembl Protein ID

ENSECAP00000009895.1

UniProt Accession

F6VDZ9; F6VDZ9_HORSE

Protein Name

Uncharacterized protein

Gene Name

FBXW11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000011756.1	ENSECAT00000012523.1	ENSECAP00000009895.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-57	189.5	400	434
UBD/Beta-Prp	6.50e-69	232.5	313	478

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 400  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 434
           8**********.44****************977665 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
           +l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ 
   Q: 313  TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR- 396
           4556679*************9..8**************************************..************************. PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           +l+gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 397  VLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 478
           ***************9..***********************************99.************..99**************7 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MPSVRCLQIS NGTSSVIVSR KRPSEGNYQK EKDLCIKYFD QWSESDQVEF VEHLISRMCH 60
YQHGHINSYL KPMLQRDFIT ALPEQGLDHI AENILSYLDA RSLCAAELVC KEWQRVISEG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGTCATGG CACTTTGGAG GTCCTACCTT GAGGGACCCC TTAATTCTTT AGCTTTGCAC 60
GTCCCGCATT CGCAGTCCAG AGCTACTTTC GGCTCAGAAT TCAGCTGCGG GCTACCAGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001397	Ailuropoda melanoleuca	100.00	0.00e+00	1036.00
IUUC-Apl-003449	Anas platyrhynchos	95.41	0.00e+00	1016.00
IUUC-Aca-004341	Anolis carolinensis	99.10	0.00e+00	911.00
IUUC-Ang-009766	Aspergillus niger	31.41	6.00e-52	198.00
IUUC-Ame-011393	Astyanax mexicanus	91.72	0.00e+00	945.00
IUUC-Bta-012920	Bos taurus	100.00	0.00e+00	1021.00
IUUC-Cel-018392	Caenorhabditis elegans	63.16	0.00e+00	634.00
IUUC-Cja-018879	Callithrix jacchus	100.00	0.00e+00	1036.00
IUUC-Cfa-020021	Canis familiaris	100.00	0.00e+00	1036.00
IUUC-Cpo-022151	Cavia porcellus	99.60	0.00e+00	1015.00
IUUC-Csa-024095	Chlorocebus sabaeus	100.00	0.00e+00	1021.00
IUUC-Cho-024658	Choloepus hoffmanni	99.55	5.00e-131	461.00
IUUC-Cin-025188	Ciona intestinalis	80.42	0.00e+00	822.00
IUUC-Dre-028160	Danio rerio	92.34	0.00e+00	954.00
IUUC-Dno-029485	Dasypus novemcinctus	88.96	0.00e+00	890.00
IUUC-Dor-030498	Dipodomys ordii	99.60	0.00e+00	1030.00
IUUC-Fca-035887	Felis catus	100.00	0.00e+00	1023.00
IUUC-Fal-036783	Ficedula albicollis	95.59	0.00e+00	1020.00
IUUC-Gmo-038590	Gadus morhua	90.44	0.00e+00	929.00
IUUC-Gga-040628	Gallus gallus	95.21	0.00e+00	1015.00
IUUC-Gac-041305	Gasterosteus aculeatus	90.04	0.00e+00	931.00
IUUC-Ggo-044604	Gorilla gorilla	100.00	0.00e+00	1036.00
IUUC-Hsa-046139	Homo sapiens	100.00	0.00e+00	1036.00
IUUC-Lch-050460	Latimeria chalumnae	97.17	0.00e+00	996.00
IUUC-Laf-053968	Loxodonta africana	95.98	0.00e+00	1025.00
IUUC-Mcc-055822	Macaca mulatta	99.60	0.00e+00	1019.00
IUUC-Mga-059225	Meleagris gallopavo	98.99	0.00e+00	1007.00
IUUC-Mvi-060284	Microbotryum violaceum	44.95	3.00e-69	256.00
IUUC-Mmr-060746	Microcebus murinus	100.00	0.00e+00	1036.00
IUUC-Mdo-062005	Monodelphis domestica	99.39	0.00e+00	1015.00
IUUC-Mmu-063851	Mus musculus	95.59	0.00e+00	1022.00
IUUC-Mpu-065716	Mustela putorius furo	100.00	0.00e+00	1022.00
IUUC-Mlu-067001	Myotis lucifugus	100.00	0.00e+00	1021.00
IUUC-Nle-069788	Nomascus leucogenys	99.80	0.00e+00	1021.00
IUUC-Opr-071229	Ochotona princeps	99.80	0.00e+00	1035.00
IUUC-Ont-071792	Oreochromis niloticus	90.64	0.00e+00	940.00
IUUC-Oan-072782	Ornithorhynchus anatinus	95.59	0.00e+00	1020.00
IUUC-Ocu-074894	Oryctolagus cuniculus	95.98	0.00e+00	1025.00
IUUC-Ola-086985	Oryzias latipes	91.52	0.00e+00	942.00
IUUC-Oga-088604	Otolemur garnettii	99.80	0.00e+00	1019.00
IUUC-Oar-090412	Ovis aries	95.98	0.00e+00	1025.00
IUUC-Ptr-091039	Pan troglodytes	99.80	0.00e+00	1035.00
IUUC-Pan-092770	Papio anubis	95.80	0.00e+00	977.00
IUUC-Psi-093887	Pelodiscus sinensis	94.83	0.00e+00	1011.00
IUUC-Pno-094808	Phaeosphaeria nodorum	29.50	2.00e-45	177.00
IUUC-Pfo-096783	Poecilia formosa	91.92	0.00e+00	945.00
IUUC-Pva-102547	Pteropus vampyrus	99.80	0.00e+00	1029.00
IUUC-Rno-105246	Rattus norvegicus	95.59	0.00e+00	1022.00
IUUC-Sha-107339	Sarcophilus harrisii	99.39	0.00e+00	1015.00
IUUC-Sja-107743	Schizosaccharomyces japonicus	35.38	5.00e-74	271.00
IUUC-Spo-108200	Schizosaccharomyces pombe	32.63	3.00e-66	246.00
IUUC-Tgu-116541	Taeniopygia guttata	95.40	0.00e+00	1016.00
IUUC-Tru-117671	Takifugu rubripes	90.71	0.00e+00	933.00
IUUC-Tni-120359	Tetraodon nigroviridis	91.11	0.00e+00	931.00
IUUC-Tbe-127418	Tupaia belangeri	93.41	0.00e+00	950.00
IUUC-Ttr-129131	Tursiops truncatus	100.00	0.00e+00	1036.00
IUUC-Vpa-130668	Vicugna pacos	100.00	0.00e+00	1036.00
IUUC-Xma-133187	Xiphophorus maculatus	95.36	1.00e-157	548.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence