iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000072803.17	ENST00000296933.10	ENSP00000296933.6
ENSG00000072803.17	ENST00000265094.9	ENSP00000265094.5
ENSG00000072803.17	ENST00000393802.6	ENSP00000377391.2
ENSG00000072803.17	ENST00000523843.5	ENSP00000430104.1
ENSG00000072803.17	ENST00000517395.5	ENSP00000428753.1
ENSG00000072803.17	ENST00000518752.1	ENSP00000429818.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	miRecords	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	17873516; 16775333; 21310048; 18782782; 7479976; 20347421
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	8909296; 17873516; 18782782; 7479976; 19966869

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	0.00072	21.3	129	167
E3 adaptor/Cullin RING/DCX/DWD	4.40e-57	189.1	441	475
UBD/Beta-Prp	2.20e-68	232.3	354	519

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 108  eeilveilklldkeellraarvcrrwqelasqkalwktv 146
           ++i  +il++ld+++l++a++vc++wq+++s+  lwk++
   Q: 129  DHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKL 167
           468999*********************99999****987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 441  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 475
           8**********.44****************977665 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetls 134
           +l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ +l+
   Q: 354  TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR-VLE 440
           4556679*************9..8**************************************..************************.*** PP
   S: 135  ghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 441  GHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 519
           ************9..***********************************99.************..99**************7 PP

Organism

Homo sapiens

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling. SCF(FBXW11) mediates the ubiquitination of phosphorylated NFKBIA, which degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. SCF(FBXW11) mediates the ubiquitination of IFNAR1. SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25503564). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1. Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint. Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2. Is target of human immunodeficiency virus type 1 (HIV-1) protein VPU to polyubiquitinate and deplete BST2 from cells and antagonize its antiviral action.

Protein Sequence
(Fasta)

MEPDSVIEDK TIELMCSVPR SLWLGCANLV ESMCALSCLQ SMPSVRCLQI SNGTSSVIVS 60
RKRPSEGNYQ KEKDLCIKYF DQWSESDQVE FVEHLISRMC HYQHGHINSY LKPMLQRDFI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAGTCGTGG CGCTCTCGAG GCCCTGCCAT GAGCAAGCTC TTAACTCTTC AGGTCTGCAC 60
GTCCTACGCC CACCGTCCAG TGCTACTCTC AGCTCGGAGT TCAGCTTCGG GCTGCCAAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
KW-0879--Wnt signaling pathway

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0000151--C:ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0038061--P:NIK/NF-kappaB signaling
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0048511--P:rhythmic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0051403--P:stress-activated MAPK cascade
GO:0050852--P:T cell receptor signaling pathway
GO:0016055--P:Wnt signaling pathway

KEGG

hsa:23291

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001397	Ailuropoda melanoleuca	100.00	0.00e+00	1120.00
IUUC-Apl-003449	Anas platyrhynchos	94.76	0.00e+00	1068.00
IUUC-Ang-009766	Aspergillus niger	31.41	5.00e-52	199.00
IUUC-Ame-011174	Astyanax mexicanus	83.92	0.00e+00	983.00
IUUC-Bta-012920	Bos taurus	100.00	0.00e+00	1023.00
IUUC-Cja-018879	Callithrix jacchus	100.00	0.00e+00	1120.00
IUUC-Cfa-020021	Canis familiaris	100.00	0.00e+00	1120.00
IUUC-Cpo-022151	Cavia porcellus	99.60	0.00e+00	1014.00
IUUC-Csa-024095	Chlorocebus sabaeus	100.00	0.00e+00	1021.00
IUUC-Cho-024658	Choloepus hoffmanni	99.62	1.00e-155	543.00
IUUC-Dre-028160	Danio rerio	92.34	0.00e+00	953.00
IUUC-Dno-029485	Dasypus novemcinctus	88.96	0.00e+00	890.00
IUUC-Dor-030498	Dipodomys ordii	99.43	0.00e+00	1082.00
IUUC-Eca-033804	Equus caballus	100.00	0.00e+00	1036.00
IUUC-Fca-035887	Felis catus	94.29	0.00e+00	1038.00
IUUC-Fal-036783	Ficedula albicollis	95.48	0.00e+00	1038.00
IUUC-Gmo-038590	Gadus morhua	88.03	0.00e+00	974.00
IUUC-Gga-040628	Gallus gallus	95.10	0.00e+00	1033.00
IUUC-Gac-041305	Gasterosteus aculeatus	88.58	0.00e+00	992.00
IUUC-Ggo-044604	Gorilla gorilla	100.00	0.00e+00	1120.00
IUUC-Lch-050460	Latimeria chalumnae	97.17	0.00e+00	996.00
IUUC-Laf-053968	Loxodonta africana	96.27	0.00e+00	1108.00
IUUC-Mcc-055822	Macaca mulatta	91.58	0.00e+00	1063.00
IUUC-Mga-059225	Meleagris gallopavo	98.99	0.00e+00	1008.00
IUUC-Mvi-060284	Microbotryum violaceum	44.95	2.00e-69	257.00
IUUC-Mmr-060746	Microcebus murinus	100.00	0.00e+00	1120.00
IUUC-Mdo-062005	Monodelphis domestica	99.39	0.00e+00	1016.00
IUUC-Mmu-063851	Mus musculus	95.91	0.00e+00	1105.00
IUUC-Mpu-065716	Mustela putorius furo	100.00	0.00e+00	1022.00
IUUC-Mlu-067001	Myotis lucifugus	100.00	0.00e+00	1021.00
IUUC-Nle-069788	Nomascus leucogenys	93.73	0.00e+00	1033.00
IUUC-Opr-071229	Ochotona princeps	99.82	0.00e+00	1118.00
IUUC-Ont-071792	Oreochromis niloticus	89.57	0.00e+00	998.00
IUUC-Oan-072782	Ornithorhynchus anatinus	95.48	0.00e+00	1038.00
IUUC-Ocu-074894	Oryctolagus cuniculus	96.27	0.00e+00	1108.00
IUUC-Ola-086985	Oryzias latipes	85.87	0.00e+00	998.00
IUUC-Oga-088604	Otolemur garnettii	99.80	0.00e+00	1020.00
IUUC-Oar-090412	Ovis aries	96.05	0.00e+00	1043.00
IUUC-Ptr-091039	Pan troglodytes	99.82	0.00e+00	1118.00
IUUC-Pan-092770	Papio anubis	96.12	0.00e+00	1060.00
IUUC-Psi-093887	Pelodiscus sinensis	94.19	0.00e+00	1063.00
IUUC-Pno-094808	Phaeosphaeria nodorum	29.50	2.00e-45	177.00
IUUC-Pfo-096783	Poecilia formosa	86.22	0.00e+00	1002.00
IUUC-Pva-102547	Pteropus vampyrus	99.81	0.00e+00	1105.00
IUUC-Rno-105246	Rattus norvegicus	95.67	0.00e+00	1041.00
IUUC-Sha-107339	Sarcophilus harrisii	99.39	0.00e+00	1016.00
IUUC-Sja-107743	Schizosaccharomyces japonicus	35.38	5.00e-74	271.00
IUUC-Tgu-116541	Taeniopygia guttata	94.75	0.00e+00	1069.00
IUUC-Tru-117671	Takifugu rubripes	85.16	0.00e+00	989.00
IUUC-Tni-120359	Tetraodon nigroviridis	85.79	0.00e+00	939.00
IUUC-Tbe-127418	Tupaia belangeri	93.74	0.00e+00	1005.00
IUUC-Ttr-129131	Tursiops truncatus	100.00	0.00e+00	1119.00
IUUC-Vpa-130668	Vicugna pacos	99.63	0.00e+00	1107.00
IUUC-Xma-133187	Xiphophorus maculatus	95.36	1.00e-157	548.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence