iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000016008.3	ENSMMUT00000063752.1	ENSMMUP00000046046.1
ENSMMUG00000016008.3	ENSMMUT00000078012.1	ENSMMUP00000049952.1
ENSMMUG00000016008.3	ENSMMUT00000058175.1	ENSMMUP00000046652.1
ENSMMUG00000016008.3	ENSMMUT00000022506.3	ENSMMUP00000021054.2
ENSMMUG00000016008.3	ENSMMUT00000022503.3	ENSMMUP00000021052.3
ENSMMUG00000016008.3	ENSMMUT00000022504.3	ENSMMUP00000021053.3
ENSMMUG00000016008.3	ENSMMUT00000068480.1	ENSMMUP00000046920.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.20e-57	190.3	471	505
UBD/Beta-Prp	2.30e-68	231.7	384	549

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 471  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 505
           8**********.44****************977665 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
           +l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ 
   Q: 384  TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR- 467
           4555679*************9..8**************************************..************************. PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           +l+gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 468  VLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 549
           ***************9..***********************************99.************..99**************7 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

QTNQSLKFWL SPPLSLWLGC ANLVESMCAL SCLQSMPSVR CLQNTSVMED QNEDESPKKN 60
TLWQVGMTAH RLDNRMLPQL INGTSSVIVS RKRPSEGNYQ KEKDLCIKYF DQWSESDQVE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTGGCGCTC TCGAGGCCCT ACCATGAGCA AGCTCTTAAC TCTTCAGGTG TGCAAGTCCT 60
ACGTCCACAG TCCAGTGCTA CTGTCAGCTT GGAGTTCAGC TTCGGGCTGC CAAGAGCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0732--Signal
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001397	Ailuropoda melanoleuca	91.58	0.00e+00	1063.00
IUUC-Apl-003449	Anas platyrhynchos	95.74	0.00e+00	1102.00
IUUC-Ang-009766	Aspergillus niger	31.12	5.00e-52	199.00
IUUC-Ame-011174	Astyanax mexicanus	83.42	0.00e+00	983.00
IUUC-Bta-012920	Bos taurus	95.71	0.00e+00	1052.00
IUUC-Cel-018392	Caenorhabditis elegans	63.16	0.00e+00	635.00
IUUC-Cja-018879	Callithrix jacchus	91.58	0.00e+00	1063.00
IUUC-Cfa-020021	Canis familiaris	91.58	0.00e+00	1063.00
IUUC-Cpo-022151	Cavia porcellus	96.41	0.00e+00	1044.00
IUUC-Csa-024095	Chlorocebus sabaeus	96.76	0.00e+00	1044.00
IUUC-Cho-024658	Choloepus hoffmanni	83.16	1.00e-138	486.00
IUUC-Dre-028160	Danio rerio	88.28	0.00e+00	961.00
IUUC-Dno-029485	Dasypus novemcinctus	86.49	0.00e+00	920.00
IUUC-Dor-030498	Dipodomys ordii	92.35	0.00e+00	1052.00
IUUC-Eca-033804	Equus caballus	99.60	0.00e+00	1019.00
IUUC-Fca-035887	Felis catus	96.61	0.00e+00	1054.00
IUUC-Fal-036783	Ficedula albicollis	96.34	0.00e+00	1082.00
IUUC-Gmo-038590	Gadus morhua	81.93	0.00e+00	939.00
IUUC-Gga-040628	Gallus gallus	95.97	0.00e+00	1076.00
IUUC-Gac-041305	Gasterosteus aculeatus	82.98	0.00e+00	958.00
IUUC-Ggo-044604	Gorilla gorilla	91.58	0.00e+00	1063.00
IUUC-Hsa-046139	Homo sapiens	91.58	0.00e+00	1063.00
IUUC-Lch-050460	Latimeria chalumnae	93.76	0.00e+00	1023.00
IUUC-Laf-053968	Loxodonta africana	95.26	0.00e+00	1117.00
IUUC-Mga-059225	Meleagris gallopavo	95.85	0.00e+00	1036.00
IUUC-Mvi-060284	Microbotryum violaceum	44.95	2.00e-69	257.00
IUUC-Mmr-060746	Microcebus murinus	91.58	0.00e+00	1063.00
IUUC-Mdo-062005	Monodelphis domestica	96.19	0.00e+00	1040.00
IUUC-Mmu-063851	Mus musculus	94.56	0.00e+00	1110.00
IUUC-Mpu-065716	Mustela putorius furo	96.05	0.00e+00	1049.00
IUUC-Mlu-067001	Myotis lucifugus	96.76	0.00e+00	1044.00
IUUC-Nle-069788	Nomascus leucogenys	100.00	0.00e+00	1018.00
IUUC-Opr-071229	Ochotona princeps	91.40	0.00e+00	1061.00
IUUC-Ont-071792	Oreochromis niloticus	83.16	0.00e+00	965.00
IUUC-Oan-072782	Ornithorhynchus anatinus	96.34	0.00e+00	1082.00
IUUC-Ocu-074894	Oryctolagus cuniculus	95.26	0.00e+00	1117.00
IUUC-Ola-086985	Oryzias latipes	84.82	0.00e+00	991.00
IUUC-Oga-088604	Otolemur garnettii	90.16	0.00e+00	1055.00
IUUC-Oar-090412	Ovis aries	96.89	0.00e+00	1088.00
IUUC-Ptr-091039	Pan troglodytes	91.40	0.00e+00	1061.00
IUUC-Pan-092770	Papio anubis	95.07	0.00e+00	1068.00
IUUC-Psi-093887	Pelodiscus sinensis	94.88	0.00e+00	1100.00
IUUC-Pno-094808	Phaeosphaeria nodorum	29.50	1.00e-45	177.00
IUUC-Pfo-096783	Poecilia formosa	85.17	0.00e+00	992.00
IUUC-Pva-102547	Pteropus vampyrus	91.40	0.00e+00	1056.00
IUUC-Rno-105246	Rattus norvegicus	96.15	0.00e+00	1081.00
IUUC-Sha-107339	Sarcophilus harrisii	96.19	0.00e+00	1040.00
IUUC-Sja-107743	Schizosaccharomyces japonicus	35.38	5.00e-74	271.00
IUUC-Tgu-116541	Taeniopygia guttata	95.73	0.00e+00	1104.00
IUUC-Tru-117671	Takifugu rubripes	84.29	0.00e+00	986.00
IUUC-Tni-120359	Tetraodon nigroviridis	87.05	0.00e+00	943.00
IUUC-Tbe-127418	Tupaia belangeri	87.01	0.00e+00	974.00
IUUC-Ttr-129131	Tursiops truncatus	91.58	0.00e+00	1063.00
IUUC-Vpa-130668	Vicugna pacos	91.58	0.00e+00	1061.00
IUUC-Xma-133187	Xiphophorus maculatus	95.36	5.00e-158	550.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence