iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067001

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02049066

Gene Name

FBXW11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000006302.2	ENSMLUT00000006309.2	ENSMLUP00000005761.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.30e-58	191.6	409	443
UBD/Beta-Prp	6.70e-69	232.4	322	487

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 409  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 443
           8**********.44****************977665 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
           +l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ 
   Q: 322  TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR- 405
           4556679*************9..8**************************************..************************. PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           +l+gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 406  VLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 487
           ***************9..***********************************99.************..99**************7 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MEDQNEDESP KKNTLWQISN GTSSVIVSRK RPSEGNYQKE KDLCIKYFDQ WSESDQVEFV 60
EHLISRMCHY QHGHINSYLK PMLQRDFITA LPEQGLDHIA ENILSYLDAR SLCAAELVCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGATC AAAATGAAGA TGAGTCCCCC AAGAAAAATA CTCTTTGGCA GGTAGGAATG 60
ACTGCGCACA GATCAGAGAG CAGTTGACTC ACTCTAGACA AGATGCCCCT CAGCTCATGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001397	Ailuropoda melanoleuca	100.00	0.00e+00	1021.00
IUUC-Apl-003449	Anas platyrhynchos	99.41	0.00e+00	1048.00
IUUC-Aca-004341	Anolis carolinensis	99.10	0.00e+00	912.00
IUUC-Ang-009766	Aspergillus niger	31.41	5.00e-52	199.00
IUUC-Ame-011393	Astyanax mexicanus	90.20	0.00e+00	954.00
IUUC-Bta-012920	Bos taurus	99.80	0.00e+00	1055.00
IUUC-Cel-018392	Caenorhabditis elegans	63.16	0.00e+00	634.00
IUUC-Cja-018879	Callithrix jacchus	100.00	0.00e+00	1021.00
IUUC-Cfa-020021	Canis familiaris	100.00	0.00e+00	1021.00
IUUC-Cpo-022151	Cavia porcellus	99.61	0.00e+00	1048.00
IUUC-Csa-024095	Chlorocebus sabaeus	100.00	0.00e+00	1056.00
IUUC-Cho-024658	Choloepus hoffmanni	99.53	1.00e-126	446.00
IUUC-Cin-025188	Ciona intestinalis	80.42	0.00e+00	823.00
IUUC-Dre-028160	Danio rerio	90.12	0.00e+00	956.00
IUUC-Dno-029485	Dasypus novemcinctus	89.30	0.00e+00	925.00
IUUC-Dor-030498	Dipodomys ordii	99.60	0.00e+00	1015.00
IUUC-Dse-031287	Dothistroma septosporum	28.95	2.00e-52	200.00
IUUC-Eca-033804	Equus caballus	100.00	0.00e+00	1021.00
IUUC-Fca-035887	Felis catus	100.00	0.00e+00	1057.00
IUUC-Fal-036783	Ficedula albicollis	99.61	0.00e+00	1053.00
IUUC-Gmo-038590	Gadus morhua	91.30	0.00e+00	929.00
IUUC-Gga-040628	Gallus gallus	99.22	0.00e+00	1048.00
IUUC-Gac-041305	Gasterosteus aculeatus	90.89	0.00e+00	931.00
IUUC-Ggo-044604	Gorilla gorilla	100.00	0.00e+00	1021.00
IUUC-Hsa-046139	Homo sapiens	100.00	0.00e+00	1021.00
IUUC-Lch-050460	Latimeria chalumnae	96.86	0.00e+00	1027.00
IUUC-Laf-053968	Loxodonta africana	100.00	0.00e+00	1057.00
IUUC-Mcc-055822	Macaca mulatta	96.76	0.00e+00	1044.00
IUUC-Mga-059225	Meleagris gallopavo	99.02	0.00e+00	1041.00
IUUC-Mvi-060284	Microbotryum violaceum	44.95	2.00e-69	257.00
IUUC-Mmr-060746	Microcebus murinus	100.00	0.00e+00	1021.00
IUUC-Mdo-062005	Monodelphis domestica	99.41	0.00e+00	1051.00
IUUC-Mmu-063851	Mus musculus	99.22	0.00e+00	1050.00
IUUC-Mpu-065716	Mustela putorius furo	100.00	0.00e+00	1056.00
IUUC-Nle-069788	Nomascus leucogenys	100.00	0.00e+00	1020.00
IUUC-Opr-071229	Ochotona princeps	99.80	0.00e+00	1020.00
IUUC-Ont-071792	Oreochromis niloticus	91.50	0.00e+00	939.00
IUUC-Oan-072782	Ornithorhynchus anatinus	99.61	0.00e+00	1053.00
IUUC-Ocu-074894	Oryctolagus cuniculus	100.00	0.00e+00	1057.00
IUUC-Ola-086985	Oryzias latipes	90.23	0.00e+00	956.00
IUUC-Oga-088604	Otolemur garnettii	94.10	0.00e+00	1039.00
IUUC-Oar-090412	Ovis aries	100.00	0.00e+00	1057.00
IUUC-Ptr-091039	Pan troglodytes	99.80	0.00e+00	1020.00
IUUC-Pan-092770	Papio anubis	100.00	0.00e+00	1009.00
IUUC-Psi-093887	Pelodiscus sinensis	98.82	0.00e+00	1043.00
IUUC-Pno-094808	Phaeosphaeria nodorum	29.50	2.00e-45	177.00
IUUC-Pfo-096783	Poecilia formosa	90.62	0.00e+00	958.00
IUUC-Pva-102547	Pteropus vampyrus	99.80	0.00e+00	1015.00
IUUC-Ptt-103853	Puccinia triticina	32.75	3.00e-60	226.00
IUUC-Rno-105246	Rattus norvegicus	99.22	0.00e+00	1050.00
IUUC-Sha-107339	Sarcophilus harrisii	99.41	0.00e+00	1051.00
IUUC-Sja-107743	Schizosaccharomyces japonicus	35.38	4.00e-74	271.00
IUUC-Spo-108200	Schizosaccharomyces pombe	32.42	3.00e-66	246.00
IUUC-Tgu-116541	Taeniopygia guttata	99.41	0.00e+00	1049.00
IUUC-Tru-117671	Takifugu rubripes	89.65	0.00e+00	949.00
IUUC-Tni-120359	Tetraodon nigroviridis	90.04	0.00e+00	946.00
IUUC-Tbe-127418	Tupaia belangeri	93.32	0.00e+00	936.00
IUUC-Ttr-129131	Tursiops truncatus	100.00	0.00e+00	1021.00
IUUC-Vpa-130668	Vicugna pacos	100.00	0.00e+00	1021.00
IUUC-Xma-133187	Xiphophorus maculatus	95.36	8.00e-158	548.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence