iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oga-088604

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAQR03006620

Gene Name

FBXW11

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000011988.2	ENSOGAT00000011991.2	ENSOGAP00000010724.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.60e-55	181.4	479	513
UBD/Beta-Prp	1.00e-68	231.7	392	557

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 479  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 513
           8**********.44****************977665 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
           +l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ 
   Q: 392  TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR- 475
           4555679*************9..8**************************************..************************. PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           +l+gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 476  VLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 557
           ***************9..***********************************99.************..99**************7 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

SPQPLWVVCI CFSASVIRAS CVTGRETCSM TILLNTSVME DQNEDESPKK NTLWQFYSQC 60
LRVCFHLFVF CFSSGSEDIG HIVSFEKISN GTSSVIVSRK RPSEGNYQKE KDLCIKYFDQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCCCACAAC CACTCTGGGT GGTTTGTATT TGTTTCAGCG CTAAAATAAC TTGCTCCAGG 60
TTACATACGT ACACACAGTA AGTGAGTGAC CAAATCAGGA ATCAAAATTC TGTCTTTAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0732--Signal
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001397	Ailuropoda melanoleuca	99.80	0.00e+00	1020.00
IUUC-Apl-003449	Anas platyrhynchos	89.66	0.00e+00	1045.00
IUUC-Ago-007794	Ashbya gossypii	29.04	6.00e-48	185.00
IUUC-Ang-009766	Aspergillus niger	31.41	6.00e-52	198.00
IUUC-Ame-011393	Astyanax mexicanus	85.04	0.00e+00	948.00
IUUC-Bta-012920	Bos taurus	93.62	0.00e+00	1047.00
IUUC-Cja-018879	Callithrix jacchus	99.80	0.00e+00	1020.00
IUUC-Cfa-020021	Canis familiaris	99.80	0.00e+00	1020.00
IUUC-Cpo-022151	Cavia porcellus	93.77	0.00e+00	1038.00
IUUC-Csa-024095	Chlorocebus sabaeus	94.10	0.00e+00	1039.00
IUUC-Cho-024658	Choloepus hoffmanni	99.07	5.00e-126	444.00
IUUC-Dre-028160	Danio rerio	85.37	0.00e+00	954.00
IUUC-Dor-030498	Dipodomys ordii	99.39	0.00e+00	1013.00
IUUC-Dse-031287	Dothistroma septosporum	29.14	2.00e-52	200.00
IUUC-Eca-033804	Equus caballus	99.80	0.00e+00	1019.00
IUUC-Fca-035887	Felis catus	93.98	0.00e+00	1050.00
IUUC-Fal-036783	Ficedula albicollis	93.12	0.00e+00	1043.00
IUUC-Gmo-038590	Gadus morhua	90.54	0.00e+00	926.00
IUUC-Gga-040628	Gallus gallus	92.75	0.00e+00	1038.00
IUUC-Gac-041305	Gasterosteus aculeatus	90.14	0.00e+00	929.00
IUUC-Ggo-044604	Gorilla gorilla	99.80	0.00e+00	1020.00
IUUC-Hsa-046139	Homo sapiens	99.80	0.00e+00	1020.00
IUUC-Lch-050460	Latimeria chalumnae	90.89	0.00e+00	1019.00
IUUC-Laf-053968	Loxodonta africana	90.33	0.00e+00	1056.00
IUUC-Mcc-055822	Macaca mulatta	90.16	0.00e+00	1055.00
IUUC-Mga-059225	Meleagris gallopavo	93.24	0.00e+00	1031.00
IUUC-Mvi-060284	Microbotryum violaceum	44.95	2.00e-69	256.00
IUUC-Mmr-060746	Microcebus murinus	99.80	0.00e+00	1020.00
IUUC-Mdo-062005	Monodelphis domestica	93.54	0.00e+00	1034.00
IUUC-Mmu-063851	Mus musculus	89.64	0.00e+00	1050.00
IUUC-Mpu-065716	Mustela putorius furo	93.43	0.00e+00	1045.00
IUUC-Mlu-067001	Myotis lucifugus	94.10	0.00e+00	1039.00
IUUC-Nle-069788	Nomascus leucogenys	100.00	0.00e+00	1019.00
IUUC-Opr-071229	Ochotona princeps	99.60	0.00e+00	1018.00
IUUC-Ont-071792	Oreochromis niloticus	90.74	0.00e+00	937.00
IUUC-Oan-072782	Ornithorhynchus anatinus	93.12	0.00e+00	1043.00
IUUC-Ocu-074894	Oryctolagus cuniculus	90.33	0.00e+00	1056.00
IUUC-Ola-086985	Oryzias latipes	81.24	0.00e+00	949.00
IUUC-Oar-090412	Ovis aries	93.48	0.00e+00	1047.00
IUUC-Ptr-091039	Pan troglodytes	99.60	0.00e+00	1018.00
IUUC-Pan-092770	Papio anubis	89.95	0.00e+00	1007.00
IUUC-Psi-093887	Pelodiscus sinensis	89.12	0.00e+00	1040.00
IUUC-Pno-094808	Phaeosphaeria nodorum	29.50	1.00e-45	177.00
IUUC-Pfo-096783	Poecilia formosa	81.48	0.00e+00	949.00
IUUC-Pva-102547	Pteropus vampyrus	99.60	0.00e+00	1013.00
IUUC-Rno-105246	Rattus norvegicus	92.75	0.00e+00	1041.00
IUUC-Sce-106343	Saccharomyces cerevisiae	30.09	4.00e-46	179.00
IUUC-Sha-107339	Sarcophilus harrisii	93.54	0.00e+00	1034.00
IUUC-Sja-107743	Schizosaccharomyces japonicus	35.38	5.00e-74	271.00
IUUC-Spo-108200	Schizosaccharomyces pombe	31.92	2.00e-66	246.00
IUUC-Tgu-116541	Taeniopygia guttata	89.64	0.00e+00	1045.00
IUUC-Tru-117671	Takifugu rubripes	80.72	0.00e+00	940.00
IUUC-Tni-120359	Tetraodon nigroviridis	84.73	0.00e+00	937.00
IUUC-Tbe-127418	Tupaia belangeri	93.12	0.00e+00	933.00
IUUC-Ttr-129131	Tursiops truncatus	99.80	0.00e+00	1019.00
IUUC-Vpa-130668	Vicugna pacos	99.80	0.00e+00	1018.00
IUUC-Xma-133187	Xiphophorus maculatus	95.36	1.00e-157	548.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence