iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000004395.7	ENSRNOT00000064079.2	ENSRNOP00000059948.1
ENSRNOG00000004395.7	ENSRNOT00000079698.1	ENSRNOP00000069447.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.00e-57	188.9	430	464
UBD/Beta-Prp	1.80e-69	234.6	343	508

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclafsd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ v+c++f d +++vsG++Dg+ikvWDl    +
   Q: 430  GHEELVRCIRF-DnKRIVSGAYDGKIKVWDLQAALD 464
           8**********.44****************977665 PP

UBD/Beta-Prp

   S: 43   kllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqclee 131
           +l r l gh a+v+ v+f+++  ++v++s Drtikvw+ st++ v+tl+gh++ + +l++      +vsGs+d+tir+wd+e g cl+ 
   Q: 343  TLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTIRLWDIECGACLR- 426
           4556679*************9..8**************************************..************************. PP
   S: 132  tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl.........ktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdl 209
           +l+gh+++v+c++++   + +vsG++D+++++Wdl         ++  +lrtl + h ++v  l+fd+  ++++s s+d t+ +wd+
   Q: 427  VLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLqaaldprapASTLCLRTLVE-HSGRVFRLQFDE--FQIISSSHDDTILIWDF 508
           ***************9..***********************************99.************..99**************7 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MCALSCLQSM PSVRCLQNTS VMEDQNEDES PKKSALWQIS NGTSSVIVSR KRPSEGNYQK 60
EKDLCIKYFD QWSESDQVEF VEHLISRMCH YQHGHINSYL KPMLQRDFIT ALPEQGLDHI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGCCCTGCC CTCCCCTAGG TGCTCTCTCC CGTGGCGGAA CCCTGGCAGA GTGGCCCGAC 60
GGCTTCTTGT TCCCATAAGG CTTAGCGATC CGCCGCGGTT GTTGGGAGTT GTAGTCTTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR021977--Beta-TrCP_D
IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR002469--Peptidase_S9B_N
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12125--Beta-TrCP_D
PF12937--F-box-like
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01028--Beta-TrCP_D
SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0019005--C:SCF ubiquitin ligase complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0042347--P:negative regulation of NF-kappaB import into nucleus
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0042753--P:positive regulation of circadian rhythm
GO:0045862--P:positive regulation of proteolysis
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006470--P:protein dephosphorylation
GO:0031648--P:protein destabilization
GO:0000209--P:protein polyubiquitination
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001397	Ailuropoda melanoleuca	95.67	0.00e+00	1041.00
IUUC-Apl-003449	Anas platyrhynchos	98.50	0.00e+00	1083.00
IUUC-Ani-009324	Aspergillus nidulans	29.87	5.00e-48	186.00
IUUC-Ang-009766	Aspergillus niger	31.65	2.00e-52	200.00
IUUC-Ame-011174	Astyanax mexicanus	87.27	0.00e+00	968.00
IUUC-Bta-012920	Bos taurus	98.46	0.00e+00	1061.00
IUUC-Cel-018392	Caenorhabditis elegans	63.36	0.00e+00	636.00
IUUC-Cja-018879	Callithrix jacchus	95.67	0.00e+00	1041.00
IUUC-Cfa-020021	Canis familiaris	95.67	0.00e+00	1041.00
IUUC-Cpo-022151	Cavia porcellus	98.83	0.00e+00	1049.00
IUUC-Csa-024095	Chlorocebus sabaeus	99.22	0.00e+00	1050.00
IUUC-Cho-024658	Choloepus hoffmanni	90.87	2.00e-132	466.00
IUUC-Cin-025188	Ciona intestinalis	80.63	0.00e+00	825.00
IUUC-Dre-028160	Danio rerio	89.62	0.00e+00	962.00
IUUC-Dno-029485	Dasypus novemcinctus	89.00	0.00e+00	928.00
IUUC-Dor-030498	Dipodomys ordii	95.29	0.00e+00	1034.00
IUUC-Eca-033804	Equus caballus	95.59	0.00e+00	1022.00
IUUC-Fca-035887	Felis catus	99.03	0.00e+00	1061.00
IUUC-Fal-036783	Ficedula albicollis	98.68	0.00e+00	1088.00
IUUC-Gmo-038590	Gadus morhua	87.01	0.00e+00	939.00
IUUC-Gga-040628	Gallus gallus	98.31	0.00e+00	1083.00
IUUC-Gac-041305	Gasterosteus aculeatus	86.82	0.00e+00	944.00
IUUC-Ggo-044604	Gorilla gorilla	95.67	0.00e+00	1041.00
IUUC-Hsa-046139	Homo sapiens	95.67	0.00e+00	1041.00
IUUC-Lch-050460	Latimeria chalumnae	97.08	0.00e+00	1036.00
IUUC-Laf-053968	Loxodonta africana	99.25	0.00e+00	1093.00
IUUC-Mcc-055822	Macaca mulatta	96.15	0.00e+00	1081.00
IUUC-Mga-059225	Meleagris gallopavo	98.25	0.00e+00	1042.00
IUUC-Mvi-060284	Microbotryum violaceum	44.95	1.00e-69	258.00
IUUC-Mmr-060746	Microcebus murinus	95.67	0.00e+00	1041.00
IUUC-Mdo-062005	Monodelphis domestica	98.63	0.00e+00	1046.00
IUUC-Mmu-063851	Mus musculus	100.00	0.00e+00	1098.00
IUUC-Mpu-065716	Mustela putorius furo	98.45	0.00e+00	1055.00
IUUC-Mlu-067001	Myotis lucifugus	99.22	0.00e+00	1050.00
IUUC-Nle-069788	Nomascus leucogenys	96.12	0.00e+00	1019.00
IUUC-Opr-071229	Ochotona princeps	95.48	0.00e+00	1039.00
IUUC-Ont-071792	Oreochromis niloticus	87.38	0.00e+00	951.00
IUUC-Oan-072782	Ornithorhynchus anatinus	98.68	0.00e+00	1088.00
IUUC-Ocu-074894	Oryctolagus cuniculus	99.25	0.00e+00	1093.00
IUUC-Ola-086985	Oryzias latipes	88.58	0.00e+00	974.00
IUUC-Oga-088604	Otolemur garnettii	92.75	0.00e+00	1041.00
IUUC-Oar-090412	Ovis aries	99.25	0.00e+00	1093.00
IUUC-Ptr-091039	Pan troglodytes	95.86	0.00e+00	1042.00
IUUC-Pan-092770	Papio anubis	99.21	0.00e+00	1045.00
IUUC-Psi-093887	Pelodiscus sinensis	97.93	0.00e+00	1078.00
IUUC-Pno-094808	Phaeosphaeria nodorum	29.50	2.00e-45	177.00
IUUC-Pfo-096783	Poecilia formosa	88.95	0.00e+00	977.00
IUUC-Pva-102547	Pteropus vampyrus	95.48	0.00e+00	1035.00
IUUC-Sha-107339	Sarcophilus harrisii	98.63	0.00e+00	1046.00
IUUC-Sja-107743	Schizosaccharomyces japonicus	35.32	4.00e-74	271.00
IUUC-Spo-108200	Schizosaccharomyces pombe	32.20	6.00e-66	244.00
IUUC-Tgu-116541	Taeniopygia guttata	98.49	0.00e+00	1083.00
IUUC-Tru-117671	Takifugu rubripes	88.39	0.00e+00	969.00
IUUC-Tni-120359	Tetraodon nigroviridis	89.58	0.00e+00	951.00
IUUC-Tbe-127418	Tupaia belangeri	89.45	0.00e+00	955.00
IUUC-Ttr-129131	Tursiops truncatus	95.67	0.00e+00	1040.00
IUUC-Vpa-130668	Vicugna pacos	95.67	0.00e+00	1040.00
IUUC-Xma-133187	Xiphophorus maculatus	95.36	5.00e-158	549.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence