iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000074266.18	ENST00000263360.10	ENSP00000263360.6
ENSG00000074266.18	ENST00000528180.5	ENSP00000431778.1
ENSG00000074266.18	ENST00000351625.10	ENSP00000338186.5
ENSG00000074266.18	ENST00000534595.1	ENSP00000436084.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	TRANSFAC	RepTar	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	17041588; 17588513

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.40e-14	54.5	188	225

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
           gH + ++ l+f   d +ll+s s D+ +++W++ t++l
   Q: 188  GHGNAINELKFhpRDpNLLLSVSKDHALRLWNIQTDTL 225
           899*********9888****************999876 PP

Organism

Homo sapiens

Functional Description
(View)

Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

Protein Sequence
(Fasta)

MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT ERPDTPTNTP 60
NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ FNWHSKEGDP LVFATVGSNR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCGCCAGA TGGGGGAAGC CAGGGGGAAG CAGGTTACTG TTTTTGCATT TCTATCTTCA 60
AGGAAGAATT AGGTTATGAA TAGTTCCGTG AATAGTCAGG AAGCGCTGTC CTCCAAGTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0024--Alternative initiation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0035098--C:ESC/E(Z) complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0045120--C:pronucleus
GO:0001739--C:sex chromatin
GO:0003682--F:chromatin binding
GO:0042054--F:histone methyltransferase activity
GO:0042802--F:identical protein binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0045814--P:negative regulation of gene expression, epigenetic
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:2000011--P:regulation of adaxial/abaxial pattern formation
GO:0006349--P:regulation of gene expression by genetic imprinting
GO:0021510--P:spinal cord development
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:8726

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000689	Aegilops tauschii	41.01	9.00e-76	277.00
IUUC-Aml-001510	Ailuropoda melanoleuca	99.32	0.00e+00	864.00
IUUC-Atr-002496	Amborella trichopoda	40.40	3.00e-69	255.00
IUUC-Apl-003768	Anas platyrhynchos	96.36	0.00e+00	829.00
IUUC-Aca-004382	Anolis carolinensis	98.35	0.00e+00	823.00
IUUC-Aly-005980	Arabidopsis lyrata	40.71	2.00e-76	279.00
IUUC-Ath-006579	Arabidopsis thaliana	40.71	1.00e-76	280.00
IUUC-Ame-010987	Astyanax mexicanus	92.74	0.00e+00	803.00
IUUC-Bta-013432	Bos taurus	99.77	0.00e+00	875.00
IUUC-Bci-013970	Botrytis cinerea	33.47	1.00e-30	127.00
IUUC-Bdi-014553	Brachypodium distachyon	43.14	1.00e-77	283.00
IUUC-Bol-016522	Brassica oleracea	40.22	9.00e-76	277.00
IUUC-Bra-017137	Brassica rapa	40.22	6.00e-76	277.00
IUUC-Cel-018494	Caenorhabditis elegans	24.36	1.00e-29	124.00
IUUC-Cja-019066	Callithrix jacchus	100.00	0.00e+00	878.00
IUUC-Cfa-021261	Canis familiaris	100.00	0.00e+00	877.00
IUUC-Cpo-022375	Cavia porcellus	94.33	0.00e+00	811.00
IUUC-Csa-024005	Chlorocebus sabaeus	100.00	0.00e+00	877.00
IUUC-Cho-024881	Choloepus hoffmanni	86.69	3.00e-158	551.00
IUUC-Cin-025697	Ciona intestinalis	61.06	6.00e-142	497.00
IUUC-Csv-026221	Ciona savignyi	63.31	3.00e-145	508.00
IUUC-Cgl-026519	Colletotrichum gloeosporioides	26.24	2.00e-24	107.00
IUUC-Cne-026877	Cryptococcus neoformans	30.20	8.00e-28	119.00
IUUC-Cme-027353	Cyanidioschyzon merolae	44.83	4.00e-33	135.00
IUUC-Dre-028346	Danio rerio	91.42	0.00e+00	785.00
IUUC-Dno-029319	Dasypus novemcinctus	99.09	0.00e+00	869.00
IUUC-Dor-030746	Dipodomys ordii	71.67	0.00e+00	647.00
IUUC-Dse-031324	Dothistroma septosporum	26.55	6.00e-27	115.00
IUUC-Dme-032029	Drosophila melanogaster	60.82	8.00e-138	483.00
IUUC-Ete-032880	Echinops telfairi	80.50	7.00e-134	470.00
IUUC-Eca-034272	Equus caballus	100.00	0.00e+00	800.00
IUUC-Eeu-035303	Erinaceus europaeus	92.06	0.00e+00	829.00
IUUC-Fca-036008	Felis catus	100.00	0.00e+00	849.00
IUUC-Fal-037577	Ficedula albicollis	98.01	0.00e+00	785.00
IUUC-Fso-038294	Fusarium solani	24.66	4.00e-27	116.00
IUUC-Gmo-039008	Gadus morhua	89.66	0.00e+00	760.00
IUUC-Ggr-039894	Gaeumannomyces graminis	30.83	5.00e-25	108.00
IUUC-Gga-040859	Gallus gallus	98.35	0.00e+00	821.00
IUUC-Gac-041667	Gasterosteus aculeatus	87.56	0.00e+00	756.00
IUUC-Gma-043832	Glycine max	39.89	4.00e-75	275.00
IUUC-Ggo-045624	Gorilla gorilla	94.64	0.00e+00	863.00
IUUC-Hvu-047228	Hordeum vulgare	37.77	6.00e-33	133.00
IUUC-Itr-048381	Ictidomys tridecemlineatus	99.77	0.00e+00	875.00
IUUC-Lch-050492	Latimeria chalumnae	96.30	0.00e+00	824.00
IUUC-Lpe-050807	Leersia perrieri	37.78	1.00e-72	266.00
IUUC-Loc-052361	Lepisosteus oculatus	92.78	0.00e+00	808.00
IUUC-Lma-053058	Leptosphaeria maculans	28.15	2.00e-21	97.40
IUUC-Laf-053941	Loxodonta africana	92.52	0.00e+00	827.00
IUUC-Mcc-055518	Macaca mulatta	94.64	0.00e+00	863.00
IUUC-Mor-056944	Magnaporthe oryzae	26.87	1.00e-27	118.00
IUUC-Mtr-058716	Medicago truncatula	42.51	1.00e-71	263.00
IUUC-Mga-059469	Meleagris gallopavo	98.35	0.00e+00	822.00
IUUC-Mmr-061026	Microcebus murinus	94.42	0.00e+00	862.00
IUUC-Mdo-062346	Monodelphis domestica	98.19	0.00e+00	862.00
IUUC-Mmu-063785	Mus musculus	100.00	0.00e+00	877.00
IUUC-Mac-064681	Musa acuminata	41.03	1.00e-79	290.00
IUUC-Mpu-066862	Mustela putorius furo	100.00	0.00e+00	877.00
IUUC-Mlu-067103	Myotis lucifugus	92.56	0.00e+00	727.00
IUUC-Ncr-068782	Neurospora crassa	30.89	5.00e-26	112.00
IUUC-Nle-069472	Nomascus leucogenys	100.00	0.00e+00	877.00
IUUC-Opr-070376	Ochotona princeps	96.94	5.00e-126	444.00
IUUC-Ont-071513	Oreochromis niloticus	91.84	0.00e+00	818.00
IUUC-Oan-073202	Ornithorhynchus anatinus	98.76	0.00e+00	790.00
IUUC-Ocu-074012	Oryctolagus cuniculus	99.77	0.00e+00	876.00
IUUC-Oba-075030	Oryza barthii	42.51	2.00e-80	292.00
IUUC-Obr-076895	Oryza brachyantha	41.98	2.00e-78	285.00
IUUC-Ogl-077522	Oryza glaberrima	42.78	1.00e-79	290.00
IUUC-Ogu-078250	Oryza glumaepatula	38.84	3.00e-68	252.00
IUUC-Oin-079886	Oryza indica	42.23	9.00e-80	290.00
IUUC-Olo-080238	Oryza longistaminata	42.51	2.00e-80	292.00
IUUC-Ome-081204	Oryza meridionalis	39.37	4.00e-67	248.00
IUUC-Oni-082388	Oryza nivara	38.63	2.00e-70	259.00
IUUC-Opu-083537	Oryza punctata	42.09	9.00e-79	287.00
IUUC-Oru-084863	Oryza rufipogon	39.12	5.00e-69	255.00
IUUC-Osa-085622	Oryza sativa	42.43	2.00e-80	293.00
IUUC-Ola-087426	Oryzias latipes	89.70	0.00e+00	802.00
IUUC-Olu-087788	Ostreococcus lucimarinus	29.89	3.00e-44	172.00
IUUC-Oga-088228	Otolemur garnettii	99.55	0.00e+00	874.00
IUUC-Oar-090139	Ovis aries	99.75	0.00e+00	798.00
IUUC-Pan-092874	Papio anubis	100.00	7.00e-159	552.00
IUUC-Psi-093927	Pelodiscus sinensis	98.51	0.00e+00	789.00
IUUC-Pma-094740	Petromyzon marinus	84.29	4.00e-138	483.00
IUUC-Pno-095072	Phaeosphaeria nodorum	28.32	2.00e-20	93.60
IUUC-Ppa-095871	Physcomitrella patens	39.02	1.00e-72	266.00
IUUC-Pfo-097208	Poecilia formosa	92.64	0.00e+00	821.00
IUUC-Pab-097658	Pongo abelii	100.00	0.00e+00	877.00
IUUC-Pop-098930	Populus trichocarpa	41.30	2.00e-78	285.00
IUUC-Ppe-101807	Prunus persica	40.65	3.00e-76	278.00
IUUC-Pva-103191	Pteropus vampyrus	85.19	0.00e+00	756.00
IUUC-Pgr-103619	Puccinia graminis	25.87	8.00e-19	88.60
IUUC-Pte-104406	Pyrenophora teres	29.19	1.00e-28	121.00
IUUC-Pyt-104821	Pyrenophora triticirepentis	26.53	8.00e-23	101.00
IUUC-Rno-105854	Rattus norvegicus	100.00	0.00e+00	877.00
IUUC-Sha-107426	Sarcophilus harrisii	97.73	0.00e+00	858.00
IUUC-Smo-109638	Selaginella moellendorffii	40.17	1.00e-75	276.00
IUUC-Sit-110481	Setaria italica	41.85	1.00e-78	286.00
IUUC-Sly-111464	Solanum lycopersicum	39.89	2.00e-75	276.00
IUUC-Stu-112910	Solanum tuberosum	39.89	2.00e-75	276.00
IUUC-Sar-113754	Sorex araneus	92.20	0.00e+00	660.00
IUUC-Sbi-114023	Sorghum bicolor	42.13	9.00e-80	290.00
IUUC-Ssc-115386	Sus scrofa	100.00	0.00e+00	877.00
IUUC-Tgu-117123	Taeniopygia guttata	97.44	0.00e+00	824.00
IUUC-Tru-117720	Takifugu rubripes	88.13	0.00e+00	801.00
IUUC-Tsy-119584	Tarsius syrichta	94.64	0.00e+00	863.00
IUUC-Tni-119695	Tetraodon nigroviridis	91.20	0.00e+00	821.00
IUUC-Tca-121787	Theobroma cacao	41.58	6.00e-78	284.00
IUUC-Tvi-122409	Trichoderma virens	24.81	9.00e-23	101.00
IUUC-Tae-124454	Triticum aestivum	41.01	9.00e-76	277.00
IUUC-Tme-126906	Tuber melanosporum	29.69	3.00e-34	139.00
IUUC-Tbe-127557	Tupaia belangeri	80.04	0.00e+00	736.00
IUUC-Vda-129774	Verticillium dahliae	25.15	5.00e-21	95.50
IUUC-Vpa-130256	Vicugna pacos	85.55	0.00e+00	717.00
IUUC-Vvi-131201	Vitis vinifera	41.58	1.00e-76	280.00
IUUC-Xtr-132206	Xenopus tropicalis	94.05	0.00e+00	818.00
IUUC-Xma-134102	Xiphophorus maculatus	92.64	0.00e+00	821.00
IUUC-Zma-135593	Zea mays	42.70	2.00e-80	292.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence