iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045694

UUCD1 version

UUC-HoS-01132

Ensembl Protein ID

ENSP00000359829.1

UniProt Accession

Q8TEY7; Q8TEY6; Q96AV6; Q9H9F0; Q9UPQ5; UBP33_HUMAN

Genbank Protein ID

AAL78314.1; AAL78315.1; BAA83049.1; BAB14279.1; AAH16663.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 33; Deubiquitinating enzyme 33; Ubiquitin thioesterase 33; Ubiquitin-specific-processing protease 33; VHL-interacting deubiquitinating enzyme 1

Genbank Nucleotide ID

AF383172; AF383173; AB029020; AK022864; AC114487

Gene Name

USP33; KIAA1097; VDU1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000077254.14	ENST00000481579.5	ENSP00000432392.1
ENSG00000077254.14	ENST00000370793.5	ENSP00000359829.1
ENSG00000077254.14	ENST00000370792.7	ENSP00000359828.3
ENSG00000077254.14	ENST00000527390.1	ENSP00000432667.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	16325574; 15933713

Classification

Family	E-value	Score	Start	End
DUB/USP	3.90e-114	383.0	185	714

Active Site

Position(s)	Description	Evidence
194	Nucleophile
673	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeqqD 91
           tGlkN+gNtCYmN++LQ+Lsn+p+l++++l+     +   +++++k +++ks+ kl++elw ks+ ++v p++l++ +k++++ f+gy+qqD
   Q: 185  TGLKNIGNTCYMNAALQALSNCPPLTQFFLD-----CGGLARTDKKPAICKSYLKLMTELWhKSRPGSVVPTTLFQGIKTVNPTFRGYSQQD 271
           7******************************.....999999*******************99***************************** PP
   S: 92   aqEflaflldqleeelkk........eknkpkeeeeeedkselsde.............................................. 129
           aqEfl++l+d l+eelk+         ++ ++ee++eedks+++ +                                              
   Q: 272  AQEFLRCLMDLLHEELKEqvmeveedPQTITTEETMEEDKSQSDVDfqscescsnsdraenengsrcfsednnettmliqddennsemskdw 363
           ****************8899998887777777788888877777779********************************************* PP
   S: 130  ............................................................................................ 129
                                                                                                       
   Q: 364  qkekmcnkinkvnsegefdkdrdsisetvdlnnqetvkvqihsraseyitdvhsndlstpqilpsnegvnprlsasppksgnlwpglapphk 455
           ******************************************************************************************** PP
   S: 130  .......aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke............................. 185
                  +++k++kk++s+isd+F+g++ s+++cl+cd+vs++ e+f+dlslp+pgke+ +k+                             
   Q: 456  kaqsaspKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLhssshptsivkagscgeayapqgwiaffm 547
           *******9**************************************************99888***************************** PP
   S: 186  ....................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
                               +lqdcL++f++++el+g+n+y+cekckk+++ +k +k++++Pe+L++hLkRf  ++e ++++ki+++v+fpl
   Q: 548  eyvkrfvvscvpswfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQNFPEILCIHLKRF--RHELMFSTKISTHVSFPL 637
           ************************************************************************..9999************** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           e Ldl+pf+++++ +q   ++Y+L++v++H+G++ssGHY+ay++n+ ++ W++fdD++Vtev+e++v++   ++aYvlfY++
   Q: 638  EgLDLQPFLAKDSPAQ--IVTYDLLSVICHHGTASSGHYIAYCRNNLNNlWYEFDDQSVTEVSESTVQN---AEAYVLFYRK 714
           ***********88777..9**************************88889*******************...********98 PP

Organism

Homo sapiens

Functional Description
(View)

Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Protein Sequence
(Fasta)

MTGSNSHITI LTLKVLPHFE SLGKQEKIPN KMSAFRNHCP HLDSVGEITK EDLIQKSLGT 60
CQDCKVQGPN LWACLENRCS YVGCGESQVD HSTIHSQETK HYLTVNLTTL RVWCYACSKE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGACACCG GAAGGAGCCG CGGCTGCTGC GGGAAGTGGC CAGTTCAGGA GGCGGACCCC 60
CCGAGGGCAG CGCTGCGGGG CCGTTTTCCG GCCCTCCTGA CGCGACACTG CCCCTCTCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0044297--C:cell body
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0030891--C:VCB complex
GO:0004197--F:cysteine-type endopeptidase activity
GO:0001664--F:G-protein coupled receptor binding
GO:0017160--F:Ral GTPase binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0007411--P:axon guidance
GO:0016477--P:cell migration
GO:0009267--P:cellular response to starvation
GO:0051298--P:centrosome duplication
GO:0006897--P:endocytosis
GO:0032091--P:negative regulation of protein binding
GO:0032092--P:positive regulation of protein binding
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:23032

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001742	Ailuropoda melanoleuca	96.06	0.00e+00	1800.00
IUUC-Apl-003987	Anas platyrhynchos	81.94	0.00e+00	1479.00
IUUC-Aca-004713	Anolis carolinensis	77.44	0.00e+00	1415.00
IUUC-Bta-013132	Bos taurus	96.60	0.00e+00	1770.00
IUUC-Cja-018811	Callithrix jacchus	97.53	0.00e+00	1834.00
IUUC-Cfa-021158	Canis familiaris	95.14	0.00e+00	1801.00
IUUC-Cpo-021910	Cavia porcellus	89.05	0.00e+00	1578.00
IUUC-Csa-023130	Chlorocebus sabaeus	98.57	0.00e+00	1803.00
IUUC-Cho-024383	Choloepus hoffmanni	78.59	0.00e+00	679.00
IUUC-Dre-028639	Danio rerio	70.08	0.00e+00	1240.00
IUUC-Dno-029416	Dasypus novemcinctus	94.19	0.00e+00	1712.00
IUUC-Ete-032994	Echinops telfairi	78.49	0.00e+00	856.00
IUUC-Eca-034248	Equus caballus	95.91	0.00e+00	1789.00
IUUC-Eeu-035357	Erinaceus europaeus	77.05	0.00e+00	1311.00
IUUC-Fca-036013	Felis catus	94.15	0.00e+00	1729.00
IUUC-Fal-037509	Ficedula albicollis	81.80	0.00e+00	1477.00
IUUC-Gmo-038944	Gadus morhua	65.77	0.00e+00	1178.00
IUUC-Gga-040647	Gallus gallus	80.94	0.00e+00	1451.00
IUUC-Gac-041752	Gasterosteus aculeatus	70.00	0.00e+00	1248.00
IUUC-Ggo-044689	Gorilla gorilla	93.05	0.00e+00	1084.00
IUUC-Itr-049041	Ictidomys tridecemlineatus	96.27	0.00e+00	1756.00
IUUC-Lch-050400	Latimeria chalumnae	70.18	0.00e+00	1259.00
IUUC-Loc-052616	Lepisosteus oculatus	70.03	0.00e+00	1325.00
IUUC-Laf-053493	Loxodonta africana	95.19	0.00e+00	1749.00
IUUC-Mcc-055542	Macaca mulatta	97.99	0.00e+00	1857.00
IUUC-Meu-056645	Macropus eugenii	73.52	0.00e+00	1298.00
IUUC-Mga-060019	Meleagris gallopavo	82.20	0.00e+00	1252.00
IUUC-Mmr-061241	Microcebus murinus	93.21	0.00e+00	1749.00
IUUC-Mmu-063786	Mus musculus	92.43	0.00e+00	1686.00
IUUC-Mpu-065772	Mustela putorius furo	96.93	0.00e+00	1472.00
IUUC-Mlu-067732	Myotis lucifugus	93.55	0.00e+00	1767.00
IUUC-Nle-069528	Nomascus leucogenys	97.37	0.00e+00	1811.00
IUUC-Opr-070606	Ochotona princeps	89.98	0.00e+00	1593.00
IUUC-Ont-071495	Oreochromis niloticus	71.24	0.00e+00	1260.00
IUUC-Oan-073695	Ornithorhynchus anatinus	85.02	0.00e+00	1035.00
IUUC-Ocu-074457	Oryctolagus cuniculus	92.93	0.00e+00	1710.00
IUUC-Ola-086739	Oryzias latipes	69.77	0.00e+00	1288.00
IUUC-Oga-088720	Otolemur garnettii	94.38	0.00e+00	1790.00
IUUC-Oar-089921	Ovis aries	95.33	0.00e+00	1804.00
IUUC-Ptr-090526	Pan troglodytes	99.25	0.00e+00	1850.00
IUUC-Pan-092396	Papio anubis	97.46	0.00e+00	1839.00
IUUC-Psi-092971	Pelodiscus sinensis	83.06	0.00e+00	1543.00
IUUC-Pfo-097415	Poecilia formosa	69.97	0.00e+00	1264.00
IUUC-Pab-098740	Pongo abelii	98.79	0.00e+00	1832.00
IUUC-Pca-100598	Procavia capensis	83.27	0.00e+00	900.00
IUUC-Pva-102820	Pteropus vampyrus	92.20	0.00e+00	1507.00
IUUC-Rno-104894	Rattus norvegicus	92.43	0.00e+00	1699.00
IUUC-Sha-107244	Sarcophilus harrisii	78.02	0.00e+00	1400.00
IUUC-Sar-113665	Sorex araneus	93.00	0.00e+00	1760.00
IUUC-Ssc-115793	Sus scrofa	93.43	0.00e+00	1682.00
IUUC-Tgu-117487	Taeniopygia guttata	82.81	0.00e+00	1449.00
IUUC-Tru-117694	Takifugu rubripes	68.94	0.00e+00	1273.00
IUUC-Tsy-119598	Tarsius syrichta	84.14	0.00e+00	1493.00
IUUC-Tni-120189	Tetraodon nigroviridis	67.35	0.00e+00	1199.00
IUUC-Tbe-128125	Tupaia belangeri	84.38	8.00e-119	421.00
IUUC-Ttr-128269	Tursiops truncatus	92.13	0.00e+00	1651.00
IUUC-Vpa-130598	Vicugna pacos	93.76	0.00e+00	1741.00
IUUC-Xtr-132044	Xenopus tropicalis	74.62	0.00e+00	1313.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence