iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000078114.18	ENST00000377122.8	ENSP00000366326.4
ENSG00000078114.18	ENST00000417816.2	ENSP00000393896.2
ENSG00000078114.18	ENST00000473616.5	ENSP00000489562.1
ENSG00000078114.18	ENST00000481592.5	ENSP00000489545.1
ENSG00000078114.18	ENST00000460652.1	ENSP00000489224.1
ENSG00000078114.18	ENST00000434381.1	ENSP00000396512.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	4.80e-13	50.5	957	1013

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ++ +++ydy+aq++de +++ Gd +  +  +  d gW++g+ + +g+ G++P+n++e +
   Q: 957  RTYRAMYDYSAQDEDEVSFRDGDYIVNV--QPIDDGWMYGTVQRTGRTGMLPANYIEFV 1013
           57799*******************9999..999***********************976 PP

Organism

Homo sapiens

Functional Description
(View)

Binds to actin and plays an important role in the assembly of the Z-disk. Isoform 2 might play a role in the assembly of focal adhesion.

Protein Sequence
(Fasta)

MRVPVFEDIK DETEEEKIGE EENEEDQVFY KPVIEDLSME LARKCTELIS DIRYKEEFKK 60
SKDKCTFVTD SPMLNHVKNI GAFISEAKYK GTIKADLSNS LYKRMPATID SVFAGEVTQL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCTGCGCGGC GGCGGCGGCG AGGCGGGGGA GCGAGTGAGC GCGAGGGGCG GGCGCGAGTG 60
ACTGTGTGAG TCACCCGTAC CTGGAGTGCG AGCGACGCAG AGCCAGCGGC GCGGAGCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0488--Methylation
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain

Interpro

IPR000900--Nebulin_repeat
IPR001452--SH3_domain

PROSITE

PS51216--NEBULIN
PS50002--SH3

Pfam

PF00880--Nebulin
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00227--NEBU
SM00326--SH3

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0031674--C:I band
GO:0001725--C:stress fiber
GO:0030018--C:Z disc
GO:0051015--F:actin filament binding
GO:0008092--F:cytoskeletal protein binding
GO:0031005--F:filamin binding
GO:0008307--F:structural constituent of muscle
GO:0005523--F:tropomyosin binding
GO:0071691--P:cardiac muscle thin filament assembly

KEGG

hsa:10529

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001872	Ailuropoda melanoleuca	91.04	0.00e+00	1830.00
IUUC-Apl-004170	Anas platyrhynchos	69.55	0.00e+00	1388.00
IUUC-Aca-004963	Anolis carolinensis	58.75	0.00e+00	1110.00
IUUC-Bta-012326	Bos taurus	90.55	0.00e+00	1801.00
IUUC-Cja-019147	Callithrix jacchus	93.28	0.00e+00	1464.00
IUUC-Cfa-021186	Canis familiaris	91.12	0.00e+00	1816.00
IUUC-Dno-030030	Dasypus novemcinctus	78.01	0.00e+00	1548.00
IUUC-Dor-030598	Dipodomys ordii	80.99	0.00e+00	1621.00
IUUC-Eca-033766	Equus caballus	90.53	0.00e+00	1821.00
IUUC-Eeu-034613	Erinaceus europaeus	82.10	0.00e+00	1652.00
IUUC-Fca-035669	Felis catus	89.64	0.00e+00	1791.00
IUUC-Fal-037225	Ficedula albicollis	70.64	0.00e+00	1390.00
IUUC-Ggo-045232	Gorilla gorilla	94.14	0.00e+00	1845.00
IUUC-Lch-049942	Latimeria chalumnae	58.29	0.00e+00	1015.00
IUUC-Loc-052746	Lepisosteus oculatus	55.80	0.00e+00	1095.00
IUUC-Mcc-055729	Macaca mulatta	97.16	0.00e+00	1948.00
IUUC-Mmr-060833	Microcebus murinus	90.24	0.00e+00	1806.00
IUUC-Mdo-062429	Monodelphis domestica	83.59	0.00e+00	1662.00
IUUC-Mmu-064027	Mus musculus	87.57	0.00e+00	1781.00
IUUC-Mpu-065952	Mustela putorius furo	86.86	0.00e+00	1771.00
IUUC-Mlu-067836	Myotis lucifugus	90.34	0.00e+00	1857.00
IUUC-Nle-069933	Nomascus leucogenys	98.32	0.00e+00	2003.00
IUUC-Ont-072606	Oreochromis niloticus	44.32	0.00e+00	781.00
IUUC-Oan-072876	Ornithorhynchus anatinus	79.79	0.00e+00	1612.00
IUUC-Ocu-074294	Oryctolagus cuniculus	91.33	0.00e+00	1846.00
IUUC-Oba-075492	Oryza barthii	23.16	6.00e-04	41.60
IUUC-Ola-087441	Oryzias latipes	43.78	0.00e+00	746.00
IUUC-Oga-088496	Otolemur garnettii	91.72	0.00e+00	1836.00
IUUC-Oar-090399	Ovis aries	89.86	0.00e+00	1818.00
IUUC-Ptr-091098	Pan troglodytes	98.92	0.00e+00	1996.00
IUUC-Pan-091758	Papio anubis	93.42	0.00e+00	1866.00
IUUC-Psi-093861	Pelodiscus sinensis	69.11	0.00e+00	1346.00
IUUC-Pfo-096752	Poecilia formosa	44.22	0.00e+00	813.00
IUUC-Pab-097615	Pongo abelii	98.82	0.00e+00	1993.00
IUUC-Pca-100634	Procavia capensis	81.30	0.00e+00	1600.00
IUUC-Pva-102532	Pteropus vampyrus	82.36	0.00e+00	1563.00
IUUC-Rno-105373	Rattus norvegicus	86.60	0.00e+00	1792.00
IUUC-Sha-106925	Sarcophilus harrisii	82.65	0.00e+00	1688.00
IUUC-Sar-113072	Sorex araneus	84.56	0.00e+00	1634.00
IUUC-Ssc-115305	Sus scrofa	90.45	0.00e+00	1807.00
IUUC-Tsy-119452	Tarsius syrichta	85.71	0.00e+00	1699.00
IUUC-Tni-119949	Tetraodon nigroviridis	43.43	0.00e+00	739.00
IUUC-Tbe-127585	Tupaia belangeri	87.10	0.00e+00	644.00
IUUC-Ttr-128428	Tursiops truncatus	91.24	0.00e+00	1847.00
IUUC-Vpa-130371	Vicugna pacos	87.33	0.00e+00	1684.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence