iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000078369.17	ENST00000378609.8	ENSP00000367872.3
ENSG00000078369.17	ENST00000439272.6	ENSP00000399741.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2	LncRNADisease
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
ClinVar	GWASdb	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.70e-42	142.1	224	260
UBD/Beta-Prp	1.30e-54	187.1	136	340

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH++++++++f ++ + +++GsdD t++++Dlr +  
   Q: 224  GHESDINAICFfPNgNAFATGSDDATCRLFDLRADQE 260
           8*********99777*****************98865 PP

UBD/Beta-Prp

   S: 45   lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsgh 136
            r+l gh++  ++++f +d   +vt+s D t  +wd++tg+++ t++gh+ +v+sls+ p++  +vsG  d  +++wd+++g c + t++gh
   Q: 136  SRELAGHTGYLSCCRFLDDN-QIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ-TFTGH 225
           5899***************7.7****************************************************************.***** PP
   S: 137  dgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl.tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvks 227
           ++ +n +++ p+gn +++Gs+D t+rl+dl+ ++ l t    +    ++s+sf+++g+ l++g +d   ++wd  + +    l gh++ v++
   Q: 226  ESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYsHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSC 317
           *********************************999999434455789******************************************** PP
   S: 228  vrfspnderlvsgssDgsiriWd 250
           + +++++  +++gs D  ++iW+
   Q: 318  LGVTDDGMAVATGSWDSFLKIWN 340
           **********************8 PP

Organism

Homo sapiens

Functional Description
(View)

G proteins are composed of 3 units, alpha, beta and gamma. Interacts with ARHGEF18 and RASD2 (PubMed:14512443, PubMed:19255495). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (PubMed:19713215).

Protein Sequence
(Fasta)

MSELDQLRQE AEQLKNQIRD ARKACADATL SQITNNIDPV GRIQMRTRRT LRGHLAKIYA 60
MHWGTDSRLL VSASQDGKLI IWDSYTTNKV HAIPLRSSWV MTCAYAPSGN YVACGGLDNI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCGCGTGG GGTTTTCCGA GGCTGCGGGC AGGGGCCCGC CGCGCCCATC CCGATGGCTG 60
GAGGCGTCTG AGGGGCGGAC GGAGGCGGCG GCGGCGGCGG CGGGAGCGGG AGCGGGCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0225--Disease mutation
KW-0991--Mental retardation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0807--Transducer
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001632--Gprotein_B
IPR016346--Guanine_nucleotide-bd_bsu
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00319--GPROTEINB
PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0044297--C:cell body
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0070062--C:extracellular exosome
GO:1903561--C:extracellular vesicle
GO:0005834--C:heterotrimeric G-protein complex
GO:0005622--C:intracellular
GO:0005765--C:lysosomal membrane
GO:0016020--C:membrane
GO:0043209--C:myelin sheath
GO:0097381--C:photoreceptor disc membrane
GO:0001917--C:photoreceptor inner segment
GO:0042622--C:photoreceptor outer segment membrane
GO:0005886--C:plasma membrane
GO:0047391--F:alkylglycerophosphoethanolamine phosphodiesterase activity
GO:0003924--F:GTPase activity
GO:0051020--F:GTPase binding
GO:0032403--F:protein complex binding
GO:0004871--F:signal transducer activity
GO:0007191--P:adenylate cyclase-activating dopamine receptor signaling pathway
GO:0010659--P:cardiac muscle cell apoptotic process
GO:0008283--P:cell proliferation
GO:0071870--P:cellular response to catecholamine stimulus
GO:0071377--P:cellular response to glucagon stimulus
GO:0071456--P:cellular response to hypoxia
GO:0071380--P:cellular response to prostaglandin E stimulus
GO:0007213--P:G-protein coupled acetylcholine receptor signaling pathway
GO:0007200--P:phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0030168--P:platelet activation
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0006457--P:protein folding
GO:0070208--P:protein heterotrimerization
GO:0007265--P:Ras protein signal transduction
GO:0060041--P:retina development in camera-type eye
GO:0016056--P:rhodopsin mediated signaling pathway
GO:0050909--P:sensory perception of taste
GO:0007165--P:signal transduction
GO:0007223--P:Wnt signaling pathway, calcium modulating pathway

KEGG

hsa:2782

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001337	Ailuropoda melanoleuca	100.00	0.00e+00	670.00
IUUC-Apl-003811	Anas platyrhynchos	97.94	0.00e+00	657.00
IUUC-Acl-008154	Aspergillus clavatus	68.55	5.00e-138	484.00
IUUC-Afl-008568	Aspergillus flavus	68.82	6.00e-140	490.00
IUUC-Afu-008789	Aspergillus fumigatus	68.55	5.00e-138	484.00
IUUC-Ani-009213	Aspergillus nidulans	69.12	3.00e-139	488.00
IUUC-Ang-009836	Aspergillus niger	68.82	5.00e-140	490.00
IUUC-Aor-010165	Aspergillus oryzae	68.82	6.00e-140	490.00
IUUC-Ame-011092	Astyanax mexicanus	98.24	0.00e+00	694.00
IUUC-Bta-012709	Bos taurus	100.00	0.00e+00	670.00
IUUC-Cja-019782	Callithrix jacchus	100.00	0.00e+00	670.00
IUUC-Cfa-020111	Canis familiaris	100.00	0.00e+00	670.00
IUUC-Cpo-022494	Cavia porcellus	100.00	0.00e+00	670.00
IUUC-Csa-023672	Chlorocebus sabaeus	100.00	0.00e+00	670.00
IUUC-Cne-026811	Cryptococcus neoformans	67.57	3.00e-138	484.00
IUUC-Dre-028478	Danio rerio	98.82	0.00e+00	696.00
IUUC-Eca-033359	Equus caballus	99.71	0.00e+00	669.00
IUUC-Fal-037004	Ficedula albicollis	97.94	0.00e+00	657.00
IUUC-Gmo-039709	Gadus morhua	98.53	0.00e+00	694.00
IUUC-Gga-041163	Gallus gallus	97.55	0.00e+00	629.00
IUUC-Gac-041386	Gasterosteus aculeatus	97.94	0.00e+00	669.00
IUUC-Gma-043322	Glycine max	45.23	9.00e-87	313.00
IUUC-Ggo-045261	Gorilla gorilla	99.69	0.00e+00	630.00
IUUC-Itr-049064	Ictidomys tridecemlineatus	100.00	0.00e+00	670.00
IUUC-Lch-049422	Latimeria chalumnae	97.65	0.00e+00	657.00
IUUC-Loc-052939	Lepisosteus oculatus	97.94	0.00e+00	671.00
IUUC-Lma-052985	Leptosphaeria maculans	67.96	2.00e-136	478.00
IUUC-Laf-054222	Loxodonta africana	100.00	0.00e+00	670.00
IUUC-Mcc-054970	Macaca mulatta	100.00	0.00e+00	670.00
IUUC-Mvi-060482	Microbotryum violaceum	72.29	2.00e-149	521.00
IUUC-Mmr-061302	Microcebus murinus	99.71	0.00e+00	669.00
IUUC-Mdo-062044	Monodelphis domestica	99.41	0.00e+00	665.00
IUUC-Mmu-063323	Mus musculus	100.00	0.00e+00	670.00
IUUC-Mlu-067309	Myotis lucifugus	100.00	0.00e+00	670.00
IUUC-Nfi-068332	Neosartorya fischeri	68.55	2.00e-137	482.00
IUUC-Nle-069791	Nomascus leucogenys	100.00	0.00e+00	670.00
IUUC-Ont-071280	Oreochromis niloticus	98.24	0.00e+00	693.00
IUUC-Oan-072780	Ornithorhynchus anatinus	98.82	0.00e+00	664.00
IUUC-Ocu-073769	Oryctolagus cuniculus	100.00	0.00e+00	670.00
IUUC-Ola-087490	Oryzias latipes	97.24	0.00e+00	639.00
IUUC-Oga-087961	Otolemur garnettii	100.00	0.00e+00	670.00
IUUC-Pan-092079	Papio anubis	100.00	0.00e+00	670.00
IUUC-Psi-093225	Pelodiscus sinensis	97.94	0.00e+00	657.00
IUUC-Pno-095135	Phaeosphaeria nodorum	67.96	3.00e-136	478.00
IUUC-Pfo-097028	Poecilia formosa	97.35	0.00e+00	669.00
IUUC-Pab-098658	Pongo abelii	100.00	0.00e+00	670.00
IUUC-Pca-100313	Procavia capensis	99.41	0.00e+00	659.00
IUUC-Pva-102636	Pteropus vampyrus	99.71	0.00e+00	668.00
IUUC-Pgr-103321	Puccinia graminis	73.19	4.00e-150	523.00
IUUC-Ptt-103728	Puccinia triticina	73.19	4.00e-150	523.00
IUUC-Pyt-104426	Pyrenophora triticirepentis	62.83	5.00e-124	437.00
IUUC-Rno-105112	Rattus norvegicus	100.00	0.00e+00	670.00
IUUC-Sha-106856	Sarcophilus harrisii	99.41	0.00e+00	665.00
IUUC-Sre-115035	Sporisorium reilianum	69.97	2.00e-140	491.00
IUUC-Tru-117793	Takifugu rubripes	97.94	0.00e+00	672.00
IUUC-Tni-120495	Tetraodon nigroviridis	97.35	0.00e+00	664.00
IUUC-Tme-126886	Tuber melanosporum	70.36	3.00e-136	478.00
IUUC-Uma-129589	Ustilago maydis	70.27	6.00e-141	493.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence