iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000078967.12	ENST00000450743.5	ENSP00000391678.1
ENSG00000078967.12	ENST00000454350.5	ENSP00000401824.1
ENSG00000078967.12	ENST00000222402.7	ENSP00000222402.2
ENSG00000078967.12	ENST00000415051.5	ENSP00000414331.1
ENSG00000078967.12	ENST00000446008.5	ENSP00000397406.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	TargetScan
RepTar	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	19690564

Classification

Family	E-value	Score	Start	End
E2/UBC	8.20e-57	192.5	5	139
UBD/UBC-like/UBD_UBC	3.10e-83	278.4	5	142

Active Site

Position(s)	Description	Evidence
85	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekW 92
           R++kel++l++dpp+++sa+pv + dl++w+++i+Gp+d+pY+ggvF l+i+fp+dYPfkPPkv f+tki+hPn+++nG++Cl+il+  ++W
   Q: 5    RIQKELTDLQRDPPAQCSAGPVGD-DLFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTKIYHPNINSNGSICLDILR--SQW 93
           9***********************.9************************************************************9..*** PP
   S: 93   spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           spal+v++vllsi+sll++pnp++pl  e+a+++k++re+y++ +r
   Q: 94   SPALTVSKVLLSICSLLCDPNPDDPLVPEIAHTYKADREKYNRLAR 139
           ******************************************9987 PP

UBD/UBC-like/UBD_UBC

   S: 1    rikkelkdllrdeeaqisadlvdddlfelratiagppdspyeggvffltiklptdypfkppkvafitkiyhpninsngsicldilrsqwsaa 92
           ri+kel dl+rd++aq+sa++v+ddlf+++ati+gp+dspy+ggvfflti++ptdypfkppkvaf+tkiyhpninsngsicldilrsqws+a
   Q: 5    RIQKELTDLQRDPPAQCSAGPVGDDLFHWQATIMGPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTKIYHPNINSNGSICLDILRSQWSPA 96
           8******************************************************************************************* PP
   S: 93   ltlskvllslcslladaepddplvaeiariyktdkekykriarewt 138
           lt+skvlls+csll+d++pddplv+eia+ yk+d+eky+r arewt
   Q: 97   LTVSKVLLSICSLLCDPNPDDPLVPEIAHTYKADREKYNRLAREWT 142
           *********************************************8 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination.

Protein Sequence
(Fasta)

MALKRIQKEL TDLQRDPPAQ CSAGPVGDDL FHWQATIMGP NDSPYQGGVF FLTIHFPTDY 60
PFKPPKVAFT TKIYHPNINS NGSICLDILR SQWSPALTVS KVLLSICSLL CDPNPDDPLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCTCCCGGC GTGCAGCTTG GTGGCGGCTG AGCCGGCAGC GGGCCGCCTC AGGCAGCCCC 60
GGCCGGGCCG CCCGGGTCCC CGGCAGCGGG GTAGGATGGC GCTAAAGCGG ATCCAGAAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0070979--P:protein K11-linked ubiquitination
GO:0044314--P:protein K27-linked ubiquitination
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0016567--P:protein ubiquitination

KEGG

hsa:51619

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000292	Aegilops tauschii	79.59	7.00e-70	255.00
IUUC-Atr-002861	Amborella trichopoda	80.95	1.00e-70	258.00
IUUC-Aly-006221	Arabidopsis lyrata	81.63	2.00e-71	260.00
IUUC-Ath-007700	Arabidopsis thaliana	81.63	2.00e-70	257.00
IUUC-Acl-008266	Aspergillus clavatus	85.03	3.00e-74	270.00
IUUC-Afl-008709	Aspergillus flavus	79.58	3.00e-69	256.00
IUUC-Afu-008956	Aspergillus fumigatus	85.71	1.00e-74	271.00
IUUC-Ani-009401	Aspergillus nidulans	83.67	4.00e-73	266.00
IUUC-Ate-010438	Aspergillus terreus	84.35	2.00e-73	267.00
IUUC-Ame-011566	Astyanax mexicanus	95.92	4.00e-83	299.00
IUUC-Bci-013661	Botrytis cinerea	83.67	3.00e-74	270.00
IUUC-Bdi-014561	Brachypodium distachyon	80.95	1.00e-71	261.00
IUUC-Bol-015722	Brassica oleracea	82.31	3.00e-72	263.00
IUUC-Bra-017985	Brassica rapa	82.31	1.00e-71	261.00
IUUC-Cja-019014	Callithrix jacchus	97.18	1.00e-81	295.00
IUUC-Cpo-021897	Cavia porcellus	97.90	3.00e-82	296.00
IUUC-Cre-022765	Chlamydomonas reinhardtii	80.27	2.00e-70	257.00
IUUC-Csa-023377	Chlorocebus sabaeus	97.20	2.00e-81	294.00
IUUC-Cgl-026490	Colletotrichum gloeosporioides	84.35	6.00e-74	269.00
IUUC-Cne-026957	Cryptococcus neoformans	80.82	4.00e-70	256.00
IUUC-Cme-027220	Cyanidioschyzon merolae	83.67	2.00e-72	263.00
IUUC-Dre-028686	Danio rerio	99.32	1.00e-85	308.00
IUUC-Dor-030323	Dipodomys ordii	99.32	1.00e-85	308.00
IUUC-Dse-031397	Dothistroma septosporum	84.35	4.00e-74	270.00
IUUC-Eca-033231	Equus caballus	100.00	3.00e-81	293.00
IUUC-Gmo-038775	Gadus morhua	91.84	2.00e-80	290.00
IUUC-Gma-043733	Glycine max	81.63	2.00e-71	261.00
IUUC-Ggo-045361	Gorilla gorilla	100.00	5.00e-86	309.00
IUUC-Hvu-047546	Hordeum vulgare	78.23	2.00e-69	254.00
IUUC-Kpa-049290	Komagataella pastoris	78.91	2.00e-69	254.00
IUUC-Lch-050109	Latimeria chalumnae	87.76	1.00e-77	281.00
IUUC-Lpe-051289	Leersia perrieri	81.63	5.00e-71	259.00
IUUC-Loc-052838	Lepisosteus oculatus	100.00	5.00e-86	309.00
IUUC-Mcc-055421	Macaca mulatta	100.00	5.00e-86	309.00
IUUC-Mtr-058257	Medicago truncatula	80.27	2.00e-70	257.00
IUUC-Mac-064668	Musa acuminata	80.27	2.00e-70	258.00
IUUC-Nfi-068599	Neosartorya fischeri	85.71	1.00e-74	271.00
IUUC-Nle-069715	Nomascus leucogenys	100.00	5.00e-86	309.00
IUUC-Ont-072562	Oreochromis niloticus	96.60	8.00e-84	301.00
IUUC-Oan-073026	Ornithorhynchus anatinus	99.29	2.00e-81	294.00
IUUC-Oba-075411	Oryza barthii	81.63	6.00e-71	259.00
IUUC-Obr-076691	Oryza brachyantha	80.95	2.00e-70	258.00
IUUC-Ogl-076968	Oryza glaberrima	81.63	8.00e-72	262.00
IUUC-Ogu-078091	Oryza glumaepatula	80.69	1.00e-70	260.00
IUUC-Oin-079659	Oryza indica	81.63	8.00e-72	262.00
IUUC-Olo-080786	Oryza longistaminata	81.63	6.00e-71	259.00
IUUC-Ome-081920	Oryza meridionalis	80.95	4.00e-70	256.00
IUUC-Oni-082391	Oryza nivara	81.63	6.00e-72	264.00
IUUC-Opu-083833	Oryza punctata	80.27	8.00e-71	258.00
IUUC-Oru-085167	Oryza rufipogon	81.63	5.00e-72	264.00
IUUC-Osa-086003	Oryza sativa	81.63	8.00e-72	262.00
IUUC-Ola-087515	Oryzias latipes	97.28	4.00e-84	303.00
IUUC-Olu-087615	Ostreococcus lucimarinus	77.55	8.00e-67	245.00
IUUC-Pan-092614	Papio anubis	97.24	2.00e-82	297.00
IUUC-Ppa-095177	Physcomitrella patens	80.95	1.00e-70	258.00
IUUC-Pfo-096867	Poecilia formosa	97.28	4.00e-84	303.00
IUUC-Pab-098760	Pongo abelii	99.32	2.00e-85	307.00
IUUC-Pop-098799	Populus trichocarpa	80.95	1.00e-70	258.00
IUUC-Ppe-101431	Prunus persica	81.63	3.00e-71	259.00
IUUC-Pte-104015	Pyrenophora teres	84.35	3.00e-74	270.00
IUUC-Pyt-104701	Pyrenophora triticirepentis	84.35	3.00e-74	270.00
IUUC-Sce-106463	Saccharomyces cerevisiae	81.25	2.00e-70	257.00
IUUC-Ssl-108443	Sclerotinia sclerotiorum	84.35	1.00e-74	271.00
IUUC-Smo-108911	Selaginella moellendorffii	80.95	4.00e-70	256.00
IUUC-Sit-109936	Setaria italica	81.63	9.00e-72	263.00
IUUC-Sly-110857	Solanum lycopersicum	81.63	2.00e-71	261.00
IUUC-Stu-112436	Solanum tuberosum	81.63	3.00e-72	263.00
IUUC-Sbi-114840	Sorghum bicolor	81.63	5.00e-72	262.00
IUUC-Ssc-115391	Sus scrofa	100.00	5.00e-86	309.00
IUUC-Tsy-118832	Tarsius syrichta	97.28	4.00e-83	299.00
IUUC-Tca-121542	Theobroma cacao	81.63	2.00e-72	265.00
IUUC-Tae-123340	Triticum aestivum	82.31	7.00e-73	265.00
IUUC-Tur-126518	Triticum urartu	79.59	3.00e-70	258.00
IUUC-Tbe-128122	Tupaia belangeri	96.77	4.00e-61	226.00
IUUC-Vda-129695	Verticillium dahliae	84.35	6.00e-74	269.00
IUUC-Vvi-131016	Vitis vinifera	80.27	5.00e-71	259.00
IUUC-Xtr-132238	Xenopus tropicalis	97.96	1.00e-84	305.00
IUUC-Zma-135267	Zea mays	80.27	3.00e-62	230.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence