iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000079999.13	ENST00000171111.9	ENSP00000171111.4
ENSG00000079999.13	ENST00000592478.5	ENSP00000468014.1
ENSG00000079999.13	ENST00000590593.1	ENSP00000467601.1
ENSG00000079999.13	ENST00000585845.1	ENSP00000466704.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
OMIM
Drug and target
DrugBank	GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	PHOSIDA	BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_3-box	BTB_3-box	17046835; 19818716; 20930034; 20865015; 26195781

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.70e-16	62.0	77	148
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	3.30e-09	35.9	181	211

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvv....g.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+l+v    +   +f ahk+vLa+sS+vF+a+f+++l+e+   + v i+++ p+v++ l++F Yt ++++ 
   Q: 77   CDVTLQVkyqdApAAQFMAHKVVLASSSPVFKAMFTNGLREQG-MEVVSIEGIHPKVMERLIEFAYTASISMG 148
           8******77552699**************************98.***********************998875 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++N++gi  fA++ +c +L+++a+++i  hF
   Q: 181  PSNAIGIANFAEQIGCVELHQRAREYIYMHF 211
           89****************************9 PP

Organism

Homo sapiens

Functional Description
(View)

Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.

Protein Sequence
(Fasta)

MQPDPRPSGA GACCRFLPLQ SQCPEGAGDA VMYASTECKA EVTPSQHGNR TFSYTLEDHT 60
KQAFGIMNEL RLSQQLCDVT LQVKYQDAPA AQFMAHKVVL ASSSPVFKAM FTNGLREQGM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATTGCGCCA CTGCACTCCA GCCTGGGCGT GCAGATCAGA GCGAGACCTT GTCTCTAAAG 60
GAAAAAAAAA AAGAAAGAAA GAAAGAAAAG AAAAGAAAAG AAAACCTAGC GAGGTAGATA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR030563--KEAP1
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0005884--C:actin filament
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005815--C:microtubule organizing center
GO:0030496--C:midbody
GO:0005654--C:nucleoplasm
GO:0008134--F:transcription factor binding
GO:0071353--P:cellular response to interleukin-4
GO:0042994--P:cytoplasmic sequestering of transcription factor
GO:0001701--P:in utero embryonic development
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0016567--P:protein ubiquitination
GO:0045604--P:regulation of epidermal cell differentiation
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:9817

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001377	Ailuropoda melanoleuca	97.60	0.00e+00	1277.00
IUUC-Aca-005389	Anolis carolinensis	86.00	0.00e+00	1083.00
IUUC-Ame-010749	Astyanax mexicanus	78.74	0.00e+00	974.00
IUUC-Bta-013505	Bos taurus	97.60	0.00e+00	1276.00
IUUC-Cja-018823	Callithrix jacchus	98.24	0.00e+00	1288.00
IUUC-Cfa-021202	Canis familiaris	97.60	0.00e+00	1276.00
IUUC-Cpo-021830	Cavia porcellus	96.12	0.00e+00	840.00
IUUC-Csa-023728	Chlorocebus sabaeus	99.04	0.00e+00	1297.00
IUUC-Cin-025195	Ciona intestinalis	55.00	0.00e+00	677.00
IUUC-Csv-026155	Ciona savignyi	53.59	2.00e-180	625.00
IUUC-Dre-027388	Danio rerio	77.25	0.00e+00	948.00
IUUC-Dno-029066	Dasypus novemcinctus	85.28	0.00e+00	1086.00
IUUC-Dor-030674	Dipodomys ordii	94.89	0.00e+00	831.00
IUUC-Dme-032165	Drosophila melanogaster	49.73	3.00e-161	562.00
IUUC-Ete-032255	Echinops telfairi	93.96	2.00e-98	352.00
IUUC-Eca-034381	Equus caballus	93.76	0.00e+00	1208.00
IUUC-Eeu-034791	Erinaceus europaeus	92.36	0.00e+00	821.00
IUUC-Fca-036067	Felis catus	97.76	0.00e+00	1280.00
IUUC-Gmo-039691	Gadus morhua	77.21	0.00e+00	953.00
IUUC-Gga-040266	Gallus gallus	79.53	0.00e+00	999.00
IUUC-Gac-041866	Gasterosteus aculeatus	77.46	0.00e+00	957.00
IUUC-Ggo-044719	Gorilla gorilla	100.00	0.00e+00	1310.00
IUUC-Itr-048457	Ictidomys tridecemlineatus	97.28	0.00e+00	1273.00
IUUC-Lch-049646	Latimeria chalumnae	82.88	0.00e+00	1041.00
IUUC-Loc-052296	Lepisosteus oculatus	56.79	0.00e+00	641.00
IUUC-Laf-054579	Loxodonta africana	97.12	0.00e+00	1275.00
IUUC-Mcc-055315	Macaca mulatta	99.04	0.00e+00	1297.00
IUUC-Meu-056288	Macropus eugenii	87.82	0.00e+00	1119.00
IUUC-Mmr-061639	Microcebus murinus	96.96	0.00e+00	1276.00
IUUC-Mdo-062072	Monodelphis domestica	94.07	0.00e+00	1222.00
IUUC-Mmu-063622	Mus musculus	94.07	0.00e+00	1239.00
IUUC-Mpu-066737	Mustela putorius furo	95.03	0.00e+00	1236.00
IUUC-Mlu-068173	Myotis lucifugus	97.12	0.00e+00	1270.00
IUUC-Nle-069336	Nomascus leucogenys	63.81	0.00e+00	734.00
IUUC-Opr-070432	Ochotona princeps	96.66	0.00e+00	1224.00
IUUC-Ont-072160	Oreochromis niloticus	77.31	0.00e+00	947.00
IUUC-Oan-072691	Ornithorhynchus anatinus	80.50	0.00e+00	976.00
IUUC-Ocu-073798	Oryctolagus cuniculus	96.15	0.00e+00	1267.00
IUUC-Ola-086367	Oryzias latipes	74.70	0.00e+00	917.00
IUUC-Oga-088231	Otolemur garnettii	97.28	0.00e+00	1276.00
IUUC-Oar-089227	Ovis aries	96.31	0.00e+00	1252.00
IUUC-Ptr-091460	Pan troglodytes	100.00	0.00e+00	1310.00
IUUC-Pan-092713	Papio anubis	99.04	0.00e+00	1297.00
IUUC-Pfo-096468	Poecilia formosa	78.10	0.00e+00	954.00
IUUC-Pab-098357	Pongo abelii	99.68	0.00e+00	1304.00
IUUC-Pca-100837	Procavia capensis	95.51	0.00e+00	1249.00
IUUC-Pva-103249	Pteropus vampyrus	94.87	0.00e+00	1210.00
IUUC-Rno-106086	Rattus norvegicus	93.59	0.00e+00	1226.00
IUUC-Sha-107245	Sarcophilus harrisii	93.91	0.00e+00	1221.00
IUUC-Sar-112985	Sorex araneus	95.67	0.00e+00	1256.00
IUUC-Ssc-115756	Sus scrofa	98.08	0.00e+00	1284.00
IUUC-Tgu-116838	Taeniopygia guttata	53.93	2.00e-119	422.00
IUUC-Tru-117644	Takifugu rubripes	77.82	0.00e+00	976.00
IUUC-Tni-120245	Tetraodon nigroviridis	78.19	0.00e+00	963.00
IUUC-Tbe-127472	Tupaia belangeri	98.78	2.00e-149	522.00
IUUC-Ttr-128953	Tursiops truncatus	96.09	0.00e+00	707.00
IUUC-Vpa-130683	Vicugna pacos	94.38	0.00e+00	1104.00
IUUC-Xtr-132827	Xenopus tropicalis	76.28	0.00e+00	952.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence