iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000081307.12	ENST00000356232.8	ENSP00000348565.4
ENSG00000081307.12	ENST00000473651.5	ENSP00000424984.1
ENSG00000081307.12	ENST00000505777.5	ENSP00000427233.1
ENSG00000081307.12	ENST00000464068.5	ENSP00000420055.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E1	E1_ThiF	15071506; 19101823

Classification

Family	E-value	Score	Start	End
E1	1.60e-51	177.6	53	231

Active Site

Position(s)	Description	Evidence
250	Glycyl thioester intermediate	{ECO:0000269\|PubMed:20368332, ECO:0000269\|PubMed:27545674}

Domain Profile

   S: 1    YDRQirl..wGeeaq.eklksakvllvGagglGcEllKnLvlaGvgsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           Y+R+++l  +G++++ ek++++ v +vG+gg+G+ ++++L+ +G+g++ ++D+d+ve++n+nr F f+++++g sK+++a+++l+++npdv 
   Q: 53   YSRLMALkrMGIVSDyEKIRTFAVAIVGVGGVGSVTAEMLTRCGIGKLLLFDYDKVELANMNRLF-FQPHQAGLSKVQAAEHTLRNINPDVL 143
           9****************************************************************.************************** PP
   S: 90   veaheesiteleeeivFfkkf...........dvVvlaldnrearrkvnrlclnarvpliesgtlG..llGqvrviikgltecyscsd 164
           +e+h+++it+ e+ ++F++++           d+V++++dn+ear+++n++c ++    +esg+    + G+++ ii+g  +c  c +
   Q: 144  FEVHNYNITTVENFQHFMDRIsnggleegkpvDLVLSCVDNFEARMTINTACNELGQTWMESGVSEnaVSGHIQLIIPGESACFACAP 231
           ***************************************************************9863367*************99975 PP

Organism

Homo sapiens

Functional Description
(View)

E1-like enzyme which activates UFM1 and SUMO2.

Protein Sequence
(Fasta)

MAESVERLQQ RVQELERELA QERSLQVPRS GDGGGGRVRI EKMSSEVVDS NPYSRLMALK 60
RMGIVSDYEK IRTFAVAIVG VGGVGSVTAE MLTRCGIGKL LLFDYDKVEL ANMNRLFFQP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGTGATAA GATAGCATCT GCTGTGGCCA GGCATCCCTG ACACCTGACA AGAAAGTAAA 60
GCCAAAAGTC AGCTGAAGAT AATGGCCATG GAGATGTCTG TGGAGAGCCG TAAAAGCCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0887--Epilepsy
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0523--Neurodegeneration
KW-0547--Nucleotide-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR029752--D-isomer_DH_CS1
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd

Pfam

PF00899--ThiF

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0071566--F:UFM1 activating enzyme activity
GO:1990592--P:protein K69-linked ufmylation
GO:0071569--P:protein ufmylation
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0034976--P:response to endoplasmic reticulum stress

KEGG

hsa:79876

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001324	Ailuropoda melanoleuca	95.61	0.00e+00	663.00
IUUC-Atr-002660	Amborella trichopoda	70.14	6.00e-112	397.00
IUUC-Apl-003722	Anas platyrhynchos	88.89	5.00e-160	556.00
IUUC-Aca-004584	Anolis carolinensis	88.60	3.00e-169	588.00
IUUC-Aly-005881	Arabidopsis lyrata	66.89	9.00e-110	390.00
IUUC-Ath-007286	Arabidopsis thaliana	71.02	1.00e-113	403.00
IUUC-Ame-011679	Astyanax mexicanus	83.33	1.00e-141	495.00
IUUC-Bta-012517	Bos taurus	95.89	0.00e+00	649.00
IUUC-Bdi-014894	Brachypodium distachyon	69.37	5.00e-111	394.00
IUUC-Bol-016054	Brassica oleracea	71.28	8.00e-114	404.00
IUUC-Bra-016708	Brassica rapa	61.90	8.00e-115	407.00
IUUC-Cel-018424	Caenorhabditis elegans	72.82	2.00e-118	419.00
IUUC-Cja-019825	Callithrix jacchus	96.68	2.00e-148	517.00
IUUC-Cfa-021160	Canis familiaris	96.04	0.00e+00	696.00
IUUC-Cpo-022255	Cavia porcellus	92.25	0.00e+00	642.00
IUUC-Csa-023827	Chlorocebus sabaeus	97.52	0.00e+00	709.00
IUUC-Cho-025078	Choloepus hoffmanni	91.03	0.00e+00	643.00
IUUC-Cin-025217	Ciona intestinalis	71.04	3.00e-152	531.00
IUUC-Dre-027578	Danio rerio	82.35	3.00e-165	574.00
IUUC-Dno-029330	Dasypus novemcinctus	90.70	0.00e+00	647.00
IUUC-Dor-030425	Dipodomys ordii	59.71	3.00e-106	378.00
IUUC-Dme-031645	Drosophila melanogaster	62.80	3.00e-129	455.00
IUUC-Ete-032912	Echinops telfairi	93.98	6.00e-54	204.00
IUUC-Eca-033247	Equus caballus	97.53	0.00e+00	655.00
IUUC-Eeu-034472	Erinaceus europaeus	96.00	3.00e-178	617.00
IUUC-Fca-035684	Felis catus	97.28	0.00e+00	666.00
IUUC-Fal-037654	Ficedula albicollis	86.41	2.00e-162	565.00
IUUC-Gmo-039449	Gadus morhua	67.76	1.00e-127	449.00
IUUC-Gga-041051	Gallus gallus	87.95	6.00e-169	587.00
IUUC-Gac-042325	Gasterosteus aculeatus	76.43	1.00e-165	575.00
IUUC-Gma-043136	Glycine max	67.20	8.00e-119	420.00
IUUC-Ggo-044414	Gorilla gorilla	99.50	0.00e+00	744.00
IUUC-Hvu-047549	Hordeum vulgare	67.97	1.00e-94	339.00
IUUC-Itr-048175	Ictidomys tridecemlineatus	95.72	0.00e+00	669.00
IUUC-Lch-050142	Latimeria chalumnae	81.73	3.00e-175	607.00
IUUC-Lpe-050769	Leersia perrieri	66.31	1.00e-101	363.00
IUUC-Loc-052405	Lepisosteus oculatus	83.75	2.00e-159	555.00
IUUC-Laf-054152	Loxodonta africana	95.05	0.00e+00	690.00
IUUC-Mcc-055618	Macaca mulatta	99.14	0.00e+00	640.00
IUUC-Meu-056486	Macropus eugenii	91.45	2.00e-166	578.00
IUUC-Mtr-057871	Medicago truncatula	71.99	5.00e-116	410.00
IUUC-Mga-059284	Meleagris gallopavo	87.95	3.00e-169	587.00
IUUC-Mmr-061242	Microcebus murinus	95.50	0.00e+00	670.00
IUUC-Mdo-063034	Monodelphis domestica	90.76	4.00e-179	620.00
IUUC-Mmu-064322	Mus musculus	88.53	3.00e-180	624.00
IUUC-Mac-065128	Musa acuminata	60.85	7.00e-69	258.00
IUUC-Mpu-066438	Mustela putorius furo	96.99	0.00e+00	660.00
IUUC-Mlu-067578	Myotis lucifugus	96.71	0.00e+00	659.00
IUUC-Nle-069542	Nomascus leucogenys	98.76	0.00e+00	702.00
IUUC-Opr-070710	Ochotona princeps	88.12	0.00e+00	629.00
IUUC-Ont-072067	Oreochromis niloticus	87.46	8.00e-162	563.00
IUUC-Oan-073593	Ornithorhynchus anatinus	88.92	6.00e-168	583.00
IUUC-Ocu-073964	Oryctolagus cuniculus	92.08	0.00e+00	672.00
IUUC-Oba-075476	Oryza barthii	64.76	3.00e-113	401.00
IUUC-Obr-076517	Oryza brachyantha	70.57	8.00e-112	397.00
IUUC-Ogu-078664	Oryza glumaepatula	65.08	1.00e-113	403.00
IUUC-Olo-081012	Oryza longistaminata	64.76	4.00e-113	401.00
IUUC-Ome-081129	Oryza meridionalis	69.58	4.00e-113	401.00
IUUC-Oni-082265	Oryza nivara	64.33	8.00e-112	397.00
IUUC-Opu-084121	Oryza punctata	70.57	2.00e-112	399.00
IUUC-Oru-084451	Oryza rufipogon	70.00	3.00e-97	348.00
IUUC-Osa-086132	Oryza sativa	64.76	3.00e-113	401.00
IUUC-Ola-086842	Oryzias latipes	81.84	1.00e-158	552.00
IUUC-Oga-088160	Otolemur garnettii	94.55	0.00e+00	654.00
IUUC-Oar-089362	Ovis aries	96.44	0.00e+00	657.00
IUUC-Ptr-091256	Pan troglodytes	99.50	0.00e+00	751.00
IUUC-Pan-092913	Papio anubis	97.94	0.00e+00	682.00
IUUC-Psi-093740	Pelodiscus sinensis	89.74	1.00e-159	555.00
IUUC-Pma-094485	Petromyzon marinus	84.30	2.00e-107	380.00
IUUC-Ppa-095673	Physcomitrella patens	69.46	1.00e-113	403.00
IUUC-Pfo-096196	Poecilia formosa	82.45	6.00e-164	570.00
IUUC-Pab-098449	Pongo abelii	98.76	0.00e+00	743.00
IUUC-Pop-099049	Populus trichocarpa	66.04	3.00e-111	395.00
IUUC-Pca-100917	Procavia capensis	95.82	2.00e-119	422.00
IUUC-Ppe-101797	Prunus persica	66.24	4.00e-116	411.00
IUUC-Pva-102852	Pteropus vampyrus	97.01	0.00e+00	657.00
IUUC-Rno-105213	Rattus norvegicus	88.03	0.00e+00	627.00
IUUC-Sha-107569	Sarcophilus harrisii	85.09	0.00e+00	627.00
IUUC-Smo-109146	Selaginella moellendorffii	67.19	3.00e-114	405.00
IUUC-Sit-109794	Setaria italica	67.45	1.00e-114	407.00
IUUC-Sly-111622	Solanum lycopersicum	71.28	2.00e-114	405.00
IUUC-Stu-112522	Solanum tuberosum	70.63	7.00e-115	407.00
IUUC-Sar-113045	Sorex araneus	82.72	2.00e-165	575.00
IUUC-Sbi-113861	Sorghum bicolor	64.87	8.00e-114	403.00
IUUC-Ssc-115290	Sus scrofa	96.72	1.00e-162	565.00
IUUC-Tgu-117125	Taeniopygia guttata	86.34	3.00e-164	571.00
IUUC-Tru-118041	Takifugu rubripes	84.24	4.00e-167	580.00
IUUC-Tsy-119300	Tarsius syrichta	85.71	3.00e-152	531.00
IUUC-Tni-120310	Tetraodon nigroviridis	83.70	9.00e-161	559.00
IUUC-Tca-121405	Theobroma cacao	66.98	4.00e-115	408.00
IUUC-Tae-123656	Triticum aestivum	64.76	1.00e-112	399.00
IUUC-Tur-125985	Triticum urartu	68.86	2.00e-112	399.00
IUUC-Tbe-127478	Tupaia belangeri	89.24	9.00e-151	526.00
IUUC-Ttr-128169	Tursiops truncatus	75.25	2.00e-145	508.00
IUUC-Vpa-130508	Vicugna pacos	89.71	5.00e-161	560.00
IUUC-Vvi-131252	Vitis vinifera	66.35	5.00e-115	407.00
IUUC-Xtr-132776	Xenopus tropicalis	83.83	4.00e-164	570.00
IUUC-Xma-133110	Xiphophorus maculatus	81.38	1.00e-164	572.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence