iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	5.70e-40	135.2	637	668
UBD/Beta-Prp	1.60e-61	209.8	57	265

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWD 29
           gHt+++t++a+   +d++lvs+s+Dgt +vWD
   Q: 637  GHTAKITSVAWsphHDGRLVSASYDGTAQVWD 668
           8***********8766**************** PP

UBD/Beta-Prp

   S: 45   lrslsgheaevtavkfspdgk...ilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp.sgdklvsGshdrtirvwdletgqcleet 132
           + +l gh++ v+  +fs++     + +t+s+D+t+k+wd++t + v     h++++ +l++sp  +d +vsG++  ++ ++  + +      
   Q: 57   IGELVGHTERVSGFTFSHHPGqynLCATSSDDGTVKIWDVETKTVVTEHALHQHTISTLHWSPrVKDLIVSGDEKGVVFCYWFNRNDSQ--H 146
           7899**************965677***************************************666**************855555555..4 PP
   S: 133  lsghdgvvncvvvhpdg.nllvsGslDrtvrlWdl.ktgkllrtltgghtdsvysls...........fdsng................... 192
           l ++ +++ c++ +p   +l++ G +D++v + d+ k g+++++l+g h+d ++s++           +                       
   Q: 147  LFIEPRTIFCLTCSPHHeDLVAIGYKDGIVVIIDIsKKGEVIHRLRG-HDDEIHSIAwcplpgedclsI---Nqeetseeaeitngnavaqa 234
           899999999999999999*****************999********9.*********777666666441...04667788888999999999 PP
   S: 193  .....kelvsgsldgtvklwdlqtgecvrtl 218
                 +l++gs+d+t+++w++++g+ v++l
   Q: 235  pvtkgCYLATGSKDQTIRIWSCSRGRGVMIL 265
           99999******************99877765 PP

Organism

Homo sapiens

Functional Description
(View)

Required for the assembly of the SMN complex that plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:16857593, PubMed:18984161, PubMed:20513430). Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:18984161). GEMIN5 acts as the snRNA-binding protein of the SMN complex (PubMed:11714716, PubMed:16857593, PubMed:19377484, PubMed:19750007, PubMed:20513430, PubMed:27834343, PubMed:27881600, PubMed:27881601). Binds to the 7-methylguanosine cap of RNA molecules (PubMed:19750007, PubMed:27834343, PubMed:27881600, PubMed:27881601, Ref.24). Binds to the 3'-UTR of SMN1 mRNA and regulates its translation; does not affect mRNA stability (PubMed:25911097). May play a role in the regulation of protein synthesis via its interaction with ribosomes (PubMed:27507887).

Protein Sequence
(Fasta)

MGQEPRTLPP SPNWYCARCS DAVPGGLFGF AARTSVFLVR VGPGAGESPG TPPFRVIGEL 60
VGHTERVSGF TFSHHPGQYN LCATSSDDGT VKIWDVETKT VVTEHALHQH TISTLHWSPR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGCTCCCT ACCTAAGGCG TGAGGCTACG AGCGGTCGGC TGTGGCAGCT TCTCTTGTCT 60
CTGACGGCTT GTAGTTATGG GGCAGGAGCC GCGGACGCTG CCGCCCTCCC CCAACTGGTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0810--Translation regulation
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR020472--G-protein_beta_WD-40_rep
IPR011047--Quinoprotein_ADH-like_supfam
IPR011990--TPR-like_helical_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0097504--C:Gemini of coiled bodies
GO:0016020--C:membrane
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0032797--C:SMN complex
GO:0034718--C:SMN-Gemin2 complex
GO:0034719--C:SMN-Sm protein complex
GO:0003730--F:mRNA 3'-UTR binding
GO:0043022--F:ribosome binding
GO:0000340--F:RNA 7-methylguanosine cap binding
GO:0003723--F:RNA binding
GO:0017069--F:snRNA binding
GO:0030619--F:U1 snRNA binding
GO:0030621--F:U4 snRNA binding
GO:0030622--F:U4atac snRNA binding
GO:0000398--P:mRNA splicing, via spliceosome
GO:0051170--P:nuclear import
GO:0006461--P:protein complex assembly
GO:0006417--P:regulation of translation
GO:0000387--P:spliceosomal snRNP assembly
GO:0006412--P:translation

KEGG

hsa:25929

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001199	Ailuropoda melanoleuca	88.89	0.00e+00	2606.00
IUUC-Apl-003586	Anas platyrhynchos	61.74	0.00e+00	1592.00
IUUC-Aca-004956	Anolis carolinensis	62.49	0.00e+00	1833.00
IUUC-Ame-010753	Astyanax mexicanus	50.20	0.00e+00	1461.00
IUUC-Bta-012315	Bos taurus	87.44	0.00e+00	2592.00
IUUC-Cja-019334	Callithrix jacchus	95.49	0.00e+00	2881.00
IUUC-Cfa-021254	Canis familiaris	88.47	0.00e+00	2664.00
IUUC-Cpo-021984	Cavia porcellus	81.79	0.00e+00	2331.00
IUUC-Csa-023650	Chlorocebus sabaeus	97.22	0.00e+00	2881.00
IUUC-Cho-024860	Choloepus hoffmanni	82.78	0.00e+00	2376.00
IUUC-Cin-025778	Ciona intestinalis	37.91	0.00e+00	666.00
IUUC-Csv-026313	Ciona savignyi	40.85	3.00e-164	572.00
IUUC-Dre-028096	Danio rerio	62.90	0.00e+00	1006.00
IUUC-Dno-029799	Dasypus novemcinctus	89.40	0.00e+00	2250.00
IUUC-Dor-030885	Dipodomys ordii	73.96	0.00e+00	1103.00
IUUC-Ete-032918	Echinops telfairi	81.06	0.00e+00	2394.00
IUUC-Eca-034144	Equus caballus	88.30	0.00e+00	2548.00
IUUC-Eeu-034843	Erinaceus europaeus	78.97	0.00e+00	1777.00
IUUC-Fca-035948	Felis catus	88.70	0.00e+00	2612.00
IUUC-Fal-037303	Ficedula albicollis	61.75	0.00e+00	1774.00
IUUC-Gmo-039591	Gadus morhua	53.02	0.00e+00	840.00
IUUC-Gga-040570	Gallus gallus	62.55	0.00e+00	1618.00
IUUC-Gac-042646	Gasterosteus aculeatus	48.25	0.00e+00	1358.00
IUUC-Ggo-045605	Gorilla gorilla	89.16	0.00e+00	2030.00
IUUC-Itr-048094	Ictidomys tridecemlineatus	91.79	0.00e+00	2334.00
IUUC-Lch-050489	Latimeria chalumnae	58.01	0.00e+00	650.00
IUUC-Loc-052259	Lepisosteus oculatus	50.63	0.00e+00	1405.00
IUUC-Laf-053338	Loxodonta africana	88.12	0.00e+00	2590.00
IUUC-Mcc-055442	Macaca mulatta	97.42	0.00e+00	2883.00
IUUC-Meu-056245	Macropus eugenii	81.31	0.00e+00	853.00
IUUC-Mga-060202	Meleagris gallopavo	62.69	0.00e+00	1681.00
IUUC-Mmr-061730	Microcebus murinus	90.06	0.00e+00	2631.00
IUUC-Mdo-062880	Monodelphis domestica	73.93	0.00e+00	2167.00
IUUC-Mmu-063930	Mus musculus	82.01	0.00e+00	2297.00
IUUC-Mpu-066605	Mustela putorius furo	88.55	0.00e+00	2631.00
IUUC-Mlu-067765	Myotis lucifugus	88.71	0.00e+00	2647.00
IUUC-Nle-069183	Nomascus leucogenys	98.01	0.00e+00	2862.00
IUUC-Opr-070659	Ochotona princeps	78.18	0.00e+00	1160.00
IUUC-Ont-072356	Oreochromis niloticus	61.93	0.00e+00	1010.00
IUUC-Oan-073056	Ornithorhynchus anatinus	71.19	0.00e+00	1963.00
IUUC-Ocu-073881	Oryctolagus cuniculus	88.84	0.00e+00	2661.00
IUUC-Ola-087120	Oryzias latipes	57.49	3.00e-67	248.00
IUUC-Olu-087648	Ostreococcus lucimarinus	22.80	2.00e-31	132.00
IUUC-Oga-088343	Otolemur garnettii	90.66	0.00e+00	2687.00
IUUC-Oar-089257	Ovis aries	87.88	0.00e+00	2619.00
IUUC-Ptr-090497	Pan troglodytes	99.40	0.00e+00	2903.00
IUUC-Pan-092638	Papio anubis	96.96	0.00e+00	2866.00
IUUC-Psi-093096	Pelodiscus sinensis	64.67	0.00e+00	1603.00
IUUC-Pma-094571	Petromyzon marinus	43.76	6.00e-87	314.00
IUUC-Pfo-096742	Poecilia formosa	49.22	0.00e+00	1358.00
IUUC-Pab-098153	Pongo abelii	98.47	0.00e+00	2914.00
IUUC-Pca-100957	Procavia capensis	81.06	0.00e+00	2405.00
IUUC-Pva-102439	Pteropus vampyrus	90.06	0.00e+00	2704.00
IUUC-Rno-105891	Rattus norvegicus	82.27	0.00e+00	2296.00
IUUC-Sha-107181	Sarcophilus harrisii	73.82	0.00e+00	2076.00
IUUC-Ssc-115413	Sus scrofa	88.04	0.00e+00	2643.00
IUUC-Tgu-117082	Taeniopygia guttata	62.33	0.00e+00	1761.00
IUUC-Tru-118491	Takifugu rubripes	59.10	0.00e+00	948.00
IUUC-Tsy-119629	Tarsius syrichta	93.77	1.00e-164	574.00
IUUC-Tni-120240	Tetraodon nigroviridis	59.73	0.00e+00	952.00
IUUC-Tbe-127673	Tupaia belangeri	78.38	0.00e+00	2173.00
IUUC-Ttr-128562	Tursiops truncatus	85.75	0.00e+00	2547.00
IUUC-Vpa-130596	Vicugna pacos	84.57	0.00e+00	1863.00
IUUC-Xtr-132469	Xenopus tropicalis	56.60	0.00e+00	1623.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence