iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ame-011847

Ensembl Protein ID

ENSAMXP00000001447.1

UniProt Accession

W5K1I7; W5K1I7_ASTMX

Genbank Protein ID

ENSAMXP00000001447

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

APWO01088436

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMXG00000001422.1	ENSAMXT00000001447.1	ENSAMXP00000001447.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.30e-117	393.2	599	928

Active Site

Position(s)	Description	Evidence
899	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s + np+hl++F+f+G++lg+al++++l+++ 
   Q: 599  EKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIINPDYALFTQSA-DGTTFQPNSNSSV-NPDHLNYFRFAGQILGLALYHRQLVNIY 684
           78999**************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i+Vt+eNk eYv+lv+e+
   Q: 685  FTRSFYKHILGIPVNYQDVSSIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVALKPGGTSIQVTQENKAEYVQLVTEL 770
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf++ ip++l++lF+e elell++G++eidv d+k++t+y++gy  ++p+iqwFw+v+e++++eer  +LqFvT
   Q: 771  RMTRAIQPQINAFLQGFHTFIPPSLIQLFDEYELELLLSGMPEIDVLDWKRNTEYTSGYDTEEPVIQWFWDVVESLTQEERVLLLQFVT 859
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa ++     ++f+i     + + lP+s+TC+n+LkLPeY+sk++l+++Ll+A + +  g
   Q: 860  GSSRVPHGGFAFIMggsgLQKFTIAAvPYTSNLLPTSSTCINMLKLPEYPSKDVLRDRLLVALHCGsYG 928
           ******************88899998677779*******************************986555 PP

Organism

Astyanax mexicanus

Protein Sequence
(Fasta)

MERAMEQLNV QLNRLTRSLR RARTVELPED NETAVYTLMP MVMADQHRSV SELLLNSKFD 60
VNYAFGRVKR SLLHIAANCG SVECLVLLLK RGANPNYQDI SGCTPLHLAA RNGQKKCMGR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATATGTTATT TCTTTAATTA CACTGTTTAA AATCAATACA ACACTAATCC AACATAGATT 60
CATATTTATC TTCCTAAATA TTTAATGAAA AGGACCTACA CGGCTAAGAA ATACAAAAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	84.49	0.00e+00	1632.00
IUUC-Apl-003400	Anas platyrhynchos	81.59	0.00e+00	1068.00
IUUC-Aca-005375	Anolis carolinensis	83.70	0.00e+00	1627.00
IUUC-Bta-012831	Bos taurus	84.83	0.00e+00	1601.00
IUUC-Cja-019160	Callithrix jacchus	84.88	0.00e+00	1644.00
IUUC-Cfa-020346	Canis familiaris	84.66	0.00e+00	1640.00
IUUC-Cpo-021766	Cavia porcellus	84.55	0.00e+00	1641.00
IUUC-Csa-023768	Chlorocebus sabaeus	84.76	0.00e+00	1645.00
IUUC-Cho-024688	Choloepus hoffmanni	77.88	0.00e+00	994.00
IUUC-Cin-025417	Ciona intestinalis	51.40	2.00e-141	496.00
IUUC-Csv-025993	Ciona savignyi	47.08	1.00e-143	503.00
IUUC-Dre-027819	Danio rerio	91.31	0.00e+00	1774.00
IUUC-Dno-029027	Dasypus novemcinctus	84.21	0.00e+00	1628.00
IUUC-Dor-030327	Dipodomys ordii	77.92	0.00e+00	1428.00
IUUC-Ete-032966	Echinops telfairi	78.41	0.00e+00	1510.00
IUUC-Eca-034339	Equus caballus	84.97	0.00e+00	1642.00
IUUC-Eeu-034544	Erinaceus europaeus	75.71	3.00e-137	482.00
IUUC-Fca-035617	Felis catus	81.18	0.00e+00	1126.00
IUUC-Fal-036687	Ficedula albicollis	84.71	0.00e+00	1659.00
IUUC-Gmo-039508	Gadus morhua	91.80	0.00e+00	866.00
IUUC-Gga-040845	Gallus gallus	84.98	0.00e+00	1669.00
IUUC-Gac-041894	Gasterosteus aculeatus	89.08	0.00e+00	1666.00
IUUC-Ggo-044465	Gorilla gorilla	81.43	0.00e+00	1568.00
IUUC-Hsa-045731	Homo sapiens	84.87	0.00e+00	1647.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	85.24	0.00e+00	1650.00
IUUC-Lch-050436	Latimeria chalumnae	86.79	0.00e+00	1680.00
IUUC-Loc-052287	Lepisosteus oculatus	88.67	0.00e+00	1755.00
IUUC-Laf-053846	Loxodonta africana	85.19	0.00e+00	1657.00
IUUC-Mcc-055845	Macaca mulatta	84.87	0.00e+00	1647.00
IUUC-Meu-056060	Macropus eugenii	84.78	0.00e+00	644.00
IUUC-Mga-059935	Meleagris gallopavo	84.29	0.00e+00	1633.00
IUUC-Mmr-060960	Microcebus murinus	84.87	0.00e+00	1647.00
IUUC-Mdo-061851	Monodelphis domestica	84.87	0.00e+00	1660.00
IUUC-Mmu-063657	Mus musculus	84.96	0.00e+00	1644.00
IUUC-Mpu-066161	Mustela putorius furo	91.96	0.00e+00	769.00
IUUC-Mlu-067354	Myotis lucifugus	83.37	0.00e+00	1565.00
IUUC-Nle-069112	Nomascus leucogenys	84.87	0.00e+00	1647.00
IUUC-Opr-070686	Ochotona princeps	82.23	0.00e+00	750.00
IUUC-Ont-072398	Oreochromis niloticus	89.27	0.00e+00	1676.00
IUUC-Oan-073194	Ornithorhynchus anatinus	84.77	0.00e+00	1585.00
IUUC-Ocu-074397	Oryctolagus cuniculus	76.74	0.00e+00	1442.00
IUUC-Ola-086777	Oryzias latipes	87.46	0.00e+00	1669.00
IUUC-Oga-088684	Otolemur garnettii	84.78	0.00e+00	1642.00
IUUC-Oar-089428	Ovis aries	84.01	0.00e+00	1604.00
IUUC-Ptr-090529	Pan troglodytes	84.76	0.00e+00	1645.00
IUUC-Pan-091702	Papio anubis	84.76	0.00e+00	1645.00
IUUC-Psi-093969	Pelodiscus sinensis	85.01	0.00e+00	1599.00
IUUC-Pfo-097364	Poecilia formosa	90.02	0.00e+00	1701.00
IUUC-Pab-098574	Pongo abelii	84.87	0.00e+00	1647.00
IUUC-Pca-100525	Procavia capensis	80.11	3.00e-167	582.00
IUUC-Pva-102365	Pteropus vampyrus	74.39	0.00e+00	1385.00
IUUC-Rno-105153	Rattus norvegicus	84.32	0.00e+00	1638.00
IUUC-Sha-107319	Sarcophilus harrisii	85.40	0.00e+00	1659.00
IUUC-Stu-112894	Solanum tuberosum	35.33	1.00e-55	211.00
IUUC-Sar-113449	Sorex araneus	63.54	2.00e-136	480.00
IUUC-Ssc-115865	Sus scrofa	84.44	0.00e+00	1639.00
IUUC-Tgu-117225	Taeniopygia guttata	85.08	0.00e+00	1665.00
IUUC-Tru-118026	Takifugu rubripes	88.89	0.00e+00	1676.00
IUUC-Tsy-119407	Tarsius syrichta	72.70	0.00e+00	1351.00
IUUC-Tni-120234	Tetraodon nigroviridis	88.89	0.00e+00	1349.00
IUUC-Tbe-127708	Tupaia belangeri	70.79	0.00e+00	722.00
IUUC-Ttr-128667	Tursiops truncatus	84.44	0.00e+00	1640.00
IUUC-Vpa-130200	Vicugna pacos	84.37	0.00e+00	1586.00
IUUC-Xtr-132176	Xenopus tropicalis	84.43	0.00e+00	1658.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence