iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027819

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase HACE1

Genbank Nucleotide ID

CU928063

Gene Name

hace1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000062280.6	ENSDART00000149463.1	ENSDARP00000124679.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.00e-118	395.6	571	901

Active Site

Position(s)	Description	Evidence
872	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           +++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s + np+hl++F+f+G++lg+al++++l+++
   Q: 571  NEKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIINPDYALFTQSA-DGTTFQPNSNSSV-NPDHLNYFRFAGQILGLALYHRQLVNI 656
           678999**************.**********************6666.67788*******9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +++sfyk++lg ++s++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g+++e+ LkpgG +i+Vt++NkeeYv+lv+e
   Q: 657  YFTRSFYKHILGIPVSYQDVSSIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGTMEEVPLKPGGTTIQVTQDNKEEYVQLVTE 742
           ***********************************99...************************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++ i+ q++af +Gf++ ip++l++lF+e elell++G++eidv d+k++t+y++gy  ++p+iqwFwev+e++++eer  +LqFv
   Q: 743  LRMTRAIQPQINAFLQGFHTFIPPSLIQLFDEYELELLLSGMPEIDVMDWKRNTEYTSGYDLQEPVIQWFWEVVENLTQEERVLLLQFV 831
           ***************************************************************************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           Tgssr+P+gGfa l+     ++f++     + + lP+s+TC+n+LkLPeY+sk++l+++Ll+A + +  g
   Q: 832  TGSSRVPHGGFAFLMggsgLQKFTVAAvPYTSNLLPTSSTCINMLKLPEYPSKDVLRDRLLVALHCGsYG 901
           *******************78888888577779*******************************986555 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MMERAMEHLN VQLNRLTRSL RRARTVELPE DSETAVYTLM PMVMADQHRS VSELLLNSKF 60
DVNYAFGRVK RSLLHIAANC GSVECLVLLL KRGANPNYQD ISGCTPLHLA ARNGQKKCMG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATGAATCA TAGAGCGGCG GAGGGACGTT CTGCGGCGGA ATGAGTCGTG AACGCAGGCA 60
GCAGCTGATG GACGAGGTCG AGGGTCTGTC ATTTCACAGA GAAAGAGAGC AAATGAGCGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	85.36	0.00e+00	1621.00
IUUC-Apl-003400	Anas platyrhynchos	78.16	0.00e+00	1032.00
IUUC-Aca-005375	Anolis carolinensis	84.71	0.00e+00	1623.00
IUUC-Ame-011847	Astyanax mexicanus	91.31	0.00e+00	1774.00
IUUC-Bta-012831	Bos taurus	85.62	0.00e+00	1588.00
IUUC-Bol-016533	Brassica oleracea	52.35	8.00e-81	293.00
IUUC-Cja-019160	Callithrix jacchus	85.65	0.00e+00	1631.00
IUUC-Cfa-020346	Canis familiaris	85.53	0.00e+00	1628.00
IUUC-Cpo-021766	Cavia porcellus	85.64	0.00e+00	1629.00
IUUC-Csa-023768	Chlorocebus sabaeus	85.53	0.00e+00	1633.00
IUUC-Cho-024688	Choloepus hoffmanni	78.62	0.00e+00	982.00
IUUC-Cin-025417	Ciona intestinalis	51.40	6.00e-141	495.00
IUUC-Csv-025993	Ciona savignyi	45.35	0.00e+00	776.00
IUUC-Dno-029027	Dasypus novemcinctus	84.76	0.00e+00	1624.00
IUUC-Dor-030327	Dipodomys ordii	78.23	0.00e+00	1416.00
IUUC-Ete-032966	Echinops telfairi	79.02	0.00e+00	1502.00
IUUC-Eca-034339	Equus caballus	85.53	0.00e+00	1630.00
IUUC-Eeu-034544	Erinaceus europaeus	58.65	1.00e-157	550.00
IUUC-Fca-035617	Felis catus	82.57	0.00e+00	1114.00
IUUC-Fal-036687	Ficedula albicollis	82.77	0.00e+00	1624.00
IUUC-Gmo-039508	Gadus morhua	81.74	0.00e+00	1221.00
IUUC-Gga-040845	Gallus gallus	82.46	0.00e+00	1632.00
IUUC-Gac-041894	Gasterosteus aculeatus	90.51	0.00e+00	1665.00
IUUC-Ggo-044465	Gorilla gorilla	82.21	0.00e+00	1558.00
IUUC-Hsa-045731	Homo sapiens	85.64	0.00e+00	1634.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	86.14	0.00e+00	1638.00
IUUC-Lch-050436	Latimeria chalumnae	87.42	0.00e+00	1669.00
IUUC-Loc-052287	Lepisosteus oculatus	86.86	0.00e+00	1720.00
IUUC-Laf-053846	Loxodonta africana	85.98	0.00e+00	1645.00
IUUC-Mcc-055845	Macaca mulatta	85.64	0.00e+00	1635.00
IUUC-Meu-056060	Macropus eugenii	89.02	0.00e+00	650.00
IUUC-Mga-059935	Meleagris gallopavo	84.63	0.00e+00	1619.00
IUUC-Mmr-060960	Microcebus murinus	85.75	0.00e+00	1635.00
IUUC-Mdo-061851	Monodelphis domestica	82.77	0.00e+00	1621.00
IUUC-Mmu-063657	Mus musculus	85.31	0.00e+00	1629.00
IUUC-Mpu-066161	Mustela putorius furo	90.70	0.00e+00	765.00
IUUC-Mlu-067354	Myotis lucifugus	84.66	0.00e+00	1560.00
IUUC-Nle-069112	Nomascus leucogenys	85.64	0.00e+00	1636.00
IUUC-Opr-070686	Ochotona princeps	81.32	0.00e+00	747.00
IUUC-Ont-072398	Oreochromis niloticus	89.71	0.00e+00	1659.00
IUUC-Oan-073194	Ornithorhynchus anatinus	86.27	0.00e+00	1587.00
IUUC-Ocu-074397	Oryctolagus cuniculus	78.07	0.00e+00	1438.00
IUUC-Ola-086777	Oryzias latipes	84.74	0.00e+00	1639.00
IUUC-Oga-088684	Otolemur garnettii	85.54	0.00e+00	1630.00
IUUC-Oar-089428	Ovis aries	84.66	0.00e+00	1592.00
IUUC-Ptr-090529	Pan troglodytes	85.53	0.00e+00	1632.00
IUUC-Pan-091702	Papio anubis	85.53	0.00e+00	1633.00
IUUC-Psi-093969	Pelodiscus sinensis	82.60	0.00e+00	1565.00
IUUC-Pfo-097364	Poecilia formosa	90.40	0.00e+00	1677.00
IUUC-Pab-098574	Pongo abelii	85.64	0.00e+00	1634.00
IUUC-Pca-100525	Procavia capensis	78.73	3.00e-164	572.00
IUUC-Pva-102365	Pteropus vampyrus	74.97	0.00e+00	1372.00
IUUC-Rno-105153	Rattus norvegicus	84.87	0.00e+00	1626.00
IUUC-Sha-107319	Sarcophilus harrisii	82.86	0.00e+00	1622.00
IUUC-Stu-112894	Solanum tuberosum	35.61	5.00e-56	213.00
IUUC-Sar-113449	Sorex araneus	65.23	8.00e-135	474.00
IUUC-Ssc-115865	Sus scrofa	85.53	0.00e+00	1627.00
IUUC-Tgu-117225	Taeniopygia guttata	82.56	0.00e+00	1630.00
IUUC-Tru-118026	Takifugu rubripes	87.81	0.00e+00	1647.00
IUUC-Tsy-119407	Tarsius syrichta	73.23	0.00e+00	1339.00
IUUC-Tni-120234	Tetraodon nigroviridis	89.19	0.00e+00	1322.00
IUUC-Tur-126774	Triticum urartu	31.52	9.00e-47	182.00
IUUC-Tbe-127708	Tupaia belangeri	72.91	0.00e+00	721.00
IUUC-Ttr-128667	Tursiops truncatus	85.20	0.00e+00	1626.00
IUUC-Vpa-130200	Vicugna pacos	85.26	0.00e+00	1574.00
IUUC-Xtr-132176	Xenopus tropicalis	82.49	0.00e+00	1624.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence