iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-053846

UUCD1 version

UUC-LoA-00102

Ensembl Protein ID

ENSLAFP00000002494.3

UniProt Accession

G3SRI5; G3SRI5_LOXAF

Protein Name

Uncharacterized protein

Gene Name

HACE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000002989.3	ENSLAFT00000002992.3	ENSLAFP00000002494.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.60e-118	395.6	577	906

Active Site

Position(s)	Description	Evidence
877	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s+ d +t+qpn++s++ np+hl++F+f+G++lg+al +++l+++ 
   Q: 577  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSA-DGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIY 662
           679999*************.**********************6666.67788*******9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i Vt++Nk eYv+lv+e+
   Q: 663  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTEL 748
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy++++p+iqwFwev+e++++eer  +LqFvT
   Q: 749  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVSDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVT 837
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa+++     + f+i     +++ lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 838  GSSRVPHGGFANIMggsgLQNFTIAAvPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 906
           ******************8888888868888********************************986555 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MERAMEQLNR LTRSLRRART VELPEDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA 60
FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT PLHLAARNGQ KKCMSKLLEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGAGAG CGATGGAGCA GCTCAACCGT CTGACGCGCT CGCTGCGCCG CGCGCGCACC 60
GTAGAGCTGC CCGAGGGTGA GCGGGACTGG GGGGCGGCGG GGGCGGGACG GGCCGTGCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0000139--C:Golgi membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration

KEGG

lav:100661959

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	98.25	0.00e+00	1858.00
IUUC-Apl-003400	Anas platyrhynchos	88.50	0.00e+00	1162.00
IUUC-Aca-005375	Anolis carolinensis	91.21	0.00e+00	1736.00
IUUC-Ame-011847	Astyanax mexicanus	85.19	0.00e+00	1657.00
IUUC-Bta-012831	Bos taurus	97.98	0.00e+00	1819.00
IUUC-Cja-019160	Callithrix jacchus	99.01	0.00e+00	1880.00
IUUC-Cfa-020346	Canis familiaris	98.35	0.00e+00	1867.00
IUUC-Cpo-021766	Cavia porcellus	97.47	0.00e+00	1854.00
IUUC-Csa-023768	Chlorocebus sabaeus	98.68	0.00e+00	1878.00
IUUC-Cho-024688	Choloepus hoffmanni	94.68	0.00e+00	1190.00
IUUC-Cin-025417	Ciona intestinalis	50.84	3.00e-139	489.00
IUUC-Csv-025993	Ciona savignyi	43.73	0.00e+00	756.00
IUUC-Dre-027819	Danio rerio	85.98	0.00e+00	1645.00
IUUC-Dno-029027	Dasypus novemcinctus	97.92	0.00e+00	1858.00
IUUC-Dor-030327	Dipodomys ordii	90.61	0.00e+00	1635.00
IUUC-Ete-032966	Echinops telfairi	90.99	0.00e+00	1721.00
IUUC-Eca-034339	Equus caballus	98.24	0.00e+00	1862.00
IUUC-Eeu-034544	Erinaceus europaeus	70.17	0.00e+00	690.00
IUUC-Fca-035617	Felis catus	98.31	0.00e+00	1331.00
IUUC-Fal-036687	Ficedula albicollis	91.61	0.00e+00	1772.00
IUUC-Gmo-039508	Gadus morhua	88.38	0.00e+00	835.00
IUUC-Gga-040845	Gallus gallus	91.83	0.00e+00	1794.00
IUUC-Gac-041894	Gasterosteus aculeatus	85.25	0.00e+00	1590.00
IUUC-Ggo-044465	Gorilla gorilla	94.96	0.00e+00	1796.00
IUUC-Hsa-045731	Homo sapiens	98.90	0.00e+00	1882.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	98.90	0.00e+00	1872.00
IUUC-Lch-050436	Latimeria chalumnae	90.05	0.00e+00	1706.00
IUUC-Loc-052287	Lepisosteus oculatus	85.40	0.00e+00	1670.00
IUUC-Mcc-055845	Macaca mulatta	98.79	0.00e+00	1880.00
IUUC-Meu-056060	Macropus eugenii	97.98	0.00e+00	706.00
IUUC-Mga-059935	Meleagris gallopavo	94.33	0.00e+00	1770.00
IUUC-Mmr-060960	Microcebus murinus	99.01	0.00e+00	1880.00
IUUC-Mdo-061851	Monodelphis domestica	93.42	0.00e+00	1826.00
IUUC-Mmu-063657	Mus musculus	96.81	0.00e+00	1845.00
IUUC-Mpu-066161	Mustela putorius furo	99.50	0.00e+00	833.00
IUUC-Mlu-067354	Myotis lucifugus	96.59	0.00e+00	1793.00
IUUC-Nle-069112	Nomascus leucogenys	98.79	0.00e+00	1879.00
IUUC-Opr-070686	Ochotona princeps	89.29	0.00e+00	813.00
IUUC-Ont-072398	Oreochromis niloticus	84.87	0.00e+00	1593.00
IUUC-Oan-073194	Ornithorhynchus anatinus	95.43	0.00e+00	1750.00
IUUC-Ocu-074397	Oryctolagus cuniculus	86.56	0.00e+00	1588.00
IUUC-Ola-086777	Oryzias latipes	81.05	0.00e+00	1568.00
IUUC-Oga-088684	Otolemur garnettii	98.79	0.00e+00	1873.00
IUUC-Oar-089428	Ovis aries	97.88	0.00e+00	1830.00
IUUC-Ptr-090529	Pan troglodytes	98.79	0.00e+00	1879.00
IUUC-Pan-091702	Papio anubis	98.68	0.00e+00	1878.00
IUUC-Psi-093969	Pelodiscus sinensis	91.30	0.00e+00	1716.00
IUUC-Pfo-097364	Poecilia formosa	86.20	0.00e+00	1615.00
IUUC-Pab-098574	Pongo abelii	98.90	0.00e+00	1882.00
IUUC-Pca-100525	Procavia capensis	87.15	9.00e-180	624.00
IUUC-Pva-102365	Pteropus vampyrus	87.14	0.00e+00	1604.00
IUUC-Rno-105153	Rattus norvegicus	96.70	0.00e+00	1846.00
IUUC-Sha-107319	Sarcophilus harrisii	93.31	0.00e+00	1818.00
IUUC-Sar-113449	Sorex araneus	81.32	9.00e-176	610.00
IUUC-Ssc-115865	Sus scrofa	98.35	0.00e+00	1866.00
IUUC-Tgu-117225	Taeniopygia guttata	91.61	0.00e+00	1790.00
IUUC-Tru-118026	Takifugu rubripes	82.50	0.00e+00	1570.00
IUUC-Tsy-119407	Tarsius syrichta	85.71	0.00e+00	1573.00
IUUC-Tni-120234	Tetraodon nigroviridis	84.13	0.00e+00	1272.00
IUUC-Tur-126774	Triticum urartu	29.17	5.00e-46	179.00
IUUC-Tbe-127708	Tupaia belangeri	88.68	0.00e+00	875.00
IUUC-Ttr-128667	Tursiops truncatus	98.13	0.00e+00	1865.00
IUUC-Vpa-130200	Vicugna pacos	98.30	0.00e+00	1809.00
IUUC-Xtr-132176	Xenopus tropicalis	87.61	0.00e+00	1707.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence