iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067354

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02042001

Gene Name

HACE1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000016249.2	ENSMLUT00000016255.2	ENSMLUP00000014811.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-118	396.5	576	906

Active Site

Position(s)	Description	Evidence
877	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlp 91
           ++lk+ + v+f gEeg+++ Gv re+++ ls+e+ npd+ lf++s++  +t+qpn++s++ np+hl++F+f+G++lg+al +++l+++ 
   Q: 576  AKLKQGIAVRFHGEEGMGQ-GVVREWFDILSNEIVNPDYALFTQSADVGTTFQPNSNSYV-NPDHLNYFRFAGQILGLALNHRQLVNIY 662
           679999*************.***************************************9.89************************** PP
   S: 92   lsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           +++sfyk++lg +++++d++++dpe++k+l++i++n   di++lgl+ltfsv+++++g ++e+ LkpgG +i Vt++NkeeYv+lv+e+
   Q: 663  FTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDN---DISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKEEYVQLVTEL 748
           **********************************99...************************************************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvT 269
           r+++ i+ q++af +Gf+  ip++l++lF+e elell++G++eidv+d+ k+t+y++gy++++p+iqwFwev+e+++ eer  +LqFvT
   Q: 749  RMTRAIQPQINAFLQGFHMFIPPSLIQLFDEFELELLLSGMPEIDVSDWIKNTEYTSGYERQDPVIQWFWEVVEDITPEERVLLLQFVT 837
           ***************************************************************************************** PP
   S: 270  gssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieet.kg 332
           gssr+P+gGfa+++     + f+i     +++ lP+s+TC+n+LkLPeY+skeilk++Ll+A + +  g
   Q: 838  GSSRVPHGGFANIMggsgLQNFTIAAvPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGsYG 906
           ******************8888888868888********************************986555 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

VYSAIETPWP MRRSCFRPGR VYFESDNETA VYTLMPMVMA DQHRSVSELL SNSKFDVNYA 60
FGRVKRSLLH IAANCGSVEC LVLLLKKGAN PNYQDISGCT PLHLAARNGQ KKCMSKLLEY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTACAGTG CGATTGAAAC TCCGTGGCCC ATGCGCAGAA GTTGTTTTCG GCCTGGGCGA 60
GTCTATTTTG AAGAAGTACT GTTGATATTT GGCTCTGTTG ACTAATGAAT TTGCTGACTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR000569--HECT_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT

Pfam

PF12796--Ank_2
PF00632--HECT

PRINTS

PR01415--ANKYRIN

SMART

SM00248--ANK
SM00119--HECTc

Gene Ontology

GO:0005783--C:endoplasmic reticulum
GO:0000139--C:Golgi membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0007030--P:Golgi organization
GO:0061025--P:membrane fusion
GO:0070936--P:protein K48-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0030334--P:regulation of cell migration

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001490	Ailuropoda melanoleuca	96.70	0.00e+00	1826.00
IUUC-Apl-003400	Anas platyrhynchos	87.26	0.00e+00	1137.00
IUUC-Aca-005375	Anolis carolinensis	88.88	0.00e+00	1672.00
IUUC-Ame-011847	Astyanax mexicanus	83.37	0.00e+00	1589.00
IUUC-Bta-012831	Bos taurus	98.42	0.00e+00	1820.00
IUUC-Cja-019160	Callithrix jacchus	96.80	0.00e+00	1832.00
IUUC-Cfa-020346	Canis familiaris	96.69	0.00e+00	1824.00
IUUC-Cpo-021766	Cavia porcellus	95.37	0.00e+00	1801.00
IUUC-Csa-023768	Chlorocebus sabaeus	96.25	0.00e+00	1821.00
IUUC-Cho-024688	Choloepus hoffmanni	93.37	0.00e+00	1163.00
IUUC-Cin-025417	Ciona intestinalis	50.52	9.00e-138	484.00
IUUC-Csv-025993	Ciona savignyi	42.98	0.00e+00	726.00
IUUC-Dre-027819	Danio rerio	84.66	0.00e+00	1584.00
IUUC-Dno-029027	Dasypus novemcinctus	95.50	0.00e+00	1798.00
IUUC-Dor-030327	Dipodomys ordii	89.82	0.00e+00	1617.00
IUUC-Ete-032966	Echinops telfairi	88.22	0.00e+00	1646.00
IUUC-Eca-034339	Equus caballus	96.58	0.00e+00	1822.00
IUUC-Eeu-034544	Erinaceus europaeus	67.44	0.00e+00	656.00
IUUC-Fca-035617	Felis catus	98.31	0.00e+00	1333.00
IUUC-Fal-036687	Ficedula albicollis	89.04	0.00e+00	1702.00
IUUC-Gmo-039508	Gadus morhua	87.05	0.00e+00	816.00
IUUC-Gga-040845	Gallus gallus	89.26	0.00e+00	1724.00
IUUC-Gac-041894	Gasterosteus aculeatus	84.63	0.00e+00	1556.00
IUUC-Ggo-044465	Gorilla gorilla	92.74	0.00e+00	1751.00
IUUC-Hsa-045731	Homo sapiens	96.47	0.00e+00	1825.00
IUUC-Itr-048716	Ictidomys tridecemlineatus	96.47	0.00e+00	1812.00
IUUC-Lch-050436	Latimeria chalumnae	86.88	0.00e+00	1637.00
IUUC-Loc-052287	Lepisosteus oculatus	83.48	0.00e+00	1606.00
IUUC-Laf-053846	Loxodonta africana	96.59	0.00e+00	1816.00
IUUC-Mcc-055845	Macaca mulatta	96.36	0.00e+00	1823.00
IUUC-Meu-056060	Macropus eugenii	97.98	0.00e+00	706.00
IUUC-Mga-059935	Meleagris gallopavo	91.99	0.00e+00	1727.00
IUUC-Mmr-060960	Microcebus murinus	96.80	0.00e+00	1824.00
IUUC-Mdo-061851	Monodelphis domestica	91.28	0.00e+00	1764.00
IUUC-Mmu-063657	Mus musculus	94.60	0.00e+00	1790.00
IUUC-Mpu-066161	Mustela putorius furo	98.25	0.00e+00	820.00
IUUC-Nle-069112	Nomascus leucogenys	96.36	0.00e+00	1821.00
IUUC-Opr-070686	Ochotona princeps	88.41	0.00e+00	800.00
IUUC-Ont-072398	Oreochromis niloticus	84.02	0.00e+00	1556.00
IUUC-Oan-073194	Ornithorhynchus anatinus	94.75	0.00e+00	1728.00
IUUC-Ocu-074397	Oryctolagus cuniculus	83.88	0.00e+00	1516.00
IUUC-Ola-086777	Oryzias latipes	79.59	0.00e+00	1513.00
IUUC-Oga-088684	Otolemur garnettii	96.69	0.00e+00	1828.00
IUUC-Oar-089428	Ovis aries	95.97	0.00e+00	1779.00
IUUC-Ptr-090529	Pan troglodytes	96.36	0.00e+00	1823.00
IUUC-Pan-091702	Papio anubis	96.25	0.00e+00	1821.00
IUUC-Psi-093969	Pelodiscus sinensis	90.43	0.00e+00	1690.00
IUUC-Pfo-097364	Poecilia formosa	85.04	0.00e+00	1572.00
IUUC-Pab-098574	Pongo abelii	96.47	0.00e+00	1825.00
IUUC-Pca-100525	Procavia capensis	82.25	4.00e-166	578.00
IUUC-Pva-102365	Pteropus vampyrus	85.34	0.00e+00	1561.00
IUUC-Rno-105153	Rattus norvegicus	94.49	0.00e+00	1791.00
IUUC-Sha-107319	Sarcophilus harrisii	91.17	0.00e+00	1758.00
IUUC-Sar-113449	Sorex araneus	81.87	5.00e-177	614.00
IUUC-Ssc-115865	Sus scrofa	96.69	0.00e+00	1823.00
IUUC-Tgu-117225	Taeniopygia guttata	89.04	0.00e+00	1719.00
IUUC-Tru-118026	Takifugu rubripes	82.19	0.00e+00	1535.00
IUUC-Tsy-119407	Tarsius syrichta	83.24	0.00e+00	1516.00
IUUC-Tni-120234	Tetraodon nigroviridis	83.58	0.00e+00	1249.00
IUUC-Tur-126774	Triticum urartu	29.17	6.00e-47	182.00
IUUC-Tbe-127708	Tupaia belangeri	88.87	0.00e+00	882.00
IUUC-Ttr-128667	Tursiops truncatus	96.47	0.00e+00	1822.00
IUUC-Vpa-130200	Vicugna pacos	98.30	0.00e+00	1808.00
IUUC-Xtr-132176	Xenopus tropicalis	85.24	0.00e+00	1643.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence