iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000085415.15	ENST00000262124.15	ENSP00000262124.10
ENSG00000085415.15	ENST00000585730.5	ENSP00000466959.1
ENSG00000085415.15	ENST00000399892.6	ENSP00000382779.1
ENSG00000085415.15	ENST00000589446.5	ENSP00000467276.1
ENSG00000085415.15	ENST00000587761.1	ENSP00000466234.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB
Disease-associated Variation
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	7.70e-21	75.0	11	40

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf..sdtllvsGsdDgtikvWD 29
           H+d +++++f  ++++++++s D ++kvWD
   Q: 11   HKDLIHDVSFdfHGRRMATCSSDQSVKVWD 40
           9*********976599************** PP

Organism

Homo sapiens

Functional Description
(View)

As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex (PubMed:23723238). It is negatively regulated by the upstream amino acid sensors SESN2 and GATSL3 (PubMed:25457612, PubMed:27487210).

Protein Sequence
(Fasta)

MFVARSIAAD HKDLIHDVSF DFHGRRMATC SSDQSVKVWD KSESGDWHCT ASWKTHSGSV 60
WRVTWAHPEF GQVLASCSFD RTAAVWEEIV GESNDKLRGQ SHWVKRTTLV DSRTSVTDVK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTCCCCGG AGGACTCTGG CTCCCGGGTA GCAAGCAGCC CACTTCCCCG GCCGCTTCCT 60
TCCCCCGGGA TGACACGTTT CTACAGGCGG ACTCTTCTAA TTCATACTAT TTCCCTACCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0132--Cell division
KW-0137--Centromere
KW-0158--Chromosome
KW-0159--Chromosome partition
KW-0181--Complete proteome
KW-0995--Kinetochore
KW-0498--Mitosis
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0811--Translocation
KW-0813--Transport
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005829--C:cytosol
GO:0061700--C:GATOR2 complex
GO:0005635--C:nuclear envelope
GO:0031080--C:nuclear pore outer ring
GO:0051315--P:attachment of mitotic spindle microtubules to kinetochore
GO:0051301--P:cell division
GO:0034629--P:cellular protein complex localization
GO:0034198--P:cellular response to amino acid starvation
GO:0002534--P:cytokine production involved in inflammatory response
GO:0050830--P:defense response to Gram-positive bacterium
GO:0031047--P:gene silencing by RNA
GO:0075733--P:intracellular transport of virus
GO:0007080--P:mitotic metaphase plate congression
GO:0007077--P:mitotic nuclear envelope disassembly
GO:0006406--P:mRNA export from nucleus
GO:0006999--P:nuclear pore organization
GO:0032008--P:positive regulation of TOR signaling
GO:1904263--P:positive regulation of TORC1 signaling
GO:0016925--P:protein sumoylation
GO:1900034--P:regulation of cellular response to heat
GO:0010827--P:regulation of glucose transport
GO:0007062--P:sister chromatid cohesion
GO:0006409--P:tRNA export from nucleus
GO:0016032--P:viral process
GO:0019083--P:viral transcription

KEGG

hsa:81929

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001926	Ailuropoda melanoleuca	95.77	0.00e+00	686.00
IUUC-Apl-003654	Anas platyrhynchos	92.45	0.00e+00	694.00
IUUC-Aca-004378	Anolis carolinensis	90.43	7.00e-169	586.00
IUUC-Ago-007816	Ashbya gossypii	34.34	7.00e-50	191.00
IUUC-Ame-011945	Astyanax mexicanus	85.47	4.00e-172	597.00
IUUC-Bta-013306	Bos taurus	98.32	0.00e+00	656.00
IUUC-Cel-018235	Caenorhabditis elegans	42.31	5.00e-75	274.00
IUUC-Cja-018849	Callithrix jacchus	96.21	0.00e+00	756.00
IUUC-Cfa-020841	Canis familiaris	90.78	2.00e-180	627.00
IUUC-Cpo-021379	Cavia porcellus	96.64	0.00e+00	647.00
IUUC-Csa-023900	Chlorocebus sabaeus	98.81	0.00e+00	772.00
IUUC-Cho-024660	Choloepus hoffmanni	94.72	0.00e+00	657.00
IUUC-Cin-025471	Ciona intestinalis	56.48	6.00e-104	370.00
IUUC-Csv-026242	Ciona savignyi	59.76	4.00e-89	320.00
IUUC-Dre-028068	Danio rerio	83.24	1.00e-180	625.00
IUUC-Dno-029981	Dasypus novemcinctus	90.00	0.00e+00	694.00
IUUC-Dme-031763	Drosophila melanogaster	58.15	4.00e-112	397.00
IUUC-Ete-032243	Echinops telfairi	62.36	2.00e-117	415.00
IUUC-Eca-033425	Equus caballus	98.12	2.00e-166	578.00
IUUC-Eeu-035119	Erinaceus europaeus	78.74	2.00e-137	481.00
IUUC-Fca-036520	Felis catus	98.01	0.00e+00	746.00
IUUC-Fal-037234	Ficedula albicollis	94.69	6.00e-176	612.00
IUUC-Gmo-039013	Gadus morhua	86.59	7.00e-178	616.00
IUUC-Gga-041059	Gallus gallus	93.11	0.00e+00	772.00
IUUC-Gac-041337	Gasterosteus aculeatus	86.03	8.00e-173	599.00
IUUC-Ggo-044944	Gorilla gorilla	99.29	0.00e+00	821.00
IUUC-Hvu-047455	Hordeum vulgare	30.70	3.00e-35	142.00
IUUC-Itr-048858	Ictidomys tridecemlineatus	98.75	5.00e-167	580.00
IUUC-Kpa-049201	Komagataella pastoris	36.45	2.00e-50	192.00
IUUC-Lch-050466	Latimeria chalumnae	80.81	0.00e+00	722.00
IUUC-Loc-052773	Lepisosteus oculatus	75.66	2.00e-170	591.00
IUUC-Laf-053409	Loxodonta africana	97.20	0.00e+00	650.00
IUUC-Meu-055958	Macropus eugenii	73.08	4.00e-156	543.00
IUUC-Mga-059348	Meleagris gallopavo	94.97	2.00e-173	601.00
IUUC-Mmr-060977	Microcebus murinus	99.18	3.00e-135	473.00
IUUC-Mdo-061806	Monodelphis domestica	95.81	0.00e+00	682.00
IUUC-Mmu-064328	Mus musculus	97.85	0.00e+00	671.00
IUUC-Mpu-066873	Mustela putorius furo	98.01	0.00e+00	700.00
IUUC-Mlu-067563	Myotis lucifugus	91.60	0.00e+00	644.00
IUUC-Nle-068977	Nomascus leucogenys	99.70	0.00e+00	654.00
IUUC-Opr-070773	Ochotona princeps	67.71	7.00e-118	417.00
IUUC-Ont-072644	Oreochromis niloticus	86.87	9.00e-178	615.00
IUUC-Oan-073098	Ornithorhynchus anatinus	95.03	3.00e-166	577.00
IUUC-Ocu-073911	Oryctolagus cuniculus	96.45	0.00e+00	789.00
IUUC-Ola-087096	Oryzias latipes	85.48	1.00e-180	625.00
IUUC-Oga-088798	Otolemur garnettii	98.32	0.00e+00	701.00
IUUC-Oar-090298	Ovis aries	97.52	1.00e-167	585.00
IUUC-Ptr-091074	Pan troglodytes	99.44	0.00e+00	708.00
IUUC-Pan-092013	Papio anubis	100.00	1.00e-142	498.00
IUUC-Psi-093508	Pelodiscus sinensis	93.75	5.00e-173	600.00
IUUC-Pma-094288	Petromyzon marinus	83.81	2.00e-103	367.00
IUUC-Ppa-095228	Physcomitrella patens	32.39	3.00e-37	149.00
IUUC-Pfo-096384	Poecilia formosa	85.75	1.00e-175	609.00
IUUC-Pab-098629	Pongo abelii	99.72	0.00e+00	708.00
IUUC-Pca-100322	Procavia capensis	72.35	9.00e-135	473.00
IUUC-Pva-102861	Pteropus vampyrus	97.76	0.00e+00	722.00
IUUC-Rno-104895	Rattus norvegicus	85.41	0.00e+00	657.00
IUUC-Sce-106420	Saccharomyces cerevisiae	34.76	3.00e-54	205.00
IUUC-Sha-106829	Sarcophilus harrisii	90.28	0.00e+00	633.00
IUUC-Sja-107923	Schizosaccharomyces japonicus	40.00	1.00e-66	246.00
IUUC-Spo-108184	Schizosaccharomyces pombe	38.44	2.00e-64	239.00
IUUC-Smo-109282	Selaginella moellendorffii	33.76	1.00e-37	150.00
IUUC-Sar-113279	Sorex araneus	97.01	0.00e+00	644.00
IUUC-Sbi-114110	Sorghum bicolor	30.34	2.00e-36	146.00
IUUC-Ssc-115589	Sus scrofa	95.64	2.00e-175	607.00
IUUC-Tgu-117523	Taeniopygia guttata	92.64	0.00e+00	768.00
IUUC-Tru-117985	Takifugu rubripes	81.69	5.00e-158	553.00
IUUC-Tsy-118913	Tarsius syrichta	96.74	0.00e+00	686.00
IUUC-Tni-120670	Tetraodon nigroviridis	86.11	3.00e-177	613.00
IUUC-Tae-122796	Triticum aestivum	30.38	9.00e-35	140.00
IUUC-Tme-126885	Tuber melanosporum	36.69	9.00e-56	210.00
IUUC-Tbe-127344	Tupaia belangeri	81.00	1.00e-169	588.00
IUUC-Ttr-128347	Tursiops truncatus	97.00	0.00e+00	644.00
IUUC-Vpa-130656	Vicugna pacos	92.60	6.00e-178	616.00
IUUC-Xtr-132736	Xenopus tropicalis	91.34	0.00e+00	650.00
IUUC-Xma-133678	Xiphophorus maculatus	86.03	1.00e-176	612.00
IUUC-Yli-134659	Yarrowia lipolytica	40.62	6.00e-63	234.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence