iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-045760

Ensembl Protein ID

ENSP00000366434.4

UniProt Accession

Q96RL1; A8MSA1; B3KMZ1; B4E3N2; Q5XKQ1; Q7Z3W7; Q8N5B9; Q9BZR1; Q9BZR5; Q9UHX7; UIMC1_HUMAN

Genbank Protein ID

AAK61871.1; AAF14875.1; AAG59851.1; AAG59855.1; BAG51153.1; BAG65544.1; CAD97618.1; AAH06078.1; AAH32561.1

Protein Name

BRCA1-A complex subunit RAP80; Receptor-associated protein 80; Retinoid X receptor-interacting protein 110; Ubiquitin interaction motif-containing protein 1

Genbank Nucleotide ID

AF349313; AF113538; AF284749; AF284753; AK023044; AK304794; BX537376; AC027318; BC032561

Gene Name

UIMC1; RAP80; RXRIP110

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000087206.16	ENST00000377227.8	ENSP00000366434.4
ENSG00000087206.16	ENST00000506128.5	ENSP00000427480.1
ENSG00000087206.16	ENST00000512031.5	ENSP00000425566.1
ENSG00000087206.16	ENST00000510698.2	ENSP00000423717.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	microRNA	TRANSFAC	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UIM	UIM	17311814; 17525341; 17525342

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UIM	2.60e-05	25.4	105	123
UBD/Alpha-Helix/UIM	0.00025	13.2	80	98

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           +E+e+L++A+a+Sl+ ++ 
   Q: 105  EEEELLRKAIAESLNSCRP 123
           7*************99875 PP

UBD/Alpha-Helix/UIM

   S: 1    dEdeeLqlAlalSlqEeee 19
           +E+e+++lAl +S qE++e
   Q: 80   TEEEQFALALKMSEQEARE 98
           59**************986 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin-binding protein (PubMed:24627472). Specifically recognizes and binds 'Lys-63'-linked ubiquitin (PubMed:19328070, Ref.36). Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.

Protein Sequence
(Fasta)

MPRRKKKVKE VSESRNLEKK DVETTSSVSV KRKRRLEDAF IVISDSDGEE PKEENGLQKT 60
KTKQSNRAKC LAKRKIAQMT EEEQFALALK MSEQEAREVN SQEEEEEELL RKAIAESLNS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGCACCCG CGCTGCCGTG CGGGACCCCG CGCTTATTTT GCTTTGCTAC CTCTGGTACC 60
TCAGAGCGTG TGCCGTGGAT TCGGAAACCT GTCGCTGATT CCGCAGCAGT GACCCCCCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation

Interpro

IPR003903--UIM_dom

PROSITE

PS50330--UIM

SMART

SM00726--UIM

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0042393--F:histone binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0006302--P:double-strand break repair
GO:0006303--P:double-strand break repair via nonhomologous end joining
GO:0031572--P:G2 DNA damage checkpoint
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0045739--P:positive regulation of DNA repair
GO:0016579--P:protein deubiquitination
GO:0010212--P:response to ionizing radiation
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:51720

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002335	Ailuropoda melanoleuca	86.84	0.00e+00	1093.00
IUUC-Apl-003971	Anas platyrhynchos	45.11	2.00e-97	349.00
IUUC-Aca-004239	Anolis carolinensis	42.76	3.00e-112	399.00
IUUC-Ame-011593	Astyanax mexicanus	49.37	9.00e-19	89.40
IUUC-Bta-012883	Bos taurus	84.53	0.00e+00	1165.00
IUUC-Cja-018904	Callithrix jacchus	91.56	0.00e+00	1093.00
IUUC-Cfa-021279	Canis familiaris	87.29	0.00e+00	1191.00
IUUC-Cpo-021857	Cavia porcellus	83.22	0.00e+00	1125.00
IUUC-Cre-022873	Chlamydomonas reinhardtii	25.00	2.50e+00	28.10
IUUC-Csa-023278	Chlorocebus sabaeus	96.31	0.00e+00	1288.00
IUUC-Cho-025002	Choloepus hoffmanni	88.68	2.00e-121	430.00
IUUC-Dre-028822	Danio rerio	61.40	6.00e-20	93.20
IUUC-Dno-029930	Dasypus novemcinctus	84.77	0.00e+00	1093.00
IUUC-Dor-031008	Dipodomys ordii	73.38	1.00e-170	593.00
IUUC-Ete-032370	Echinops telfairi	74.23	0.00e+00	948.00
IUUC-Eca-033353	Equus caballus	86.49	0.00e+00	845.00
IUUC-Eeu-034724	Erinaceus europaeus	68.78	0.00e+00	785.00
IUUC-Fca-035721	Felis catus	87.08	0.00e+00	1181.00
IUUC-Fal-036888	Ficedula albicollis	44.09	3.00e-113	402.00
IUUC-Gga-040932	Gallus gallus	39.17	1.00e-63	238.00
IUUC-Ggo-045465	Gorilla gorilla	98.44	0.00e+00	1318.00
IUUC-Itr-048407	Ictidomys tridecemlineatus	91.81	1.00e-166	579.00
IUUC-Lch-050225	Latimeria chalumnae	34.75	1.00e-80	294.00
IUUC-Loc-052879	Lepisosteus oculatus	30.10	6.00e-38	151.00
IUUC-Laf-053871	Loxodonta africana	82.84	0.00e+00	1053.00
IUUC-Mcc-055478	Macaca mulatta	96.30	0.00e+00	1285.00
IUUC-Meu-056617	Macropus eugenii	49.67	1.00e-128	453.00
IUUC-Mor-057086	Magnaporthe oryzae	45.10	1.70e-02	32.00
IUUC-Mga-059771	Meleagris gallopavo	44.35	7.00e-92	331.00
IUUC-Mmr-061450	Microcebus murinus	87.11	0.00e+00	1134.00
IUUC-Mdo-061927	Monodelphis domestica	55.25	0.00e+00	644.00
IUUC-Mmu-063821	Mus musculus	75.81	0.00e+00	983.00
IUUC-Mpu-065921	Mustela putorius furo	87.62	0.00e+00	1063.00
IUUC-Mlu-067296	Myotis lucifugus	83.36	0.00e+00	1066.00
IUUC-Nle-069257	Nomascus leucogenys	97.72	0.00e+00	1301.00
IUUC-Opr-071016	Ochotona princeps	72.99	0.00e+00	907.00
IUUC-Ont-071282	Oreochromis niloticus	32.49	1.00e-19	91.70
IUUC-Ocu-074580	Oryctolagus cuniculus	86.51	0.00e+00	1156.00
IUUC-Olo-080293	Oryza longistaminata	33.33	1.30e-02	33.10
IUUC-Oga-088521	Otolemur garnettii	85.26	0.00e+00	1127.00
IUUC-Ptr-091227	Pan troglodytes	98.44	0.00e+00	1320.00
IUUC-Pan-092193	Papio anubis	92.11	0.00e+00	1266.00
IUUC-Pfo-096691	Poecilia formosa	62.50	2.00e-18	88.20
IUUC-Pab-098460	Pongo abelii	96.17	0.00e+00	1293.00
IUUC-Pca-100892	Procavia capensis	73.52	0.00e+00	971.00
IUUC-Pva-102816	Pteropus vampyrus	83.46	0.00e+00	1008.00
IUUC-Rno-105049	Rattus norvegicus	71.10	0.00e+00	930.00
IUUC-Sha-106502	Sarcophilus harrisii	54.61	5.00e-154	538.00
IUUC-Sar-113108	Sorex araneus	66.45	4.00e-142	498.00
IUUC-Ssc-115306	Sus scrofa	85.45	0.00e+00	1104.00
IUUC-Tgu-116746	Taeniopygia guttata	45.71	3.00e-92	332.00
IUUC-Tsy-119018	Tarsius syrichta	62.98	5.00e-168	584.00
IUUC-Tbe-127389	Tupaia belangeri	83.96	0.00e+00	650.00
IUUC-Ttr-128880	Tursiops truncatus	80.13	2.00e-139	489.00
IUUC-Xtr-132854	Xenopus tropicalis	34.32	2.00e-72	266.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence