iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000088808.16	ENST00000557587.1	ENSP00000451433.1
ENSG00000088808.16	ENST00000202556.13	ENSP00000202556.9
ENSG00000088808.16	ENST00000556597.1	ENSP00000451739.1
ENSG00000088808.16	ENST00000557082.5	ENSP00000451396.1
ENSG00000088808.16	ENST00000553739.2	ENSP00000450734.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM	SZDB
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Variation
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.80e-11	45.4	1023	1074

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlvi.ekeeqdegWlkgvkelegkrGlfPen 57
           +  +l+dyeaqn+deL++++Gd ++++  k+e + +W+ +   l  ++G +P+n
   Q: 1023 VAYALWDYEAQNSDELSFHEGDALTILrRKDESETEWWWA--RLGDREGYVPKN 1074
           5679***********************99*********99..8**********9 PP

Organism

Homo sapiens

Functional Description
(View)

Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.

Protein Sequence
(Fasta)

MMPMILTVFL SNNEQILTEV PITPETTCRD VVEFCKEPGE GSCHLAEVWR GNERPIPFDH 60
MMYEHLQKWG PRREEVKFFL RHEDSPTENS EQGGRQTQEQ RTQRNVINVP GEKRTENGVG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGCGGGCGG GCCGCAGGCT GTCGGGCTGG GGCTGAGGCT GAGGCTGAGG TTGAGGCGGC 60
GGCGGCGGCG GCCGGGTGCC CGGGACAGCG ACGCAGCGCG CCGGCGGCCG CGACAGGGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0040--ANK repeat
KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain

Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR028319--ASPP_1
IPR001452--SH3_domain
IPR029071--Ubiquitin-rel_dom

PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50002--SH3

Pfam

PF12796--Ank_2
PF00018--SH3_1

PRINTS

PR00452--SH3DOMAIN

SMART

SM00248--ANK
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0072332--P:intrinsic apoptotic signaling pathway by p53 class mediator
GO:0045786--P:negative regulation of cell cycle
GO:1901216--P:positive regulation of neuron death
GO:1900740--P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0042981--P:regulation of apoptotic process
GO:1901796--P:regulation of signal transduction by p53 class mediator

KEGG

hsa:23368

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001642	Ailuropoda melanoleuca	90.59	0.00e+00	1831.00
IUUC-Apl-004077	Anas platyrhynchos	79.98	0.00e+00	1577.00
IUUC-Aca-004550	Anolis carolinensis	69.80	0.00e+00	1447.00
IUUC-Ame-011289	Astyanax mexicanus	62.59	0.00e+00	646.00
IUUC-Bta-012477	Bos taurus	89.42	0.00e+00	1691.00
IUUC-Cel-018245	Caenorhabditis elegans	50.28	1.00e-52	201.00
IUUC-Cja-019672	Callithrix jacchus	97.52	0.00e+00	1873.00
IUUC-Cfa-020703	Canis familiaris	91.48	0.00e+00	1792.00
IUUC-Cpo-022364	Cavia porcellus	90.93	0.00e+00	1768.00
IUUC-Csa-023051	Chlorocebus sabaeus	98.35	0.00e+00	1906.00
IUUC-Dre-028211	Danio rerio	59.39	0.00e+00	1174.00
IUUC-Dor-030295	Dipodomys ordii	82.92	0.00e+00	1125.00
IUUC-Eca-033910	Equus caballus	92.67	0.00e+00	1771.00
IUUC-Eeu-035287	Erinaceus europaeus	80.82	0.00e+00	1360.00
IUUC-Fca-035913	Felis catus	91.20	0.00e+00	1778.00
IUUC-Fal-036698	Ficedula albicollis	80.42	0.00e+00	1574.00
IUUC-Gga-041256	Gallus gallus	76.00	0.00e+00	1556.00
IUUC-Gac-041539	Gasterosteus aculeatus	64.41	0.00e+00	645.00
IUUC-Ggo-045619	Gorilla gorilla	99.45	0.00e+00	1812.00
IUUC-Itr-048178	Ictidomys tridecemlineatus	83.32	0.00e+00	1634.00
IUUC-Lch-050122	Latimeria chalumnae	74.45	0.00e+00	1522.00
IUUC-Loc-052306	Lepisosteus oculatus	57.26	0.00e+00	743.00
IUUC-Laf-053834	Loxodonta africana	89.62	0.00e+00	1721.00
IUUC-Mcc-055785	Macaca mulatta	98.17	0.00e+00	1870.00
IUUC-Meu-056089	Macropus eugenii	71.76	5.00e-150	525.00
IUUC-Mga-059590	Meleagris gallopavo	79.23	0.00e+00	1436.00
IUUC-Mmr-060975	Microcebus murinus	94.50	0.00e+00	1790.00
IUUC-Mdo-062632	Monodelphis domestica	81.50	0.00e+00	1665.00
IUUC-Mmu-064285	Mus musculus	91.83	0.00e+00	1831.00
IUUC-Mpu-066414	Mustela putorius furo	90.10	0.00e+00	1758.00
IUUC-Mlu-068059	Myotis lucifugus	85.71	0.00e+00	1709.00
IUUC-Opr-070603	Ochotona princeps	84.78	0.00e+00	1461.00
IUUC-Ont-072410	Oreochromis niloticus	62.20	0.00e+00	651.00
IUUC-Ocu-074964	Oryctolagus cuniculus	88.32	0.00e+00	1691.00
IUUC-Ola-087385	Oryzias latipes	61.59	0.00e+00	1082.00
IUUC-Oga-088492	Otolemur garnettii	92.31	0.00e+00	1825.00
IUUC-Ptr-091354	Pan troglodytes	99.45	0.00e+00	1875.00
IUUC-Pan-092354	Papio anubis	98.17	0.00e+00	1870.00
IUUC-Psi-093223	Pelodiscus sinensis	80.18	0.00e+00	1607.00
IUUC-Pfo-097053	Poecilia formosa	70.71	9.00e-150	525.00
IUUC-Pab-097758	Pongo abelii	99.16	0.00e+00	1160.00
IUUC-Pca-100736	Procavia capensis	84.51	0.00e+00	748.00
IUUC-Pva-102307	Pteropus vampyrus	85.10	0.00e+00	1605.00
IUUC-Rno-105716	Rattus norvegicus	91.90	0.00e+00	1756.00
IUUC-Sha-107553	Sarcophilus harrisii	81.70	0.00e+00	1573.00
IUUC-Ssc-115833	Sus scrofa	80.97	0.00e+00	1398.00
IUUC-Tgu-116995	Taeniopygia guttata	80.70	0.00e+00	1578.00
IUUC-Tru-117861	Takifugu rubripes	60.09	0.00e+00	1158.00
IUUC-Tni-120130	Tetraodon nigroviridis	64.98	0.00e+00	666.00
IUUC-Tbe-127866	Tupaia belangeri	90.50	0.00e+00	1117.00
IUUC-Xtr-132886	Xenopus tropicalis	72.67	0.00e+00	1429.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence